Prostamol Uno: instructions for use, analogues. Price and reviews of the medicine

Pharmacodynamics and pharmacokinetics

The drug inhibits the formation of prostaglandins , which are responsible for the occurrence and development of the inflammatory process of the prostate gland and reduces vascular permeability.

Inhibits 5-alpha reductase , which is responsible for converting testosterone into dehydrotestosterone and increasing the size of the inflamed organ. Thus, Prostamol Uno has an antiandrogenic effect.

pharmachologic effect

Pharmacological action - antiexudative, antiandrogenic, anti-inflammatory.

Inhibits the synthesis of dihydrotestosterone (due to blockade of 5-alpha reductase types I and II) and its fixation to cytosolic receptors, which prevents the penetration of the hormone into the nucleus and leads to a decrease in protein synthesis. Reduces the formation of dihydrotestosterone and phospholipase A2 and the release of arachidonic acid, reduces the synthesis of PGs, which regulate the tone and peristalsis of the lower urinary tract. It has a vasoprotective and anti-inflammatory effect, reduces vascular permeability. Antiandrogenic and vasoprotective actions help reduce the symptoms of benign prostatic hypertrophy.

Analogues of Prostamol Uno

Level 4 ATC code matches: Trianol
Prostagut Forte

Reviews of Prostamol Uno

Reviews from doctors : The effectiveness of the drug increases when taken simultaneously with other drugs. Adverse reactions occur rarely. Often, 2 or more courses of medication must be taken to achieve a therapeutic effect.

Reviews on forums : few positive. The drug is effective only with long-term use and in combination with other medications. Some write that the pills don’t help at all or don’t help much. Often, together with the tablet form of the drug for the treatment of prostate diseases, suppositories with a high content of other medicinal components are used. The price of suppositories is often higher than tablets. Therefore, many patients consider taking Prostamol Uno inappropriate.

Prostamol Uno 320 mg No. 60 caps.

Instructions for medical use of the drug ProstamolÒ Uno Trade name ProstamolÒ Uno International nonproprietary name No Dosage form Capsule 320 mg Composition One capsule contains the active substance - alcoholic extract of Serenoa repens (9-11: 1) 320 mg excipients: shell composition: succinylated gelatin, glycerin , titanium dioxide (E 171), black iron oxide (E 172), cochineal red A 80% (E 124), purified water. Description Soft gelatin capsules are oval in shape, with an opaque two-color red/black shell. The contents of the capsule are a greenish-brown liquid with a characteristic odor. Pharmacotherapeutic group Drugs for the treatment of urological diseases. Drugs for the treatment of benign prostatic hypertrophy. Other drugs for the treatment of benign prostatic hypertrophy. Palm creeping drug. ATC code G04CX02 Pharmacological properties Pharmacokinetics The extract of the fruits of the creeping palm tree (Serenoa repens) is quickly absorbed. After oral administration, maximum plasma concentrations are achieved after approximately 1.5 hours. No other information regarding pharmacokinetics is available. Pharmacodynamics The extract of the fruits of the creeping palm tree (Serenoa repens), also known as a synonym for the fruits of the small serrata (Sabalis serrulatae), has antiproliferative, antiandrogenic, anti-inflammatory, and decongestant effects that are selectively manifested at the level of the prostate gland. The drug does not affect the level of sex hormones in the blood plasma, does not affect potency and libido, and does not change the level of prostate-specific antigen in the blood plasma. The local antiproliferative effect of the drug is manifested by a decrease in the activity of growth factors (primarily epidermal and fibroblastic), inhibition of the binding of prolactin receptors with subsequent disruption of signal transmission processes in prostate cells and acceleration of the processes of apoptosis of prostate cells, which is reflected in the inhibition of prostate volume growth. The mechanism of local antiandrogenic action is due to inhibition of the synthesis of dihydrotestosterone from testosterone (due to inhibition of the enzyme 5-alpha reductase types I and II) and its fixation to the cytosolic receptors of prostate cells, which prevents the penetration of the hormone into the nucleus. As a result, protein synthesis decreases. The mechanism of local anti-inflammatory action is due to the fact that the extract of the fruits of the creeping palm tree (Serenoa repens) inhibits the activity of phospholipase A2, 5-lipoxygenase and the release of arachidonic acid, thereby reducing the synthesis of prostaglandins and leukotrienes, which are mediators of inflammation. Prostamol® Uno reduces capillary permeability and vascular stasis, reduces swelling and inflammation in the prostate, eliminates compression of the bladder neck and urinary canal, improving urodynamics. The drug Prostamol® Uno helps to reduce the severity of pathological symptoms of benign prostatic hyperplasia (dysuria, pollakiuria, nocturia, pain and a feeling of tension when urinating, incomplete emptying of the bladder), increasing the volume and force of urination. With the use of the drug, further growth and increase in the volume of the prostate gland slows down. Indications for use: impaired urination in benign prostatic hyperplasia stages I and II; elimination of dysuric symptoms (urinary disorder, nocturnal pollakiuria, pain, etc.) in chronic prostatitis. Method of administration and dosage Prostamol® Uno should be taken 1 capsule (320 mg) once a day after meals, without chewing, with a sufficient amount of liquid, at the same time of day (preferably in the evening). The duration of use depends on the type, severity and course of the disease and is not limited in time. Relief of symptoms can be expected after approximately six weeks. Full effectiveness is achieved no earlier than three months. If complaints do not decrease or intensify, you should consult a doctor. Side effects Rarely - discomfort from the gastrointestinal tract (nausea, abdominal pain). - allergic reactions to cochineal red dye A. Contraindications - hypersensitivity to the active substance, cochineal red dye A (E124) or other excipients. Drug interactions Interactions with other drugs are not known. Special instructions Prostamoluno does not affect sexual function. Prostamoluno only weakens the symptoms of prostate enlargement, without eliminating the enlargement itself. Therefore, the patient should regularly visit the doctor, especially if hematuria or acute urinary retention occurs. The drug is not used in pediatrics. Peculiarities of the drug's influence on the ability to drive a vehicle or potentially dangerous machinery. It has no effect. Overdose No cases of overdose have been reported so far. Symptoms: increased side effects Treatment: symptomatic. Release form and packaging 15 capsules in a blister pack made of polyvinyl chloride film, coated with a layer of polyvinylidene chloride, and aluminum foil welded to it. 2 or 4 contour packages together with instructions for medical use in the state and Russian languages are placed in a cardboard pack. Storage conditions Store at a temperature not exceeding 30°C. Keep out of the reach of children! Shelf life: 3 years Do not use after the expiration date indicated on the package. Conditions for dispensing from pharmacies Without a prescription Manufacturer Berlin Chemie AG (Menarini Group), Glinker Weg 125 12489 Berlin, Germany Registration certificate holder Berlin Chemie AG (Menarini Group), Germany Address of the organization that accepts claims from consumers regarding product quality in the territory of the Republic of Kazakhstan (product): Representative office of JSC Berlin-Chemie AG in the Republic of Kazakhstan Tel.: +7 727 2446183, 2446184, 2446185 Fax: +7 727 2446180 Email address

Prostamol Uno price, where to buy

The price of tablets in Ukraine is about 142 UAH for 30 tablets. You can buy 60 tablets for 275 UAH.

How much does Prostamol cost in Russia? Price 30 capsules – 633 rubles, 60 – 1047 rubles.

Online pharmacies in RussiaRussia
Online pharmacies in UkraineUkraine
Online pharmacies in KazakhstanKazakhstan

ZdravCity

Prostamol Uno capsules 320 mg 60 pcs. Catalent Germany Eberbach GmbH/ZAO Berlin-Pharma
1425 rub. order
Prostamol Uno capsules 320 mg 30 pcs. Catalent Germany Eberbach GmbH/ZAO Berlin-Pharma
RUB 832 order
Prostamol Uno capsules 320 mg 90 pcs. Catalent Germany Eberbach GmbH/ZAO Berlin-Pharma
RUR 2,030 order

Pharmacy Dialogue

Prostamol Uno (caps. 320 mg No. 30)Berlin-Chemie AG/Menarini
RUB 837 order
Prostamol Uno (caps. 320 mg No. 60) Berlin-Chemie AG/Berlin-Pharma ZAO
RUB 1,372 order
Prostamol Uno (caps. 320 mg No. 60)Berlin-Chemie AG/Menarini
RUB 1,383 order
Prostamol Uno (caps. 320 mg No. 90)Berlin-Chemie AG/Menarini
RUB 1,866 order

Pharmacy24

Prostamol Uno No. 30 capsules Berlin Chemi AG, Nimechchina
251 UAH.order
Prostamol Uno No. 60 capsules R.P.Scherer GmbH i Co. KG/Berlin Chemie AG (Menarini Group), Nimecchina/Nimecchina
496 UAH. order

PaniPharmacy

Prostamol uno capsule Prostamol uno capsule. 320 mg No. 30 Germany, Berlin-Chemie
276 UAH. order
Prostamol uno capsule Prostamol uno capsule. 320 mg No. 60 Germany, Berlin-Chemie
561 UAH order

Prostamol uno 320 mg 30 pcs. capsules

pharmachologic effect

Herbal remedy for benign prostate hyperplasia.

Composition and release form Prostamol uno 320 mg 30 pcs. capsules

Capsules - 1 capsule:

Active ingredient: Alcohol extract of the fruits of the creeping palm tree (9-11:1) - 320 mg;
Capsule shell: succinylated gelatin - 120.20 - 141.11 mg, glycerol - 45.20 - 53.07 mg, purified water - 7.98 - 9.36 mg, titanium dioxide - 0.65 - 0.77 mg, iron oxide black dye - 0.78 - 0.92 mg, crimson dye [Ponceau 4R] - 1.05 - 1.23 mg.

15 capsules per blister (PVC/PVDC/aluminum foil).

1, 2, 4 or 6 blisters with instructions for use in a cardboard box.

Description of the dosage form

Oval, soft, gelatin capsules with an opaque two-color red and black shell. Capsule contents: greenish-brown liquid with a characteristic odor.

Directions for use and doses

The drug Prostamol® Uno is used 1 capsule (320 mg) 1 time per day at the same time, after meals, without chewing, with a sufficient amount of liquid. The duration of the course of treatment is not limited in time. The recommended duration of therapy is at least three months.

Pharmacodynamics

The extract of the fruits of the creeping palm (Serenoa repens) has antiproliferative, antiandrogenic, anti-inflammatory, and decongestant effects that selectively manifest themselves at the level of the prostate gland. At the same time, the drug does not affect the level of sex hormones in the blood plasma, does not affect potency and libido, and does not change the level of prostate-specific antigen in the blood plasma.

The local antiproliferative effect of the drug is manifested by a decrease in the activity of growth factors (primarily epidermal and fibroblastic), inhibition of the binding of prolactin receptors with subsequent disruption of signal transmission processes in prostate cells and acceleration of the processes of apoptosis of prostate cells, which is reflected in the inhibition of prostate volume growth.

The mechanism of local antiandrogenic action is due to inhibition of the synthesis of dihydrotestosterone from testosterone (due to inhibition of the enzyme 5-alpha reductase types I and II) and its fixation to the cytosolic receptors of prostate cells, which prevents the penetration of the hormone into the nucleus. As a result, protein synthesis decreases.

The mechanism of local anti-inflammatory action is due to the fact that the extract of the fruits of the creeping palm tree (Serenoa repens) inhibits the activity of phospholipase A2, 5-lipoxygenase and the release of arachidonic acid, thereby reducing the synthesis of prostaglandins and leukotrienes, which are mediators of inflammation. Prostamol® Uno reduces capillary permeability and vascular stasis, reduces swelling and inflammation in the prostate, eliminates compression of the bladder neck and urinary canal, improving urodynamics.

Thus, the drug Prostamol® Uno helps, on the one hand, to reduce the severity of pathological symptoms of benign prostatic hyperplasia (dysuria, pollakiuria, nocturia, pain and a feeling of tension when urinating, incomplete emptying of the bladder), increasing the volume and force of urination. On the other hand, the use of the drug slows down further growth and increase in the volume of the prostate gland.

Pharmacokinetics

Palm tree (Serenoa repens) fruit extract is quickly absorbed. After oral administration, maximum plasma concentrations are achieved after approximately 1.5 hours.

Indications for use Prostamol uno 320 mg 30 pcs. capsules

Benign prostatic hyperplasia (stages I and II).

Elimination of dysuric symptoms (urinary disorder, nocturnal pollakiuria, pain syndrome, etc.) in chronic prostatitis.

Contraindications

Individual intolerance to the components of the drug.

Application Prostamol uno 320 mg 30 pcs. capsules during pregnancy and breastfeeding

The drug is not prescribed to women and children.

special instructions

Prostamol® Uno reduces the severity of symptoms of an enlarged prostate gland, without eliminating its enlarged size. Prevents further growth of prostate tissue. Prostamol® Uno does not affect sexual function.

Impact on the ability to drive vehicles and operate machinery

Prostamol® Uno does not affect the ability to drive vehicles or work requiring increased concentration.

Overdose

There have been no cases of overdose of Prostamol® Uno.

Side effects Prostamol uno 320 mg 30 pcs. capsules

Allergic reactions to the components of the drug are possible. In rare cases, discomfort from the gastrointestinal tract: nausea, heartburn (when taken on an empty stomach).

Drug interactions

No interactions with other medicinal substances have been identified.