Composition and features
Vitamin C in effervescent form is available in the form of large flat tablets of yellow, pink or orange color, without shells, with a rough surface, with the taste of berries, lemon or orange. One or both sides may be marked “C” and indicate the dosage of ascorbic acid. Pills have a dosage of 250 to 1200 mg, packaged in cylindrical plastic tubes with caps of 10–20 or more pieces. In addition to the active substance, the effervescent drug contains:
- sodium salts;
- lemon acid;
- flavorings;
- sugar or sweeteners;
- formative additives.
The main purpose of effervescent vitamin C is to quickly restore the deficiency of the substance in the body and prevent various pathologies.
Note!
Description of the drug Vitamin C table. chewing 500 mg orange No. 10 on this page is a simplified author’s version of the apteka911 website, created on the basis of the instructions for use.
Before purchasing or using the drug, you should consult your doctor and read the manufacturer's original instructions (attached to each package of the drug). Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide to prescribe the drug, as well as determine the dose and methods of its use.
Mechanism of action of the drug
Ascorbic acid is involved in almost all metabolic processes, redox reactions, synthesis and absorption of other vitamins, transformation of glucose, fats and protein. Vitamin C has a powerful antioxidant effect, regulates blood circulation, is responsible for the permeability of cell membranes, the integrity of vascular walls, and the health of mucous membranes and skin. Its deficiency leads to weakening of cellular and humoral immunity, insufficient function of the liver, kidneys, thyroid gland, heart, kidneys, deterioration of muscle tissue, disruption of hormone production, formation of red blood cells, and increases the risk of thrombosis.
Vitamin C is consumed daily in large quantities, is not synthesized or accumulated in the body, and comes only from the outside. Its costs increase with stress, infectious and other diseases, with smoking, heavy physical activity, taking potent medications, during the period of active development, during pregnancy and lactation. Therefore, deficiency occurs quite often, and hypervitaminosis is extremely rare. The main reason for the lack of ascorbic acid is poor nutrition. Vitamin C is concentrated in fresh fruits and greens, but is easily destroyed during long-term storage and heat treatment of products.
Pharmaceutical preparations are additional sources of ascorbic acid. The effervescent form of the vitamin in the form of a liquid solution ensures almost instantaneous absorption into the blood from the intestines. Then the substance penetrates the tissues of all internal organs and biological fluids. Excess ascorbic acid is filtered by the kidneys and excreted in the urine.
Adverse reactions
Vitamin C is well tolerated in recommended doses, but the following adverse reactions may occur:
- from the digestive tract: when used in a dose of more than 1000 mg/day - irritation of the mucous membrane of the digestive tract, heartburn, nausea, vomiting, diarrhea, stomach cramps;
- from the urinary system: damage to the glomerular apparatus of the kidneys, renal failure, crystalluria, formation of urate, cystine and oxalate stones in the kidneys and urinary tract;
- allergic reactions: sometimes - eczema, urticaria, itching, skin rash, angioedema, anaphylactic shock in the presence of sensitization;
- from the endocrine system: damage to the insular apparatus of the pancreas (hyperglycemia, glucosuria) and impaired glycogen synthesis up to the onset of diabetes mellitus;
- from the cardiovascular system: arterial hypertension, myocardial dystrophy.
When is the drug indicated?
Vitamin C in effervescent form is recommended:
- in complex therapy of viral diseases, as their prevention;
- to eliminate and prevent ascorbic acid deficiency: in case of nutritional disorders, pregnancy, increased stress on the body, stress;
- for various types of hypovitaminosis: for complete absorption of other vitamins;
- during the recovery period after severe pathologies, to prevent complications;
- for the treatment of asthenic conditions;
- to strengthen the immune system;
- in complex treatment: for cardiac, endocrine diseases, circulatory disorders, hormonal imbalance, obesity, menstrual irregularities.
Tablets with a dosage of 250 and 500 mg. recommended for preventive purposes. To compensate for acute vitamin deficiency and treatment, it is optimal to take the drug 900–1200 mg.
Contraindications and side effects
Effervescent vitamin C should not be used for inflammatory and erosive diseases of the gastrointestinal tract:
- peptic ulcer;
- gastritis, gastroduodenitis;
- pancreatitis;
- irritable bowel syndrome;
- ulcerative colitis.
Caution is necessary in case of impaired renal function. Tablets containing sugar may be contraindicated in diabetes. The drug is in a dosage of 1000 mg. Not recommended for use by children under 18 years of age. Another contraindication: individual intolerance to the components.
During treatment with effervescent vitamin C, belching, nausea, heartburn, pain in the stomach, and increased gas formation are likely to occur. When consuming large doses, insomnia, rapid heartbeat, bloating, and diarrhea may occur. To eliminate discomfort, you should increase the volume of fluid you drink.
Effervescent tablets should not be combined with aspirin, other NSAIDs, or oral contraceptives. The effectiveness of ascorbic acid is also reduced when washed down with alkaline drinks and mineral water. Under the influence of the vitamin, the activity of the adrenal glands increases, so it is important to adjust the doses of glucocorticoid hormones taken, as well as control blood pressure.
Contraindications
Hypersensitivity to ascorbic acid and other components of the drug.
Predisposition to thrombosis; thrombophlebitis; diabetes; urolithiasis disease.
Children's age up to 14 years.
Particular caution should be used in patients with impaired iron metabolism (hemosiderosis, hemochromatosis, thalassemia).
Fructose intolerance; glucose/galactose malabsorption syndrome.
Severe kidney disease. Phenylketonuria (since the drug contains aspartame).
How to take effervescent vitamin C
The pharmaceutical drug is prescribed in courses lasting 10–15 days. Before use, one vitamin tablet is diluted in warm or cool water: about 200 ml, then drunk after meals, preferably in the morning. You should not dissolve such pills in your mouth or try to dissolve them in food, carbonated drinks, or coffee.
Vitamin 900–1200 mg is taken once a day. Tablets with a dosage of 250–500 mg. drink 1–2 times a day with a break of 5–8 hours. If necessary, a more precise regimen is recommended by the attending physician. If heartburn, bloating, abdominal pain, or bowel dysfunction occurs, you must stop taking it and choose a different form of the vitamin.
Vitamin C tablets spike 1000 mg No. 20
Compound
Active substance: ascorbic acid 1000 mg.
Excipients: sodium bicarbonate - 821 mg, sodium carbonate - 152 mg, citric acid - 1030 mg, sorbitol - 808 mg, lemon flavor - 75 mg, sodium riboflavin phosphate - 1 mg, sodium saccharinate - 5 mg, macrogol 6000 - 60 mg , sodium benzoate - 40 mg, povidone-K30 - 8 mg.
Pharmacokinetics
Suction
Absorbed from the gastrointestinal tract (mainly from the jejunum). With an increase in dose to 200 mg, up to 140 mg (70%) is absorbed; with a further increase in dose, absorption decreases (50-20%). Gastrointestinal diseases (peptic ulcer of the stomach and duodenum, constipation or diarrhea, helminthic infestation, giardiasis), consumption of fresh fruit and vegetable juices, and alkaline drinking reduce the absorption of ascorbate from the intestine.
The normal concentration of ascorbic acid in plasma is approximately 10-20 mcg/ml, body reserves are about 1.5 g when taken at daily recommended doses and 2.5 g when taken at 200 mg/day, the time to reach Cmax after oral administration is 4 hours.
Distribution
Plasma protein binding - 25%. Easily penetrates into leukocytes, platelets, and then into all tissues; the highest concentration is achieved in the glandular organs, leukocytes, liver and lens of the eye; deposited in the posterior lobe of the pituitary gland, adrenal cortex, ocular epithelium, interstitial cells of the seminal glands, ovaries, liver, spleen, pancreas, lungs, kidneys, intestinal wall, heart, muscles, thyroid gland; penetrates the placental barrier. The concentration of ascorbic acid in leukocytes and platelets is higher than in erythrocytes and plasma. In deficiency states, leukocyte concentrations decline later and more slowly and are considered a better measure of deficiency than plasma concentrations.
Metabolism
Metabolized primarily in the liver into deoxyascorbic acid and further into oxaloacetic and diketogulonic acids.
Removal
It is excreted by the kidneys, through the intestines, with sweat, and breast milk in the form of unchanged ascorbate and metabolites.
When used in high doses, the rate of elimination increases dramatically. Smoking and drinking ethanol accelerate the destruction of ascorbic acid (conversion into inactive metabolites), sharply reducing reserves in the body. Excreted during hemodialysis.
Indications for use
For tablets containing 1000 mg ascorbic acid
- treatment of vitamin C deficiency.
For tablets containing 250 mg ascorbic acid
Treatment and prevention of hypo- and avitaminosis C, incl. caused by a state of increased need for ascorbic acid with:
- increased physical and mental stress;
- in complex therapy of colds, ARVI;
- for asthenic conditions;
- during the recovery period after illnesses;
- pregnancy (especially multiple pregnancy, against the background of nicotine or drug addiction).
Contraindications
- Children and adolescents up to 18 years of age (for this dosage form);
- long-term use in large doses (more than 500 mg): diabetes mellitus, hyperoxaluria, nephrolithiasis, hemochromatosis, thalassemia;
- hypersensitivity to the components of the drug.
With caution: diabetes mellitus, glucose-6-phosphate dehydrogenase deficiency, hemochromatosis, sideroblastic anemia, thalassemia, hyperoxaluria, oxalosis, urolithiasis.
Directions for use and doses
The drug is taken orally after meals. 1 tablet is dissolved in a glass of water (200 ml). The tablets should not be swallowed, chewed or dissolved in the mouth.
To treat vitamin C deficiency, 1000 mg/day is prescribed.
For the treatment and prevention of hypo- and avitaminosis C, 250 mg is prescribed 1-2 times a day.
During pregnancy, the drug is prescribed at a maximum daily dose of 250 mg for 10-15 days.
Storage conditions
The drug should be stored out of the reach of children, in a dry place, protected from light at a temperature of 15° to 25°C.
Best before date
2 years. Do not use after the expiration date stated on the packaging.
special instructions
Foods rich in ascorbic acid: citrus fruits, greens, vegetables (peppers, broccoli, cabbage, tomatoes, potatoes). When storing food (including long-term freezing, drying, salting, pickling), cooking (especially in copper utensils), chopping vegetables and fruits in salads, and preparing purees, ascorbic acid is partially destroyed (up to 30-50% during heat treatment).
Due to the stimulating effect of ascorbic acid on the synthesis of corticosteroid hormones, it is necessary to monitor adrenal function and blood pressure.
With long-term use in high doses, inhibition of the function of the pancreatic insular apparatus is possible, so it must be regularly monitored during treatment.
In patients with high iron levels in the body, ascorbic acid should be used in minimal doses.
Currently, the effectiveness of using ascorbic acid for the prevention of diseases of the cardiovascular system and some types of malignant tumors is considered unproven.
Ascorbic acid is not recommended for use in cases of pyorrhea, infectious gum diseases, hemorrhagic phenomena, hematuria, hemorrhage in the retina, disorders of the immune system, depression not associated with vitamin C deficiency.
Prescribing ascorbic acid to patients with rapidly proliferating and intensively metastasizing tumors can aggravate the process.
Ascorbic acid, as a reducing agent, can distort the results of various laboratory tests (blood glucose, bilirubin, liver transaminase and LDH activity).
Description
Vitamin preparation.
Pharmacodynamics
Ascorbic acid is a vitamin, has a metabolic effect, is not formed in the human body, and comes only with food. With an unbalanced and inadequate diet, a person experiences a deficiency in ascorbic acid.
Participates in the regulation of redox processes, carbohydrate metabolism, blood clotting, tissue regeneration; increases the body's resistance to infections, reduces vascular permeability, reduces the need for vitamins B1, B2, A, E, folic acid, pantothenic acid.
Participates in the metabolism of phenylalanine, tyrosine, folic acid, norepinephrine, histamine, iron, utilization of carbohydrates, synthesis of lipids, proteins, carnitine, immune reactions, hydroxylation of serotonin, enhances the absorption of non-heme iron.
It has antiplatelet and pronounced antioxidant properties.
Regulates hydrogen transport in many biochemical reactions, improves the use of glucose in the tricarboxylic acid cycle, participates in the formation of tetrahydrofolic acid and tissue regeneration, the synthesis of steroid hormones, collagen, procollagen.
Maintains the colloidal state of the intercellular substance and normal capillary permeability (inhibits hyaluronidase).
Activates proteolytic enzymes, participates in the metabolism of aromatic amino acids, pigments and cholesterol, promotes the accumulation of glycogen in the liver. Due to the activation of respiratory enzymes in the liver, it enhances its detoxification and protein-forming functions, and increases the synthesis of prothrombin.
Improves bile secretion, restores exocrine function of the pancreas and endocrine function of the thyroid gland.
Regulates immunological reactions (activates the synthesis of antibodies, C3 component of complement, interferon), promotes phagocytosis, increases the body's resistance to infections. Inhibits the release and accelerates the degradation of histamine, inhibits the formation of prostaglandins and other mediators of inflammation and allergic reactions.
In low doses (150-250 mg/day orally) it improves the complexing function of deferoxamine in chronic intoxication with iron preparations, which leads to increased excretion of the latter.
Side effects
From the side of the central nervous system: with long-term use in high doses (more than 1000 mg) - headache, increased excitability of the central nervous system, insomnia.
From the digestive system: irritation of the gastrointestinal mucosa, with long-term use in high doses - nausea, vomiting, diarrhea, hyperacid gastritis, ulceration of the gastrointestinal mucosa.
From the endocrine system: inhibition of the function of the insular apparatus of the pancreas (hyperglycemia, glycosuria).
From the urinary system: moderate pollakiuria (when taken at a dose of more than 600 mg/day), with long-term use in high doses - hyperoxaluria, nephrolithiasis (from calcium oxalate), damage to the glomerular apparatus of the kidneys.
From the cardiovascular system: with long-term use in high doses - a decrease in capillary permeability (possible deterioration of tissue trophism, increased blood pressure, hypercoagulation, development of microangiopathies).
Allergic reactions: skin rash, skin hyperemia.
Laboratory indicators: thrombocytosis, hyperprothrombinemia, erythropenia, neutrophilic leukocytosis, hypokalemia.
Other: hypervitaminosis, metabolic disorders, feeling of heat, with prolonged use in high doses - sodium and fluid retention, metabolic disorders of zinc and copper.
If any side effects occur, the patient should stop taking the drug and consult a doctor.
Use during pregnancy and breastfeeding
The minimum daily requirement for ascorbic acid in the second and third trimesters of pregnancy is about 60 mg. It should be borne in mind that the fetus can adapt to high doses of ascorbic acid taken by a pregnant woman, and then the newborn may develop withdrawal symptoms.
The minimum daily requirement during lactation is 80 mg. A maternal diet containing adequate amounts of ascorbic acid is sufficient to prevent deficiency in the infant. Theoretically, there is a danger to the child when the mother uses ascorbic acid in high doses (it is recommended that a nursing mother not exceed the daily requirement for ascorbic acid).
Interaction
Increases the concentration of benzylpenicillin and tetracyclines in the blood; at a dose of 1 g/day increases the bioavailability of ethinyl estradiol (including that included in oral contraceptives).
Improves the absorption of iron preparations in the intestines (converts ferric iron to divalent iron), can increase the excretion of iron when used simultaneously with deferoxamine.
Reduces the effectiveness of heparin and indirect anticoagulants.
Acetylsalicylic acid (ASA), oral contraceptives, fresh juices and alkaline drinks reduce the absorption and absorption of ascorbic acid.
When used simultaneously with ASA, the urinary excretion of ascorbic acid increases and the excretion of ASA decreases. ASA reduces the absorption of ascorbic acid by approximately 30%.
Increases the risk of developing crystalluria during treatment with salicylates and short-acting sulfonamides, slows down the excretion of acids by the kidneys, increases the excretion of drugs that have an alkaline reaction (including alkaloids), and reduces the concentration of oral contraceptives in the blood.
Increases the overall clearance of ethanol, which, in turn, reduces the concentration of ascorbic acid in the body.
Quinoline drugs, calcium chloride, salicylates, corticosteroids, when used for a long time, deplete ascorbic acid reserves.
When used simultaneously, it reduces the chronotropic effect of isoprenaline.
Long-term use or use in high doses may interfere with the disulfiram-ethanol interaction.
In high doses, it increases the excretion of mexiletine by the kidneys.
Barbiturates and primidone increase the excretion of ascorbic acid in the urine.
Reduces the therapeutic effect of neuroleptics - phenothiazine derivatives, tubular reabsorption of amphetamine and tricyclic antidepressants.
Overdose
Symptoms: with long-term use in high doses (more than 1000 mg/day), nausea, heartburn, diarrhea, irritation of the gastrointestinal mucosa, flatulence, spastic abdominal pain, frequent urination, nephrolithiasis, insomnia, irritability, hypoglycemia are possible.
Treatment: symptomatic therapy, forced diuresis.
