The drug is a combination drug recommended for use when symptoms of headache, joint pain, or toothache appear. The drug can be used for migraine attacks. When combined with caffeine, aspirin, and paracetamol, the medication enhances and improves the spectrum of action of the pain-relieving components.
"Citramon": composition and other characteristics
"Citramon" is an anesthetic that prevents inflammatory processes and also has an antipyretic effect. The only form of release is tablets. They are packaged in cardboard packages, each containing 10 or 6 pieces.
The active ingredient is acetylsalicylic acid (240 mg per tablet). The following are used as auxiliary components:
- citric acid (20 mg);
- phenacetin (180 mg);
- caffeine (20 mg).
The composition and dosage of components may vary significantly, as determined by manufacturers. The features of the tablet may also differ. For example, “Citramon Ultra”, unlike the classic “Citramon”, is a drug with film-coated tablets. This makes oral administration easier.
The effect on the body is complex:
- Acetylsalicylic acid reduces temperature and resists inflammatory processes.
- Caffeine stimulates excitation processes in the central nervous system and activates the brain.
- In combination with acetylsalicylic acid and paracetamol, the drug has a pronounced analgesic effect.
The product is available freely and does not require a prescription. Stored at normal room temperature up to 25 degrees. The shelf life is 2 years from the date of production.
For reference
One of the common types of the drug is Citramon P. Along with the main components, it contains paracetamol, which enhances the analgesic and antipyretic effect.
Low pressure exposure
Among the list of medical symptoms of low blood pressure are: dizziness, problems with the quality of vision - this is especially felt when driving a car. All of these symptoms indicate low blood pressure and can cause loss of concentration and sluggish reactions. The symptoms can be easily suppressed with Citramon.
Low blood pressure indicates other pathologies. A list of popular diseases and conditions is presented below:
- excessive bleeding
- complex course of infection,
- dehydration,
- heart attack or heart failure,
- severe allergic reaction,
- diseases of the endocrine system affecting the thyroid gland, low blood sugar, and the formation of diabetes mellitus.
I wonder if Citramon increases or decreases blood pressure ? Doctors do not recommend taking the drug frequently to improve blood pressure levels. The drug has a short-term effect and is not indicated for long-term treatment. Thanks to the caffeine it contains, the medicine increases blood pressure rather than lowers it. Caffeine is present in many common foods that people consume every day. Coffee fans feel addicted to it. A similar condition occurs with frequent use:
- strong black tea,
- sweet soda,
- energy workers.
People who prefer these drinks feel a constant need for caffeine. The use of tablets that contain it does not affect intracranial pressure and does not increase it.
What do Citramon tablets help with?
The main purpose of the drug is to relieve moderate and mild pain in the presence of concomitant diseases:
- ARVI;
- flu;
- general malaise;
- febrile syndrome;
- neuralgia;
- arthralgia;
- algodysmenorrhea;
- migraine;
- myalgia;
The drug is used to treat headaches, muscle pain, dental pain, and joint pain. "Citramon" is effective in relieving any pain that is associated with inflammatory processes. It contains several active components that mutually enhance each other's actions.
Analogs
Level 4 ATC code matches:
Acetylsalicylic acid
Aspirin-S
Citropak
Aspirin
Coficil-Plus
Farmadol
Askofen-P
Cefekon N
Aquacitramon
Upsarin UPSA
Citrapack
Alca Prim
Thrombopol
Citrapar
Analogs with the same composition of active ingredients:
- Citramon-Darnitsa
- Citramon-Borimed
- Citramon-Ultra
- Citramon-LekT
- Aquacitramon
- Atsepar
- Askofen-P
- Cofficil-plus
- Citrapar
- Excedrin
- Migrenol Extra
Contraindications for use
Restrictions associated with the use of the product contain a fairly large list of disorders and diseases:
- nasal polyposis;
- bronchial asthma;
- hypersensitivity to one or more components;
- bleeding of the gastrointestinal tract;
- diathesis of hemorrhagic type;
- erosion, ulcer of the gastrointestinal tract (in the acute stage);
- portal hypertension"
- severe course of coronary heart disease;
- hemophilia;
- renal failure;
- increased nervous excitability;
- kidney failure;
- sleep problems;
- bleeding during operations;
- severe hypertension;
- glaucoma;
- simultaneous use of anticoagulant drugs;
- aortic aneurysm;
- pregnancy period (especially during the 1st and 3rd trimesters);
- feeding period (any stage);
- children up to 15 years old inclusive.
There are also relative contraindications in which Citramon should be taken with caution. These are liver dysfunctions, as well as gout.
Citramon P
Acetylsalicylic acid
Other non-steroidal anti-inflammatory drugs: due to the increased damaging effect on the gastrointestinal mucosa and increased risk of gastrointestinal bleeding, simultaneous use is not recommended. If simultaneous use is necessary, it is recommended to use gastroprotectors for the prevention of NSAID-induced gastrointestinal ulcers.
Glucocorticosteroids: due to the increased damaging effect on the gastrointestinal mucosa and increased risk of gastrointestinal bleeding, simultaneous use is not recommended. If simultaneous use is necessary, it is recommended to use gastroprotectors, especially in persons over 65 years of age.
Oral anticoagulants (for example, coumarin derivatives): Acetylsalicylic acid (ASA) may potentiate the effect of anticoagulants. Clinical and laboratory monitoring of bleeding time and prothrombin time is necessary. Simultaneous use is not recommended.
Heparin: increased risk of bleeding. Clinical and laboratory monitoring of bleeding time is required. Simultaneous use is not recommended.
Thrombolytics: increased risk of bleeding. The use of ASA in patients within the first 24 hours after an acute stroke is not recommended. Simultaneous use is not recommended.
Platelet aggregation inhibitors (ticlopidine, paracetamol, clopidogrel, cilostazol): increased risk of bleeding. Clinical and laboratory monitoring of bleeding time is required. Simultaneous use is not recommended.
Selective serotonin reuptake inhibitors (SSRIs): Concomitant use may affect blood clotting or platelet function, resulting in an increased risk of bleeding in general, and gastrointestinal bleeding in particular, and concomitant use is not recommended.
Phenytoin: ASA increases plasma concentrations of phenytoin, which requires monitoring.
Valproic acid: ASA interferes with plasma protein binding and may therefore increase its toxicity. Monitoring of plasma concentrations of valproic acid is necessary.
Aldosterone antagonists (spironolactone, canrenoate): ASA may reduce their activity due to impaired sodium excretion; proper blood pressure control is necessary.
Loop diuretics (eg, furosemide): ASA may reduce their activity due to impaired glomerular filtration due to inhibition of prostaglandin synthesis in the kidneys. Concomitant use of nonsteroidal anti-inflammatory drugs (NSAIDs) may lead to acute renal failure, especially in dehydrated patients. If diuretics are used concomitantly with ASA, ensure the patient is adequately rehydrated and monitor renal function and blood pressure, especially when diuretic treatment is initiated.
Antihypertensive drugs (ACE inhibitors, angiotensin II receptor antagonists, blockers of “slow” calcium channels): ASA can reduce their activity due to inhibition of prostaglandin synthesis in the kidneys. Concomitant use may lead to acute renal failure in elderly or dehydrated patients. If diuretics are used concomitantly with ASA, it is necessary to ensure adequate rehydration of the patient and monitor renal function and blood pressure. When used concomitantly with verapamil, bleeding time should be monitored.
Uricosurics (eg, probenecid, sulfinpyrazone): ASA may reduce their activity by inhibiting tubular reabsorption, leading to high plasma concentrations of ASA.
Methotrexate ≤ 15 mg/week: ASA, like all NSAIDs, reduces the tubular secretion of methotrexate, increasing its plasma concentration and, thus, toxicity. In this regard, the simultaneous use of NSAIDs in patients receiving high doses of methotrexate is not recommended (see section "Contraindications"). In patients taking low doses of methotrexate, the risk of interaction between methotrexate and NSAIDs should also be considered, especially if renal function is impaired. If combination therapy is necessary, it is necessary to monitor a general blood count, liver and kidney function, especially in the first days of treatment.
Sulfonylureas and insulin: ASA enhances their hypoglycemic effect, so when taken in high doses, a reduction in the dose of hypoglycemic drugs may be necessary. It is recommended to monitor blood glucose levels more often.
Alcohol: increases the risk of gastrointestinal bleeding; concomitant use should be avoided.
Paracetamol
Inducers of liver microsomal enzymes or potentially hepatotoxic substances (for example, alcohol, rifampicin, isoniazid, hypnotics and antiepileptics, including phenobarbital, phenytoin and carbamazepine): increased toxicity of paracetamol, which can lead to liver damage even at non-toxic doses of paracetamol, so liver function should be monitored . Simultaneous use is not recommended.
Chloramphenicol: Paracetamol may increase the risk of increased chloramphenicol concentrations. Simultaneous use is not recommended.
Zidovudine: Paracetamol may increase the tendency to develop neutropenia, and therefore hematological parameters should be monitored. Simultaneous use is possible only with the permission of a doctor.
Probenecid: Probenecid reduces the clearance of paracetamol, requiring a reduction in the dose of paracetamol. Simultaneous use is not recommended.
Indirect anticoagulants: Repeated use of paracetamol over a period of more than one week increases the anticoagulant effect. Occasional use of paracetamol has no significant effect.
Propantheline and other drugs that slow gastric emptying: Reduce the rate of absorption of paracetamol, which may delay or reduce rapid pain relief. Metoclopramide and other drugs that accelerate gastric emptying: increase the rate of absorption of paracetamol and, accordingly, the effectiveness and onset of analgesic action.
Cholestyramine: reduces the rate of absorption of paracetamol, therefore, if maximum analgesia is required, colestyramine is taken no earlier than 1 hour after taking paracetamol.
Caffeine
Hypnotics (eg, benzodiazepines, barbiturates, H1-blockers): Concomitant use may reduce the hypnotic effect or reduce the anticonvulsant effect of barbiturates, so concomitant use is not recommended. If simultaneous use is necessary, it is advisable to take the combination in the morning.
Lithium: Caffeine withdrawal may increase plasma lithium concentrations because caffeine increases the renal clearance of lithium, so a lithium dosage reduction may be necessary when caffeine is withdrawn. Simultaneous use is not recommended.
Disulfiram: Patients being treated with disulfiram should be advised to avoid caffeine to avoid the risk of worsening alcohol withdrawal syndrome due to the stimulating effects of caffeine on the cardiovascular and central nervous systems.
Ephedrine-like substances: increased risk of developing drug dependence. Simultaneous use is not recommended.
Sympathomimetics or levothyroxine: due to mutual potentiation, they can enhance the chronotropic effect. Simultaneous use is not recommended.
Theophylline: with simultaneous use, the excretion of theophylline is reduced.
Antibacterial drugs from the quinolone group (ciprofloxacin, enoxacin and pipemidic acid), terbinafia, cimetidine, fluvoxamine and oral contraceptives: increased half-life of caffeine due to inhibition of liver cytochrome P450, therefore patients with impaired liver function, cardiac arrhythmias and latent epilepsy should avoid caffeine .
Nicotine, phenytoin and phenylpropanolamine: reduce the terminal half-life of caffeine.
Clozapine: Caffeine increases clozapine serum concentrations, likely through both pharmacokinetic and pharmacodynamic mechanisms. Monitoring of serum concentrations of clozapine is necessary. Simultaneous use is not recommended. Effect on laboratory tests
High doses of ASA can distort the results of a number of clinical and biochemical laboratory studies.
The use of paracetamol may affect the results of determining uric acid using the phosphotungstic acid method and glycemia using the glucose oxidase/peroxidase method.
Caffeine may reverse the effects of dipyridamole on myocardial blood flow, thereby confounding the results of this study. During the study, it is necessary to refrain from taking caffeine for 8-12 hours.
Side effects
In case of overdose, long-term use, chronic diseases, as well as individual intolerance to the components, side effects are possible:
- anorexia;
- nausea;
- bleeding of the gastrointestinal tract;
- the appearance of ulcers on the mucous membranes of the gastrointestinal tract;
- liver failure;
- hypersensitivity;
- nephrotic syndrome;
- kidney failure;
- anemia;
- fatty hepatosis in acute form;
- complications associated with heart failure;
- sleep disorders, insomnia;
- headaches;
- tinnitus;
- dizziness;
- increased anxiety;
- heart rhythm disturbances;
- high blood pressure;
- psychological dependence (only in case of long-term use of high doses).
Can children take Citramon?
The use of ASA-containing drugs for the treatment of ARVI in children (with or without hyperthermia
With some viral infections (particularly those caused by varicella zoster or influenza A or B ), there is a risk of developing acute hepatic encephalopathy ( Reye's syndrome ), which requires immediate medical attention. One of the signs of Reye's syndrome is prolonged vomiting.
Taking into account the above reasons, the use of tablets in patients under sixteen years of age is contraindicated.
Since the drug has a large number of side effects, it is better for children with a headache or toothache to choose safer remedies.
Cases of overdose
In small quantities, an overdose leads to ringing in the ears, nausea, vomiting, dizziness, and pale skin. In case of severe overdose, more serious disorders are observed:
- breathing problems;
- circulatory disorders;
- increased anxiety;
- feeling dazed;
- headache;
- nausea;
- bleeding;
- sweating;
- fatigue, increased drowsiness;
- convulsions;
- extremely rarely - coma.
In these cases, you must immediately stop taking the drug and its analogues with the same active ingredients. If the symptoms are severe, you will need to seek emergency medical help.
Use for high blood pressure
In Citramon, the instructions for increasing or lowering blood pressure detail all available contraindications for taking Citramon. The guidelines note that treatment is prohibited in the presence of persistently elevated intracranial pressure. Taking it aggravates the condition; before starting therapy, it is necessary to conduct a laboratory diagnostic study and find out why the headache hurts.
Medical signs of high blood pressure include:
- cephalalgia - pressing, dull,
- impaired visual acuity with a feeling of blurriness,
- nosebleeds,
- dizziness.
The following symptoms appear with low blood pressure:
- dizziness,
- short-term fainting,
- decreased vision,
- weakness,
- vomit,
- nausea.
Certain medical manifestations are observed with both high and low blood pressure. To correctly assess the condition, you should take into account the following data:
- The use of the product is permitted in case of pale skin, thirst and hunger, chills (only with low intracranial pressure).
- The product should not be taken if you have symptoms of a hypertensive crisis, headaches, or throbbing in the temples.
Therapy with Citramon in the latter situation will cause aggravation of cephalalgia. Treatment is necessary only for low blood pressure, otherwise the body's reaction to the drug will be unpredictable. Doctors recommend not to take any medications uncontrollably, especially if you feel pain. Without diagnosis and proper identification of the causes of poor health, you can make things worse and provoke an exacerbation of hidden pathological processes. Headaches of the pathological type require complex therapy, and not temporary relief of symptoms with analgesics. People are interested in whether Citramon is for high or low blood pressure ? If you experience low blood pressure, this drug increases it.
Alcohol compatibility
During treatment with Citramon, you should avoid drinking alcohol, since alcohol increases the likelihood of a toxic effect of paracetamol on the liver and ASA on the gastrointestinal tract.
The use of ethyl alcohol with ASA contributes to damage to the mucous membrane of the digestive canal. The synergism of alcohol and ASA also results in prolongation of bleeding time.
Citramon for hangover
Citramon for a hangover is not the most advantageous option, since the use of this drug allows you to relieve headaches only temporarily, but does not eliminate the main causes of poor health - imbalance of water and electrolytes, as well as intoxication.
The headache that accompanies hangover syndrome is associated with impaired venous outflow from the head, tissue swelling (in particular, swelling of the meninges ) and inhibition of the analgesic (antinociceptive) system, part of which is the action of serotonin and dopamine.
ASA partially unloads the membranes of the brain, caffeine stimulates metabolism in neurons and has an invigorating effect, cocoa reduces the relative deficiency of intracerebral serotonin and dopamine, citric acid reduces the severity of symptoms of alcohol intoxication.
However, the paracetamol contained in the tablets puts a lot of strain on the liver, which, in combination with alcohol breakdown products, can aggravate hangover symptoms and damage the body.
Citramon price
The price of Citramon depends on which company produced the drug. So, for example, the price of Citramon P is from 15 rubles, and the price of Citramon Ultra is from 50 rubles.
In Ukraine, a package of tablets can be purchased from 5 to 20 UAH.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Citramon-LekT tab.
No. 20 OJSC "Tyumen Chemical Plant" 42 rub. order - Citramon P tablets 20 pcs. Anzhero-Sudzhensky plant LLC Avexima Siberia
59 RUR order
- Citramon P tablets 20 pcs. AO Update PFK
84 rub. order
- Citramon P tablets 10 pcs. JSC "PFK Obnovlenye"
50 rub. order
- Citramon-ExtraCap capsules 240 mg + 27.45 mg + 180 mg 10 pcs. Pharmstandard-Leksredstva OJSC
74 RUR order
Pharmacy Dialogue
- Citramon-P tablets No. 20Update PFK CJSC
89 rub. order
- Citramon-P tablets No. 10FS.-Leksredstva
28 RUR order
- Citramon-ultra tablets No. 20PharmVilar
70 rub. order
- Citramon P Medisorb tablets No. 20 Medisorb
43 RUR order
- Citramon-P Update tablet No. 10Update PFK CJSC
57 RUR order
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Pharmacy24
- Citramon-M No. 6 tablets PAT "Khimpharmzavod" Chervona Zirka", Kharkov, Ukraine
4 UAH. order - Citramon Fitofarm forte N12 capsules PRAT "Fitofarm", Ukraine
20 UAH order
- Citramon-M No. 10 tablets PAT "Khimpharmzavod" Chervona Zirka", Kharkov, Ukraine
5 UAH order
- Citramon Euro N10 tablets Mibe GmbH Arznam., Germany
32 UAH order
- Citramon-forte No. 100 tablets PAT "Lubnipharm", Ukraine
85 UAH order
PaniPharmacy
- Citramon In tablet Citramon In tablet. No. 6 Ukraine, Lubnyfarm PJSC
3 UAH order
- Citramon F tablets Citramon tablets. No. 6 Ukraine, Fitofarm ChAO
4 UAH order
- Citramon M tablets Citramon-M tablets. No. 10 Ukraine, Red Star JSC
6 UAH order
- Citramon tablets Citramon-Darnitsa tablets No. 6 Ukraine, Darnitsa ChAO
7 UAH order
- Citramon tablets Citramon-Darnitsa tablets No. 10 Ukraine, Darnitsa ChAO
13 UAH order
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Reviews
Most people, despite the fact that the drug is considered potentially unsafe, leave good reviews about Citramon, calling it their savior from headaches (including migraine attacks).
Although there are also those that mention the dangers of tablets for the liver and gastrointestinal tract, and also that with long-term use they cause a kind of addiction (patients can no longer do without Citramon for a long time and experience a constant need for it).
Based on all available reviews, the following conclusion can be drawn: the pills should be taken taking into account existing contraindications, as well as having previously compared the expected benefits from them and potential risks.
One or two tablets taken to relieve an attack of pain are not capable of harming the body; systematic, uncontrolled use, of course, threatens with very serious consequences.
