Antigrippin-Express Raspberry bags 6 pcs. powder for preparing a solution for oral administration in Moscow

Antigrippin

Antigrippin (paracetamol + ascorbic acid + chlorphenamine) is a combination drug for symptomatic pharmacotherapy of acute respiratory viral infections (ARVI). According to statistics from the World Health Organization, the latter account for up to 90% of all clinical cases of infectious diseases. Every year in our country tens of millions of people become victims of ARVI. Each specific case of the disease has its own specific features: for example, influenza viruses, adenoviruses and respiratory syncytial viruses attack the epithelium of the upper and lower respiratory tract, rhinoviruses attack the epithelium of the nasal cavity, parainfluenza viruses attack the larynx, and adenoviruses cause conjunctivitis. Such “invasion campaigns” occur as follows: infectious agents, having an affinity for the mucous membrane of the respiratory tract, invade epithelial cells, triggering the flywheel of a local inflammatory reaction. The resulting cell breakdown products “poison” the systemic bloodstream with toxins, as a result of which a painfully familiar picture with clinical claims develops: headaches and muscle pain, lethargy, weakness, fever, local reactions (cough, runny nose, sore throat and sore throat). There are many pitfalls in the treatment of ARVI, but the biggest problem here is the impossibility of prescribing pathophysiological therapy aimed at the cause of the disease. In this regard, practitioners have to be content with symptomatic treatment. Fortunately, today there is a whole arsenal of medicines for this, including non-steroidal anti-inflammatory drugs, anticongestants (relieving swelling of the mucous membranes), antitussives, bronchodilators, immunomodulators, etc. But the prescription of antibiotics for acute respiratory viral infections is not always advisable and is justified only in the case of an associated bacterial infection. Since many different viruses are responsible for the occurrence of ARVI, the optimal option for symptomatic treatment of this group of diseases should be considered the use of certain combination drugs that can cover the entire symptom complex of ARVI.

The non-steroidal anti-inflammatory drug paracetamol is one of the most common components of such drugs. Its antipyretic effect is realized through the suppression of the synthesis of prostaglandin inflammatory mediators in the central nervous system, which becomes possible due to the ability of the drug to inactivate cyclooxygenase. Paracetamol is distinguished from other NSAIDs by its safety in relation to the gastrointestinal tract: it blocks the synthesis of prostaglandins in the hypothalamic centers of thermoregulation and pain, without affecting other organs and tissues. In order to prevent nasal congestion, antihistamines, for example, chlorphenamine, are added to combined anti-influenza drugs: it eliminates allergy symptoms (sneezing, red eyes, lacrimation), and facilitates nasal breathing. Another “regular” of multi-symptomatic means of combating the manifestations of ARVI is vitamin C or ascorbic acid. It stimulates the production of the immune protein interferon, normalizes the processes of free radical oxidation of lipids, reduces the permeability of the vascular wall, and eliminates the deficiency in itself that has developed against the background of the disease. The drug antigrippin, which includes all of the above components, is today one of the most balanced anti-influenza complexes. It is available in the form of soluble tablets in a variety of flavors. The drug should be taken between meals, 1 tablet 2-3 times a day, dissolving them in a glass of warm water. The maximum daily dose should not exceed 3 tablets. The duration of use of antigrippin as part of self-medication is no more than 5 days (as an analgesic) and no more than 3 days (as an antipyretic). The drug does not contain sugar (with the exception of chamomile and honey-lemon flavors), so it can be used in patients suffering from diabetes.

Antigrippin powder for the preparation of solution for internal use, chamomile N 10

Active substance

paracetamol (paracetamol)

ATX code

N02BE51 (Paracetamol in combination with other drugs (excluding psycholeptics))

Dosage forms

powder for solution for oral administration

Release form, packaging and composition of the drug

◊ Powder for preparing a solution for oral administration, honey-lemon

varying degrees of granulation, consisting of particles from white to grayish-beige in color, with a specific odor; inclusions of dark brown color are allowed.

[PRING] sodium bicarbonate - 644 mg, citric acid - 1328 mg; sorbitol - 317 mg; povidone - 16 mg; sucrose - 1793 mg; sodium cyclamate - 42 mg; aspartame - 20 mg; acesulfame potassium - 15 mg; lemon flavoring - 55 mg, caramel coloring - 15 mg, honey flavoring - 45 mg.

5 g - bags (3) - cardboard packs. 5 g - sachets (10) - cardboard packs.

◊ Chamomile powder for oral solution

varying degrees of granulation, consisting of particles from white to beige and light brown, with a specific odor; inclusions of brown color are allowed.

[PRING] sodium bicarbonate - 644 mg, citric acid - 928 mg; sorbitol - 317 mg; povidone - 16 mg; sucrose - 2058 mg; sodium cyclamate - 42 mg; aspartame - 20 mg; acesulfame potassium - 15 mg; chamomile extract - 250 mg.

5 g - sachets (10) - cardboard packs.

Clinical and pharmacological group

Drug for symptomatic treatment of acute respiratory diseases

Pharmacotherapeutic group

A remedy for eliminating the symptoms of acute respiratory infections and “colds” (non-narcotic analgesic + H1-histamine receptor blocker + vitamin)

Indications for use

• infectious and inflammatory diseases (ARVI, influenza), accompanied by fever, chills, headache, joint and muscle pain, nasal congestion and pain in the throat and sinuses.

Dosage

The drug is taken orally. The contents of the sachet should be completely dissolved in a glass (200 ml) of warm water (50-60°C) and the resulting solution should be drunk immediately. It is better to take the drug between meals.

Adults and children over 15 years old

- 1 sachet 2-3 times/day. The interval between doses of the drug should be at least 4 hours. The maximum daily dose is 3 sachets.

In patients with impaired liver or kidney function

and
elderly patients,
the interval between doses of the drug should be at least 8 hours.

The duration of use of the drug without consulting a doctor is no more than 5 days when prescribed as an analgesic and 3 days as an antipyretic.

Contraindications

• erosive and ulcerative lesions of the gastrointestinal tract (in the acute phase);
• severe renal and/or liver failure;
• alcoholism;
• angle-closure glaucoma;
• phenylketonuria;
• prostatic hyperplasia;
• children under 15 years of age;
• pregnancy;
• lactation period;
• hypersensitivity to paracetamol, ascorbic acid, chlorphenamine or any other component of the drug.

Carefully:

renal and/or liver failure, glucose-6-phosphate dehydrogenase deficiency, congenital hyperbilirubinemia (Gilbert, Dubin-Johnson and Rotor syndromes), viral hepatitis, alcoholic hepatitis, old age.

Overdose

Symptoms of a drug overdose are caused by the substances included in its composition. The clinical picture of acute intoxication with paracetamol develops within 6-14 hours after taking it. Symptoms of chronic intoxication appear 2-4 days after an overdose.

Symptoms of acute paracetamol intoxication:

diarrhea, loss of appetite, nausea and vomiting, abdominal discomfort and/or abdominal pain, increased sweating.

Symptoms of chlorphenamine intoxication:

dizziness, agitation, sleep disturbances, depression, convulsions.

Treatment:

symptomatic.

Side effects

The drug is well tolerated in recommended doses.

From the nervous system:

in isolated cases - headache, feeling of fatigue.

From the digestive system:

in isolated cases - nausea, pain in the epigastric region.

From the endocrine system:

in isolated cases - hypoglycemia (up to the development of coma).

From the hematopoietic system:

in isolated cases - anemia, hemolytic anemia (especially for patients with glucose-6-phosphate dehydrogenase deficiency); extremely rarely - thrombocytopenia.

Allergic reactions:

in isolated cases - skin rash, itching, urticaria, Quincke's edema, anaphylactoid reactions (including anaphylactic shock), exudative erythema multiforme (including Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome).

Other:

in isolated cases - hypervitaminosis C, metabolic disorders, feeling of heat, dry mouth, accommodation paresis, urinary retention, drowsiness.

The patient should report all side effects of the drug to the doctor.

Overdose

Ascorbic acid

Increases the concentration of benzylpenicillin and tetracyclines in the blood.

Improves the absorption of iron preparations in the intestines (converts ferric iron to divalent iron); may increase iron excretion when used concomitantly with deferoxamine.

Increases the risk of developing crystalluria during treatment with salicylates and short-acting sulfonamides, slows down the excretion of acids by the kidneys, increases the excretion of drugs that have an alkaline reaction (including alkaloids), and reduces the concentration of oral contraceptives in the blood.

Increases overall ethanol clearance.

When used simultaneously, it reduces the chronotropic effect of isoprenaline.

It can either increase or decrease the effect of anticoagulant drugs.

Reduces the therapeutic effect of antipsychotic drugs (neuroleptics) - phenothiazine derivatives, tubular reabsorption of amphetamine and tricyclic antidepressants.

Concomitant use of barbiturates increases the excretion of ascorbic acid in the urine.

Chlorphenamine maleate

Chlorphenamine maleate enhances the effect of hypnotics.

Antidepressants, antiparkinsonian drugs, antipsychotic drugs (phenothiazine derivatives) increase the risk of side effects (urinary retention, dry mouth, constipation).

Glucocorticoids increase the risk of developing glaucoma.

Ethanol enhances the sedative effect of chlorphenamine maleate.

Paracetamol

When paracetamol interacts with inducers of microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants), the production of hydroxylated active metabolites increases, which makes it possible to develop severe intoxications with small overdoses.

While taking paracetamol, ethanol contributes to the development of acute pancreatitis.

Inhibitors of microsomal oxidation (including cimetidine) reduce the risk of hepatotoxicity.

The simultaneous use of diflunisal and paracetamol increases the plasma concentration of the latter by 50%, increasing hepatotoxicity.

Concomitant use of barbiturates reduces the effectiveness of paracetamol.

Paracetamol reduces the effectiveness of uricosuric drugs.

Storage conditions

The drug should be stored out of the reach of children at a temperature of 10-30°C. Shelf life: 3 years. Do not use after the expiration date.

Conditions for dispensing from pharmacies

The drug is available without a prescription.

RUS-FLU-ANG-GPR-07-2018-1218

Special Instructions

If you are taking metoclopramide, domperidone or cholestyramine, you should also consult your doctor.

With long-term use in doses significantly higher than recommended, the likelihood of impaired liver and kidney function increases; monitoring of the peripheral blood picture is necessary.

Paracetamol and ascorbic acid can distort laboratory tests (quantitative determination of glucose and uric acid in blood plasma, bilirubin, liver transaminase activity, LDH).

To avoid toxic liver damage, paracetamol should not be combined with alcoholic beverages, or taken by persons prone to chronic alcohol consumption. The risk of developing liver damage increases in patients with alcoholic hepatosis.

Prescribing ascorbic acid to patients with rapidly proliferating and intensively metastasizing tumors can aggravate the process.

In patients with high iron levels in the body, ascorbic acid should be used in minimal doses.

1 sachet of honey-lemon powder contains 1.793 g of sugar, which corresponds to 0.15 XE.

1 sachet of chamomile powder contains 2.058 g of sugar, which corresponds to 0.17 XE.