Spasmalgon is a combination medicine. It contains several active components. This guarantees high efficiency in relieving pain of moderate intensity. In addition, the drug has weak antipyretic and anti-inflammatory properties. When taken, it is possible to eliminate the discomfort associated with pain in a short time. Spasmalgon is often prescribed in the postoperative period, as well as after diagnosis.
Compound
The drug contains metamizole sodium , pitofenone (antispasmodic myotropic agent) and fenpiverinium bromide (m-anticholinergic).
Spazmalgon tablets contain 500 mg + 5 mg + 100 mcg of active ingredients, respectively. Additional elements are: gelatin, lactose monohydrate, magnesium stearate, wheat starch, sodium bicarbonate, talc.
The solution contains active ingredients in the amount of:
- 500 mg + 20 mcg + 2 mg;
- 1000 mg + 40 mcg + 4 mg;
- 2500 mg + 100 mcg + 10 mg.
And also injection water.
Indications for use of Spazmalgon
What do pills and injections help with? For pain syndrome of mild and moderate severity, for renal, hepatic colic, algodismenorrhea . Can be used for symptomatic, short-term treatment of neuralgia, joint pain, myalgia, and sciatica.
What else are these tablets used for and for what purpose? They are used as an auxiliary pain reliever after diagnostic and surgical interventions. Spazmalgon helps with headaches, toothaches, and menstruation.
Also, indications for the use of Spasmalgon are infectious-inflammatory and colds, in which the drug effectively reduces elevated body temperature.
What does the medicine help with?
Spasmalgon, the instructions for use confirm this, has a wide range of uses. The drug effectively relieves moderate pain of various etiologies.
The medicine has proven its effectiveness against toothache. Its important feature is associated with the properties of smooth muscle relaxation, which eliminates the irradiation of pain in the ear and cheek area, which is practically impossible to endure stoically.
Medicine is prescribed to reduce joint pain in the development of various pathologies. In addition, it is used in the complex treatment of neuralgia and myalgia. After surgical operations, spasmalgon is prescribed as an adjuvant. It is permissible to prescribe medications to reduce fever when treating colds.
With the help of spasmalgon, you can relieve headaches if they are not associated with increased arterial or intracranial pressure, and are also not provoked by cerebrovascular accident. The effectiveness of the drug for migraine, which is characterized by an additional symptom – stomach spasm, has been proven. Thanks to its pronounced antispasmodic properties, spasmalgon successfully copes with this problem.
In addition, the drug effectively copes with headaches caused by sudden changes in weather. This means that it is indispensable for weather-sensitive people.
Spasmalgon copes with pain in organs located in the abdominal cavity. It is recommended to use the medicine for women who suffer from menstrual pain. The drug is considered highly effective for eliminating intestinal, renal, hepatic or biliary colic.
Often among the reviews regarding what spazlmalgon helps with, there are recommendations for using the product for headaches caused by a hangover. But to get a positive result, you need to completely cleanse your body of alcohol. This can be done, for example, with the help of diuretics.
Contraindications
Allergy to components of the drug, pyrazolone . Stable, unstable angina , suppression of bone marrow hematopoiesis, chronic heart failure (stage of decompensation ), serious disorders of the kidneys, liver, tachyarrhythmia, prostatic hyperplasia with urinary retention, angle-closure glaucoma, granulocytopenia, megacolon, pregnancy, breastfeeding. The drug is contraindicated for use in children under 6 years of age. Spasmalgon is prescribed with caution for diseases of the renal and hepatic systems, low blood pressure (systolic reading below 100 mm Hg), a contraindication is a tendency to bronchospasm.
Side effects
Dry mouth, burning sensation in the epigastrium . Dizziness, headaches, decreased sweating, difficulty urinating, accommodation paresis. Cyanosis , tachycardia , decreased blood pressure. Oliguria , renal dysfunction, anuria , interstitial nephritis, polyuria , red urine color. Agranulocytosis, leukopenia, thrombocytopenia - with long-term use. Allergic reactions: bronchospasm, urticaria, anaphylactic shock, Stevens-Jones syndrome, Lyell's syndrome, Quincke's edema .
Spasmaton Neo tablets p/o No. 10x2
Name
Spasmaton Neo No. 20
Description
Film-coated tablets, white, round, with a biconvex surface.
Main active ingredient
Ibuprofen+pitofenone+fenpiverinium bromide
Release form
film-coated tablets
special instructions
It is necessary to monitor serum creatinine 48–72 hours after the start of administration in patients with chronic heart failure of functional class III-IV according to the New York classification and chronic renal failure with a glomerular filtration rate of less than 60 ml/min. With long-term use (more than a week), monitoring of the peripheral blood picture and the functional state of the liver and kidneys is necessary. In patients with arterial hypertension and diabetes mellitus, monitoring of renal function is mandatory even in the first week of use. In patients for whom the production of prostaglandins has a compensatory role in maintaining renal blood flow (states of dehydration, impaired renal and liver function, heart failure, severe atherosclerosis, taking diuretics, angiotensin-converting enzyme inhibitors (ACE inhibitors), old age), the risk of developing complications from kidney To reduce the risk of developing adverse events from the gastrointestinal tract, the minimum effective dose should be used. When symptoms of gastropathy appear, careful monitoring is indicated, including esophagogastroduodenoscopy, a blood test to determine hemoglobin and hematocrit, and a stool test for occult blood. If it is necessary to determine 17-ketosteroids, drugs should be discontinued 48 hours before the study. During the treatment period you should refrain from drinking alcohol.
Pharmacological properties
Pharmacodynamics
Combined analgesic, anti-inflammatory and antispasmodic agent. The drug contains the non-steroidal anti-inflammatory drug ibuprofen, the myotropic antispasmodic - pitofenone and the M-anticholinergic drug - fenpiverinium bromide. The combination of drug components (drug) leads to mutual potentiation of their pharmacological action. Ibuprofen is a derivative of phenylpropionic acid. It has analgesic, anti-inflammatory and antipyretic effects. The main mechanism of action is inhibition of the synthesis of prostaglandins - modulators of pain sensitivity, thermoregulation and inflammation in the central nervous system (CNS) and peripheral tissues. In women with primary dysmenorrhea, it reduces the increased level of prostaglandins in the myometrium and thereby reduces intrauterine pressure and the frequency of uterine contractions. Pitophenone hydrochloride has a direct myotropic antispasmodic effect on the smooth muscles of internal organs and causes its relaxation (papaverine-like effect). Phenpiverinium bromide has an M-anticholinergic effect and has an additional relaxing effect on smooth muscles.
Pharmacokinetics
Absorption and distribution When taken orally, the components of the drug Spazmaton Neo® are well absorbed in the gastrointestinal tract (GIT). Cmax in blood plasma is achieved in approximately 1–2 hours. The main drug component ibuprofen is 99% bound to blood plasma proteins and accumulates in the synovial fluid. Metabolism and excretion Ibuprofen is metabolized in the liver and is excreted 90% in the urine in the form of metabolites and conjugates. A small portion of ibuprofen is excreted in bile. T? from blood plasma is 2 hours. The pharmacokinetics of pitofenone hydrochloride and fenpiverinium bromide have not been sufficiently studied.
Indications for use
- pain syndrome (mild or moderate) with spasms of smooth muscles of internal organs: renal and biliary colic, biliary dyskinesia, intestinal colic;
- dysmenorrhea;
- headache, incl. migraine character;
- for short-term symptomatic treatment of joint pain, neuralgia, sciatica, myalgia.
Directions for use and doses
Orally, 1 hour before or 3 hours after meals. To avoid irritating effects on the stomach, you can take the drug immediately after meals or wash it down with milk. In the absence of special instructions from a doctor, Spazmaton Neo® is recommended to be taken for spastic pain, 1 tablet up to 3 times a day. The maximum daily dose is 3 tablets. Do not exceed the indicated dose! The course of treatment with Spasmaton Neo®, without consulting a doctor, should not exceed 5 days. Longer use is possible under the supervision of a physician with monitoring of peripheral blood parameters and the functional state of the liver.
Use during pregnancy and lactation
The drug is contraindicated during pregnancy and lactation (breastfeeding).
Interaction with other drugs
When taken as recommended, the risk of developing significant drug interactions is low. Inducers of microsomal oxidation enzymes in the liver (phenytoin, ethanol, barbiturates, flumecinol, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites, increasing the risk of developing severe intoxications. Microsomal oxidation inhibitors reduce the risk of hepatotoxicity. The risk of developing undesirable interactions and impaired renal function increases when administered simultaneously with drugs that block the renin-angiotensin-aldosterone system. The drug reduces the hypotensive activity of vasodilators and the natriuretic effect of furosemide and hydrochlorothiazide. Reduces the effectiveness of uricosuric drugs. Strengthens the effect of indirect anticoagulants, antiplatelet agents, fibrinolytics (which increases the risk of bleeding). Increases the side effects of mineralocorticosteroids, glucocorticosteroids (increases the risk of gastrointestinal bleeding), estrogens, ethanol. Enhances the hypoglycemic effect of sulfonylurea derivatives. Antacids and cholestyramine reduce the absorption of ibuprofen. The drug increases the concentration of digoxin, lithium, and methotrexate in the blood. Enhances the effect of m-anticholinergic blockers, histamine H1 receptor blockers, butyrophenones, phenothiazines, amantadine and quinidine. Concomitant administration of other NSAIDs increases the incidence of side effects. Caffeine enhances the analgesic effect. When administered simultaneously, it reduces the anti-inflammatory and antiplatelet effect of acetylsalicylic acid (it is possible to increase the incidence of acute coronary insufficiency in patients receiving small doses of acetylsalicylic acid as an antiplatelet agent after starting to take Spazmaton Neo®). Cefamandole, cefoperazone, cefotetan, valproic acid, plicamycin increase the incidence of hypoprothrombinemia when administered simultaneously. Myelotoxic drugs increase the manifestations of hematotoxicity of drugs. Cyclosporine and gold preparations enhance the effect of ibuprofen on the synthesis of prostaglandins in the kidneys, which is manifested by increased nephrotoxicity. Ibuprofen increases the plasma concentration of cyclosporine and the likelihood of developing its hepatotoxic effects. Drugs that block tubular secretion reduce excretion and increase plasma concentrations of ibuprofen.
Contraindications
- erosive and ulcerative changes in the mucous membrane of the stomach or duodenum, active gastrointestinal bleeding;
- inflammatory bowel diseases in the acute phase, incl. ulcerative colitis;
- anamnestic data on an attack of bronchial obstruction, rhinitis, urticaria, after taking acetylsalicylic acid or another non-steroidal anti-inflammatory drug (NSAID) (complete or incomplete acetylsalicylic acid intolerance syndrome - rhinosinusitis, urticaria, polyps of the nasal mucosa, bronchial asthma);
- liver failure or active liver disease;
- renal failure creatinine clearance ((creatinine clearance) less than 30 ml/min), progressive kidney disease;
- confirmed hyperkalemia;
- hemophilia and other bleeding disorders (including hypocoagulation), hemorrhagic diathesis;
- period after coronary artery bypass surgery;
- acute intermittent porphyria;
- granulocytopenia;
- hematopoietic disorders;
- deficiency of glucose-6-phosphate dehydrogenase;
- tachyarrhythmias;
- angle-closure glaucoma;
- optic nerve diseases;
- prostatic hyperplasia;
- intestinal obstruction;
- pregnancy and lactation (breastfeeding);
- age up to 16 years;
- hypersensitivity to any component of the drug.
Carefully
- elderly age;
- congestive heart failure;
- cerebrovascular diseases;
- arterial hypertension;
- cardiac ischemia;
- dyslipidemia/hyperlipidemia;
- diabetes;
- peripheral arterial disease;
- nephrotic syndrome;
- CC 30–60 ml/min or less;
- hyperbilirubinemia;
- peptic ulcer of the stomach and duodenum (history);
- presence of Helicobacter pylori infection;
- gastritis, enteritis, colitis;
- long-term use of NSAIDs;
- blood diseases of unknown etiology (leukopenia, anemia);
- smoking;
- frequent drinking of alcohol (alcoholism);
- severe somatic diseases;
- concomitant therapy with the following drugs: anticoagulants (for example, warfarin), antiplatelet agents (for example, acetylsalicylic acid, clopidogrel), oral glucocorticosteroids (GCS) (for example, prednisolone), selective serotonin reuptake inhibitors (for example, citalopram, fluoxetine, paroxetine, sertraline).
Compound
One tablet contains: active ingredients – ibuprofen – 400 mg, pitofenone hydrochloride – 5 mg, fenpiverinium bromide – 0.1 mg; excipients – microcrystalline cellulose, starch 1500 (partially pregelatinized corn starch), croscarmellose sodium, glycerin, colloidal anhydrous silicon dioxide, talc, magnesium stearate, Opadry II (including polyvinyl alcohol, partially hydrolyzed, talc, macrogol 3350, titanium dioxide E 171).
Overdose
Symptoms: abdominal pain, nausea, vomiting, lethargy, drowsiness, depression, headache, tinnitus, metabolic acidosis, coma, acute renal failure, decreased blood pressure (BP), bradycardia, tachycardia, atrial fibrillation, respiratory arrest. Treatment: gastric lavage (only within an hour after administration), activated charcoal, alkaline drinking, forced diuresis, symptomatic therapy (correction of acid-base status, blood pressure). There is no specific antidote.
Side effect
From the digestive system: NSAID gastropathy (abdominal pain, nausea, vomiting, heartburn, loss of appetite, diarrhea, flatulence, constipation, ulceration of the gastrointestinal mucosa, which, in some cases, are complicated by perforation and bleeding; irritation or dryness of the oral mucosa , pain in the mouth, ulceration of the gum mucosa, aphthous stomatitis), pancreatitis, hepatitis. From the respiratory system: shortness of breath, bronchospasm. From the central nervous system and peripheral nervous system: headache, dizziness, insomnia, anxiety, nervousness and irritability, psychomotor agitation, drowsiness, depression, confusion, hallucinations, aseptic meningitis (more often in patients with autoimmune diseases). On the part of the hearing organs: hearing loss, hearing loss, ringing in the ears. From the organs of vision: visual impairment (toxic damage to the optic nerve, blurred visual perception, scotoma, dryness and irritation of the eyes, swelling of the conjunctiva and eyelids (allergic origin), accommodation paresis). From the cardiovascular system: heart failure, tachycardia, increased blood pressure. From the urinary system: acute renal failure, allergic nephritis, nephrotic syndrome (edema), oliguria, anuria, polyuria, proteinuria, cystitis, red staining of urine. Allergic reactions: skin rash (usually erythematous or urticaria), skin itching, angioedema, anaphylactoid reactions, anaphylactic shock, bronchospasm or dyspnea, fever, erythema multiforme exudative (including Stevens-Johnson syndrome), toxic epidermal necrolysis (syndrome) Lyell), eosinophilia, allergic rhinitis. From the hematopoietic organs: anemia (including hemolytic, aplastic), thrombocytopenia and thrombocytopenic purpura, agranulocytosis, leukopenia. Other: increased or decreased sweating. From laboratory parameters: bleeding time may increase, serum glucose concentration may decrease, creatinine clearance may decrease, hematocrit or hemoglobin may decrease, serum creatinine concentration may increase, hepatic transaminase activity may increase.
Storage conditions
In a place protected from light and moisture, at a temperature not exceeding 25? C. Keep out of the reach of children.
Instructions for use of Spazmalgon (Method and dosage)
Spazmalgon tablets, instructions for use
Adults, children over 15 years old: 1-2 tablets after meals 2-3 times a day. The maximum daily dose should not exceed 6 tablets. The period of admission is no more than 5 days.
Spazmalgon for children: 6-8 l – 1/2 tablet, 9-12 l – ¾ tablet, 13-15 l – 1 t. 2-3 rubles per day.
Instructions for use of Spazmalgon in ampoules
Injections are given up to 5 ml 3 times a day. The maximum dose is 10 ml. The product is usually used for 5 days.
Before use, the ampoule must be warmed in your hands.
Composition of drugs, its effects and release form
The effectiveness of the drug is ensured by the combined composition. The main effects of taking the drug spasmalgon, the instructions for use indicate this, are a pronounced analgesic and antispasmodic effect. Additionally, the medicine lowers body temperature. You need to know what spasmalgon helps with in order to use it correctly.
The peculiarity of the effects of using the product is associated with the following properties of the main components:
- Metamizole sodium effectively relieves pain, lowers body temperature and reduces inflammation.
- Pitophenone hydrochloride has a direct myotropic effect, providing an antispasmodic and vasodilating effect, which helps relieve discomfort.
- Enhances the relaxing effect of the drug fenpiverinium bromide, which belongs to the group of M-anticholinergics.
A special feature of spasmalgon is the high speed of obtaining results. When taking tablets or performing an injection, it is possible to relieve pain in no more than 40 minutes. The number of main components differs in different forms.
You can purchase spasmalgon, which has a combined composition, in a cardboard box in two forms:
- Tablets in blisters.
- Ampoules for injection.
Interaction
Spasmalgon and non-narcotic analgesics, when taken simultaneously, can lead to increased toxic effects of the drugs. Allopurinol , COCs, tricyclic antidepressants disrupt the metabolism of metamizole in the liver, resulting in increased toxicity. Inducers of microsomal liver enzymes reduce the effectiveness of metamizole. Tranquilizers and sedatives increase the severity of the analgesic effect. The simultaneous use of cyclosporine and spasmalgon reduces the concentration of the former in the blood. Spasmalgon enhances the effect of ethanol. Concomitant use with phenothiazine derivatives increases body temperature. Cytostatics and thiamazole increase the risk of developing leukopenia. The effectiveness of the drug is increased by H2-histamine receptor blockers, codeine , propranolol .
The effect of "Spazmalgon" on blood pressure
With arterial hypertension, the elasticity of the walls of blood vessels decreases, as a result of which their permeability deteriorates several times. Accordingly, the pulse quickens, arrhythmias appear, and blood pressure rises. After taking Spazmalgon, the walls of blood vessels gradually relax and blood circulation improves. As a result, high blood pressure normalizes and any symptoms of hypertension disappear.
Therefore, many doctors recommend taking this drug to people with high blood pressure.
Patients with hypotension should not take such tablets because they can reduce blood pressure to critical levels.
special instructions
When taking the drug for more than 7 days, it is necessary to monitor the peripheral blood picture and evaluate the condition of the liver. If thrombocytopenia is present or agranulocytosis is suspected, it is necessary to stop using the drug. Drinking alcohol is prohibited during treatment. Spasmalgon reduces the speed of mental and physical reactions.
Does the drug increase or decrease blood pressure?
The medicine is not used to stabilize blood pressure, however, when using the medicine, spasms of blood vessels are relieved, which may result in a decrease in blood pressure.
Spasmalgon's analogues
Level 4 ATC code matches:
Analdim
Reopirin
Tempalgin
Spazgan
Benalgin
Pentalgin ICN
Pentalgin N
Pentalgin
Analgin
Renalgan
Tetralgin
Spasmalin
Maxigan
Sedal-M
Piralgin
Baralgin M
Sedalgin Plus
Baralgetas
Revalgin
Andipal
the drugs : Baralgetas , Baralgin , Baralginus , Bral , Maxigan , Realgin , Spazgan , Spazmadol , Spasmogard , Trinalgin .
Spasmalgon price, where to buy
The price of Spazmalgon in tablets of 20 pieces per package is 130 rubles.
The cost of 10 ampoules of 2 ml solution is 240 rubles.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
ZdravCity
- Spazmalgon tablets 50 pcs. Balkanpharma/Zdravle HFZ
370 rub. order - Spazmalgon tablets 20 pcs.Balkanpharma/Zdravle HFZ
RUB 179 order
- Spazmalgon effect tablets p.p.o 30 pcs. Balkanpharma-Dupnitsa AD
RUR 364 order
- Spazmalgon effect tablets p.p.o 10 pcs. Balkanpharma-Dupnitsa AD
RUB 158 order
- Spasmalgon solution for injection. 5ml 10 pcs Sopharma AD
370 rub. order
Pharmacy Dialogue
- Spazmalgon tablets No. 20Balkanpharma
RUB 168 order
- Spazmalgon tablets No. 10Balkanpharma
RUB 149 order
- Spazmalgon Effect tablets No. 10Balkanpharma Dupnitza AD
RUB 151 order
- Spazmalgon tablets No. 50Balkanpharma
RUB 351 order
- Spasmalgon ampoules 5ml No. 10Sopharma
RUR 348 order
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Pharmacy24
- Spazmalgon 5 ml No. 10 solution for injection AT "Sopharma", Bulgaria
327 UAH. order - Spazmalgon 2 ml No. 5 injection solution AT "Sopharma", Bulgaria
130 UAH order
- Spazmalgon N10 tablets Balkanfarma-Dupnitsya AT, Bulgaria/Pharmaceutical and Chemical Industry, Zdravle AT, Serbia
30 UAH order
- Spazmalgon No. 20 tablets Balkanfarma-Dupnitsya AD, Bulgaria
48 UAH order
- Spazmalgon N50 tablets Balkanfarma-Dupnitsya AT, Bulgaria/Pharmaceutical and Chemical Industry, Zdravle AT, Serbia
117 UAH. order
Admission rules
The dosage of the medicine for the treatment of various diseases is prescribed by the doctor. They depend on the age of the patient and the form of the drug. Spasmalgon tablets, the price of which is affordable, can be taken by adult patients once in an amount of no more than 2 pieces. You are allowed to take no more than 6 tablets per day. Allowable treatment time is 5 days. Its extension is possible only after consultation with a doctor.
Children can take the medicine no more than 2 times a day only as prescribed by the doctor. The recommended dosage for age is indicated in the instructions.
Intramuscular injections to adult patients are given 2-3 times, 2-5 ml of solution. The procedure involves slowly administering the medication. The permissible daily dosage is 10 ml. The maximum duration of treatment is 5 days. The permitted quantities of medicinal solution for children are indicated in the instructions.
