Phezam is a drug that improves cerebral circulation

The drug Fezam belongs to the group of psychostimulants and nootropics. It stimulates cognitive functions, has a positive effect on intelligence, and improves cerebral circulation. The drug is widely used in the treatment of many pathologies and its high effectiveness has been proven in practice.

pharmachologic effect

The abstract indicates that Phezam is a combined agent that provides nootropic, antihypoxic and vasodilating effects. There is a mutual potentiation of a decrease in cerebral vascular resistance, improving blood flow in these vessels.

As Wikipedia informs, the therapeutic effect and its mechanism are determined by the main active substances that are part of the drug Phezam. The main effect observed after taking the medicine is improvement of blood circulation in the brain and metabolic processes in nerve fibers and brain cells.

The substance piracetam has a nootropic effect, activating brain activity and positively affecting metabolism in the body. Under the influence of the substance, the rate of consumption of glucose, which is the main nutrient for the brain, increases. Thus, under the influence of piracetam, more active nutrition of cells occurs, which leads to the production of more energy and activation of brain function. Piracetam helps increase the speed of impulse transmission between neurons. As a result, memory increases, concentration improves, which leads to increased intellectual function.

Piracetam also helps improve blood flow in those areas of the brain where there are damaged vessels, and ischemia , that is, oxygen starvation. Since microcirculation improves, ischemic zones that arise due to lack of oxygen disappear, and the entire volume of neurons participates in brain function.

In addition, there is an indirect effect of this component, which helps to activate blood flow. It is ensured by inhibiting the process of platelet adhesion, which essentially prevents the formation of blood clots. The piracetam component not only activates blood flow, but also improves its properties. Thus, blood circulates more actively through microvessels.

hypoxia increases . Piracetam improves the integrative function of the brain, activates intellectual work, facilitates the process of assimilation of new material, and ensures restoration and support of brain functions in older people.

The substance cinnarizine has a pronounced effect directly on the blood vessels of the brain, dilating them. Also, under the influence of this substance, the tone of smooth muscles decreases, their response to active substances that constrict blood vessels decreases. Due to the fact that the substance dilates blood vessels, blood flow is activated, and more oxygen and nutrients enter the brain. Due to improved blood flow, the resistance of brain tissue to oxygen deficiency also increases. Moreover, despite the vasodilating effect, cinnarizine does not affect blood pressure and intracranial pressure .

The presence of these two components in Phezam simultaneously ensures a mutual enhancement of the effects of the active components. Consequently, the severity of the effect of the drug is more pronounced compared to taking these components separately.

When taking Phezam, there is a predominance of the sedative effect of cinnarizine, from which the medicine does not lead to the manifestation of psychomotor agitation, as happens when taking piracetam.

Phezam and alcoholic drinks

The drug fezam enhances the ethanol-initiated effect on the central nervous system and brain.
This process must be considered in two stages, following one after the other.

With mild intoxication, mental inhibition decreases, which increases activity, causes a surge of strength and removes barriers. A person gets into an exaggeratedly excited state, which puts a lot of stress on the nervous system.

As the dose of alcohol increases, affectation is replaced by apathy and depression, which is caused by the load experienced by the central nervous system.

At the first stage of intoxication, blood pressure decreases under the influence of alcohol. A sharp decrease in pressure under the influence of two strong substances can lead to acute vascular insufficiency. A drop in vascular tone and a decrease in circulating blood volume can lead to depression of vital organs. How the body will tolerate such an impact depends only on the physical well-being of the patient.

At the next stage of intoxication, a negative effect occurs on the respiratory center located in the brain, which can lead to respiratory arrest. It is not possible to predict the processes that will be initiated by the combined action of the drug and alcoholic beverages. Loss of consciousness, excessive intoxication, headache, insomnia, and depression may occur.

If the simultaneous use of Phezam and ethanol does not entail serious complications, the desired result from the treatment, that is, bringing intellectual abilities to an effective state, will not follow, since the drug restores brain function, and ethanol neutralizes this effect.

In addition to the ban on alcohol, the contraindications specified in the instructions cannot be ignored. Treatment with Fezam is carried out according to direct medical prescription after passing all the necessary tests.

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Pharmacokinetics and pharmacodynamics

After the patient has taken Phezam tablets orally, the active substances are completely absorbed from the gastrointestinal tract. The highest concentration of piracetam in plasma is observed after 2-6 hours, cinnarizine - after 1-4 hours. The bioavailability level of piracetam is 100%.

Piracetam does not bind to plasma proteins, cinnarizine binds 91%. Penetrates the BBB, is detected in all tissues and organs, and passes through the placental barrier. Its selective accumulation in the cerebral cortex is noted.

The substance piracetam is not metabolized, the metabolism of cinnarizine occurs in the liver.

The half-life of piracetam is 4-5 hours from the blood, 8.5 hours from the cerebrospinal fluid. Mainly excreted through the kidneys. The half-life of cinnarizine is 4 hours. Metabolites are excreted mostly in urine and also in feces. In people with renal failure, the half-life of piracetam is increased.

Indications for use of Phezam

Before using the medicine Phezam, you should definitely take into account the indications for use. The drug is prescribed in the following cases:

• with insufficiency of blood flow in the brain (in the case of vascular atherosclerosis , during the recovery period after an ischemic or hemorrhagic stroke , with encephalopathy of various origins, after a TBI);
• in case of intoxication;
• in diseases of the central nervous system, in which there is a decrease in intellectual-mnestic functions, that is, deterioration of attention, memory, mood;
• with psychoorganic syndrome, in which signs of asthenia and adynamia ;
• consequences of traumatic brain injury;
• labyrinthopathy (tinnitus, dizziness, nausea and vomiting);
• asthenic syndrome associated with psychogenic origin;
• Meniere's syndrome;
• for the purpose of preventing migraine , kinetosis ;
• in the complex therapy of children who have a psychoorganic syndrome, which has led to low learning ability.

The most dangerous combinations and consequences

The combination of alcohol and chemical-based drugs can lead to serious disorders in the body, and in some cases to fatal consequences.

List of medications and their side effects in combination with alcohol:

Contraindications

Phezam should not be taken in the following cases:

• in severe forms of renal and liver failure;
• during periods of increased psychomotor agitation;
• with Huntington's chorea ;
• during pregnancy and breastfeeding;
• when the patient is under 5 years of age;
• with high sensitivity to the components of the product.

The medicine is prescribed with caution to those patients who have been diagnosed with Parkinson's disease , hemostasis disorders, impaired liver or kidney function, and severe bleeding .

Phezam - to make the head work better

There are two main active ingredients in Phezam - piracetam and cinnarizine. In appearance they are white capsules, inside there is powdery contents.

The drug has the following effects:

• antihypoxic – a condition in which brain cells do not receive enough oxygen and nutrients;
• nootropic – improving the resistance of brain vessels to various adverse effects, regulation of higher nervous activity;
• vasodilators - lowering blood pressure, improving tissue nutrition;
• antihistamine – relieves swelling;
• sedative – reduces the excitability of the nervous system, has a calming effect.

The main active ingredients support and enhance each other's effects.

Indications for the use of Phezam:

• cerebrovascular accident;
• various intoxications;
• disturbance of higher nervous activity;
• traumatic brain injuries;
• psychoorganic syndrome;
• chronic fatigue syndrome;
• loss of coordination, tinnitus, nausea, vomiting;
• inner ear disease - Meniere's disease;
• various types of kenetosis - seasickness and so on;
• headaches of various etiologies - including migraines;
• low learning ability in adolescents with neurological disorders.

The dosage of the drug is selected by the attending physician. When taken correctly, cases of overdose have not been observed.

For adults, this is 1-2 capsules 3 times a day. For children, the dose is reduced - 1–2 pcs. 2 times a day - after breakfast and dinner.

Contraindications for taking Phezam:

• renal and liver failure in severe forms;
• Huntington's chorea;
• the period of waiting and feeding the baby;
• age up to 5 years;
• individual intolerance.

Side effects after taking the drug are rare. Most often these are dyspeptic symptoms - nausea, vomiting, diarrhea. After taking the capsules, it is not advisable to drive or work with precise and dangerous mechanisms.

Side effects of Phezam

The following side effects are possible during treatment:

• Nervous system: nervousness, feeling of drowsiness, hyperkinesia. In rare cases - headaches, dizziness , insomnia , ataxia , agitation, anxiety.
• Allergic manifestations: in rare cases - skin rash, dermatitis , swelling, itching, photosensitivity.
• Digestive system: severe salivation, nausea, vomiting, abdominal pain, diarrhea .
• Other manifestations: increased libido.

Phezam tablets, instructions for use (Method and dosage)

The instructions for use of Phezam, which are provided in the annotation for the drug, indicate that the medicine should be taken 1-2 capsules three times a day for one to three months. The duration of treatment depends on the severity of the disease. The drug is usually taken in courses - 2-3 courses annually.

Children over 5 years old are advised to take 1-2 capsules 1-2 times a day. Capsules are used for one and a half to three months. Capsules should be taken by swallowing them whole, without violating the integrity of the capsule. The tablet should be taken with half a glass of non-hot water.

Many users ask about capsules and how to take them - before or after meals. The instructions say that there is no particular difference in whether to take the product before or after meals. But it is optimal to drink capsules 20-30 minutes after eating. It is advisable to take the medicine at the same time every day.

Doctors warn that you cannot take the medicine for longer than 3 months - a break is necessary between courses.

Composition and form of the product

Phezam is a combination drug that is produced in tablet form. Active ingredients in the product:

• 400 mg piracetam.
• 25 mg cinnarizine.

Phezam tablets are available in the form of cylindrical hard gelatin capsules. Their contents are white powder. It may contain conglomerates, which, when pressed, also take on a powdery appearance.

Other ingredients are also used in the production of the drug. All of them are indicated in the instructions for use.

Interaction

Not all medications can be taken with Phezam tablets at the same time, so the interaction of this medication with other medications should be taken into account.

When taking medications simultaneously with Phezam that depress the action of the central nervous system, ethanol , tricyclic antidepressants , their sedative effect may increase.

When taking Phezam, the effect of nootropic and antihypertensive drugs is potentiated.

Vasodilator medications enhance the effect of Phezam.

Due to the presence of cinnarizine in the drug, the activity of hypertensive drugs .

When taking Phezam simultaneously, there is an increase in the activity of thyroid hormones , which can lead to tremor and anxiety.

Due to the antihistamine effect, cinnarizine can mask the manifestation of positive reactions in relation to factors of skin reactivity during skin tests. To avoid this effect, you must stop using the medication 4 days before such tests.

Phezam may enhance the effect of oral anticoagulants .

Can I take medicine with alcohol?

The drug to improve cerebral circulation cannot be combined in any way with alcohol. There are many reasons for this. It is worth knowing what consequences a person can expect if he violates the rules for taking Phezam.

Consequences of combination with ethanol

In order to understand what you can expect when mixing medicine and alcohol, the mechanism of action of alcohol on the body in combination with most medications, including Phezam, is explained below:

1. Any alcohol has a destructive effect on the brain. Over time, the cerebral cortex is destroyed and the person becomes weak-minded. Brain cells (neurons) die without the possibility of subsequent recovery. As a result, it turns out that what Phezam treats, we destroy with our own hands by drinking alcohol. Thus, the therapeutic effect is not achieved.
2. Fezam has a mild sedative effect. With the simultaneous intake of alcohol, this effect is enhanced significantly. In addition, no one can predict in advance how the nervous system will behave under such conditions. For some, taking medication with ethanol will have an inhibitory effect, for others it will have a stimulating effect on the nervous system.
3. Phezam is aimed at dilating the blood vessels of the brain, while alcohol, on the contrary, narrows them, which leads to significant dissonance in the body. Blood pressure can either rise to extreme levels or drop significantly. There is a risk of developing hemorrhagic stroke.
4. Both alcohol and medications put a certain amount of stress on the liver. When several toxic substances enter the body at once, this load increases significantly. If the liver has previously been negatively affected, it may not be able to withstand it and the person will experience acute liver failure.
5. There is also a risk of developing allergies and side effects.

special instructions

If Fezam is prescribed to patients with impaired liver function, liver enzyme levels should be monitored.

The medicine activates the functions of thyroid hormones, which is why patients undergoing treatment may experience anxiety and tremors .

Since cinnarizine can cause drowsiness, during treatment you should drive carefully and work with precise and dangerous machinery.

When treating elderly people, it is necessary to regularly monitor kidney function indicators and, if necessary, adjust the dose.

Active components are able to penetrate the filter membranes of hemodialysis .

The medication should be avoided in case of porphyria .

When taking Phezam, a false positive result may occur during doping control in athletes, also due to the presence of iodine-containing dyes in the capsule shell. A false positive result may occur in the radioiodine test .

Since piracetam reduces platelet aggregation, it should be prescribed with caution when hemostasis is impaired in patients, as well as in conditions accompanied by hemorrhages. You should not take the medicine during complex surgical operations, with severe bleeding and a history of hemorrhagic strokes

Phezam can provoke irritation in the epigastric region; when used after meals, a decrease in the severity of gastric irritation may be observed, for which purpose the medicine should be used with caution in patients suffering from gastrointestinal diseases.

lactose as an auxiliary component .

Description of the drug Fezam

The active ingredients are piracetam and cinnarizine.

The drug is able to enhance the metabolic process in brain cells, improve the utilization of glucose breakdown products, and also create resistance to hypoxic phenomena. Additionally, the drug has some antihistamine activity and is aimed at reducing the excitability of the vestibular apparatus.

Fezam is indicated for disorders of brain activity (for example, if they are caused by a stroke), for portal hypertension, encephalopathy, for comatose states after various brain injuries and for some other diseases that are accompanied by disorders of brain activity.

Indications include hypersensitivity to the components of the drug (individual intolerance), renal or liver failure, and children under 1 year of age.

The list of side effects is truly small. It is limited to dyspepsia, sleep disorders, irritability and allergic reactions.

But what happens if fezam and strong drinks are taken at the same time?

Phezam's analogs

Level 4 ATX code matches:
Bravinton

Acefen

Carnicetine

Pyracesin

Nooclerin

Semax

Piracetam

Olatropil

Vinpocetine

Cerebrocurin

Cavinton Forte

Calcium hopantenate

Glutamic acid

Cephabol

Olanzapine

Cerebrolysate

Pramistar

Sidnocarb

Vinpotropil

Glycine Ozone

Phezam and its analogues should be prescribed by a doctor after an accurate diagnosis. Active components similar to those contained in the drug Fezam are included in the following drugs: Combitropil , Piracezin , Omaron , NooKam . The price of analogues depends on the manufacturer of the drug and its packaging.

Medicines also have a similar pharmacological effect on the patient’s body: Acefen , Vinpocetine , Demanol , Memotropil , Combitropil , Pantogam , Pyriditol , Cellex , Encephabol , etc.

Omaron or Fezam - which is better?

Omaron drug and has the same indications for use, contraindications and causes similar side effects. At the same time, the price of the drug Omaron is lower compared to Fezam.

Reviews of Fezam

Most often, reviews about Phezam on forums are positive, they talk about improving the condition of patients when taking this medicine. Users write that after taking it, memory normalizes, attention and performance improve. Also, under the influence of the medicine, stress and anxiety .

Similar positive reviews appear when capsules are used for children.

On forums where the drug Phezam is discussed, reviews from doctors are also often positive. However, there are also negative comments that the drug causes drowsiness, as well as the lack of positive effects during treatment.

Fezam and alcohol: are they compatible?

The simultaneous use of these two substances can lead to very serious negative consequences in the human body.

The thing is that piracetam contained in phezam helps to activate the nervous system, but the second component (cinnarizine), on the contrary, has a calming effect. Since this is a combination drug, these two effects complement each other well. But as soon as you take alcohol, everything changes.

At the first stage, a person begins to feel very excited, it seems to him that the sea is knee-deep. If alcohol intake continues, then a sharp depression of the nervous system is observed, and the person himself becomes passive. All this is fraught with surges in pressure, which only a very healthy person can withstand. As a result, the drunk is in a state of insanity.

And such jumps in blood pressure are fraught with consequences for the cardiovascular system, and for health in general. This is especially dangerous if you already have problems with blood pressure. By the way, this reaction is evidenced by numerous reviews.

And, of course, you shouldn’t forget about the liver, because for it, taking medications and drinking alcohol are equally stressful. This is doubly dangerous in tandem.

Even if everything described does not happen, the medical effect of the drug will simply go unnoticed. And this is completely undesirable if a person is being treated for something.

Now we can say with complete confidence that the simultaneous use of Phezam and alcohol is unacceptable. Let all the arguments be convincing enough so that you don’t risk your health because of a banal desire to drink. If it turns out that you will combine fezam with alcohol, be sure to consult your doctor.

Phezam price, where to buy

The price of Phezam capsules in Moscow is on average 270 rubles for 60 pieces. You can buy them at any pharmacy with a doctor's prescription.

The price of Phezam in Ukraine (Kyiv, Kharkov, etc.) is from 200 UAH. per pack 60 capsules.

• Online pharmacies in RussiaRussia
• Online pharmacies in UkraineUkraine
• Online pharmacies in KazakhstanKazakhstan

ZdravCity

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