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INSTRUCTIONS

Learn more about the product NEOBIOTIK LACTOBALANCE® - a balanced combination of probiotic microorganisms (bifidobacteria and lactobacilli), lactic acid bacteria, prebiotics to restore normal intestinal microbiota, increase the protective function of the immune system and the general resistance of the human body, absorption of nutrients and synthesis of important vitamins and amino acids.

Innovative patented double-shell technology2,3 increases the survival rate of bacteria by 100 times, which allows for the long-term preservation of bifidobacteria and lactobacilli, which are sensitive to external and internal environmental factors and can be easily exposed during the production, storage and administration of the probiotic.2,24,25

The inner (1st) layer of the shell, consisting of proteins and peptides, protects lacto- and bifidobacteria from gastric juice and bile salts in the stomach and duodenum, ensuring their guaranteed delivery to the small intestine.

The outer (2nd) layer of the shell is a hydrocolloidal polysaccharide matrix that protects lactic acid bacteria from moisture, heat and mechanical pressure during production, storage and movement.

When the capsule enters the neutral intestine, the pH-dependent release mechanism is activated and bacteria are released to multiply, attach to the intestinal wall and establish colonies in the intestine.

Thanks to double shell technology there is

Protection of beneficial bacteria included in NEOBIOTIK LACTOBALANCE®
Their guaranteed delivery to the desired part of the intestine2,3

Compound

Fructooligosaccharides, corn starch, capsule shell (hydroxypropyl methylcellulose carrier), maltodextrin, vitamin C (ascorbic acid), magnesium stearate (anti-caking agent), bifidobacterium (Bifidobacterium longum CBT BG7, Bifidobacterium lactis CBT BL3, Bifidobacterium bifidum CBT BF3), lactobacilli (Lact obacillus acidophilus CBT LA1, Lactobacillus rhamnosus CBT LR5), Streptococcus thermophilus CBT ST3.

One capsule contains

Recommended intake (1 capsule) contains

Probiotic complex:	not less than 5.0×109 CFU
Total number of living bifidobacteria (Bifidobacterium longum CBT BG7, Bifidobacterium lactis CBT BL3, Bifidobacterium bifidum CBT BF3)	Not less than 24.4×10 CFU/g
Total number of live lactobacilli (Lactobacillus acidophilus CBT LA1, Lactobacillus rhamnosus CBT LR5)	Not less than 16.8×108 CFU/g
Total number of live lactic acid microorganisms Streptococcus thermophilus CBT ST3	Not less than 8.8×108 CFU/g
Fructooligosaccharides	175 mg
Vitamin C	12 mg (20)*

* - % of the recommended level of daily consumption (TR CU 022/2011).
Does not exceed the upper permissible level of consumption per day. Excipients: maltodextrin 46.55 mg, corn starch - 80.38 mg, magnesium stearate 3.5 mg.

Capsule shell

Carrier - hydroxypropyl methylcellulose - 75 mg

Nutrients	Nutritional value per 1 capsule (350 mg)	% of RDI per 1 capsule (350 mg)	Nutritional value per 100g
Energy value (kJ/kcal)	5.68 kJ/ 1.36 kcal	1623.4 kJ/ 388.0 kcal
Squirrels	0.00 g	0%	0.00 g
Carbohydrates	0.33 g	0,13%	95.00 g
Fats	0.00 g	0%	0.00 g

Release form

Capsules weighing 350 mg, 10, 20 or 30 capsules in plastic bottles, 1 bottle per cardboard pack.

The bifidobacteria, lactobacilli, lactic acid bacteria and fructooligosaccharides included in the NEOBIOTIK LACTOBALANCE® probiotic contribute to

Prevention and treatment of intestinal dysbiosis of various etiologies, including gastric and duodenal ulcers, pancreatitis, cholecystitis, hepatitis and other diseases of the digestive1 system;
Prevention of the development of intestinal infection (inhibits the growth of pathogenic bacteria);
Reducing the incidence of chronic constipation/diarrhea during long-term antibacterial therapy; relief of constipation (normalizes bowel function);15,16
Addition to standard Helicobacter pylori eradication therapy;5,6
Strengthening anti-inflammatory properties in patients with ulcerative colitis and other inflammatory bowel diseases (inhibiting the secretion or destroying toxins released by some “pathogenic” bacteria in the human body);
Prevention of hospital infections and dysbacteriosis in patients who often suffer from acute respiratory viral infections; helps reduce fatigue and fatigue;
Increases immunity (helps maintain a sufficient amount of circulating antibodies in the blood);
Reducing cholesterol levels; have a positive effect on the functioning of the liver and kidneys in patients with hypercholesterolemia; getting rid of excess weight;8.14
Providing conditions for the action of digestive enzymes, the production and absorption of vitamins, minerals and amino acids; as well as maintaining healthy skin and nervous system;1,4
Prevention of allergic reactions (reduces the incidence of nutritional allergic reactions), prevention of the development of atopic dermatitis;
Reducing intoxication manifestations of hepatic encephalopathy in persons with liver cirrhosis;
Restoring and maintaining normal vaginal microflora during dysbiosis, restoring the natural acidic environment in the vagina (pH 3.8–4.5) and increasing the resistance of the mucous membrane to the effects of pathogenic microorganisms;
Maintaining normal intestinal function during climate change;
Reducing the formation of toxins and harmful carcinogenic substances in the intestines, such as ammonia, indole and hydrogen sulfide.

Probiotic microorganisms included in NEOBIOTIK LACTOBALANCE®

Characterized by stability at room temperature,
Does not require storage in the refrigerator,
Maintain stability throughout the shelf life,
Characterized by a high degree of safety.

NEOBIOTIK LACTOBALANCE® does not contain

Artificial preservatives and colors;
Sahara;
Gluten and gelatin of animal origin;
Lactose, a derivative of milk and casein, can therefore be used for lactose intolerance and allergies to dairy products.

Application area

Recommended as a biologically active food supplement - a source of probiotic microorganisms (bifidobacteria and lactobacilli), lactic acid microorganisms, fructooligosaccharides and an additional source of vitamin C for: natural restoration of normal intestinal microbiota in chronic conditions of the gastrointestinal tract, prevention of dysbiosis, antibacterial therapy, maintenance maintaining normal intestinal function during climate change, maintaining immunity, reducing the risk of allergies, and lactase deficiency. Helps restore microbiota and normalize intestinal function.

Recommendations for use

Adults: 1 capsule per day with meals. Duration of treatment is from 10 to 30 days. If necessary, the reception can be repeated. It is recommended to consult a doctor before use.

Contraindications

Individual intolerance to components

Best before date

3 years

Storage conditions

Store out of the reach of children, at a temperature of 15°C to 25°C and a relative humidity of no more than 60%. Does not require storage in the refrigerator.

Terms of sale

Through a pharmacy chain and specialized stores, departments of a retail chain.

Certificate of state registration

AM.01.48.01.003.R.000178.09.19 dated 09/13/2019

, 50, Egibon-ro, 409 Beon-gil, Wolgot-miyon, Gimpo, 415-872, Korea, production address: 397, Egibon-ro, Wolgot-miyon, Gimpo, Prov. Gyeonggi-do, Korea for Unipharm, Inc., 350 Fifth Avenue, Suite 6701, New York, NY 10118, USA / Cell Biotech Co., Ltd., 50, Aegibong-ro, 409 Beon -gil, Wolgot-myeon, Gimpo-si, 415-872, Korea, manufacturing address: 397, Aegibong-ro, Wolgot-myeon, Gimpo-si, Gyeonggi-do, Korea for "Unipharm, Inc.", 350, Fifth Avenue, Suite 6701, New York, NY 10118, USA.

Importer and organization authorized to accept consumer complaints

Unipharm LLC, 115162, Moscow, st. Shabolovka, 31, building B, Russia

Literature

V.N. Drozdov, A.A. Astapovsky, G.S. Anikin, S.Yu. Serebrova, Lazareva N.B., E.V. Shih. Clinical efficacy of probiotic strains of the Lactobacillaceae family. Federal State Autonomous Educational Institution of Higher Education “First Moscow State Medical University named after. I.M. Sechenov" Ministry of Health of Russia (Sechenov University), Department of Clinical Pharmacology and Propaedeutics of Internal Diseases, Faculty of Medicine, Moscow, Russia. 2019
Patent for double coating technology of bacteria. EUROPEAN PATENT APPLICATION. Lactic acid bacteria powder double-coated using protein and polysaccharide and method preparing the same and a dosage form thereof. Application number: 03255553.4. 2005
#1. Frost & Sullivan South Korea Functional Food Company of the Year Award for innovation. 2015.
Probiotics and prebiotics / World Gastroenterology Organization (WGO). Practical recommendations. 2008.
Standards for the diagnosis and treatment of acid-dependent and Helicobacter pylori-associated diseases (fifth Moscow agreement) // XIII Congress of the NOGR. March 12, 2013
Lazebnik L.B., Rustamov M.N. The use of probiotics in the eradication of HELICOBACTER PYLORI // XII Congress of Scientific. Society of Gastroenterologists of Russia “Classical and Applied Gastroenterology” Abstracts of reports. March 1 - 2, 2012 M. S. 18-19
Insert leaflet for dietary supplement Lactiale
Gilliland, S. E., C. R. Nelson, and C. Maxwell. "Assimilation of cholesterol by Lactobacillus acidophilus." Applied and environmental microbiology2 (1985): 377-381.
The domestication of the probiotic bacterium Lactobacillus acidophilus, Matthew J. Bull, Nature, Scientific Reports, 2014
The life history of Lactobacillus acidophilus as a probiotic: a tale of revisionary taxonomy, misidentification and commercial success, Matthew Bull, Federation of European Microbiological Societies, 2013
Probiotics and prebiotics, General practical recommendations of the World Gastroenterological Organization (2011), Liki of Ukraine, 2012
Nutraceutical & Functional Foods Newsletter: October 28, 2010
Passion for Lactobacillus acidophilus, Tatyana Krivomaz, Ph.D. biol. Sciences, “Pharmacist Practitioner” #10′ 2014.
Effect of Probiotics on Blood Lipid Concentrations, A Meta-Analysis of Randomized Controlled Trials, Young Ae Cho, Medicine, October 2015.
Probiotic bacteria Lactobacillus acidophilus NCFM and Bifidobacterium lactis Bi-07 versus placebo for the symptoms of bloating in patients with functional bowel disorders: a double-blind s Ringel-Kulka T1, Palsson OS, Maier D, Carroll I, Galanko JA, Leyer G, Ringel Y, 2011.
Therapeutic effect of Lactobacillus acidophilus-SDC 2012, 2013 in patients with irritable bowel syndrome. Sinn DH1, Song JH, Kim HJ, Lee JH, Son HJ, Chang DK, Kim YH, Kim JJ, Rhee JC, Rhee PL, 2008.
Orally administered multispecies probiotic formulations to prevent uro-genital infections: a randomized placebo-controlled pilot study. Mezzasalma V, Manfrini E, Ferri E, Boccarusso M, Di Gennaro P, Schiano I, Michelotti A, Labra M, 2021.
Efficacy of vaginal probiotic capsules for recurrent bacterial vaginosis: a double-blind, randomized, placebo-controlled study. Ya W, Reifer C, Miller LE, 2010.
Probiotics for the control of obesity — Its effect on weight change, Ana Lídia Rouxinol-Dias, Porto Biomedical Journal, 2015
The Impact of Lactobacillus acidophilus Strain L-92 on Allergic Disease, A review of the literature By Ginny Bank, MS
The Variable Regions of Lactobacillus rhamnosus Genomes Reveal the Dynamic Evolution of Metabolic and Host-Adaptation Repertoires, Corina Ceapa, Mark Davids, Jarmo Ritari, Genome Biology and Evolution, 2016
Towards a better understanding of Lactobacillus rhamnosus GG—host interactions, Marijke E Segersand Sarah Lebeer, Microbial Cell Factories, 2014
Efficacy of Lactobacillus GG in maintaining remission of ulcerative colitis, A. ZOCCO, L. ZILERI DAL VERME, F. CREMONIN, Alimentary Pharmacology and Therapeutics, 2006
Probiotics in human disease, Erika Isolauri, The American Journal of Clinical Nutrition, 2001
Min Kyung Cha, Myung Joon Chung, Jin Jung Kim, Kang Oh Lee and Nam Joo Ha. Comparison of double-coated (bifidobacterium strains) and non-coated lactic acid bacteria from potential probiotics. Biotechnology and biotechnological equipment. 2011, 25 (3), Pages 2489-2493.
Joo Young Kang, Do Kyung Lee, Jae Yoon Park, Min Ji Kim, Jung-Soo Lee, Jae-Goo Seo, Myung Joon Chung, Hee Soon Shin and Nam Joo Ha. Double coating improves the survival of probiotic strains when exposed to simulated gastrointestinal conditions. Korean Journal of Microbiology, Vol. 49, N3, pp. 275 – 281, 2013.