Calcium D3 Meligen caps. 570 mg No. 100 with vitamins
Calcium - takes part in the formation of bone tissue, mineralization of teeth, blood clotting processes, muscle contractions, and is necessary to maintain stable activity of the cardiovascular and nervous systems.
Colecalciferol (vitamin D3) regulates the exchange of calcium and phosphorus in the body, enhances the absorption of calcium in the intestine, reduces resorption and increases bone density.
Vitamin C – is involved in collagen synthesis and redox processes, regulates carbohydrate metabolism, blood clotting, synthesis of steroid hormones, ensures tissue regeneration, and increases the body’s resistance to infections. It gives a particularly pronounced effect in combination with other vitamins.
Vitamin A – improves immunity, promotes normal metabolism, regulates the functions of cellular and subcellular membranes, plays an important role in the formation of bones and teeth, is necessary for the growth of new cells, improves vision, ensures the preservation of fertility, slows down the aging process, rejuvenates the skin, keeping it elastic , elastic and smooth.
Vitamin E - has a pronounced antioxidant and immunostimulating effect, improves circulation and ensures normal blood clotting, promotes the healing of skin damage, maintains the health of nerves and muscles, relieves leg cramps, strengthens capillary walls, prevents anemia, and is good for women's health.
Vitamin B1 (thiamine) has a calming effect on the nervous system, promotes wound healing, actively participating in cellular metabolism, and has analgesic properties.
Vitamin B2 (riboflavin) intensifies metabolic processes in the body, participating in the metabolism of proteins, fats and carbohydrates, and is necessary for the formation of red blood cells and antibodies, for respiration and cell growth. It facilitates the absorption of oxygen by the cells of the skin, nails and hair, improves the condition of the organs of vision, reduces eye fatigue and plays a major role in the prevention of cataracts; has a positive effect on the mucous membranes of the digestive tract, minimizing the negative effects of toxins on the respiratory tract.
Vitamin B5 (calcium pantothenate) is necessary for the metabolism of fats, carbohydrates, amino acids, the synthesis of vital fatty acids, cholesterol, histamine, acetylcholine, and hemoglobin.
Vitamin B6 (pyridoxine) plays an important role in metabolism, is necessary for the normal functioning of the central and peripheral nervous system, reduces cholesterol and lipid levels in the blood, improves myocardial contractility, promotes the conversion of folic acid into its active form, and improves lipid metabolism.
Vitamin B7 (biotin) stabilizes blood sugar, helps absorb protein, participates in the breakdown of fatty acids and fat burning; it can be called a beauty vitamin for skin, hair and nails.
Vitamin B9 (folic acid) is involved in the synthesis of amino acids, nucleic acids, purines and pyrimidines, and in choline metabolism. During pregnancy, it protects the body from the effects of teratogenic factors.
Vitamin B12 (cyanocobalamin) has a pronounced lipotropic effect, prevents fatty infiltration of the liver, increases oxygen consumption by cells during acute and chronic hypoxia.
Vitamin PP (nicotinamide) regulates redox processes in the body.
“Ask the Doctor” with endocrinologist E.N. Dudinskaya
On November 14, concerned citizens of all countries celebrate World Diabetes Day. The date was set by WHO together with the International Diabetes Federation in 1991 and was dedicated to the birthday of Frederick Banting, the scientist who first gave a life-saving injection of insulin to a diabetic boy. Every year, World Diabetes Day reminds healthy people that there are always people nearby who may need urgent help.
On the eve of World Diabetes Day, GNICM invited its readers on social networks to ask questions of interest to an endocrinologist.
Ekaterina Nailievna Dudinskaya, endocrinologist, candidate of medical sciences, senior researcher, answered the questions.
Inna N.
Hello, please tell me what measures are there to prevent diabetes? What should you do to never encounter this disease?
Hello, Inna!
We are talking about the prevention of type 2 diabetes mellitus, since it is for this that there are concepts of risk factors. These include age over 45 years, the presence of relatives in the family with type 2 diabetes, excess body weight, increased cholesterol levels in the blood, increased blood pressure, a sedentary lifestyle, and the birth of a child weighing more than 4000 grams. From this information it follows that we cannot change age and heredity. But other risk factors are completely correctable: you need to monitor your body weight, lead an active and healthy lifestyle, monitor your cholesterol and blood pressure levels, and then the risk of developing type 2 diabetes becomes as low as possible!
Natalya V.
I wonder if it makes sense to take thyroid hormones while taking birth control pills? Or is it better to do an ultrasound of the thyroid gland in this case? For the purpose of routine prevention of thyroid diseases.
Hello, Natalia!
Taking contraceptive medications, as a rule, does not affect the functioning of the thyroid gland. But since diseases of this organ are quite common, it makes sense to monitor TSH levels and conduct an ultrasound of the thyroid gland every 2-3 years.
Nadezhda Sh.
Hello. I have osteoporosis. I take Calcemin Advance, but since the tablet is very large, I have to break it. Please tell me, is it possible to do this? Other tablets such as Calcium D3 nikomed, complevit are not suitable due to the content of aspartame, the sweetness of which makes you very sick. Suspensions usually contain preservatives such as citric acid or vitamin C, and I have gastrointestinal diseases, which means I have a reaction to such things. Perhaps you can recommend some other suitable drug. And one more question about vitamin D. According to tests, it is low in me, and therefore the doctor prescribed Aquadetrim 2-3 drops. But my gastrointestinal tract reacts very much, apparently, to the benzene alcohol included in the composition. I saw Vegantol on sale, but it is oily, and I am worried that it will also affect the gall and pancreas. Are there any other vitamin D preparations that will not negatively affect the gastrointestinal tract?
Hello, Nadezhda!
Of course, medications must be taken entirely, since the tablets are often coated with a special coating in order to deliver the drug to the intestines, bypassing the aggressive environment of the stomach. But sometimes large tablets are difficult to swallow, so you can chew them. There are also individual reactions to a drug with impaired integrity - problems with the stomach and intestines may appear. But all these phenomena may occur in some people, but not in others. And the selection of calcium supplements is also very individual; you can go through many options before you find yours.
The same applies to native vitamin D3 preparations - Aquadetrim and Vigantol. If you have reactions to an aqueous solution - Aquadetrim, you can also try an oil solution - Vigantol. But no one can guarantee that you will tolerate it well.
There are also active metabolites of vitamin D3, preparations in capsules, not drops. But their selection must be carried out on the basis of a face-to-face consultation with the results of a study of bone metabolism, biochemical analysis of blood and urine.
Nellia H.
My aunt has one of the hormones that is not produced correctly, which means she has problems with digestion and intestines. Her daughter was recently diagnosed with the same thing. What is the likelihood of me having similar hormonal problems?
Hello Nellie!
What hormone is your aunt producing incorrectly? What did you find out about your daughter? Seek a face-to-face consultation with details of your relatives' violations.
Evgenia E.
Is there such thing as diabetes insipidus? I recently heard the definition and was very surprised.
Hello, Evgenia!
Yes, diabetes insipidus does happen. It develops due to disorders in the pituitary gland or kidneys and is manifested by severe thirst and excessive frequent urination. These symptoms are also typical for diabetes mellitus, but in the case of diabetes insipidus, the blood glucose level remains normal.
Ekaterina K.
Is it possible to cure chronic hypothyroidism? If the diagnosis was made in childhood, the TSH level often showed an excess of the norm (sometimes by several times), but pills were taken, can the disease go away or can we only talk about remission? Thank you!
Hello, Ekaterina!
Hypothyroidism is a disease of the thyroid gland due to the absence or decrease in the number of cells that produce hormones. And then medications are prescribed - the same thyroid hormones, but in tablets, that is, we make up for the deficiency from the outside. But we don’t grow new cells. Therefore, thyroid hormone replacement therapy is usually lifelong. Periodic monitoring of TSH levels is necessary to clarify whether the dose of thyroxine is sufficient or not.
Sergey D.
Mom has seen and read a lot of different things and now pesters me with the fact that according to the latest data, everyone who is overweight has diabetes, but it only occurs in a hidden form. Makes me regularly check my sugar level using the express method (using a home meter). I myself am overweight, but the device shows that my sugar is not elevated. I also feel normal. Can diabetes develop asymptomatically, and do I need to donate sugar from a vein to make sure that everything is fine with my health?
And also, please tell me what is the likelihood of developing diabetes in young people (I’m 32).
Hello, Sergey!
Your mother is right in many ways - prediabetes is very common in overweight people. Not yet the disease itself, but certain disorders of carbohydrate metabolism that can develop into type 2 diabetes. This diagnosis cannot be made based on changes in sugar with a glucometer. It is necessary to conduct a test in a laboratory with a load of 75 g of glucose. And then all the subtleties of changes in carbohydrate metabolism will be revealed.
And yes, type 2 diabetes is insidious because it remains asymptomatic for a long time. It is often diagnosed already at the time of the development of complications: for example, a patient is admitted with a myocardial infarction and, upon examination, long-term diabetes is revealed. Recently, type 2 diabetes has been getting younger, and doctors are seeing this disease not only in older people, but also in young people and even children.
Given your excess weight, you need to periodically donate blood from a vein for glucose. It's better to do a glucose test. If the results are normal, such a test should be performed once every 3 years.
Marina T.
Can changes in thyroid hormone levels affect memory impairment?
Hello, Marina!
Yes, dysfunction of the thyroid gland - that is, changes in thyroid hormones - can lead to memory impairment, difficulty remembering information and other psycho-neurological symptoms.
To make an appointment with an endocrinologist or find out how you can donate blood for sugar testing, please call the reception numbers:
Petroverigsky lane, 10
Kitaygorodsky pr-d, 7
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Calcium-D3-MIK
Pharmacodynamics
Calcium-D3-MIC is a combination drug that regulates the metabolism of calcium and phosphorus.
Calcium is a vital mineral element necessary to maintain the balance of electrolytes in the body and the adequate functioning of regulatory mechanisms. Calcium carbonate is involved in the formation of bone tissue, is necessary for the mineralization of teeth, regulation of nerve conduction, muscle contractions, maintaining stable cardiac activity and is a component of the blood coagulation system. Calcium (in ionized form and in the form of complexes) plays a key role in cell division and differentiation, conduction of nerve impulses and in the contraction-relaxation cycle (together with tropin) of smooth and striated muscles, transmembrane ion reactions involving selective calcium channels, activity neuroselective organs, the production and effects of a number of hormones, enzymes and other protein, as well as non-protein biologically active substances. The participation of calcium in such diverse processes is explained by its universal function as a secondary messenger (transmitter) that transmits and implements a biological signal in various types of cells.
Vitamin D3 stimulates the absorption of calcium and phosphorus in the intestines, the reabsorption of calcium and phosphorus in the kidneys, the transport of calcium through membranes and cells, the development of the immune system, cell proliferation and differentiation, the synthesis of lipids and a number of hormones, the functional activity of the cardiovascular system and gastrointestinal tract , reduces the level of parathyroid hormone in the blood. It is necessary for the normal functioning of the parathyroid glands and takes part in the synthesis of ATP.
Vitamin D3 and its active metabolites have a multifaceted effect on bone tissue: they increase the absorption of calcium in the intestine, stimulating the synthesis of calcium-binding proteins; increase calcium reabsorption in the renal tubules; activate bone remodeling processes by increasing the synthesis of collagen I and matrix proteins, by activating the synthesis of osteoblasts; improve bone quality by influencing osteoclast activity; regulate the secretion of parathyroid hormone by two mechanisms: directly suppressing the proliferation of parathyroid cells and through increasing the level of calcium in the blood; stimulate the differentiation of cells - precursors of bone and cartilage tissue; have a positive effect on neuromuscular conduction through the regulation of calcium channels and protein kinase A activity.
The use of a combination drug containing calcium and vitamin D3 is justified, since vitamin D3 increases the absorption of calcium in the intestine and the combined use of calcium and vitamin D3 prevents an increase in the production of parathyroid hormone (PTH), which is a stimulator of increased bone resorption (leaching of calcium from the bones).
Thus, Calcium-D3-MIC regulates the exchange of calcium and phosphates, reduces resorption and increases bone density, compensates for the lack of calcium and vitamin D3 in the body, enhances the absorption of calcium in the intestines and the reabsorption of phosphates in the kidneys, and promotes bone mineralization.
Pharmacokinetics
Calcium. Calcium absorption occurs in the duodenum, jejunum and colon. This process is carried out with the participation of two mechanisms: active absorption and passive diffusion, with the participation of which less than 10% of the element supplied with food is absorbed. The main regulator of active absorption is the vitamin D metabolite, calcitriol, which stimulates the biosynthesis of calcium-binding proteins in intestinal enterocytes. After being absorbed into the systemic circulation, calcium is distributed among organs and systems and primarily enters bone tissue.
Under physiological conditions, the excretion of calcium from the body (except for the part excreted in feces that is not absorbed in the intestine) is approximately 250–300 mg per day, which includes 140–180 mg that has not undergone reabsorption in the kidneys and enters the urine, as well as 80–100 mg, excreted into the intestines with bile and pancreatic secretions.
Calcium absorption increases during pregnancy and lactation.
Penetrates the placental barrier and is excreted in breast milk.
Cholecalciferol. Absorption of cholecalciferol occurs in the small intestine in the presence of bile. Usually 50-70% of the taken dose of the vitamin is absorbed. Incomplete absorption is observed with obstructive jaundice and severe steatorrhea.
The maximum concentration is reached after 8-18 hours. From the bloodstream, about 70% of vitamin D3 is absorbed by the liver, where it is metabolized. The resulting metabolite (25-hydroxycholecalciferol) is transported to the kidneys, where the formation of biologically active compounds occurs, among which 1,25-dihydroxycholecalciferol (1,25 (OH)2 D3) and 24,25-dihydroxycholecalciferol (24, 25 (OH)2D3).
The metabolism of cholecalciferol is disrupted in chronic renal failure, with the prescription of protein synthesis inhibitors (actinomycin, glucocorticoids), with long-term use of phenobarbital and diphenine.
Vitamin D3 has cumulative properties. It accumulates in the liver in non-parenchymal cells, from where it is transported to hepatocytes, where it is metabolized.
Penetrates the placental barrier and is excreted in breast milk.
T1/2 from blood plasma is up to several days and may be longer in case of impaired renal function.
In elderly patients, renal function may decrease, which should be taken into account when dosing the drug.
In patients with chronic liver failure, hypocalcemia may be a consequence of a decrease in the synthesis in the liver of 25-hydroxy-cholecalciferol as a substrate for the formation of 1,25-dihydroxy-cholecalciferol in the kidneys, that is, a vitamin D hormone that increases the intestinal absorption of ionized calcium.
Chronic renal failure is accompanied by a decrease in the synthesis of vitamin D hormone, which in some patients causes hypocalcemia. In patients with nephrotic syndrome, urinary loss of 25-hydroxycholecalciferol leads to hypocalcemia. Hypocalcemia due to loss of 25-hydroxycholecalciferol can be caused by a blockade of its physiological circulation between the intestinal lumen and the liver, due to a decrease in intestinal absorption.
