Phezam is a drug that improves cerebral circulation

The drug Fezam belongs to the group of psychostimulants and nootropics. It stimulates cognitive functions, has a positive effect on intelligence, and improves cerebral circulation. The drug is widely used in the treatment of many pathologies and its high effectiveness has been proven in practice.

Composition and form of the product

Phezam is a combination drug that is produced in tablet form. Active ingredients in the product:

400 mg piracetam.
25 mg cinnarizine.

Phezam tablets are available in the form of cylindrical hard gelatin capsules. Their contents are white powder. It may contain conglomerates, which, when pressed, also take on a powdery appearance.

Other ingredients are also used in the production of the drug. All of them are indicated in the instructions for use.

Comparison of addiction in Phezam and Omaron

Like safety, addiction also involves many factors that must be considered when evaluating a drug.

So, the totality of the values of such parameters as “o syndrome” in Fezam is quite similar to the similar values in Omaron. Withdrawal syndrome is a pathological condition that occurs after the cessation of intake of addictive or dependent substances into the body. And resistance is understood as initial immunity to a drug; in this it differs from addiction, when immunity to a drug develops over a certain period of time. The presence of resistance can only be stated if an attempt has been made to increase the dose of the drug to the maximum possible. At the same time, Fezam has quite a small value of the “syndrome”, however, just like Omaron.

Phezam: effect of the drug

Phezam, the instructions for use emphasize this, has a pronounced antihypoxic, nootropic and vasodilating effect.

The active ingredient in piracetam is a nootropic substance. It activates blood circulation and metabolic processes in the brain. This allows you to improve memory, increase the threshold of intellectual fatigue and learning ability. In addition, piracetam provides protection to the brain during oxygen starvation, which minimizes the risks of damage and death of brain cells due to hypoxia.

Another active component, cinnarizine, has a vasodilating effect and reduces blood viscosity. This allows for improved tissue nutrition. The substance has moderate antihistamine activity, reduces the tone of the sympathetic nervous system and stimulation of the vestibular apparatus.

The drug is quickly and almost completely absorbed from the gastrointestinal tract. The maximum concentration of active components in the blood is reached in approximately an hour.

Still, “Fezam” or “Omaron” - which is better?

As experts note, these drugs are practically no different. The first remedy is more expensive than the second. If we talk about indications, the list of prescriptions is the same for both medications. Due to the fact that the drugs contain the same active ingredients, side effects and contraindications are also similar. In particular, both drugs are not recommended for impaired liver function during pregnancy. Therapy for breastfeeding patients is not permitted. All popular analogues of Phezam are not prescribed to children under five years of age.

What does the drug treat?

Fezam, the instructions for use confirm this, is indicated for the treatment of various intellectual and cognitive disorders. It improves memory and the thinking process, promotes the development of attention. When taken, it is possible to reduce emotional negative reactions such as irritability and apathy.

The drug has proven its effectiveness in the treatment of pathologies caused by cerebrovascular accidents. Fezam is prescribed after:

Traumatic brain injuries.
Hemorrhages.
Intoxication.

It is possible to improve the condition of patients with psychoorganic disorders when using Phezam. This group includes a number of diseases characterized by:

Deterioration of intellectual abilities.
Weakening of memory, which causes difficulty in remembering new information and activating previously learned information.
Emotional instability, which is expressed by a sharp change in mood.

Other indications for use of the medicine:

Encephalopathy, which is associated with metabolic disorders in brain cells.
Meniere's disease, the symptoms of which are dizziness and progressive hearing loss.
Cognitive disorders.
Asthenic syndrome, a characteristic feature of which is increased fatigue, significantly worsening the quality of life.
Arterial hypertension caused by increased blood pressure.

Phezam is also used for preventive purposes. Taking it reduces the risk of developing a migraine attack. In addition, it is possible to prevent various unpleasant reactions of the body to acceleration and weightlessness: dizziness and motion sickness.

Additional Information

When prescribing any of the above drugs, combined use with similar drugs is not allowed. Otherwise, an increase in sedative effect and depression of central nervous system functions is likely. Adults are advised to refrain from drinking alcohol and alcohol-containing products. Medicines that have a vasoconstrictor effect enhance the therapeutic effect of nootropics. Phezam analogs increase the tolerability of tricyclic antidepressants and antipsychotic medications. If the dosage regimen is followed, the drugs do not provoke intoxication. All nootropic drugs are available in pharmacies with a prescription.

If medications are not effective, it is highly recommended not to exceed the prescribed dosage. Changing the treatment regimen on your own increases the risk of side effects. If the condition worsens or if treatment is unsuccessful, you should visit a specialist. You should not independently replace the prescribed drug with another. Among the medications “Combitropil”, “Nookam”, “Fezam” or “Omaron” - the doctor decides which is best for the patient. For pathologies of the liver or kidneys, nootropics are recommended in a reduced dosage or taken at long intervals. During therapy, constant monitoring of transaminase activity should be ensured. In case of high intraocular pressure or Parkinson's disease, the use of medications is carried out under the close supervision of a specialist. Since the drugs have an effect on the central nervous system, persons whose activities are considered potentially dangerous should refrain from them. In particular, this applies to transport drivers and people working with complex mechanisms. If it is necessary to treat nursing patients, it is recommended to stop lactation. The duration of the therapeutic course should not exceed three months.

Fezam: contraindications

A contraindication to taking the drug is hypersensitivity to the active substances and other components that make up the drug. Their list is indicated in the instructions for use.

Drug treatment is not prescribed for children under 5 years of age. It is prohibited to use the drug when diagnosing serious disorders in the functioning of the liver and kidneys.

Treatment with the drug is contraindicated during pregnancy and lactation, since studies that confirm the absence of a negative effect of the drug on the fetus and newborn child have not been conducted.

Fezam is prohibited for hemorrhagic stroke, Parkinson's disease and Huntington's chorea. When taking the drug, it is important to exclude psychomotor agitation. Use medication with caution in the presence of bleeding disorders.

Purpose

The medication is recommended for cerebrovascular disorders due to vascular atherosclerosis and ischemic stroke. The drug is prescribed during the rehabilitation of patients who have suffered a hemorrhagic stroke. The remedy is indicated after TBI. The use of Phezam is recommended for disorders of mental activity, memory, concentration, and mood changes (depression or irritability).

The medicine is effective for Meniere's syndrome, labyrinthopathy of various origins (tinnitus, dizziness, nystagmus, vomiting, nausea). The drug is prescribed to prevent migraine and kinetosis. The medication is recommended for children with delayed intellectual development to enhance learning and memory. Phezam analogues contain the same active ingredients, but if other additional substances are present, the medications may have a slightly different range of indications and limitations.

Negative effects

Negative reactions when taking Phezam can be observed from different systems of the human body. But the most frequently recorded negative neuropsychic effects are:

Coordination disorders.
Fast fatiguability.
Depression.
Drowsiness.
Internal anxiety.

During treatment with the drug, disruptions in the gastrointestinal tract may occur, which can provoke a complex of dyspepsia phenomena. There is a possibility of allergic reactions: swelling, urticaria, itching of the skin, etc.

An overdose causes abdominal pain. When it is confirmed, it is necessary to perform gastric lavage. There is no specific antidote, but the condition can be stabilized with hemodialysis. Symptomatic therapy is also indicated.

What are the side effects when taking nootropics?

Any remedy can provoke undesirable consequences. During therapy, an allergic reaction is most often observed. Usually, it is caused by hypersensitivity to the components. Taking medications by mouth causes dyspepsia in some patients. In particular, there is a disorder in the functioning of the digestive system, dry mouth, and discomfort in the stomach. Nootropic drugs have a negative effect in some cases on the central nervous system. During treatment, sleep may be disturbed and headaches may appear. If any side effects occur, you should visit your doctor immediately.

Rules of use and special instructions

Tablets are taken 3 times a day, 1-2 pieces. Course duration is up to 3 months. As a maintenance therapy, it is recommended to take fezam 2-3 times a year.

When taking doping tests, athletes must stop taking the drug 2–3 days before testing. This is due to the fact that cinnarizine in the drug can give positive tests.

Since Fezam can cause drowsiness, when using it, you should be careful when operating various mechanisms and when driving a car. You should also avoid alcohol, as this can cause brain cell death.

Comparison of the effectiveness of Fezam and Omaron

The effectiveness of Phezam is quite similar to Omaron - this means that the ability of the drug substance to provide the maximum possible effect is similar.
For example, if the therapeutic effect of Phezam is more pronounced, then using Omaron even in large doses will not achieve this effect.

Also, the speed of therapy - an indicator of the speed of therapeutic action - is approximately the same for Fezam and Omaron. And bioavailability, that is, the amount of a drug reaching its site of action in the body, is similar. The higher the bioavailability, the less it will be lost during absorption and use by the body.

Buy Phezam capsules 400mg+25mg No. 60 in pharmacies

Trade name of the drug:

Phezam®

International nonproprietary or generic name:

piracetam + cinnarizine

Dosage form:

capsules

Composition 1 capsule contains:

active ingredients – piracetam 400.0 mg, cinnarizine 25.0 mg;

excipients – lactose monohydrate 55.0 mg, colloidal silicon dioxide 15.0 mg, magnesium stearate 5.0 mg. The capsule shell contains titanium dioxide 2%, gelatin 98%.

Description

Hard, cylindrical gelatin capsules, white, No. 0.

Powdery mixture, from white to almost white, may contain conglomerates, which, when pressed with a glass rod, easily turn into powder.

Pharmacotherapeutic group:

Nootropic drug

pharmachologic effect

Pharmacodynamics

A combined drug with a pronounced antihypoxic, nootropic and vasodilating effect. The components mutually potentiate a decrease in cerebral vascular resistance and help increase blood flow in them.

Piracetam activates metabolic processes in the brain by enhancing energy and protein metabolism, accelerating the utilization of glucose by cells and increasing their resistance to hypoxia; improves interneuronal transmission in the central nervous system (CNS), improves regional blood flow in the ischemic area.

Cinnarizine is a selective blocker of slow calcium channels and an antagonist of histamine H1 receptors. It has been established that it inhibits the entry of calcium ions into cells and reduces their content in the plasma membrane depot, reduces the tone of the smooth muscles of arterioles, and reduces their response to biogenic vasoconstrictors (catecholamines, angiotensin and vasopressin). It has a vasodilating effect (especially in relation to cerebral vessels, enhancing the antihypoxic effect of piracetam), without having a significant effect on blood pressure. It exhibits moderate antihistamine activity, reduces the excitability of the vestibular apparatus, and lowers the tone of the sympathetic nervous system. Increases the elasticity of red blood cell membranes, their ability to deform, and reduces blood viscosity.

Pharmacokinetics

The drug is quickly and completely absorbed from the gastrointestinal tract. The maximum concentration of piracetam in plasma is created after 2-6 hours. It freely penetrates the blood-brain barrier, the maximum concentration in the cerebrospinal fluid is after 2-8 hours. Bioavailability is 100%. Does not bind to plasma proteins. The apparent volume of distribution of piracetam is about 0.6 l/kg. Penetrates all organs and tissues, passes the placental barrier. Selectively accumulates in the cerebral cortex, mainly in the frontal, parietal and occipital lobes, cerebellum and basal ganglia. Not metabolized. The half-life (T1/2) from blood plasma is 4-5 hours, from cerebrospinal fluid - 8.5 hours. 80-100% of piracetam is excreted unchanged by the kidneys by renal filtration. The renal clearance of piracetam in healthy volunteers is 86 ml/min.

T1/2 is prolonged in renal failure. The pharmacokinetics of piracetam does not change in patients with liver failure. Penetrates through the filter membranes of hemodialysis machines.

After oral administration, absorption of cinnarizine is slow. The maximum concentration of cinnarizine in plasma is achieved after 1-4 hours. 91% bound to plasma proteins. Actively and completely metabolized by liver isoenzymes CYP2D6 through dealkylation. T1/2 is 4 hours. 1/3 of the metabolites are excreted by the kidneys, 2/3 through the intestines.

Indications for use

— Insufficiency of cerebral circulation (atherosclerosis of cerebral vessels, recovery period of ischemic and hemorrhagic strokes, traumatic brain injuries, encephalopathy of various origins). - Intoxication. — Diseases of the central nervous system, accompanied by a decrease in intellectual and mental functions (impaired memory, attention, mood). — Conditions after a traumatic brain injury. — Psychoorganic syndrome with a predominance of signs of asthenia and adynamia. — Asthenic syndrome of psychogenic origin. — Labyrinthopathies – dizziness, tinnitus, nausea, vomiting; nystagmus. - Meniere's syndrome. — Prevention of migraine and kinetosis. — As part of complex therapy for learning disabilities in children with psychoorganic syndrome.

Contraindications

- Hypersensitivity to piracetam, cinnarizine or to any of the excipients included in the drug; — Severe renal (creatinine clearance <20 ml/min) and/or liver failure; — Psychomotor agitation at the time of drug prescription; - Huntington's chorea; — Children under 5 years of age; — Pregnancy and lactation; — Hemorrhagic stroke; — Patients with rare hereditary diseases: galactose intolerance, lactase deficiency or glucose-galactose malabsorption (contains lactose monohydrate).

Carefully

Parkinson's disease; conditions associated with increased intraocular pressure; impaired liver and/or kidney function, impaired hemostasis, severe bleeding.

Pregnancy and lactation

Despite the lack of data on the presence of teratogenic effects of piracetam and cinnarizine, the use of the drug during pregnancy is not recommended. The use of Phezam for pregnant women is indicated only if the expected benefit to the mother outweighs the potential risk to the fetus.

Piracetam is excreted in breast milk, so it is recommended to stop breastfeeding while taking it.

Directions for use and doses

Inside.

The usual dose for adults is 1-2 capsules three times a day for 1-3 months, depending on the severity of the disease. The course of treatment is 2-3 times a year.

Children (over 5 years old) - 1-2 capsules 1-2 times a day.

The course of treatment is 1.5 -3 months.

Side effect

In very rare cases, hypersensitivity reactions - allergic reactions in the form of skin rash, dermatitis, itching, swelling, photosensitivity.

From the gastrointestinal tract: in some cases, increased salivation, nausea, vomiting, diarrhea, and abdominal pain are possible.

From the central and peripheral nervous system: hyperkinesia, nervousness, drowsiness, depression; in isolated cases - dizziness, headaches, ataxia, imbalance, insomnia, confusion, agitation, anxiety, hallucinations.

Other: increased sexual activity.

With long-term therapy, tremor may occur in elderly patients.

Overdose

Phezam® is very well tolerated by patients; in case of overdose, no serious side effects requiring discontinuation of the drug are observed.

In case of overdose in children, symptoms of excitement dominate: insomnia, anxiety, euphoria, irritability, tremors and, in rare cases, nightmares, hallucinations and convulsions.

Treatment is symptomatic, which may include hemodialysis. Gastric lavage should be performed and vomiting should be induced. There is no specific antidote.

Interaction with other drugs

When taken simultaneously with drugs that depress the central nervous system, tricyclic antidepressants and alcohol, the sedative effects are enhanced.

The drug potentiates the effect of nootropic and antihypertensive drugs.

Vasodilators enhance the effect of the drug.

Improves tolerability of antipsychotic drugs and tricyclic antidepressants.

The effect of oral anticoagulants may be enhanced.

Precautions for use

The drug should be prescribed with caution to persons with liver and/or kidney disease. In cases of mild to moderate renal failure (especially if creatinine clearance is less than 60 ml/min), the therapeutic dose should be reduced or the intervals between doses should be increased.

In persons with impaired liver function, monitoring of liver enzyme levels is necessary.

You should avoid drinking alcohol during treatment.

The drug can cause a false-positive reaction when monitoring doping agents in athletes.

The drug increases the activity of thyroid hormones and may cause tremors and anxiety.

Impact on the ability to drive a car and other mechanisms

During treatment, care should be taken when driving vehicles and working with machinery and equipment, since at the beginning of treatment, cinnarizine may cause drowsiness.

Release form

Capsules, 400 mg+25 mg.

In production at Balkanfarma-Dupnitsa AD, Bulgaria

10 capsules in Al/PVC blister.

3 or 6 blisters along with instructions for use in a cardboard box with first opening control.

During production at JSC HFZ "Zdravlje", Serbia

10 capsules in Al/PVC blister.

3 or 6 blisters along with instructions for use in a cardboard box, on which additional protective stickers can be applied.

Storage conditions

At a temperature not higher than 25 ºС.

Keep out of the reach of children!

Best before date