Mydocalm tablets. Analogs are cheaper, instructions, prices, reviews

Has restrictions during pregnancy

Prohibited during breastfeeding

Prohibited for children

Has restrictions for older people

Has limitations for liver problems

Has limitations for kidney problems

Muscle relaxants are widely used to relieve spasms, increase the mobility of affected muscles and relieve pain symptoms. Mydocalm is an effective and frequently prescribed remedy in this group, which has a rapid effect and helps reduce muscle tone. However, in some cases it is necessary to use inexpensive analogues of Mydocalm, which no less quickly have the desired effect and are not inferior in their characteristics to expensive equivalents.

The main active ingredient in Mydocalm is tolperisone, which acts as a centrally acting muscle relaxant, helps to relieve the manifestations of diseases of the musculoskeletal system, improves the functioning of the nervous system and copes with inflammatory diseases. The advantage of the drug is that it is available in two forms: tablets and ampoules.

Mechanism of action of Mydocalm

Its bioavailability is 15-20%. The drug actively interacts with nervous tissue, reaching high concentrations in the spinal cord and brain, as well as in the peripheral nervous system. Mydocalm reduces the excitability of motor neurons and inhibits the activity of sodium channels, increasing blood circulation.

The medication is most often prescribed for the following pathologies:

• muscle spasms;
• arthrosis of large joints;
• postoperative period in traumatology.

Contraindications to the use of this drug are:

• drowsiness;
• headache and pain in limbs;
• noise in ears;
• heat;
• irritability.

Release forms and composition of the drug

Mydocalm is a large round tablet with a protective enteric film coating. The medicine has a mild medicinal odor. Each tablet contains 50 or 150 mg of the main pharmacologically active component - tolperisone hydrochloride.

It has a biconvex geometric configuration and a dividing line in the middle for taking a half dose. The concentration of the active substance is indicated on the tablet by appropriate engraving. Manufacturer: Hungarian pharmaceutical company Gedeon Richter.

Mydocalm tablets (cheaper analogues - Sirdalud and Baclofen) are supplied to pharmacies in cardboard boxes, which indicate:

• name of the drug;
• dosage;
• number of units of the drug;
• manufacturer and other basic information.

Tablets 10 pcs. packaged in hermetically sealed sterile blisters made of aluminum foil and transparent medical polymer. Each cardboard box contains 3 blocks of medicine and paper instructions for use.

The solution for intramuscular injection is available in 1 ml tinted glass ampoules. This dosage form is a clear liquid without foreign inclusions or odor. The secondary packaging is a contoured cellular plastic block containing 5 ampoules.

In addition to the main active ingredient, the pharmacological formula of the tablets includes the following auxiliary components:

The injection solution contains 100 mg of tolperisone and 2.5 mg of lidocaine. Diethylene glycol, distilled water and methylated parahydroxybenzoate are used as excipients.

Reviews about Mydocalm

Reviews about Mydocalm tablets left by patients who have undergone treatment with it are quite contradictory. Some note the high effectiveness of the drug, its availability and the absence of side effects.

Someone, on the contrary, points out that there were no visible results after therapy, but such phenomena as swelling , nausea or urticaria .

Most often you can find reviews about Mydocalm on forums where children's health issues are discussed. The drug is often prescribed to children diagnosed with hypertension . However, most parents do not risk giving it to children under one year old, given the age limit specified in the instructions, and limit treatment to physiotherapy and massage courses.

For this reason, there are not many positive reviews about the use of Mydocalm in children. By the way, some note as a disadvantage of the drug that the manufacturer does not have a dosage form in the form of a syrup, which would make it easier for infants to take.

Reviews from doctors about Mydocalm are positive. At the same time, most experts note that the greatest effectiveness from treatment with the drug can be achieved only by choosing the right dosage tactics, and also, in some cases, by correctly combining it with other medications.

Pharmacological properties

Tolperisone hydrochloride has a local anesthetic effect. It is classified as an aminoketone muscle relaxant. Mydocalm stabilizes the cell membranes of nerve tissues and muscle fibers. The pharmacologically active component of the drug restores trophism and increases muscle tone.

The drug reduces musculoskeletal tension, relaxes musculoskeletal structures, and prevents the occurrence of their spasmodic state. The pronounced analgesic properties of tolperisone hydrochloride allow the drug to be used in the relief of neurological pain.

Mydocalm tablets, cheaper analogs and other drugs with similar therapeutic properties intensify tissue circulation, improve lymphatic function, and stabilize blood pressure.

The drug has a generalized effect. The spasmodic state of muscle structures is the body’s natural reaction to pain, which limits the mobility and activity of the musculoskeletal mechanism.

This physiological process leads to the opposite effect - even greater compression of the nerve endings, which increases the severity of myalgia. Mydocalm breaks the vicious circle of pathology through muscle relaxation.

Pharmacodynamics and pharmacokinetics

The mechanism of the therapeutic effect of the drug is based on the ability of tolperisone hydrochloride to block the oxidation of fatty acids and increase the activity of membrane-bound enzymes.

Mydocalm stops the transmission of signals in primary afferent nerve-conducting tissues and neuronal cells, which, in the implementation of motor function, play the role of transporting information signals from the central nervous system and cerebral organ to the effector molecules of muscle fibers.

This causes blocking of poly- and monosynaptic reflexes of the spinal apparatus. The pharmacodynamic characteristics of Mydocalm have not been fully studied. There is a possibility of secondary inhibition by tolperisone hydrochloride of the release of neurotransmitter compounds.

This physiological effect is achieved by blocking calcium channels at the sites of functional interaction of Ca+ with spinal neurons. In the spinal trunk, Mydocalm reduces nervous excitation of synapses, distributed to muscle tissue along the reticulospinal tract.

A drug:

• activates blood circulation in peripheral vessels;
• reduces pathological hypertonicity of the adductor muscles;
• eliminates muscular rigidity - a state of hardness, spasms and intractability that occurs due to the lack of a natural response to stimuli or resistance;
• reduces the severity of diffuse myalgic syndrome;
• suppresses voluntary motor disorders.

Such therapeutic effects are due to the antispasmodic and adenoblocking properties of tolperisone hydrochloride. Mydocalm reduces the toxicity of strychnine, a special alkaloid of the indole group.

The medication eliminates the increased reflex excitation of synapses caused by this chemical compound. The medicine has pronounced vasodilating activity.

The drug selectively suppresses spastic signals traveling to muscle fibers from the caudal element of the spinal cord and the thalamus in the rostral direction. Tolperisone hydrochloride has a moderate generalized H-anticholinergic effect.

This effect is due to the ability of the main component of the neurological drug to influence the functioning of nicotinic receptors in:

• skeletal muscle synapses;
• ganglion nodes of the autonomic nervous system;
• the membrane of the adrenal glands;
• sinocarotid fibers.

By entering into a biochemical connection with H-cholinolytic receptors, tolperisone hydrochloride suppresses their ability to perceive acetylcholine. As a result, nerve impulses do not travel through blocked synapses.

Mydocalm tablets are quickly absorbed from the gastric cavity by overcoming the gastroenterological barrier. Analogues that are cheaper have the same pharmacokinetic characteristics, but a greater number of clinical restrictions on use and negative systemic effects on the body.

Maximum saturation of blood plasma with tolperisone hydrochloride is observed after 60-90 minutes. after entering the gastric cavity. The physiological activity of the active substance of the tablet medication reaches 20%.

Tolperisone and auxiliary components of the neurological muscle relaxant are metabolized in the renal and hepatic tissues. The drug is eliminated through the urinary canals.

Tolperisone

Centrally acting muscle relaxant. The decrease in pathologically increased skeletal muscle tone is explained by the ability of tolperisone to suppress spinal polysynaptic reflexes and the inhibitory effect on the caudal part of the reticular formation.

It has central n-anticholinergic properties. Does not have a significant effect on the peripheral parts of the nervous system. It has a weak antispasmodic and vasodilator effect.

Release form and composition: Film-coated tablets, white or almost white, round, biconvex, with a characteristic odor.

1 tab. tolperisone hydrochloride 50 mg. Excipients: microcrystalline cellulose - 72.6 mg, lactose monohydrate (milk sugar) - 45.1 mg, croscarmellose sodium - 7.6 mg, hypromellose - 1.9 mg, citric acid monohydrate - 1.5 mg, magnesium stearate - 1.3 mg.

Film shell composition: hypromellose - 3 mg, macrogol 4000 - 0.75 mg, titanium dioxide - 1.25 mg.

Indications for use

Spinal and cerebral palsy (hypertonicity, muscle spasms, spinal automatism; contracture of the limbs).

Diseases accompanied by dystonia, rigidity, muscle spasm; obliterating diseases of the arteries: obliterating atherosclerosis of the vessels of the extremities, diabetic angiopathy, thromboangiitis obliterans (Buerger's disease), Raynaud's syndrome.

Consequences of disorders of vascular innervation (acrocyanosis, intermittent angioedema). Extrapyramidal disorders (postencephalitic and atherosclerotic parkinsonism).

Postthrombotic disorders of lymph circulation and venous circulation, trophic leg ulcer, spastic infantile paralysis (Little's disease), epilepsy, encephalopathy of vascular origin; hypertonicity in combination with another type of muscle tone disorder.

special instructions

Frequent side effects of the drug are hypersensitivity reactions, which can manifest from mild cutaneous to severe systemic, including anaphylactic shock. Symptoms of an allergic reaction are rash, redness, itching, urticaria, Quincke's edema, shortness of breath, arterial hypotension, tachycardia.

Women with a history of allergic or hypersensitivity reactions to other drugs are at higher risk.

Increased caution should be exercised in cases of known hypersensitivity to lidocaine, as cross-reactions may occur.

Patients should be warned to be alert for any possible hypersensitivity symptoms. If they develop, you should immediately stop taking the drug and consult a doctor. After an episode of hypersensitivity, re-prescription of tolperisone is prohibited.

Influence on the ability to drive vehicles and operate machinery. Use with caution in patients whose activities require increased attention and speed of psychomotor reactions.

Indications for use

Mydocalm is prescribed for numerous diseases of the musculoskeletal system and neurological disorders accompanied by muscle spasms and myalgic syndrome. The injectable drug is used in clinical practice for intensive therapy, maintenance treatment and prolongation of the period of remission.

Main indications for the use of tablet medication:

• destructive changes in musculoskeletal fibers;
• spondyloarthrosis – degenerative pathology of the arcuate processes of articular joints, cartilage, underlying bone, tendons and ligaments;
• spondylosis – involutional wear and tear of the anatomical structures of the spinal column during the aging process;
• cervical syndrome;
• lumbago;
• multiple sclerosis;
• osteochondrosis;
• myelopathic conditions;
• encephalomyelitis;
• myogenic contractures;
• cholelithiasis;
• hemorrhoids;
• menstrual pain.

A muscle relaxant is used to suppress postoperative pain and is included in the combined drug treatment of obliterating lesions of the blood vessels. Tablets are used for diabetic angiopathy.

With their help, various vasoplastic diseases are treated - angiotrophoneurosis, thromboangiitis, and others. Mydocalm is used for muscle relaxation in patients who have suffered a stroke.

The drug is indicated for pathological conditions associated with disorders of vascular innervation. For osteochondrosis, the tablets have a mild sedative effect and block spinal reflexes.

Inexpensive substitutes in ampoules

In addition to the tablet form of muscle relaxants, there are cheap analogues in ampoules, which allows the medicine to be administered by injection. The advantage of these analogues is the quickly achieved therapeutic effect.

Ambien

Ambene is a combination drug whose action is aimed at relieving inflammation, fever and providing an analgesic effect. The medicine is quickly absorbed into the bloodstream after administration. Ambene is indicated for use if the patient has:

1. Arthritis.
2. Pain syndromes caused by degenerative diseases of the spine.
3. Neuralgia.

Indications for use

The medication is used no more than three times a week, the injection is given daily or every other day. The drug must be administered intramuscularly and slowly. In this case, the patient should be in a horizontal position. The temperature of the administered medication should correspond to the patient's body temperature. If repeated treatment is necessary, an interval of several weeks must be observed between therapeutic courses.

It is possible that some side effects may occur from the nervous and digestive systems, which may include:

1. Stomach pain.
2. Lack of appetite.
3. Nausea and vomiting.
4. Dizziness.
5. Sleep disturbance.
6. Psychosis.

Amelotex

Ampoules are not the only form of this drug: it is also available in the form of gel, tablets and rectal suppositories. The Amelotex solution contained in ampoules is a light yellow liquid containing meloxicam. The medication has an analgesic effect, helps reduce fever and effectively reduces the area of ​​inflammation. Amelotex is administered intramuscularly once a day. The maximum permissible daily dose is 15 mg.

The medicine is indicated for use in the following cases:

• arthritis;
• Bekhterev's disease;
• inflammation of the joints, which are accompanied by pain;
• osteoarthritis.

Indications for administration of Amelotex

A course of Amelotex injections is strictly contraindicated for the following problems:

• any bleeding;
• stomach ulcer;
• bronchial asthma;
• pregnancy.

Arthrozan

The medication is a non-steroidal drug that has an anti-inflammatory effect. Artrosan injections have a short-term effect in treating the symptoms of arthritis, spondylitis, osteoarthritis, relieve pain in the lower back and shoulders, and also help with diseases of the muscular system. The daily dose is 15 mg, and the therapeutic effect after its administration occurs within an hour. The drug should not be used if the patient has:

1. Stomach ulcer.
2. Bleeding.
3. Ulcerative colitis.

Benefits of Artrosan

Artrosan should be prescribed with extreme caution to people with gastrointestinal diseases, congestive heart failure, coronary heart disease, diabetes mellitus and alcoholism. The drug is contraindicated for children, pregnant and breastfeeding women.

Dexamethasone

The use of Dexamethasone in ampoules is most often due to the impossibility of using the tablet form. The drug is prescribed if the patient has:

• severe bronchospasm;
• anaphylactic shock;
• cerebral edema;
• severe dermatosis;
• arthritis;
• blood diseases.

Pharmacological features of Dexamethasone

The introduction of Dexamethasone into a joint is prohibited in the presence of severe bone deformation, instability and bone fractures. The dose should be reduced if the patient suffers from infectious, gastrointestinal and cardiovascular diseases. Use during pregnancy is acceptable if treatment is agreed upon with a doctor.

The average dose of Dexamethasone is up to 6 mg, a single injection every three days. In case of overdose, an increase in blood pressure, the appearance of edema, and impaired consciousness are observed. Undesirable effects of the drug include metabolic failure and heart failure.

Mesipol

Mesipol is a solution for deep intramuscular injection. This is a non-steroidal drug that actively fights inflammation, protects and renews connective tissue.

Mesipol injections can be administered only for the first two days after the start of treatment.

After this period, the patient must be transferred to treatment with a tablet form of the medication. The daily dose is no more than 7-15 mg per day. The drug is indicated for the treatment of arthritis and is actively used to treat ankylosing spondylitis.

Neurobion

The medication contains a complex of useful substances (vitamins and microelements), which not only replenishes vitamin deficiencies in diseases, but also stimulates the launch of natural mechanisms for the restoration of nerve tissue. Indications for taking Neurobion are neurological diseases:

• neuritis;
• neuralgia;
• neuropathic pain;
• diseases of the spine.

Dosage of the drug

Neurobion is not suitable for all age groups of patients: children are not allowed to take the drug. You cannot be treated with Neurobion during pregnancy and breastfeeding.

Contraindications

The drug has no toxic properties and is absolutely safe to use. The tablets have virtually no contraindications for use. They should be used with extreme caution in patients with kidney dysfunction and inflammation of the urinary ducts.

The injection solution is not used if there is an established allergy to lidocaine. If you are hypersensitive to the components of the chemical formula of the drug, side effects may develop. It is not advisable to use a muscle relaxant during pregnancy and breastfeeding.

Instructions for use, dosage

The tablets are taken orally after meals. The standard frequency of use for adults is 3 times a day. Depending on the clinical picture and severity of symptoms, the dose is doubled according to the doctor’s decision.

The maximum recommended and therapeutically appropriate daily dose is 300-500 mg of the active substance. For the treatment of children under 12 years of age, Mydocalm is used in a dosage of 50 mg of tolperisone hydrochloride.

The daily volume of the drug is divided into 3 doses. It is calculated based on the child's body weight and age. At 1-3 years old, use 2-4 mg/1 kg of body weight. The norm for children 3-6 years old is 5 mg/1 kg of weight. The tablets should be taken whole - without chewing or grinding into powder.

Children 7-14 years old are prescribed Mydocalm at the rate of 6-10 mg per 1 kg of body weight. The frequency of application remains unchanged. The drug begins to act after 40 minutes. after oral administration. The analgesic effect lasts on average 4-6 hours.

The therapeutic effectiveness of Mydocalm depends on the functioning of the renal blood filtration mechanism. An injectable muscle relaxant is administered intramuscularly at 200 mg 2 times a day. In acute conditions, Mydocalm is used intravenously. It is given once a day at a dosage of 100 mg.

Tolperil

Centrally acting muscle relaxant. The mechanism of action is due to inhibition of the conduction of impulses of primary afferent fibers and motor neurons as a result of membrane stabilizing and local anesthetic effects, which leads to blocking of spinal mono- and polysynaptic reflexes.

By inhibiting the entry of Ca 2+ into synapses, it secondarily prevents the release of mediators. Inhibits the conduction of excitation along the reticulospinal pathway. Increases peripheral blood flow regardless of the influence of the central nervous system. The weak antispasmodic and antiadrenergic effect of tolperisone may play a role in the development of this effect.

Pharmacokinetics. Bioavailability due to pronounced metabolism is about 20%. Metabolized in the liver and kidneys. The pharmacological activity of the metabolites is unknown. T ½ after intravenous administration is approximately 1.5 hours. It is excreted by the kidneys, 99% in the form of metabolites.

Interaction with other drugs and other types of interactions Co-administration of tolperisone increases blood concentrations of drugs predominantly metabolized by CYP2D6, in particular thioridazine, tolterodine, venlafaxine, atomoxetine, desipramine, dextromethorphan, metoprolol, nebivolol, perphenazine. No significant inhibition or induction of other CYP isoenzymes (2B6, 2C8, 2C9, 2C19, 1A2, 3A4) was detected.

When administered concomitantly with other CYP2D6 substrates and/or other drugs, exposure to tolperisone is not expected to increase due to the variety of metabolic pathways of tolperisone. Tolperisone enhances the effect of niflumic acid, therefore, with simultaneous use, it may be necessary to reduce the dose of the latter, as well as other NSAIDs.

Although tolperisone is a centrally acting drug, the likelihood of developing a sedative effect when used is low. In case of simultaneous administration with other centrally acting muscle relaxants, it is necessary to consider reducing the dose of tolperisone.

Features of application

The drug should not be prescribed to children. The most commonly reported reaction with tolperisone was hypersensitivity reaction. Their severity varies from mild skin reactions to severe systemic reactions, including anaphylactic shock. Symptoms of allergic reactions may include erythema, rash, urticaria, pruritus, angioedema, tachycardia, hypotension, or shortness of breath.

Women with hypersensitivity to other drugs or a history of allergic conditions are at higher risk of allergic reactions when using tolperisone.

Patients should be advised to be aware of the possibility of allergies. Patients should be informed that if allergy symptoms occur, stop taking tolperisone and seek immediate medical attention.

After an episode of hypersensitivity to tolperisone, tolperisone cannot be re-prescribed. The drug contains lidocaine, therefore, in case of known hypersensitivity to lidocaine and other amide local anesthetics, the drug should not be used due to the possibility of cross-allergic reactions.

Use during pregnancy or breastfeeding. There is evidence that tolperisone does not have a teratogenic effect in animals. The use of the drug in the first trimester of pregnancy is contraindicated. The use of the drug in the second and third trimesters of pregnancy is possible when, in the opinion of the doctor, the expected benefit significantly outweighs the potential risk to the fetus/child.

Since it is unknown whether tolperisone passes into breast milk, the use of the drug during breastfeeding is contraindicated.

The ability to influence the reaction rate when driving vehicles or other mechanisms. Considering the possibility of developing dizziness, drowsiness, impaired attention, epilepsy, blurred vision, it should be used with caution when driving vehicles and other mechanisms.

Directions for use and doses

For parenteral administration to adults only, the drug should be administered intramuscularly, 1 ml 2 times a day, or slowly intravenously, 1 ml 1 time a day. The duration of treatment is determined by the doctor depending on the nature of the disease and the effectiveness of treatment. Children. The injection solution should not be used for children.

Overdose. Data on overdose are limited. The drug has a wide therapeutic index; according to a dose of 600 mg, it was administered orally to children and did not cause overdose symptoms.

Irritability was observed when children were given 300-600 mg per day orally. There is evidence that the administration of high doses caused ataxia, tonic-clonic convulsions, difficulty and cessation of breathing.

Treatment: drug withdrawal, symptomatic and supportive therapy. There is no specific antidote.

Adverse reactions

Approximately 50-60% of cases of adverse reactions associated with the use of tolperisone were hypersensitivity reactions. In general, these reactions were not serious and went away on their own. Hypersensitivity reactions that are life-threatening have occurred rarely.

From the blood and lymphatic system: anemia, lymphadenopathy. From the immune system: hypersensitivity reaction, anaphylactic reactions, anaphylactic shock. Mental disorders: insomnia, sleep disturbance, decreased activity, depression, confusion.

From the nervous system: headache, dizziness, drowsiness, impaired attention, tremor, convulsions, hypoesthesia, paresthesia, lethargy. From the senses: blurred vision, tinnitus, vertigo.

From the vascular system: hypotension, skin hyperemia. From the heart: angina pectoris, tachycardia, rapid heartbeat, decreased blood pressure, bradycardia. From the respiratory system: difficulty breathing, nosebleeds, shortness of breath.

From the digestive system: nausea, vomiting, abdominal discomfort, diarrhea, dry oral mucosa, dyspepsia, epigastric pain, constipation, flatulence, mild liver damage.

Skin: allergic dermatitis, hyperhidrosis, itching, urticaria, rash. From the musculoskeletal system: muscle weakness, myalgia, discomfort/pain in the extremities, osteopenia. From the urinary system: enuresis, proteinuria.

General disorders: asthenia, discomfort, increased fatigue, anorexia, feeling of intoxication, feeling of heat, irritability, thirst, polydipsia, discomfort in the chest, changes at the site of drug administration (including redness).

From laboratory parameters: increased concentration of bilirubin in the blood, changes in the activity of liver enzymes, decreased platelet count, leukocytosis, increased concentration of creatinine in the blood.

Side effects

Mydocalm is well tolerated by most patients. Side effects occur only in cases of hypersensitivity or biological immunity to the pharmacologically active components of the drug.

Such manifestations disappear on their own after the body gets used to it or the dose is reduced.

If you are allergic to the components of the chemical formula of the drug, the following are possible:

• nausea;
• vascular hypotension;
• decreased muscle tone;
• headache;
• skin rash and itching;
• angioedema.

Bronchospasm and other severe anaphylactic reactions were not recorded.

Overdose

Mydocalm in tablets (cheaper analogues are characterized by identical properties) has a wide therapeutic range. There are known cases of use of a dosage of 600 mg in children.

However, no signs of drug intoxication or side effects were detected. In laboratory experiments on animals, ataxic disorders, tonic convulsions, and respiratory spasm were noted.

An antidote to tolperisone hydrochloride has not been developed. In case of overdose, one should limit oneself to the use of symptomatic therapy methods in the form of gastric lavage and taking absorbent medication.

special instructions

Treatment with Mydocalm can be combined with drinking alcohol. The active component and excipients of the drug do not affect psycho-emotional and mental activity, or physical reactions.

During the therapy period, you can drive vehicles, dangerous machinery and perform responsible work. The teratogenic properties of the muscle relaxant and its ability to pass into breast milk have not been established. During pregnancy and lactation, it is recommended to consult a doctor first.

Sirdalud or Mydocalm - which is better?

If the question arises of what to replace Mydocalm with, then the most popular analogue is the Swiss drug Sirdalud.

This medication is similar to Mydocalm not in the active substance, but in the principle of its effect on the body.

The active component of Sirdalud is tizanidine. The medicine is sold in tablet form, one tablet contains 2 or 4 mg of tizanidine.

The Swiss analogue has a significant advantage over the original drug. Tizanidine, once in the human body, is not absorbed from the tablet immediately, but gradually, so that the medicine acts evenly throughout the day.

The main effect of tizanidine is inhibition of the transmission of nervous excitation, leading to a weakening of muscle tension. Sirdalud is not only a muscle relaxant, but also an analgesic of moderate activity. The medicine begins to act an hour after administration. The spent active substance leaves the body in 3–4 hours.

Sirdalud is prescribed for the following pathologies:

• osteochondrosis and other diseases of the spinal column, complicated by painful spasms of the spinal muscles;
• pathological changes in bone and joint tissue;
• multiple sclerosis;
• stroke;
• convulsive states of any origin;
• cerebral palsy;
• some diseases of the spinal cord;
• negative consequences of spinal surgery.

It is forbidden to take the medication if:

• liver dysfunction;
• intolerance to the active substance;
• treatment with antidepressants, fluoroquinolone antibiotics, CYP1A2 inhibitors;
• feeding a child with breast milk.

The effect of a muscle relaxant on a developing embryo in the womb has not been studied. Therefore, it is not advisable to take the medicine during pregnancy. Doctors prescribe Sirdalud to pregnant patients only as a last resort, when the need for recovery is more important than the likely risk to the fetus.

Sirdalud gives more side effects than Mydocalm. When taking Swiss medication, the following unpleasant phenomena are possible:

• weakness, powerlessness;
• liver dysfunction;
• nausea;
• drying of the oral mucosa;
• disruption of the digestive tract;
• decreased blood pressure;
• slowing heart rate.

Taking Sirdalud can provoke serious pathological changes in the functioning of the liver. Therefore, during therapy, it is recommended to periodically undergo laboratory tests to check the condition of the liver tissue. The drug also has a negative effect on concentration.

Overdose is accompanied by the following symptoms:

• significant decrease in blood pressure;
• nausea;
• weakness, malaise;
• dizziness;
• respiratory dysfunction.

In case of severe overdose, the patient may fall into a coma.

• Calcium is an important substance for the human body;
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• - analogues of Lamisil.

Drug interactions

There is no scientific data on the negative mutual influence of Mydocalm and other medications. There are no clinical restrictions on drug combinations. Tablets or injections can be combined with potent sedatives and hypnotics, or any tranquilizers.

A slight increase in the pharmacological properties of tolperisone hydrochloride was observed when used simultaneously with surgical drugs that are used for general anesthesia. Peripheral muscle relaxants, clonidine and psychotropic compounds have a similar effect on Mydocalm.

The drug combines well with Movalis and Milgamma. They are often combined into complex drug therapy for musculoskeletal disorders. Such pathologies are in most cases accompanied by severe joint and muscle pain.

The combined use of these drugs provides rapid relief of symptoms and effective treatment. This therapy suppresses muscle spasm and eliminates hypertonicity of the adductor fibers.

Movalis is neutral in relation to cartilaginous tissues, which are affected by Mydocalm. Milgamma contains B vitamins. They stimulate nerve conduction in relaxed and spasmodic tissues.

The parallel use of Milgamma and Mydocalm gives a general strengthening neurological effect. This therapy is characterized by a pronounced improvement in metabolic characteristics, strong analgesic effects and neuroprotective properties.

When taken together with neurotropic vitamin compounds, Mydocalm suppresses inflammatory processes in nerve fibers and mitigates degenerative changes that affect the central nervous system and the musculoskeletal mechanism.

Cheap analogues of the drug

For myalgia and neurological disorders, you can use medications with an identical principle of action, but at a more affordable price.

These include:

• Sirdalud. Tablet muscle relaxant based on tizanidine hydrochloride. Has a generalized effect. Prescribed for dysfunction of the lumbar and cervical spine, spastic condition of skeletal muscles. Price – 194 rub.

  
  Sirdalud is a complete analogue of Mydocalm

• Tolisor. The drug is intended to relieve muscle spasms in patients who have suffered a stroke. It has low toxicity and a minimum number of contraindications. Tolizor in pharmacies costs approximately 210 rubles.
• Calmirex. Injectable medication with membrane-stabilizing, local anesthetic and muscle relaxant properties. Used for hypertonicity of striated muscles and in complex therapy of diabetic angiopathy. Approximate cost: 210 rubles.
• Tizalud. Muscle relaxant tablets. Intended for long-term course treatment of chronic musculoskeletal disorders accompanied by muscle pain. It costs about 120 rubles in pharmacies.

All the drugs presented are cheaper than Mydocalm, but no less effective. They have no contraindications, except for individual intolerance, there is no overdose or side effects.

Mydocalm analogues are cheaper (list with prices)

Mydocalm is a popular drug. It is one of the most commonly purchased muscle relaxants. However, pharmacies sell a large number of analogues that cost less than Mydocalm. Substitutes in composition and principle of action, produced by different manufacturers, cost 200 - 500 rubles, and have several forms of release.

Below are listed analogues cheaper than Mydocalm, available in injections and tablets:

• Tolperisone – 280 rubles;
• Sirdalud – 340 rubles;
• Baklosan – 370 rubles;
• Baclofen – 380 rubles;
• Miolgin – 230 rubles;
• Texamen – 240 rubles;
• Vitaxon – 190 rubles;
• Trigamma – 145 rubles;
• Meloxicam – 155 rubles;
• Calmirex – 450 rubles.