Unidox Solutab dispersible tablets 100 mg 10 pcs. in Moscow

Doxycycline ~ Antibiotic, tetracycline

Price in pharmacies from 293.00 to 650.00 rub.*

Doxycycline (the active ingredient of the drug) is a broad-spectrum antibiotic from the tetracycline group. It acts bacteriostatically, suppresses protein synthesis in the microbial cell by interacting with the 30S ribosomal subunit. Active against many gram-positive and gram-negative microorganisms: Streptococcus spp., Treponema spp., Staphylococcus spp., Klebsiella spp., Enterobacter spp. (including E. aerugenes), Neisseria gonorrhoeae, Neisseria meningitidis, Haemophilus influenzae, Chlamydia spp., Mycoplasma spp., Ureaplasma urealyticum, Listeria monocytogenes, Rickettsia spp., Typhus exanthematicus, Escherichia coli, Shigella spp., Campylobacter fetus, Vibrio cholerae, Yersinia spp. (including Yersinia pestis), Brucella spp., Francisella tularensis, Bacillus anthracis, Bartonella bacilliformis, Pasteurella multocida, Borrelia recurrentis, Clostridium spp. (except Clostridium difficile), Actinomyces spp., Fusobacterium fusiforme, Calymmatobacterium granulomatosis, Propionibacterium acnes, some protozoa (Entamoeba spp., Plasmodium falciparum). More about the drug »

ATTENTION! ALWAYS check with your doctor or pharmacist to see if the found analogue can serve as a full replacement for the drug prescribed to you or the drug you are looking for. This is due to the need to use the dosage forms and doses prescribed specifically for you, which may differ even among analogues (more about analogues of drugs).

Pharmacodynamics and pharmacokinetics

Is Unidox Solutab an antibiotic or not?

The active ingredient of the drug doxycycline is an antibiotic from the tetracycline group. It inhibits the activity of pathogenic bacteria, affecting the ribosomal membranes in the cell. It does not allow the processes of RNA synthesis of some organisms to occur.

The medicine is active against such gram-positive bacteria as Streptococcus haemolyticus, Streptococcus viridans, Listeria spp., Streptococcus faecalis, Streptococcus pneumoniae, Staphylococcus aureus, Staphylococcus epidermidis.

The drug inhibits the vital activity of gram-negative bacteria: Bacillus anthracis, Neisseria meningitidis, Brucella spp., Escherichia coli, Neisseria gonorrhoeae, Haemophilus influence, Clostridium spp., Salmonella spp., Pasteurella spp., Enterobacter spp., Entamoeba., Shigella spp. etc.

Doxycycline is also used to treat diseases caused by Mycoplasma spp., Rickettsia spp., Chlamydia spp. and Spirochaeta spp. .

Doxycycline is absorbed from the gastrointestinal tract. Within 2 hours after administration, it can be detected in almost all tissues of the body (teeth, saliva), with the exception of cerebrospinal fluid. About half of the drug is excreted by the kidneys, the rest through the gastrointestinal tract. The drug can be detected in blood plasma after 19 hours with a single dose and after 48 hours during a course.

Unidox Solutab 100 mg n10 dispersible tablets

Release form

Dispersible tablets.

Package

10 pieces.

pharmachologic effect

Broad-spectrum antibiotic from the tetracycline group. It acts bacteriostatically, suppresses protein synthesis in the microbial cell by interacting with the 30S ribosomal subunit. Active against many gram-positive and gram-negative microorganisms: Streptococcus spp., Treponema spp., Staphylococcus spp., Klebsiella spp., Enterobacter spp. (including E. aerugenes), Neisseria gonorrhoeae, Neisseria meningitidis, Haemophilus influenzae, Chlamydia spp., Mycoplasma spp., Ureaplasma urealyticum, Listeria monocytogenes, Rickettsia spp., Typhus exanthematicus, Escherichia coli, Shigella spp., Campylobacter fetus, Vibrio cholerae, Yersinia spp. (including Yersinia pestis), Brucella spp., Francisella tularensis, Bacillus anthracis, Bartonella bacilliformis, Pasteurella multocida, Borrelia recurrentis, Clostridium spp. (except Clostridium difficile), Actinomyces spp., Fusobacterium fusiforme, Calymmatobacterium granulomatosis, Propionibacterium acnes, some protozoa (Entamoeba spp., Plasmodium falciparum).

As a rule, it has no effect on Acinetobacter spp., Proteus spp., Pseudomonas spp., Serratia spp., Providencia spp., Enterococcus spp.

The possibility of acquired resistance to doxycycline in a number of pathogens, which is often cross-linked within a group, should be taken into account (i.e., strains resistant to doxycycline will simultaneously be resistant to the entire group of tetracyclines).

Indications

Infectious and inflammatory diseases caused by microorganisms sensitive to the drug:

• respiratory tract infections (including pharyngitis, acute bronchitis, exacerbation of chronic obstructive pulmonary disease, tracheitis, bronchopneumonia, lobar pneumonia, community-acquired pneumonia, lung abscess, pleural empyema);
• infections of the ENT organs (including otitis media, sinusitis, tonsillitis);
• infections of the genitourinary system (cystitis, pyelonephritis, bacterial prostatitis, urethritis, urethrocystitis, urogenital mycoplasmosis, acute orchiepididymitis; endometritis, endocervicitis and salpingoophoritis /as part of combination therapy/);
• sexually transmitted infections (urogenital chlamydia, syphilis in patients with penicillin intolerance, uncomplicated gonorrhea /as an alternative therapy/, granuloma inguinale, lymphogranuloma venereum);
• infections of the gastrointestinal tract and biliary tract (cholera, yersiniosis, cholecystitis, cholangitis, gastroenterocolitis, bacillary and amoebic dysentery, travelers' diarrhea);
• infections of the skin and soft tissues (including wound infections after animal bites), severe acne (as part of combination therapy);
• other diseases: yaws, legionellosis, chlamydia of various localizations (including prostatitis and proctitis), rickettsiosis, Q fever, Rocky Mountain spotted fever, typhus (including typhus, tick-borne relapsing), Lyme disease (stage I) - erythema migrans/, tularemia, plague, actinomycosis, malaria, leptospirosis, psittacosis, psittacosis, anthrax (including pulmonary form), bartonellosis, granulocytic ehrlichiosis, whooping cough, brucellosis;
• infectious eye diseases (as part of combination therapy) - trachoma;
• osteomyelitis;
• sepsis;
• subacute septic endocarditis;
• peritonitis.

Prevention of postoperative purulent complications and malaria caused by Plasmodium falciparum during short-term travel (less than 4 months) to areas where strains resistant to chloroquine and/or pyrimethamine-sulfadoxine are common.

Contraindications

• severe impairment of liver and/or kidney function;
• porphyria;
• pregnancy;
• lactation period (breastfeeding);
• children under 8 years of age;
• hypersensitivity to antibiotics of the tetracycline group.

Use during pregnancy and breastfeeding

Doxycycline penetrates the blood-placental barrier. Tetracyclines have an adverse effect on the fetus (slowing osteogenesis) and on the formation of tooth enamel (irreversible discoloration, hypoplasia). Due to this, as well as the increased risk of liver damage in the mother, tetracyclines are not used during pregnancy, except in cases where the drug is the only remedy for the treatment or prevention of particularly dangerous and severe infections (Rocky Mountain spotted fever, inhalation exposure to Bacillus anthracis and others).

Before prescribing doxycycline to women of childbearing age, pregnancy should first be excluded.

Doxycycline passes into breast milk. Due to its adverse effects on the fetus, doxycycline, like other tetracyclines, should not be used during breastfeeding. If the prescription of tetracyclines is necessary, breastfeeding should be discontinued.

special instructions

There is a possibility of cross-resistance and hypersensitivity with other tetracycline drugs.

Tetracyclines may increase prothrombin time; the use of tetracyclines in patients with coagulopathies should be carefully monitored.

The anti-anabolic effect of tetracyclines can lead to an increase in the level of residual urea nitrogen in the blood. As a rule, this is not significant for patients with normal renal function. However, in patients with renal failure, an increase in azotemia may occur. The use of tetracyclines in patients with impaired renal function requires medical supervision.

With long-term use of the drug, periodic monitoring of laboratory blood parameters, liver and kidney function is required.

Due to the possible development of photodermatitis, it is necessary to limit insolation during treatment and for 4-5 days after it.

When using the drug, both while taking it and 2-3 weeks after stopping treatment, diarrhea caused by Clostridium dificile may develop. In mild cases, it is sufficient to cancel treatment and use ion exchange resins (cholestyramine, colestipol); in severe cases, replacement of loss of fluid, electrolytes and protein is indicated,

prescribing vancomycin or metronidazole.

Do not use medications that inhibit intestinal motility.

Long-term use of the drug can cause dysbacteriosis and, as a result, the development of hypovitaminosis (especially B vitamins).

To prevent dyspeptic symptoms, it is recommended to take the drug with meals.

To avoid the development of esophagitis or esophageal ulcers, it is necessary to take the drug with plenty of water and avoid using the drug immediately before bedtime.

Impact on the ability to drive vehicles and operate machinery

The effect on the ability to drive vehicles, machines and mechanisms is unknown. If you develop dizziness, blurred vision or double vision, driving vehicles or using machinery is not recommended.

Compound

Doxycycline monohydrate, equivalent to doxycycline 100 mg.

Excipients: microcrystalline cellulose - 45 mg, saccharin - 10 mg, hyprolose (low-substituted) - 18.75 mg, hypromellose - 3.75 mg, colloidal silicon dioxide (anhydrous) - 0.625 mg, magnesium stearate - 2 mg, lactose monohydrate - up to 250 mg.

Directions for use and doses

The tablets are dispersed (dissolved) in a small amount of water (about 20 ml) to obtain a suspension. The tablets can also be swallowed whole, split into pieces, or chewed with water.

It is preferable to take the drug with meals. Take the tablets while sitting or standing, which reduces the likelihood of developing esophagitis and esophageal ulcers. The drug should not be taken immediately before bedtime.

Usually the duration of treatment is 5-10 days.

Adults and children over 8 years of age weighing more than 50 kg are prescribed 200 mg/day in 1 or 2 doses on the first day of treatment, and 100 mg/day in 1 dose on subsequent days of treatment. In case of severe infections, 200 mg/day is prescribed throughout the entire treatment period.

For children aged 8-12 years with body weight less than 50 kg, the average daily dose is 4 mg/kg on the first day, then 2 mg/kg/day (in 1-2 doses). In cases of severe infections, the drug is prescribed at a dose of 4 mg/kg daily throughout treatment.

For infection caused by Streptococcus pyogenes, the duration of treatment is at least 10 days.

For uncomplicated gonorrhea (except for anorectal infections in men), adults are prescribed 100 mg 2 times a day until complete cure (on average within 7 days), or 600 mg is prescribed for one day - 300 mg in 2 doses (second dose 1 hour after the first).

For primary syphilis, 100 mg 2 times a day is prescribed for 14 days, for secondary syphilis - 100 mg 2 times a day for 28 days.

For uncomplicated urogenital infections caused by Chlamydia trachomatis, cervicitis, non-gonococcal urethritis caused by Ureaplasma urealiticum, 100 mg is prescribed 2 times a day for 7 days.

For acne, 100 mg/day is prescribed, the course of treatment is 6-12 weeks.

To prevent malaria, prescribe 100 mg 1 time / day 1-2 days before the trip, then daily during the trip and for 4 weeks after returning; children over 8 years old - 2 mg/kg 1 time/day. The duration of prophylaxis should not exceed 4 months.

For the prevention of travelers' diarrhea - 200 mg on the first day of the trip in 1 or 2 doses, then 100 mg 1 time / day during the entire stay in the region (no more than 3 weeks).

For the treatment of leptospirosis - 100 mg orally 2 times a day for 7 days; for the prevention of leptospirosis - 200 mg 1 time/week during stay in a disadvantaged area and 200 mg - at the end of the trip.

To prevent infections during medical abortion, 100 mg is prescribed 1 hour before and 200 mg after the intervention.

Maximum daily doses for adults are up to 300 mg/day or up to 600 mg/day for 5 days for severe gonococcal infections. For children over 8 years old weighing more than 50 kg - up to 200 mg, for children 8-12 years old weighing less than 50 kg - 4 mg/kg daily throughout treatment.

In case of renal (creatinine clearance less than 60 ml/min) and/or liver failure, a reduction in the daily dose of doxycycline is required, since it gradually accumulates in the body (risk of hepatotoxicity).

Side effects

From the digestive system: anorexia, nausea, vomiting, dysphagia, diarrhea, enterocolitis, pseudomembranous colitis, esophagitis, esophageal ulcer, dark staining of the tongue, liver damage (during long-term use or in patients with renal or hepatic insufficiency), cholestasis.

Dermatological reactions: photosensitivity, maculopapular and erythematous rash, exfoliative dermatitis.

Allergic reactions: urticaria, angioedema, anaphylactic reactions, exacerbation of systemic lupus erythematosus, pericarditis, a syndrome similar to serum sickness, erythema multiforme.

From the hematopoietic system: hemolytic anemia, thrombocytopenia, neutropenia, eosinophilia, decreased prothrombin activity.

From the endocrine system: in patients receiving doxycycline for a long time, reversible dark brown discoloration of the thyroid tissue is possible.

From the side of the central nervous system: benign increase in intracranial pressure (anorexia, vomiting, headache, papilledema), vestibular disorders (dizziness or instability), blurred vision, double vision.

From the urinary system: increase in residual urea nitrogen (due to the anti-anabolic effect).

From the musculoskeletal system: doxycycline slows down osteogenesis, disrupts the normal development of teeth in children (irreversibly changes the color of teeth, enamel hypoplasia develops).

Other: candidiasis (glossitis, stomatitis, proctitis, vaginitis) as manifestations of superinfection.

Drug interactions

Antacids containing aluminum, magnesium, calcium, iron preparations, sodium bicarbonate, magnesium-containing laxatives reduce the absorption of doxycycline, so their use should be separated by a 3-hour interval.

Due to the suppression of intestinal microflora by doxycycline, the prothrombin index decreases, which requires dose adjustment of indirect anticoagulants.

When doxycilline is combined with bactericidal antibiotics that disrupt cell wall synthesis (penicillins, cephalosporins), the effectiveness of the latter is reduced, which should be taken into account when treating meningitis and tonsillopharyngitis caused by Streptococcus pyogenes.

Doxycycline reduces the reliability of contraception and increases the frequency of acyclic bleeding when taking estrogen-containing hormonal contraceptives.

Ethanol, barbiturates, rifampicin, carbamazepine, phenytoin, accelerating the metabolism of doxycycline, reduce its concentration in the blood plasma.

The simultaneous use of doxycycline and retinol increases intracranial pressure.

Overdose

Symptoms: increased adverse reactions caused by liver damage - vomiting, fever, jaundice, azotemia, increased transaminase levels, increased prothrombin time.

Treatment: immediately after taking large doses, gastric lavage, drinking plenty of fluids, and, if necessary, inducing vomiting are recommended. Take activated carbon and osmotic laxatives. Hemodialysis and peritoneal dialysis are not recommended due to low efficiency.

Storage conditions

The drug should be stored out of the reach of children at a temperature of 15° to 25°C.

Best before date

5 years.

Indications for use

What are Unidox Solutab tablets for?

The drug is prescribed for the treatment of diseases caused by microorganisms sensitive to doxycycline:

• ENT diseases: otitis media, tonsillitis , etc.;
• respiratory tract diseases: pharyngitis , tracheitis , lung abscess , acute and chronic bronchitis ;
• cystitis , prostatitis , pyelonephritis , urethritis , endometritis ;
• PPI: for ureaplasmosis , syphilis , gonorrhea , chlamydia ;
• gastrointestinal tract infections: cholera , cholecystitis , gastroenterocolitis , diarrhea , yersiniosis ;
• trachoma , sepsis , peritonitis , osteomyelitis ;
• prevention of malaria and postoperative suppuration.

What else does Unidox Solutab treat?

Yaws , rickettsiosis , legionellosis , Q fever , , first stage Lyme disease, Rocky Mountain spotted fever , tularemia , actinomycosis , plague , malaria , psittacosis , leptospirosis psittacosis, bartonellosis , anthrax , whooping cough , granulocytic ehrlichiosis , brucellosis , acne .

Side effects

• nausea , vomiting , loss of appetite , enterocolitis , inflammation in the genital area due to increased growth of the Candida fungus, stomatitis ;
• dermatitis , urticaria , anaphylaxis , pericarditis and erythema ;
• renal and liver failure, albuminuria , lack of potassium in the blood, increased nitrogen levels in the blood plasma;
• anemia , porphyria , thrombocytopenia ;
• tinnitus , hallucinations ;
• fragility of bones and teeth, discoloration of enamel;
• hyperemia , anaphylactic shock , decreased blood pressure, tachycardia , difficulty breathing.

Instructions for use Unidox Solutab (Method and dosage)

The duration of use and dosage of the drug should be prescribed by a doctor, depending on the disease and its course. The tablets are swallowed whole or crushed into powder and mixed with water.

According to the instructions for Unidox Solutab, adults are prescribed 0.2 g of doxycycline per day (the first day), in one or two doses. In subsequent days, the dosage can be reduced to 0.1 g, at the discretion of the attending physician.

For gonorrhea , syphilis and other serious STDs, the daily dose is usually 0.3 g. Tablets are taken for 5-10 days.

For children over 8 years old, if their weight is less than 50 kg, the calculation is based on the principle of 0.004 g of antibiotic per 1 kg. Or half as much at the end of the first day of use.

Unidox Solutab or Sumamed – which is better?

Manufacturer: TEVA, Croatia
Release form: tablets, capsules, powder

Active ingredient: azithromycin

Sumamed is a prescription analogue that is a bacteriostatic antibiotic. The drug inhibits protein synthesis of pathogenic cells. It is excreted unchanged along with feces and urine.

Prescribed for similar disorders that are infectious and inflammatory in nature.

The analogue of Unidox Solutaba Sumamed is recommended for adults and children over 12 years of age.

Interaction

Taken together with magnesium-containing laxatives, iron preparations, sodium bicarbonate , calcium, magnesium and aluminum should occur at least 3 hours after the antibiotic.

The drug reduces the effectiveness of antibiotics such as penicillin and cephalosporin .

The medicine may cause a decrease in the prothrombin index and the effectiveness of hormonal contraceptives . Also, when taken simultaneously with retinol, in intracranial pressure may be observed .

The concentration of doxycycline in the blood will decrease if you combine the drug with ethanol , rifampicin , phenytoin , barbiturates and carbamazepine .

Analogues of Unidox Solutab

Level 4 ATC code matches:
Vibramycin

Doxycycline hydrochloride

Doxycycline

The most common analogues:

• Doxycycline
• Vidoccin
• Vibramycin
• Doxibene
• Doxa-M-Ratiopharm
• Tigacil

The price of analogues differs significantly from the original, most often it is lower.

Doxycycline or Unidox Solutab - which is better?

The main difference between the drugs is the fact that Unidox does not have such a strong effect on the stomach and does not cause side effects characteristic of Doxycycline ( stomach ulcer , gastritis ). Absorption of the active substance occurs in the intestines and almost 100% of the medicine is absorbed by the body. The only advantage of doxycycline is its extremely low cost compared to the original.

What is the difference between Unidox and Unidox Solutab?

The prefix “Solyutab” in the name of the drug means that the tablet can be crushed and dissolved in water to prepare a suspension for administration. This method of taking the medicine is preferable for children.

Unidox Solutab or Doxycycline - which is better, what is the difference

Manufacturer: BELMEDPREPRATY, Belarus
Release form: capsules

Active ingredient: doxycycline

Doxycycline Solution Tablets is a bacteriostatic antibiotic, which is a full-fledged analogue of Unidox tablets. Refers to a semi-synthetic tetracycline. It has a detrimental effect on pathogenic microorganisms that contribute to the development of infectious and inflammatory pathologies.

To a lesser extent than other tetracycline antibacterial agents, it inhibits intestinal microflora. Has a longer lasting effect. Absorbed quickly and completely. Metabolized in the liver. It is excreted along with bile.

Doxycycline is prescribed for infectious and inflammatory pathologies of the respiratory tract, ENT organs, genitourinary system, biliary tract and gastrointestinal tract, skin, eyes. Reviews about these drugs are equally positive, since they do not differ in effectiveness and composition. The main difference is the cost and degree of purification of the drug.

Reviews about Unidox Solutab

Reviews in gynecology. The drug has good reviews in the treatment of gynecological diseases, for example chlamydia . Patients who were prescribed the drug for chlamydia note that the antibiotic is easily tolerated and effective. Although sometimes side effects occur in the form of headaches and disruption of the digestive system.

Reviews for use against ureaplasma are also good, many are of the opinion that the drug is almost the only effective way to get rid of the disease.

Reviews of Unidox Solutab for acne. a dermatologist may prescribe antibiotics to treat acne For most patients, acne medication helps, but then other problems arise due to the medication's side effects. For many, following a therapeutic diet helped better than those taking an antibiotic.

Unidox Solutab or Vilprafen - which is better?

Manufacturer: Famar Health Care Services, France
Release form: tablets, granules for suspension preparation

Active ingredient: josamycin

If you don’t know what to replace Unidox Solutab for gynecological diseases, then use Vilprafen. A prescription drug with few restrictions.

Belongs to the macrolide group of antibiotics. The product has a bacteriostatic and bactericidal effect (when high concentrations of the active ingredient are created at the site of inflammation).

The analogue Vilprafen is prescribed to patients with infectious and inflammatory pathologies, as well as chlamydia, mycoplasma and mixed infections of the genitourinary system.

Unidox Solutab price, where to buy

The average price of tablets in Russia is about 300 rubles. per pack 10 pcs.

• Online pharmacies in RussiaRussia
• Online pharmacies in UkraineUkraine
• Online pharmacies in KazakhstanKazakhstan

ZdravCity

• Unidox Solutab dispersible tablets 100 mg 10 pcs. ZiO-Zdorovye ZAO
  316 rub. order
• Unidox solutab dispersant tablets. 100 mg 20 pcs. ZiO-Zdorovye ZAO

  RUR 596 order

Pharmacy Dialogue

• Unidox Solutab (table dispersant 100 mg No. 10) ZiO-Zdorovye CJSC/Astellas Pharma Europe B.V.

  RUB 314 order

• Unidox Solutab (table dispersant 100 mg No. 20)Astellas Pharma/ZiO-Zdorovye CJSC

  RUR 597 order

• Unidox Solutab (table dispersant 100 mg No. 10) ZiO-Zdorovye CJSC/Astellas Pharma Europe B.V.

  RUB 310 order

• Unidox Solutab (table dispersant 100 mg No. 20)Astellas Pharma/ZiO-Zdorovye CJSC

  RUR 607 order

show more

Pharmacy24

• Unidox Solutab 100 mg N10 tablets Astellas Pharma Europe B.V., Netherlands
  141 UAH.order

PaniPharmacy

• Unidox solutab tablets Unidox salutab tablets. 100 mg No. 10 Netherlands, Astellas Pharma Europe

  152 UAH order

show more