Acetylsalicylic acid: a time-tested medicine

Composition and effectiveness

In its pure form, ASA is a white, finely crystalline powder with a noticeably sour taste. It is an acetic ester, soluble in water and alcohols. The drug quickly relieves pain and has a pronounced antipyretic, anti-inflammatory, and antiplatelet effect. Its effectiveness is similar to other NSAIDs - non-narcotic analgesics.

The analgesic properties of ASA are due to its effect on the central nervous system, the activity of prostaglandins and other mediators of pain sensitivity.
A decrease in body temperature occurs due to the correction of the thermoregulation center, vasodilation and a pronounced diaphoretic effect.
Inflammatory reactions are eliminated due to the effect of acetylsalicylic acid on the capillary network: reducing the permeability of vascular walls, blocking enzymatic and energetic activity in pathological foci.
Aspirin has the ability of an anticoagulant: it prevents platelet aggregation (sticking together), slows down the synthesis of prothrombin, which is responsible for blood clotting. This reduces the risk of thrombosis and associated life-threatening conditions.

Acetylsalicylic acid is absorbed almost completely into the bloodstream from the stomach cavity within 10–15 minutes. Severe symptoms of the disease subside immediately:

dizziness, headache, joint and muscle pain decreases;
temperature indicators decrease;
the feeling of heat and other signs of malaise disappear.

As a result of taking aspirin, a decrease in temperature in patients is often accompanied by profuse sweating.

The decay period of acetylsalicylic acid in the body is about 1–2 hours. Metabolites are excreted in the urine. The therapeutic effect of the drug persists for some time.

Due to its rapid therapeutic effect and effectiveness in treating a variety of diseases, acetylsalicylic acid is classified as an emergency medicine and is on the list of vital drugs.

Interaction

Increases the toxicity of barbituric drugs , valproic acid , methotrexate , the effects of oral hypoglycemic drugs, Digoxin , narcotic analgesics , Triiodothyronine , sulfonamide drugs .

Weakens the effects of diuretics (potassium-sparing and loop), antihypertensive drugs from the group of ACE inhibitors, and the effect of uricosuric drugs .

When used simultaneously with antithrombotic drugs , thrombolytics , indirect anticoagulants, it increases the risk of bleeding.

GCS enhance the toxic effect of ASA on the mucous membrane of the digestive canal, increase its clearance and reduce plasma concentration.

When used simultaneously with Li salts, it increases the plasma concentration of Li+ ions.

Strengthens the toxic effect of alcohol on the mucous membrane of the digestive canal.

Indications and doses

Acetylsalicylic acid is prescribed for the following pathologies:

febrile symptoms of inflammatory and infectious diseases;
mild and moderate pain syndromes of various origins: migraine, neuralgic manifestations, myalgia;
rheumatic joint damage;
risk of thrombosis and thromboembolism;
the risk of development and consequences of myocardial infarction;
acute ischemic stroke;
in complex therapy: alcohol withdrawal syndrome.

The recommended dose of the drug depends on the type and severity of the disease:

for high fever, ARVI, pain - 100–500 mg three times a day;
for intense fever - up to 1.5 g per day;
for rheumatoid polyarthritis, other joint inflammations, myocardial diseases - up to 4 g daily.

Acetylsalicylic acid should be taken after meals. It is recommended to grind the non-coated tablets into powder and wash them down with plenty of warm water. You can use a slightly alkaline mineral one. The effervescent drug must first be dissolved in 50–60 ml of liquid. In liquid form, acetylsalicylic acid is absorbed faster into the blood and has less contact with the gastric mucosa.

Contraindications

Taking ASA is contraindicated in:

“aspirin” asthma;
during the period of exacerbation of erosive and ulcerative lesions of the digestive canal ;
stomach/intestinal bleeding;
vitamin deficiency K;
hemophilia , hypoprothrombinemia , hemorrhagic diathesis ;
G6PD enzyme deficiency
portal hypertension;
renal/liver failure;
aortic dissection;
during treatment with Methotrexate (if the weekly dose of the drug exceeds 15/mg);
gouty arthritis, gout;
pregnancy (absolute contraindications are the first three and last three months);
breastfeeding;
hypersensitivity to ASA/salicylates.

Side effects

Side effects of acetylsalicylic acid include:

dyspeptic symptoms: nausea, cramps, epigastric discomfort, lack of appetite;
noise in the ears and head, weakness, dizziness;
allergic urticaria;
in severe cases: Quincke's edema or anaphylactic shock.

Aspirin intoxication develops after exceeding the maximum dose. It manifests itself as increased side effects: hearing loss, dizziness, heartburn, dryness and an unpleasant taste in the mouth.

Analogs

Level 4 ATC code matches:
Aspirin-S

Citropak

Aspirin

Citramon

Coficil-Plus

Farmadol

Askofen-P

Cefekon N

Aquacitramon

Upsarin UPSA

Citrapack

Alca Prim

Thrombopol

Citrapar

Acetylsalicylic acid-UBF, Asprovit , Aspinat , Aspivatrin , Nextrim Fast , Fluspirin , Taspir , Aspirin.

For children

In children, ASA cannot be used for hyperthermia associated with a viral infection , since this combination can cause the development of a life-threatening condition for the child - Reye's syndrome .

In newborn infants, salicylic acid can displace bilirubin from its association with albumin and contribute to the development of encephalopathy .

ASA easily penetrates into all fluids and tissues of the body, including cerebrospinal, synovial and peritoneal fluid.

In the presence of edema and inflammation, the penetration of salicylate into the joint cavity is accelerated. In the stage of inflammation, on the contrary, it slows down.

Acetylsalicylic acid price

The price of ASK in Ukraine is from 2.88 UAH, in Russia - from 7 rubles.

Online pharmacies in RussiaRussia
Online pharmacies in UkraineUkraine
Online pharmacies in KazakhstanKazakhstan

ZdravCity

Acetylsalicylic acid tablets 500 mg 20 pcs. Pharmstandard-Leksredstva OJSC
21 rub. order
Acetylsalicylic acid Renewal tab. p/o captivity. 500 mg 20 pcs JSC "PFK Obnovlenye"
93 RUR order
Acetylsalicylic acid Cardio tab. intestinal p/o captivity. 0.05g 30pcs JSC Alium
58 RUR order
Acetylsalicylic acid cardio tab. p.o ksh/sol. 100 mg No. 30 JSC Obolenskoe farm. company
67 RUR order
Acetylsalicylic acid cardio tablets p.p.o 100 mg 30 pcs. JSC Tatkhimfarmpreparaty
38 rub. order

Pharmacy Dialogue

Acetylsalicylic acid Renewal (tab.p.pl/vol. 500 mg No. 20)Update of PFC CJSC
77 RUR order
Acetylsalicylic acid tablets 500 mg No. 10FS.-Leksredstva
8 rubles order

Pharmacy24

Acetylsalicylic acid (Aspirin) 500 mg No. 10 tablets PAT "Kiivmedpreparat", Ukraine/PAT "Galichfarm", Ukraine
7 UAH. order
Acetylsalicylic acid (Aspirin) 500 mg No. 10 tablets PAT "Lubnipharm", Ukraine
3 UAH order
Acetylsalicylic acid (Aspirin) 500 mg No. 10 tablets PAT Monfarm, Ukraine
3 UAH order
Acetylsalicylic acid Darnitsa (Aspirin) No. 10 tablets PrAT" Pharmaceutical company "Darnitsa", Ukraine
6 UAH order

PaniPharmacy

Acetylsalicylic acid tablets Acetylsalicylic acid tablets. 0.5g No. 10 Ukraine, Monfarm JSC
3 UAH order
Acetylsalicylic acid tablets Acetylsalicylic acid tablets. 0.5g No. 10 Ukraine, Lubnyfarm PJSC
3 UAH order
Acetylsalicylic acid tablets Acetylsalicylic acid tablets. 0.5g No. 10 Ukraine, Kievmedpreparat OJSC
7 UAH order
Acetylsalicylic acid tablets Acetylsalicylic acid tablets. 0.05g No. 10 Ukraine, Tekhnolog ChAO
3 UAH order

Reviews

Almost all reviews left about ASK are positive. The drug is inexpensive, effective, well studied, and has a wide range of applications. The tablets perfectly relieve inflammation and fever, and regular use of ASA in small doses can reduce the risk of cardiovascular complications in predisposed patients.

Potential side effects are usually referred to as the disadvantages of the drug. However, as most people note, to avoid them, during the treatment period it is enough to simply follow certain rules: at a minimum, before taking the pills, you should carefully read the instructions and give up alcohol for the entire treatment period.