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Povidon Jod

Release form, composition and packaging

Solution for external use 10% in the form of a dark brown liquid with a characteristic odor of iodine. 100 ml povidone-iodine 10 g. Excipients: nonoxynol, glycerol, disodium hydrogen phosphate 12-hydrate, citric acid, sodium hydroxide, demineralized water.

Foaming solution for external use 7.5% in the form of a dark brown liquid with a characteristic odor of iodine; Foams when shaken. 100 ml povidone-iodine 7.5 g. Excipients: lauric acid diethanolamide, ammonium nonylphenylethoxylate sulfonic acid, sodium phosphate 12-hydrate, citric acid, demineralized water.

Solution for local use concentrated 8.5% 1 ml povidone-iodine 85 mg Ointment for external use 10% dark brown, homogeneous, with a characteristic odor of iodine. 100 g povidone-iodine 10 g Excipients: macrogol 4000, purified water. Vaginal suppositories 1 sup. povidone-iodine 200 mg Clinical and pharmacological group: Antiseptic for external and local use.

pharmachologic effect

Antiseptic and disinfectant drug. Released from the complex with polyvinylpyrrolidone upon contact with the skin and mucous membranes, iodine forms iodamines with bacterial cell proteins, coagulates them and causes the death of microorganisms. It has a rapid bactericidal effect on gram-positive and gram-negative bacteria (with the exception of Mycobacterium tuberculosis). It is also active against fungi, viruses, and protozoa. It has a longer action compared to a solution of inorganic iodine.

Pharmacokinetics

When applied externally, the reabsorption of iodine from the surface of the skin or mucous membrane or wounds is extremely insignificant.

Indications

Solution for external use 10%

treatment and prevention of wound infections in surgery, traumatology, combustiology, dentistry;
treatment of bacterial, fungal and viral skin infections, prevention of superinfection in dermatological practice;
treatment of bedsores, trophic ulcers, diabetic foot;
disinfection of the skin and mucous membranes of patients in preparation for surgical interventions, invasive studies (including punctures, biopsies, injections);
disinfection of the skin around drainages, catheters, probes;
disinfection of the oral cavity during dental operations;
disinfection of the birth canal during minor gynecological operations (including artificial termination of pregnancy, insertion of an intrauterine device, coagulation of erosion and polyp).

Foaming solution for external use 7.5%

disinfectant baths - for complete and partial treatment of the patient before operations;
hygienic treatment of patients;
hand hygiene when in contact with infected patients;
processing of instruments (not metal) and patient care items.

Concentrated topical solution 8.5%

for rinsing the mouth and throat.

Ointment for external use 10%

bacterial and fungal skin infections;
burns;
trophic ulcers;
bedsores;
infectious dermatitis;
abrasions;
wounds.

Vaginal suppositories

candidiasis;
trichomoniasis;
nonspecific vaginitis.

Dosage regimen

Solution for external use 10% For treating the skin and mucous membranes, use undiluted for lubrication, rinsing or as a wet compress. For use in drainage systems, the solution is diluted 10 to 100 times.

Foaming solution for external use 7.5% To disinfect the hands of surgical personnel, apply 5 ml of undiluted solution to pre-washed hands and distribute it evenly to the elbows, rubbing for 2.5 minutes with palms or a brush until foam forms (the foam is washed off with sterile water or removed with a sterile napkin); then the treatment is repeated.

To disinfect the skin of the surgical field, apply the drug to shaved and moistened skin with water and rub it in to form foam. 1 ml of the drug is enough to apply to the skin surface of 50-70 cm2 by rubbing for 5 minutes. The foam is removed using a sterile gauze pad soaked in water, after which the skin is lubricated with an undiluted solution and dried.

Concentrated solution for topical use 8.5% To rinse the mouth and throat, dilute 1 teaspoon of solution in 1/4 glass of water. Rinsing is carried out several times a day. Ointment for external use 10% The ointment is applied in a thin layer to the affected area 2-3 times a day, can be used under an occlusive dressing.

Vaginal suppositories

Prescribed 1-2 pieces/day. Duration of treatment is 14 days or as directed by a doctor. Before using vaginal suppositories, sanitation is necessary.

Side effect

Possible: allergic reactions. Local reactions: in some cases, allergic reactions to iodine - hyperemia, burning, itching, swelling, pain (drug discontinuation required). Systemic reactions: when used on a large area of the wound surface and mucous membranes, systemic reabsorption of iodine is possible, which can cause neutropenia, as well as change the results of tests of functional activity of the thyroid gland; with long-term use (more than 7-10 days), symptoms of iodism are possible (including a metallic taste in the mouth, increased salivation, swelling of the eyelids or larynx).

Contraindications

hyperthyroidism;
thyroid adenoma;
heart failure;
chronic renal failure;
Dühring's dermatitis herpetiformis;
simultaneous use of radioactive iodine;
premature and newborn babies;
children under 8 years of age (ointment for external use);
pregnancy;
lactation;
hypersensitivity to iodine and other components of the drug.

Pregnancy and lactation

The drug is contraindicated for use during pregnancy and lactation (breastfeeding).

Use for renal impairment

Contraindicated in chronic renal failure.

special instructions

If side effects develop, discontinuation of the drug is required. The presence of blood and pus may reduce the antimicrobial effect of the drug. Do not use for bites from insects, domestic or wild animals. The patient should be warned about the need to consult a doctor if systemic reactions occur. It is necessary to ensure that no excess solution remains under the patient. A colored film is formed at the site of application, which remains until the entire amount of active iodine is released, i.e. its disappearance means the drug has ceased to act. Coloring on leather and fabrics is easily washed off with water. Do not heat before use.

Overdose

Symptoms: local irritation, allergic reactions. Treatment: reducing the frequency of use or completely stopping the use of the drug.

Drug interactions

Povidone iodine is incompatible with other disinfectants and antiseptics, especially those containing alkalis, enzymes and mercury. In an acidic environment, the activity of the drug decreases.

Storage conditions and periods

List B. Solutions should be stored in a place protected from light, tightly closed, at a temperature of 0° to 25°C. The ointment should be stored in its original packaging at a temperature between 0° and 25°C. The shelf life of the drug in the form of a solution for external use 10%, an ointment for external use 10% and vaginal suppositories is 3 years. The shelf life of a solution for external use, foaming 7.5%, and a solution for topical use, concentrated 8.5%, is 2 years.

“Povidone-iodine” is a cure for sore throat!

October 31, 2017Tatyana DeinarovichChildren's immunity

Any disease has its own “secondary benefit”. For children, everything at first glance is simple and lies on the surface: “I don’t want to do anything around the house tomorrow, we’d better eat ice cream and get a sore throat!” Familiar vagaries? For a child, a sore throat is better than help with housework, but... until the first signs of it. In the summer it is difficult to deny yourself the pleasure of eating something cold. The ice cream and fruit ice production industry already works almost flawlessly, and even more so during school holidays. And “envious eyes, raking hands” often do not know the measures in anything, especially if the prospect of classes or spring cleaning looms ahead. Due to cold food, the already weakened immunity weakens and a streptococcal infection covers the child’s throat. Sore throat can occur in different forms, the mildest of which is catarrhal. In this case, the child’s throat becomes sore, he feels nauseous, and he refuses to eat or play his favorite games. With proper treatment, catarrhal tonsillitis can be defeated in 4-5 days, otherwise it will go into another stage - follicular tonsillitis, when yellow blisters and suppuration appear on the tonsils. The patient's lymph nodes enlarge, the temperature rises to 38-41 degrees, and a headache occurs. If the disease continues further, a white or yellow coating appears on the throat - a sign of lacunar tonsillitis. In no case should you self-medicate, as improper treatment of sore throat can lead to the development of chronic diseases. Only a specialist can select the necessary medications. Povidone-iodine , will be a faithful assistant in the treatment of sore throat .

Upon contact with the skin and mucous membranes, organic iodine is released from Povidone-iodine , which has a wide spectrum of antimicrobial action. Povidone-iodine is intended for rinsing the mouth and throat for inflammatory and infectious diseases of the oral cavity and pharynx, such as tonsillitis, pharyngitis, tonsillopharyngitis, glossitis, aft; as an additional agent for antibacterial therapy of streptococcal tonsillitis. Povidone-iodine also indicated for use in the treatment of skin lesions (burns, wounds, ulcers, abrasions) and to prevent infection of wound surfaces; in case of influenza conditions during the prodrome; for the treatment of infections of the oral cavity and pharynx that occur during chemotherapy; for surgical interventions on the respiratory tract and oral cavity, for treating the patient’s skin before and after surgery, research (biopsy, puncture, blood drawing, injections, etc.); before and after postoperative treatment of the hands of surgeons and medical personnel, treatment of hands when caring for infected patients; for processing instruments and patient care items.

Returning to the topic of treating sore throat, it should be noted that the dosage of the drug must be prescribed by a doctor. In the first days of the disease, until the temperature normalizes, he, as a rule, prescribes bed rest to the patient, and this rule must be strictly observed. With proper and timely treatment, a sore throat can be defeated quite quickly. But how can you avoid getting it again?

The main cause of sore throat is a weakened immune system, and parents often, due to lack of time, do not take measures to strengthen the immunity of children and prevent sore throat. However, you should try to follow a number of fairly simple rules:

1. Treat tonsillitis qualitatively, this will help avoid frequent relapses of the disease;

2. Increase immunity in children. Provide them with quality nutrition, restful sleep, and vitamin supplements in spring and autumn. During the dangerous off-season period, fight the infection on your own, gargle daily with a solution of salt or baking soda, gradually reducing the temperature of the solution from warm to cool;

4. Monitor the condition of the child’s teeth. Teeth affected by caries are a breeding ground for pathogenic bacteria, which, when they get on the tonsils, can cause inflammation;

5. Temper the child. Spend time with him in the fresh air more often; in the summer, allow him to run on the grass and dry sand. Another effective method is hardening the throat. You can gradually teach your child to drink cold drinks in small doses.

6. Singing is an excellent means of prevention. If your child has talent, you can join a singing club. Doctors have found that while singing, blood supply to the vocal cords and tonsils improves. Local immunity in the mouth and throat increases, which means these organs become much less sensitive to infection.

Be healthy!

Povidone-iodine ointment 100 mg/g 20 g No. 1

Name

Povidone-iodine ointment 20g

Compound

Each tube (20 g) contains: active ingredient: iodized povidone – 2 g; excipients: macrogol 4000, sodium hydroxide, purified water, macrogol 400. 1 gram of ointment contains iodized povidone 100 mg/g.

Description

The ointment is brown in color with a faint odor of iodine and has a uniform consistency.

Pharmacotherapeutic group

Dermatotropic agents. Iodine-containing antiseptic drugs. ATX code: D08AG02.

Pharmacological properties

Pharmacodynamics Povidone-iodine is a complex of iodine and a polymer of polyvinylpyrrolidone, from which iodine is released for some time after application of the drug and a constant concentration of active free iodine is ensured. Free iodine (I2) has a strong bactericidal effect. In in vitro studies, it quickly destroys bacteria, viruses, fungi and some protozoa. In vitro, most microorganisms die within less than one minute, with the greatest bactericidal effect observed within the first 15-30 seconds. Drug resistance is unknown. Pharmacokinetics Absorption Systemic absorption of iodine after topical application to healthy subjects is negligible. Povidone (PVP) Absorption and especially renal excretion of povidone depend on its molecular weight. Since its molecular weight ranges from 35,000 – 50,000, delays should be expected. Iodine Absorption of iodized povidone or iodides is similar to that of iodine from other sources. Excretion is mainly by the kidneys.

Indications for use

for local treatment of wounds or minor cuts and prevention of infection of minor burns;
in complex therapy of fungal or bacterial skin infections, infected bedsores and trophic ulcers.

Contraindications

hypersensitivity to iodine and other components of the drug;
contraindicated in patients with thyroid diseases: nodular, colloid, endemic goiter, Hashimoto's thyroiditis, thyrotoxicosis, thyroid adenoma;
Dühring's dermatitis herpetiformis;
before and after radioactive iodine therapy or scintigraphy;
neonatal period;
children under 2 years of age;
pregnancy (II-III trimester) and lactation period.

Directions for use and doses

For local use only. Dosage The drug is used externally and locally. The ointment is applied in a thin layer, without rubbing, to the affected area. The frequency of use of the ointment is 1-2 times a day. Duration of therapy is 7-14 days. The affected area should be cleaned and dried in advance before applying the ointment, since its effectiveness in the presence of various organic substances, such as blood and pus, is reduced as they oxidize and bind active iodine. When treating infected wounds, bedsores and trophic ulcers, after applying the ointment, you can use a gauze bandage if necessary.

Side effect

Adverse reactions are listed according to the classification of undesirable side effects in accordance with the damage to organs and organ systems and the frequency of development: very often (? 1/10), often (? 1/100 to

Interaction with other drugs

The combined use of Povidone-iodine ointment and enzyme preparations used in the treatment of wound surfaces leads to a decrease in the effectiveness of both drugs. Simultaneous or sequential use of drugs containing iodized povidone and antiseptics containing octenidine may cause temporary darkening of the skin at the site of use. Attention! The oxidative properties of iodized povidone may interfere with some diagnostic tests, resulting in false-positive test results for determining urinary or fecal hemoglobin and urine glucose in patients using iodized povidone preparations. When using drugs containing iodized povidone, the absorption of iodine by the thyroid gland may be reduced, which may distort the results of diagnostic studies using radioactive iodine preparations and reduce the effectiveness of iodine therapy for the thyroid gland. Thyroid scintigraphy may be recommended no earlier than 1-2 weeks after completion of treatment with drugs containing iodinated povidone. Pharmaceutically incompatible with disinfectants containing mercury or oxidizing agents, alkali solutions (accelerated destruction of the iodine-polyvinylpyrrolidone complex occurs). Weakens the effect of antitumor therapy with radioactive iodine and the effect of thyreostatic agents from the thioamides group (thiamazole, propyl thiouracil). When used simultaneously with potassium iodide and amiodarone, it increases the risk of developing iodism and thyroid dysfunction. In the presence of blood, the bactericidal effect is reduced. Should not be used simultaneously with medications containing the following ingredients: chlorhexidine, tannic acid, silver.

Precautionary measures

Povidone-iodine ointment is intended for topical use. Avoid contact with eyes. Long-term use may cause skin irritation, rarely? serious skin reactions. If local irritation or hypersensitivity occurs, treatment should be discontinued. Do not reheat before use. Keep out of the reach of children. When used over large areas of the skin and during long-term treatment - for example, when treating burns or wounds - significant amounts of iodine can be absorbed and cause hyperthyroidism. It is recommended to avoid applying the ointment to areas of skin whose total area exceeds 10 percent of the body surface area and/or to use the ointment for more than 14 days. The patient's condition should be monitored for symptoms of iodism, hyperthyroidism, and thyroid function, especially when Povidone-iodine ointment is used over large areas and/or for a long time. Use in patients with impaired liver function and chronic renal failure requires increased caution. Povidone-iodine ointment is not recommended for use in patients receiving lithium therapy. Caution when prescribing should be observed in persons with impaired thyroid function. The use of ointment in this group of patients should be limited as much as possible and carried out only under conditions of careful monitoring of thyroid function. Use in pediatrics. The use of ointment in newborns and children under 2 years of age is contraindicated. Effect on laboratory parameters. During treatment with ointment, it is possible to obtain false results when determining the level of thyroid hormones and protein-bound iodine in the blood plasma.

Use during pregnancy and lactation

Atomic iodine and iodide ion easily penetrate the placental barrier, are released into breast milk and can cause the development of goiter in a child. The use of ointment during pregnancy (from the 3rd month) is contraindicated. If it is necessary to use it during lactation, it is necessary to avoid breastfeeding for the entire period of treatment and for 1 week after its completion.

Impact on the ability to drive vehicles and operate machinery

Povidone-iodine does not affect the ability to drive a vehicle or engage in any potentially hazardous activities.

Overdose

Acute iodine intoxication can have the following effects:

metallic taste in the mouth, salivation, burning, pain in the mouth, throat;
eye irritation and swelling;
skin diseases;
abdominal fullness, diarrhea;
renal dysfunction, anuria;
heart failure;
swelling of the glottis, associated asphyxia and pulmonary edema, metabolic acidosis and hypernatremia.

Treatment. Symptomatic therapy and supportive therapy are used. Particular attention is paid to the correction of electrolyte disturbances, normalization of kidney and thyroid function.

Package

20 g in aluminum tubes. Each tube, together with a leaflet, is placed in a cardboard pack (package No. 1).

Storage conditions

At a temperature not higher than 25 °C. Keep out of the reach of children.

Best before date

2 years. Do not use the medicine after the expiration date.

Conditions for dispensing from pharmacies

Over the counter.

Povidone-iodine 10% 500ml solution for external use