In addition to the fact that the incidence of coronavirus is growing, doctors - as well as places in hospitals - are becoming less and less, test results are waiting for a long time, those doctors who remain in service make a number of mistakes when prescribing a treatment regimen.
An infectious disease doctor and researcher at PSPbSMU named after A.V. helped to understand the situation Academician I.P. Pavlova Oksana Stanevich together with the “Not in vain” foundation.
We will talk about what mistakes doctors make, what examinations, in addition to the COVID-19 test, show the presence of coronavirus, why you should not immediately take antibiotics, and what medications you should have at home.
Pharmacodynamics and pharmacokinetics
The mechanism of action of aminophylline (in Latin - aminophylline) is associated with its ability to block purine (adenosine) A2-type receptors of bronchial smooth muscle cells, increase the accumulation of cyclic AMP in tissues, suppress PDE, reduce the flow of Ca ions through plasma membrane channels (cell membranes), reduce contractile activity smooth muscle activity.
The effects of the drug manifest themselves as:
- relaxation of the bronchial muscles;
- stimulation of diaphragm contractions;
- increasing mucociliary clearance;
- improving the function of intercostal and respiratory muscles;
- stimulation of the respiratory center and increasing its sensitivity to CO2;
- improving alveolar ventilation.
All this helps to reduce the severity and frequency of episodes of respiratory arrest ( apnea ).
By normalizing breathing, it ensures better oxygen saturation of the blood and helps reduce CO2 concentration. Stimulates the activity of the heart muscle, increases the number and strength of its contractions, improves blood circulation through the blood vessels of the heart and increases the myocardial need for oxygen.
Reduces tension in the vascular walls, promotes dilation of peripheral vessels, reduces vascular resistance in the lungs, and reduces pressure in the pulmonary circulation.
It is a diuretic of moderate strength, increases the volume of blood flow in the kidneys, promotes the dilation of the bile ducts, suppresses platelet aggregation, increases the resistance of red blood cells to deformation (improves blood rheology), normalizes microcirculation and reduces thrombus formation.
Reduces the excitability and contractility of the myometrium (tocolytic effect), in high doses it has an epileptogenic effect .
Absorption from the gastrointestinal tract when taken orally is rapid. Food does not change its magnitude, but reduces its speed. The degree of absorption also depends on the dose: the higher it is, the slower aminophylline .
In a healthy adult, about 60% of the dose of aminophylline is bound to plasma proteins, in a patient with liver cirrhosis - about 35%, in infants during the newborn period - 36%.
TSmax for regular tablets is 60-120 minutes.
In the liver, part of the administered dose of aminophylline is biotransformed into caffeine . T1/2 of caffeine in children under 3 years of age is longer than in adults. The concentration of the substance in a child can reach 30% of the concentration of aminophylline .
In patients older than three years of age, the phenomenon of caffeine is not observed.
The T1/2 indicator is influenced by concomitant diseases and the patient’s age. In children under six months of age, as well as in adult patients with heart failure , COPD and cor pulmonale, it is more than 24 hours, in children over six months of age - 3.7, in non-asthmatic adults - 8.7, in people who smoke more than 20 cigarettes a day - 4-5 hours. After quitting smoking, it takes at least 3 months for the pharmacokinetics of the drug to normalize.
Eliminated by the kidneys, about 10% is excreted in pure form in adults, and about half of the taken dose of aminophylline is excreted in children.
What additional examination is needed?
When infected with coronavirus, it is necessary to constantly monitor saturation indicators, which are measured with a pulse oximeter. This device looks like a clothespin that is attached to your finger. It shows how saturated the blood is with oxygen, i.e. saturation. It is measured as a percentage, and the norm for a healthy person without diseases of the lungs and cardiovascular system is 98−99%.
During coronavirus infection, saturation should be measured at least 4 times a day and for at least 30 seconds.
Photo: Vladimir Gerdo/TASS
Additional examination, which should be prescribed by the attending physician, may include a chest examination on a computed tomography (CT) scanner, a complete blood count, a blood test for c-reactive protein* and d-dimer*.
Based on these indicators, it is possible to timely determine the criteria for hospitalization, even if saturation indicators do not deviate greatly from the norm.
Example: a 49-year-old woman had a temperature above 38.5 for five days, a terrible cough, and shortness of breath. At the same time, saturation did not fall below 95%. She took tests, and the value for c-reactive protein was 126. The norm for this indicator is up to 5. Such a pronounced increase can be considered the start of a cytokine storm*, which is considered a complication of coronavirus infection. The woman called an ambulance, the doctor listened to her and did not hear anything in the lungs, which happens very often with covid pneumonia. The doctor told her that the blood tests meant nothing at all and left. She, breaking quarantine, came to the hospital through an acquaintance, where she underwent a CT scan, which showed that 65% of her lungs were affected. This corresponds to the third degree of lung damage out of four.
*Cytokine storm is an excessive immune response of the body to an infection that affects organs without the participation of a pathogen.
*C-reactive protein (CRP) is a highly sensitive indicator of inflammation and infection and responds to significant tissue damage.
*D-dimer - intensity and nature of thrombus formation processes.
A significant increase in c-reactive protein begins with a reading above 50.
In the photo: a patient undergoing examination on a computed tomography machine (Photo: Sergey Savostyanov/TASS)
Indications for use of Eufillin
Eufillin - what are these pills for?
Indications for use of Eufillin tablets:
- bronchial asthma (BA);
- Pickwick's syndrome (paroxysmal sleep apnea);
- chronic obstructive bronchitis (COB);
- chronic “pulmonary heart”;
- emphysema.
Eufillin is the drug of choice for exercise-induced asthma; for other forms of the disease it is used in combination with other drugs.
When is Euphyllin in ampoules prescribed?
Indications for Eufillin in ampoules are:
- broncho-obstructive syndrome due to bronchitis , asthma, cardiac asthma (mainly to relieve attacks) or emphysema ;
- cerebrovascular insufficiency of the brain (the solution is used in combination with other drugs to reduce intracranial pressure);
- hypertension in the pulmonary circulation;
- migraine;
- left ventricular failure , accompanied by periodic breathing of the Cheyne-Stokes type and bronchospasm (in combination with other drugs).
Composition and release form
The composition of the drug depends on the form of release of the drug. Eufillin is produced in the following versions:
- Pills. One piece contains the active substance - aminophylline (150 milligrams), as well as auxiliary components. The latter include calcium, stearic acid and potato starch.
- Ampoules (solution for injection). Aminophylline is also the main substance. Each ampoule contains 24 milligrams of the active ingredient. In addition to it, the composition also contains water for injection.
Contraindications for Eufillin solution and tablets
Contraindications to the use of tablets:
- intolerance to aminophylline or any other xanthine ;
- myocardial infarction (MI) in the acute stage;
- hypertrophic cardiomyopathy with obstruction;
- tachyarrhythmia;
- exacerbation of symptoms of stomach/duodenal ulcer ;
- severe functional impairment of the kidneys/liver;
- epilepsy;
- hyperthyroidism.
In pediatrics, it is not prescribed to children under six years of age, or in combination with Phedrine .
Injection of the drug is contraindicated in the following cases:
- hypersensitivity to aminophylline and other xanthine ;
- MI in the acute stage;
- angina pectoris;
- OSN;
- extrasystoles;
- paroxysmal tachycardia;
- severe arterial hypotension/hypertension;
- pulmonary edema;
- vascular atherosclerosis;
- hemorrhagic stroke;
- there is an indication of any spontaneous bleeding in the anamnesis;
- hemorrhage into the retinal tissue;
- peptic ulcer in the acute stage;
- epilepsy;
- increased threshold of convulsive readiness;
- gastroesophageal reflux (GER);
- uncontrolled hypothyroidism ;
- thyrotoxicosis;
- hyperthyroidism;
- porphyria;
- sepsis;
- kidney and/or liver dysfunction.
Due to the likelihood of side effects, it is not recommended to use the solution in children under 14 years of age. Children under three years of age are contraindicated to administer Eufillin intravenously; in children over three years of age, the medicine can be used for health reasons and for no more than 14 days.
Coronavirus therapy now [RECOMMENDATIONS] First aid kit for Covid
These recommendations from our expert should only be used after consultation with your doctor.
- If possible, buy a pulse oximeter and monitor your saturation readings.
- Of the medications, first of all, it is necessary to have any antipyretics. The WHO warning that some antipyretics worsen the course of the new coronavirus infection has now been completely debunked. This warning was withdrawn back in March.
- You can also use any usual painkillers (in the absence of individual contraindications).
- For those taking birth control pills or who have a tendency to clot, it is necessary to have anticoagulants. These are drugs that thin the blood and prevent the formation of blood clots.
- When taking anticoagulants and antipyretics, you need to remember to protect the stomach (omeprazole, famotidine, etc.) to avoid gastrointestinal bleeding.
- If you have a new coronavirus infection, you should drink more fluids to prevent dehydration and kidney problems.
Do not forget that the doctor must explain to the patient what he is prescribing and why.
*Based on materials from Oksana Stanevich’s broadcast for the “Not in vain” foundation and personal consultation for the “SP” publication.
Side effects
Side effects of using Eufillin tablets:
- sleep disturbances, anxiety, dizziness, convulsions, tremor;
- irregular heart rhythm, palpitations;
- hematuria , albuminuria ;
- hypoglycemia (rare).
Against the background of injection therapy, the following are possible:
- headache, anxiety, dizziness, agitation, irritability, tremor, insomnia ;
- arrhythmias , tachycardia (including in the fetus, if the woman took the drug in the 3rd trimester of pregnancy), palpitations, cardialgia , decreased blood pressure, unstable angina ;
- nausea, diarrhea , heartburn, gastralgia , vomiting, exacerbation of symptoms of peptic ulcer , GER, with long-term use - loss of appetite;
- itching of the skin, skin rashes, fever;
- tachypnea , chest pain, hypoglycemia , albuminuria , increased diuresis, hematuria , increased sweating, feeling of heat in the face.
Side effects are dose-dependent, that is, to relieve them, it is often enough to reduce the dose of the drug.
Local reactions to the injection of the solution manifest themselves in the form of skin hyperemia, pain and the formation of a seal at the injection site.
Instructions for use of Eufillin
Eufillin tablets: instructions for use
The Vidal reference book states that the tablets should be taken orally after meals with plenty of liquid. The dosage of the drug is selected individually, taking into account the different rates of elimination of aminophylline in different patients.
If necessary, the dose is increased every three days until the desired effect is achieved.
Patients weighing more than 50 kg (including teenagers) are prescribed Eufillin for bronchitis and other conditions accompanied by bronchial obstruction at 450-900 mg/day, if necessary, the dose can be increased to 1.2 g with a frequency of use of 4 times ./day with an interval of 6 hours.
For patients weighing less than 50 kg and adolescents whose weight is in the range of 45-55 kg, Eufillin tablets are prescribed to take 450-600 mg/day.
For children 6-17 years old with bronchitis and other broncho-obstructive conditions, tablets are given at the rate of 13 mg/kg, usually 1 tablet 3 times a day.
For COPD in the acute phase, treatment begins with a dose of 5-6 mg/kg (for adults) with further increases. Serum concentration should not exceed 0.02 mg/ml. An increase in the dose for every 0.5 mg/kg leads to an increase in the concentration of the drug in the blood by 0.001 mg/ml.
Outside of an exacerbation, the initial dose of Eufillin for an adult with COPD is 6-8 mg/kg/day, the highest (in the initial stages of treatment) is 400 mg/day. It is recommended to divide it into 3-4 doses.
If used during pregnancy, the dosage (as well as the method of administration) is determined by the doctor. It should be borne in mind that for the mother, an overdose is associated with the risk of cardiac dysfunction (and sometimes cardiac arrest), and for the fetus, high doses of Eufillin are dangerous due to the likelihood of hypoxia and antenatal death.
Eufillin ampoules: instructions for use
For conditions that require emergency care, adult patients are advised to use an infusion with a loading dose of the drug: Eufillin is administered intravenously over half an hour at a dose of 5.6 mg/kg. To prepare a dropper, 10-20 ml of solution is combined with a similar volume of 0.9% aqueous NaCl solution and then the medicine is diluted in 0.25-0.5 liters of physiological solution.
During maintenance therapy, Eufillin is infused into the patient intravenously for 1-3.5 times at a dose of 0.9 mg/kg.
If the patient has previously taken theophylline , the dose of aminophylline should be reduced by at least half.
For status asthmaticus, 720 to 750 mg of aminophylline .
The permissible upper limit of the daily dose for an adult is 0.4-0.5 ml/kg.
Children under 3 months are administered intravenously from 30 to 60 mg of aminophylline per day; for older children and adolescents, the dose varies from 60 to 500 mg/day.
Intravenous injections of Eufillin in emergency conditions are performed for at least five minutes. A single dose for an adult is 6 mg/kg. Before giving the injection, the drug is diluted in 10-20 ml of a 0.9% aqueous solution of NaCl.
The daily dose for intramuscular administration is from 0.1 to 0.5 mg.
For children with COPD, Eufillin is administered at a dose of 5-6 mg/kg (initial dose); during maintenance therapy for children under six months of age, the drug is administered every 8 hours at a dose calculated by the formula: child’s age in weeks * 0.07 + 1, 7.
For children aged six months to one year, the maintenance dose is calculated using the formula: child’s age in weeks * 0.05 + 1.25. The interval between injections is 6 hours.
Children from one to 9 years old are administered 5 mg/kg, children 9-12 years old - 4 mg/kg, children 12-16 years old - 3 mg/kg every 6 hours.
Outside of exacerbation, the initial dose for a child is 16 mg/kg/day, the highest dose is 400 mg/day. It should be divided into 3-4 injections.
If necessary and if Eufillin is well tolerated, the dose is increased every couple of days by 25% to the highest daily dose, which for children under one year old is calculated using the formula “age in weeks * 0.3 +8”, for children under 9 years old it is 22, for children up to 12 years old - 20, for adolescents under 16 years old - 18, for patients over 16 years old - 13 mg/kg.
Eufillin is administered intramuscularly to children at a dose of 15 mg/kg/day. The maximum duration of parenteral use in children is 14 days.
For apnea in children of the first year of life (accompanied by bradycardia and cyanosis , in which the child does not breathe for periods of 15 seconds), the starting dose is 5 mg/kg (the medicine is administered through a nasogastric tube). When carrying out maintenance therapy, the child is recommended to use 2 mg/kg in two doses.
Treatment can last up to several months (usually several weeks).
Electrophoresis with Eufillin
Euphylline for electrophoresis in adults is used to treat arthrosis and osteochondrosis . For electrophoresis, it is prescribed to children for dysplasia , as well as when it is necessary to relieve muscle hypertonicity or reduce intracranial pressure .
In case of cerebrovascular insufficiency or intracranial hypertension , it is performed on the cervical vertebrae; in case of hypertonicity of the child’s legs, it is performed in the lumbar region.
Electrophoresis with Eufillin is a procedure that allows you to create the desired concentration of the active substance directly in the affected tissues. Acting locally, the medicine does not cause systemic side effects, so it can be used in infants older than one month.
The doctor places a gauze cloth soaked in Eufillin solution on the sore spot and secures the electrodes. Exposure time is 15 minutes. This is enough for the drug to penetrate deep into the tissue. The course of treatment is designed for ten sessions.
To restore organ function after birth injuries in newborns, cerebral circulation in pathologies of the cervical spine , as well as in cerebral palsy , electrophoresis according to Ratner is recommended.
The essence of this method is that the patient is placed on two pads impregnated with different drugs: the first (with Eufillin solution 0.5%) - on the cervical vertebrae, the second (with papaverine 1%) - on the ribs, to the right of the sternum. Exposure time is 15 minutes. Current strength is 1-2 mA.
It should be noted that both children and adults tolerate the procedure equally well, so in the absence of contraindications, it can be performed without any fear.
Electrophoresis is contraindicated for any skin diseases, arterial hypertension , arrhythmia , heart failure , or the presence of neoplasms in the patient (any location).
Inhalations with Eufillin for children - effective or inappropriate?
Prescription of Eufillin for children with cough and bronchial obstruction allows them to expand the bronchi, relieve spasm and facilitate the discharge of sputum. However, the drug has these effects only when it enters the systemic circulation.
The use of Eufillin for inhalation belongs to the “off-label” prescribing category. Despite the lack of instructions in the manufacturer's instructions regarding the possibility of using the drug in this way, many people often prescribe this treatment for themselves and, moreover, treat their children in this way.
Most doctors unanimously believe that the effectiveness of inhalations with Eufillin is extremely low, since when inhaling vapors, the drug settles on the mucous membrane and, therefore, does not enter the systemic bloodstream in a therapeutically effective concentration.
The positive effect on the bronchi (their relaxation and improvement of sputum discharge) is due to the fact that during inhalation water vapor enters them. This means that the effectiveness of the drug when used in inhalation is comparable to the effectiveness of ordinary water.
Eufillin for cellulite
One of the properties of aminophylline is the ability to dilate peripheral vessels and restore the functioning of the circulatory system, which in turn cannot. Cellulite, as is known, occurs when blood circulation is impaired and cells begin to suffer from a lack of oxygen. The use of Eufillin allows you to tighten the upper layers of the skin, remove excess fluid and reduce swelling.
For weight loss and getting rid of orange peel, the product is used in the form of creams, masks and wraps. Massage with Eufillin also gives a good effect.
To prepare the composition, the medicine should be mixed with any massage cream, and then add a small amount of Dimexide , which in this case will act as a transporter (thanks to it, aminophylline will be able to penetrate very deeply into the tissues).
For wraps, you can use a mixture of regular baby cream, Dimexide , Euphyllin and tangerine or lemon essential oil (6-8 drops). The composition is applied to the skin cleansed with a scrub and covered with cling film. While it “works” (impact time is usually about 30 minutes), it is recommended to move intensively to enhance the effect.
To prepare anti-cellulite cream based on Eufillin, use the following recipe:
- petrolatum;
- moisturizing cream;
- 1 powdered tablet or the contents of 1 ampoule (5 ml) of Eufillin (this dose of the drug is suitable for women weighing less than 75 kg);
- Dimexide (for one five-milliliter ampoule of solution, take 2 ml of Dimexide concentrate).
You can also add the drug to a ready-made pharmaceutical anti-cellulite product. The optimal proportion of ingredients is 1:5.
Reviews about Eufillin for cellulite can be found very different - some are completely dissatisfied with the result, others claim that the result exceeded all expectations. Based on this, we can draw the following conclusion - if the remedy works, then definitely not from the first procedure.
Overdose
The annotation states that overdose symptoms develop when the plasma concentration of aminophylline exceeds 0.02 mg/ml. Characteristics are:
- diarrhea;
- prolonged vomiting;
- facial hyperemia;
- excitation;
- arrhythmia;
- tremor;
- photophobia;
- convulsions.
When the blood concentration exceeds 0.04 mg/ml, the patient falls into a coma.
Helpful measures include stopping the administration of Eufillin to the patient and enhancing natural detoxification by stimulating kidney function (forced diuresis).
If the aminophylline exceeds 0.05 mg/ml, plasmapheresis , hemosorption , peritoneal dialysis or hemodialysis , respiratory support (ventilation and oxygen supply), and monitoring of hemodynamic parameters are indicated.
To relieve convulsive syndrome, the patient is administered diazepam (intramuscularly). The use of barbiturates is contraindicated!
Interaction
The effect of aminophylline is enhanced by use in combination with furosemide , ephedrine, caffeine , and β-adrenergic stimulants .
When used simultaneously with phenytoin , phenobarbital , isoniazid , rifampicin , sulfinpyrazone , carbamazepine of aminophylline is observed , which is accompanied by a decrease in its therapeutic effectiveness and may require an increase in the dose used.
Acceleration of aminophylline is also observed in heavy smokers (at least 20 cigarettes per day).
Use in combination with drugs from the macrolide group, allopurine , isoprenaline , COCs , cimetidine , lincomycin , viloxazine , fluvoxamine , disulfiram , β-blockers , influenza vaccines leads to a slower elimination of aminophylline , an increase in its plasma concentration and, consequently, a reduction in the dose of Euphyllin.
If the drug is prescribed in combination with drugs of the fluoroquinolone group, the dose of Eufillin is reduced to 25% of the usually recommended one.
Aminophylline weakens the therapeutic effect of Li drugs and β-blockers. β-blockers, in turn, weaken the bronchodilator effect of aminophylline .
When taking Eufillin together with corticosteroids (for example, with dexamethasone ), diuretics and β-adrenergic agonists, hypoglycemia increases .
Aminophylline may cause side effects of fluorinated derivatives of general anesthesia ( ventricular arrhythmias ), mineralocorticosteroids (hypernatremia), and drugs that excite the central nervous system ( neurotoxicity ).
May enhance the effect of anticoagulants .
The solution is incompatible with solutions of acids, fructose, glucose and levulose. When preparing for intravenous infusion of an infusion solution, it is necessary to take into account the pH of the solutions used.
Should be used with caution in combination with purine derivatives , theophylline derivatives , and anticoagulants . During the treatment period, it is prohibited to take substances that contain xanthines (including tea and coffee).
In one syringe, Eufillin solution can only be mixed with isotonic NaCl solution.
The deficit we create ourselves
Since spring, people in panic began to buy everything they thought they needed. At first it was buckwheat and toilet paper, then lemons, garlic and ginger, then medical masks, and gradually the turn came to basic mercury thermometers and medicines.
Those who have encountered coronavirus infection more closely may know about the drug dexamethasone, its analogue is prednisolone. Now it is almost impossible to find dexamethasone in pharmacies. There have been rumors that it can supposedly cure cytokine storm, is effective in preventing coronavirus, or can stop the more complex, fatal course of covid.
In the photo: oxygen concentrator (Photo: Sergey Malgavko/TASS)
“Back in the summer, a study was conducted in the UK, which showed that the administration of dexamethasone actually improved the outcome of the disease and made it possible not to develop more severe respiratory failure. However, there was one “but”, which for some reason is again not taken into account anywhere. The benefit of dexamethasone has been shown only in combination with oxygen support (prescribed when saturation decreases below 95%). In the absence of oxygen support, outcomes did not improve and there was even a trend towards worse outcomes.”
In outpatient treatment, dexamethasone cannot help. And if you decide to buy it “just in case,” then do not forget to buy an oxygen concentrator, the cost of which varies around 60-70 thousand rubles.
special instructions
The bronchodilator effect of the drug occurs when the concentration of the active substance reaches 0.01-0.02 mg/ml. A concentration exceeding 0.02 mg/ml is toxic.
The stimulating effect on the respiratory center is realized when the content of aminophylline in the blood is in the range from 0.005 to 0.01 mg/ml.
In newborn infants and people over 55 years of age, the medicine is used with caution due to the insufficient activity of the liver enzymatic systems involved in the biotransformation of aminophylline .
In geriatrics, aminophylline should be used in minimal doses while monitoring the plasma concentration of aminophylline .
During the treatment period, you should not eat foods that contain xanthine derivatives: mate, chocolate, coffee, cocoa, strong tea.
The solution is heated to body temperature before administration.
Time for antibiotics: when needed
In the early stages - up to the 8th-9th day - there can be no talk of antibiotics at all. During this period, coronavirus pneumonia develops, which cannot be stopped by prescribing antibiotics.
Some may develop secondary bacterial pneumonia. This occurs more often in people with an initially suppressed immune status. For example, with decompensated diabetes mellitus.
“When there is a lot of glucose in the blood, bacterial microflora has a greater chance of superimposing viral pneumonia and stimulating the proliferation of bacteria in the lungs. It has certain laboratory signs. We cannot prescribe antibiotics for diabetes and Covid for prevention. Because it won’t work for prevention, antibiotics don’t prevent secondary bacterial pneumonia, they only treat it.”
To prevent the development of bacterial pneumonia, it is necessary to reduce glucose levels with the help of glucose-lowering drugs or insulin under the supervision of a doctor.
Photo: Vladimir Gerdo/TASS
Analogs
Level 4 ATC code matches:
Aerophyllin
Theotard
Teopek
Theophylline
Aminophylline
Neophylline
Analogs of Eufillin: Aminophyllin-Eskom , Eufillin-pharm , Eufillin-Darnitsa .
Drugs with a similar mechanism of action: Diprophylline , Neo-Teofedrine , Neoteopek A , Teobiolong , Theobromine , Theotard , Teofedrine-N , Theophylline .
Eufillin during pregnancy
The manufacturer, in the instructions for Eufillin, warns that the use of solution/tablets during pregnancy may create concentrations of aminophylline and caffeine that are potentially hazardous to the health of the fetus/newborn.
Children whose mothers received the drug during pregnancy (especially in the third trimester) should be under medical supervision during the neonatal period to monitor possible symptoms of intoxication with methyl xanthine derivatives.
Prescription of Eufillin during pregnancy and lactation is possible only for extreme health reasons and requires an assessment of possible risks for the fetus/child.
Why can Eufillin be prescribed during pregnancy?
Gynecologists recommend the use of Eufillin for edema during pregnancy, for placental insufficiency, in the complex treatment of gestosis , as well as for other conditions that require urgent use of this medicine due to a threat to the life of the mother.
There is no clear treatment regimen for Eufillin during pregnancy, since the manufacturer’s instructions list pregnancy as one of the contraindications for use. The doctor makes all appointments depending on the condition of a particular patient.
Reviews of Eufillin during pregnancy allow us to conclude that the medicine is far from harmless (some women say that after the dropper they felt a strong heartbeat, weakness and dizziness), but for many it helps them to return to normal.
Interaction with other drugs
Ephedrine and caffeine enhance the effect of the drug.
Pharmaceutically incompatible with acid solutions.
Increases the likelihood of developing side effects of glucocorticosteroids, mineralocorticosteroids (hypernatremia), drugs for general anesthesia (increases the risk of ventricular arrhythmias), drugs that excite the central nervous system (increases neurotoxicity).
Antidiarrheal drugs and enterosorbents reduce the absorption of aminophylline.
Rifampicin, phenobarbital, phenytoin, isoniazid, carbamazepine, sulfinpyrazone,
aminoglutethimide, oral estrogen-containing contraceptives and moracizine, being inducers of microsomal oxidation, increase the clearance of aminophylline, which may require an increase in its dose.
When used simultaneously with macrolide antibiotics, lincomycin, allopurinol, cimetidine, isoprenaline, enoxacin, small doses of ethanol, disulfiram, fluoroquinolones, recombinant interferon alpha, methotrexate, mexiletine, propafenone, thiabendazole, ticlopidine, verapamil, and with influenza vaccination, the intensity of action of aminophylline may increase, which may require a reduction in its dose.
Enhances the effect of beta-adrenergic stimulants and diuretics (including by increasing glomerular filtration), reduces the effectiveness of lithium preparations and beta-blockers.
Compatible with antispasmodics, do not use in combination with other xanthine derivatives.
Prescribe with caution simultaneously with anticoagulants, with other theophylline or purine derivatives.
Reviews about Eufillin
The drug is most often used to treat diseases accompanied by airway obstruction , therefore most of the reviews about Eufillin are reviews of its use for bronchitis and asthma .
People who have taken the medicine note that the drug effectively relieves attacks of painful coughing, accelerates the removal of mucus and makes breathing easier. Moreover, improvement occurs literally within 10 minutes after taking the tablet or administering the solution.
During pregnancy (if used correctly in accordance with the doctor's recommendations), the medicine helps to remove excess fluid, normalize the condition and avoid hospitalization in the department of pathology of pregnant women.
There are few negative reviews about the drug and they are primarily associated with individual sensitivity to its active substance.
A separate category of reviews about Eufillin are reviews about the use of tablets and solution for weight loss and against cellulite. For cellulite, the drug is used as an additive to the main anti-cellulite agent, as well as in combination with Dimexide and essential oils.
It is quite difficult to judge the effectiveness of Eufillin against cellulite, since reviews of the results of its use in cosmetology are quite contradictory. Most women claim that it is possible to achieve smooth skin with the help of the drug, but the effect usually becomes noticeable after completing the full course of procedures.
Eufillin price
The price of Eufillin tablets (150 mg No. 30) in Russian pharmacies is 10-12 rubles, a 2.4% solution in 5 ml ampoules (package No. 10) can be bought for 35 rubles, in 10 ml ampoules (package No. 10) - for 40 rubles
In Ukraine, the cost of tablets is from 13 UAH, the price of Eufillin ampoules is from 21 UAH.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Eufillin solution intravenously.
24mg/ml amp. 5ml 10pcs JSC Dalkhimfarm 48 RUR order - Eufillin tablets 150 mg 30 pcs. Pharmstandard-Leksredstva OJSC
34 RUR order
Pharmacy Dialogue
- Eufillin (amp. 2.4% 10ml No. 10)Novosibkhimpharm OJSC
99 RUR order
- Eufillin (tab. 150 mg No. 30 (bl.)) Ozon LLC
35 rub. order
- Eufillin (amp. 2.4% 5ml No. 10) DHF JSC
46 RUR order
- Eufillin (tab. 150 mg No. 30 (bl.)) Usolye-Sibirsky Chemical Physics Complex
32 RUR order
- Eufillin (tab. 150 mg No. 30 (bl.)) BZMP
20 rub. order
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Pharmacy24
- Eufillin-pharm 0.4 g No. 30 capsules TOV VTF "Farmakom", Ukraine
23 UAH. order - Eufillin-N 200 2% 5 ml No. 10 solution PAT "Farmak", Ukraine
22 UAH order
- Eufillin-Darnitsa 2% 5 ml No. 10 solution
30 UAH order
- Eufillin-pharm 0.25 g No. 40 tablets TOV VTF "Farmakom", Ukraine
17 UAH order
- Eufillin-pharm 0.25 g No. 80 tablets TOV VTF "Farmakom", Ukraine
31 UAH order
PaniPharmacy
- Eufillin ampoule Eufillin 200 solution d/in. 2% amp. 5ml No. 10 Ukraine, Darnitsa ChAO
33 UAH order
- Eufillin ampoule Eufillin solution d/in. 2% amp. 5ml No. 10 Ukraine, Health LLC
30 UAH order
- Eufillin-pharm tablets 0.25g N40 Ukraine, Farmakom PTF LLC
17 UAH order
- Eufillin-pharm tablets 0.25g N80 Ukraine, Farmakom PTF LLC
30 UAH order
- Eufillin-pharm capsules 0.4g No. 30 Ukraine, Farmakom PTF LLC
24 UAH order
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