"Trombital" is a drug for the prevention* of heart attacks and strokes with a special composition

Treatment of cardiovascular pathologies involves a whole range of medications aimed both at maintaining the functioning of the heart muscle and at preventing relapses. The drugs Cardiomagnyl, Trombital and Thrombo Ass are the most common for the use of these disorders. Which one is better according to cardiologists is indicated below.

Description of Trombital

The tablets are produced in Russia; they contain 2 main components - acetylsalicylic acid and magnesium hydroxide. They have an antithrombotic and antiaggregation effect. A favorable result is achieved by influencing platelets. The medicine inhibits the process of thromboxane synthesis, as a result of which their activity in connecting with the walls of blood vessels decreases. The adhesion to each other is also inhibited, which prevents the formation of blood clots. The result is noticeable within a week of use.

Properties of Trombital:

1. Acetylsalicylic acid has a positive effect on the cardiovascular system. Treatment with the drug reduces mortality in myocardial infarction.
2. Prothrombin time increases, the intensity of prothrombin production in the liver and the concentration of coagulation factors decreases.
3. Additional qualities: has antipyretic, anti-inflammatory, analgesic effect. Enhances the excretion of uric acid.

The disadvantage of Trombital is its adverse effect on the mucous membrane of the gastrointestinal tract.

To prevent the risk of complications, a second substance was added to the composition - magnesium hydroxide.

Main indications for taking tablets:

• prevention of pathologies of the heart and arteries;
• unstable angina;
• prevention of blood clots;
• decreased likelihood of recurrent myocardial infarction;
• prevention of thromboembolism after capillary surgery.

You should not take Trombital under 18 years of age, during pregnancy, lactation, with heart failure, intestinal or cerebral hemorrhages, sensitivity to constituent substances, liver or kidney disorders, or bronchial asthma.

Comparison of Trombital and Cardiomagnyl

Similarities

First of all, the medications have identical composition.

The dosage of active components is the same. Due to this, the same side effects appear.

Indications for use and contraindications for Trombital and Cardiomagnyl are also the same. If for some reason the first drug is not suitable for the patient, then it is not recommended to change it to a direct analogue, since in this case hypersensitivity may also develop.

The medications have identical composition. The dosage of active components is the same. Due to this, the same side effects appear.

Difference

Trombital is produced in the form of film-coated tablets, which reduces the degree of negative impact on the mucous membranes of the stomach and intestines.

Cardiomagnyl is available in uncoated tablets, and acetylsalicylic acid has a more aggressive effect on the gastrointestinal tract.

Which is cheaper?

There is a difference in cost. Considering that both products are produced in Russia, their price is low. Trombital can be purchased for 115 rubles. (tablets contain a minimum dosage of active substances; there are 30 of them in a package). The price of Cardiomagnyl is 140 rubles. (30 pieces per package with a minimum dosage of active ingredients).

Characteristics of Thrombo Ass

The antiplatelet agent reduces the intensity of blood clotting, additionally preventing thrombosis. The main component is acetylsalicylic acid, 1 tablet. contains 100 mg of the component. Auxiliary properties - reduction of temperature, pain, inflammation.

The blood thinning effect of aspirin has a positive effect on patients with varicose veins, reduces the risk of cancer, and is used during preeclampsia. Thrombo Ass improves the flow of blood, which passes through small vessels without difficulty. The drug is approved for continuous use, but the therapeutic regimen should be discussed with a cardiologist/surgeon.

Indications for use of Thrombo Ass:

• restoration of cerebral circulation in the presence of ischemic heart disease;
• heart attack prevention;
• prevention of thrombosis, embolism.

The drug is gentle on the body, so it is suitable for patients with a susceptible stomach. The following can be noted as negative actions and contraindications:

• peptic ulcers of the gastrointestinal tract;
• hemophilia, increased bleeding, hypothrombinemia;
• limited to persons under 18 years of age and during lactation.

Use in the 1st-2nd trimester of pregnancy is acceptable, but combination with other medications (anticoagulants, glucocorticoids, diuretics) is prohibited. Adverse effects include dizziness, dyspeptic disorders, changes in the menstrual cycle, bronchospasm, and iron deficiency anemia. It is allowed with great caution in patients with liver and kidney failure. But all this can be avoided if the dosage is followed correctly.

Features of Cardiomagnyl

Cardiomagnyl is also an antiplatelet agent, but has the widest spectrum of action due to its chemical composition. The medicine is produced in the form of tablets (75 mg and 150 mg). The main substance is acetylsalicylic acid, which functions in combination with magnesium hydroxide, and it is the viscosity of the blood and the heart muscle that is affected. The mechanism of action is determined by preventing the connection of platelets. The price of the drug ranges from 140-300 rubles.

Magnesium protects the gastric mucosa, reducing the risk of adverse effects of acetylsalicylic acid on the condition of the organ.

Cardiomagnyl is prescribed in the following cases:

• prevention of various stages of heart attack;
• acute heart failure;

• angina pectoris;
• heart surgery;
• preventive measures for thrombosis and embolism.

Cardiomagnyl has a huge number of contraindications: increased bleeding, peptic ulcers, kidney and liver failure. You should not take the drug in the 1st and 3rd trimester of pregnancy, during lactation, or before the age of 18.

The medication is incompatible with anticoagulants, methotrexate, and dioxin. Also not used along with valproic acid, hypoglycemic substances. With an increased dosage of Cardiomagnyl, urticaria, vomiting, heartburn, worsening peptic ulcer disease, Quincke's edema, bronchospasm, a decrease in the number of leukocytes, platelets in the blood, dizziness, and anaphylactic shock may develop.

Characteristics of Trombital

Cardiomagnyl or Trombital is best used to prevent heart and vascular diseases when, according to the results of a diagnostic examination, pathologies are detected that increase the risk of blood clots.

Release form

Trombital is a medicine that is produced in the form of rich white tablets, coated with a protective coating with a dividing line in the center. The drug is packaged in dark glass bottles of 30 or 100 tablets. in everyone.

The main packaging of the drug is a cardboard box, inside of which there are detailed instructions for using this antiplatelet agent. Trombital contains 2 main components. This is acetylsalicylic acid with a concentration of 75 mg and magnesium hydroxide, the mass fraction of which is 0.15 mg.

Indications and contraindications for use

The antiplatelet drug Trombital is indicated for use by adult men and women who have the following diseases or pathological conditions of the tissues of the heart and vascular walls:

• unstable angina;
• the period of postoperative rehabilitation based on the results of coronary artery bypass surgery or angioplasty of the coronary vessels;
• previous myocardial infarction, as well as the presence of a significant risk of recurrent acute heart attack;
• impaired patency of blood vessels caused by thrombosis;
• risk of developing thromboembolism of the great vessels.

Trombital may be used as a prophylactic drug to prevent acute heart failure or thrombosis in patients at potential risk. These are people suffering from excess body weight, high blood sugar, arterial hypertension, and abusing alcohol and smoking.

Trombital tablets are strictly contraindicated for use by patients of all age groups under the following circumstances:

• intolerance by the body of the main or additional components of the antiplatelet agent;
• peptic ulcer with a risk of internal bleeding;
• bronchial asthma;
• functional failure of kidney and liver tissue;
• diathesis of hemorrhagic type;
• age under 18 years;
• previous hemorrhage in brain tissue;
• thrombocytopenia;
• state of pregnancy or lactation of a newborn child with breast milk;
• chronic heart failure.

Trombital is prescribed with extreme caution to patients who have concomitant diseases of the body such as gout and hyperuricemia. This warning is justified by the fact that acetylsalicylic acid can suppress the excretion of uric acid, which can lead to an exacerbation of these diseases.

In case of planned surgery, including dental treatment, Trombital should be discontinued. The pharmacological effect of the active components of the drug can cause prolonged bleeding, which continues for several days after discontinuation of the medication.

Elderly patients taking Trombital to prevent thrombosis or heart failure should be supervised by medical personnel.

Instructions

For the prevention and treatment of thrombosis, heart failure, myocardial infarction, prevention of postoperative complications following coronary artery bypass grafting, Trombital is prescribed to take 1-2 tablets once a day. For faster absorption of the medication in the gastrointestinal tract, it is recommended to chew it and then drink a sufficient amount of water without gases.

The drug is not used as symptomatic therapy, but is intended for long-term use over several weeks or even months. The duration of treatment is determined by a cardiologist or therapist. The duration of therapy depends on the type of pathology of the heart and blood vessels.

Side effects and overdose

Trombital tablets are well tolerated by most patients of all age groups, but the risk of developing the following side effects cannot be ruled out:

• nosebleeds;
• formation of subcutaneous hematomas;
• leukopenia;
• opening of gastrointestinal bleeding;
• increased blood pressure (especially in people suffering from hypertension);
• hemorrhage in brain tissue;
• aplastic anemia;
• pale skin;
• allergic reactions in the form of skin itching, urticaria, rash, swelling of epithelial tissues;
• bronchial spasm;
• renal failure;
• nausea and vomiting;
• diarrhea;
• colitis;
• complete or partial loss of appetite;
• increased activity of liver enzymes;
• heartburn;
• stomatitis.

If the above symptoms appear, you should stop further taking Trombital and also seek help from your doctor. The occurrence of internal bleeding requires urgent therapeutic manipulations.

It is better to take Trombital or Cardiomagnyl after prior consultation with your doctor.

Violation of the dosing rules for Trombital tablets can lead to an overdose, which is accompanied by the following symptoms:

• dizziness;
• extraneous sounds in the ears;
• metabolic acidosis;
• development of pulmonary edema;
• respiratory depression;
• visual impairment;
• nausea;
• diarrhea;
• vomit;
• respiratory alkalosis;
• attacks of severe headache;
• renal failure;
• encephalopathy;
• dysfunctions of the central nervous system;
• drowsiness;
• general loss of physical strength, weakness;
• internal bleeding;
• confusion;
• coma;
• severe intoxication leading to death.

Clinical studies of the drug have shown that an overdose of this medication occurs after a single dose of more than 500 mg of acetylsalicylic acid. Patients with the above symptoms should be placed in a hospital toxicology department to perform gastrointestinal lavage, alkalization of the body, and take sorbent preparations.

Analogs

There are the following medicines based on acetylsalicylic acid, which are analogues of Trombital:

• CardiASK-Magnesium;

• Trombital Forte;
• Fasostabil;
• Thrombomag.

The above drugs are indicated for use for the prevention and long-term treatment of thrombosis of the great vessels, all forms of heart failure, and faster postoperative recovery.

Trombital or Cardiomagnyl

In terms of composition, number of active components, indications and limitations, Trombital and Cardiomagnyl are analogues. Similarities of medicines:

• identical composition of medications;
• the content of the main substance is equal, which leads to the same negative manifestations;

• contraindications and purposes are similar; If one drug does not work, there is no point in replacing it with another.

Pharmacologically and for safety reasons, the drugs have equal characteristics. The only advantage of Trombital in relation to Cardiomagnyl is its reduced cost. The difference in price is insignificant, both drugs are manufactured in Russia, Trombital sells from 157 rubles, Cardiomagnyl - from 209 rubles.

Medicines are recommended as a preventive measure, without leading the cardiovascular system to a pathological state. Medicines are used both for independent treatment and along with other means. Trombital is often prescribed to people with vascular disorders, and Cardiomagnyl is effective in preventing thrombosis, heart attack, and stroke. The benefits of taking both drugs are high.

Comparison table of advantages and disadvantages

It is best to take Trombital or Cardiomagnyl after prior consultation with a physician or cardiologist. The table below shows the main advantages and disadvantages of these drugs.

Trombital or Cardiomagnyl

Before purchasing Cardiomagnyl or Trombital, you must study in detail the instructions for use of these medications, consult with your doctor, and only then purchase one of these medications.

Cardiomagnyl or Thrombo Ass

Reviews from doctors about Thromboassa and Cardiomagnyl are positive. Doctors prescribe both drugs, indicating their mild effect compared to simple Aspirin. Some believe that the difference is only in the cost of drugs.

What are they suitable for:

1. Cardiomagnyl
   - an effective remedy that copes with cardiovascular pathologies with a convenient dose. Magnesium hydroxide contained in the drug neutralizes gastric juice, which is secreted in excess in patients with gastrointestinal disorders. Both medications are effective in eliminating thrombosis.
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2. Thrombo Ass
   is an excellent prevention of ischemia and heart attack. However, both drugs have a beneficial effect in the treatment of thrombophlebitis and venous embolism. The frequency of side effects in relation to acetylsalicylic acid in pure form is significantly lower with drugs.

Thrombo Ass has a soluble coating that instantly dissolves in the intestines, which allows you to reliably protect the digestive tract. The composition of Cardiomagnyl includes acetylsalicylic acid and magnesium hydroxide. This element reduces acidity and has a beneficial effect on the stomach. Prevents the formation of pain, vomiting, nausea, burning sensation in the sternum.

The safety of both medications lies in the reliability of the protective shell of Trombo Ass and in the effective functioning of magnesium hydroxide in the second product. If the film of the first is not broken, then the medicine is safe for the gastrointestinal tract. Cardiomagnyl does not cause problems, since the second substance neutralizes acetylsalicylic acid.

Patient reviews

Marina, 29 years old, Stary Oskol

I took Cardiomagnyl. A good drug, inexpensive, effective. I did not complete the course of treatment because my condition improved significantly. I can’t say anything about any side effects, because in my case there were no complications.

Olga, 33 years old, Yaroslavl

I took Trombital Forte (with the maximum dosage of active substances). There were side effects: sleep disturbance, headache, dizziness, nausea. I switched to Trombital with a minimum dose of the main components. She underwent the course of treatment without complications.

Effective drug analogues

The following drugs are analogues of Cardiomagnyl, Thrombo Ass, Trombital. Many of them have different active components, but the properties and purposes are identical. Of course, the price category of the drugs also differs.

Table with effective medications:

After a thorough analysis of blood thinning drugs with different active substances, it is clear that in this field there is an extensive list of medications that are indicated for patients with different disorders.

Acecardol is an antiplatelet agent

One tablet of Acecardol contains 50/100 mg of the main element - acetylsalicylic acid. Excipients: magnesium stearate, talc, povidone, starch. High doses of the drug exhibit an antipyretic and analgesic effect. The component is completely absorbed into the digestive canal and is only partially metabolized during absorption. The price of Acecardol is cheap and amounts to 25 rubles. for 50 mg.

What is Acecardol used for:

• unstable angina;
• prevention of recurrent myocardial infarction;
• prevention of deep vein thrombosis;
• warning of pulmonary embolism;
• disorder of the blood supply to the brain to prevent ischemic stroke;
• after invasive procedures and vascular operations to prevent thromboembolism (stenting, bypass surgery).

The tablets are contraindicated for people with erosive and ulcerative pathologies of the gastrointestinal tract, hemorrhagic diathesis, hemorrhages from the duodenum, and stomach. Bronchial asthma, provoked by the use of salicylates, becomes a limitation. It is also prohibited in case of heart failure, liver failure, or during lactation. Compatibility with methotrexate at a dose of more than 15 mg per 7 days is not acceptable. The use of Acecardol is not allowed for patients with gout, nasal polyposis, or drug allergies. Acetylsalicylic acid is often the cause of bleeding during operations.

Fasostabil - analogue of Cardiomagnyl, Trombital

The main substance of Fazostabil is acetylsalicylic acid, magnesium hydroxide. In essence, the mechanism of action of ASA is the irreversible inhibition of cyclooxygenase, as a result of which thromboxane synthesis is suppressed and platelet aggregation is inhibited. The second component in the composition exhibits an antacid effect and protects the mucous membrane of the digestive tract from the negative effects of ASA.

What does Fazostabil help with:

• prevention of secondary myocardial infarction, thrombosis of blood arteries;
• unstable angina;
• prevention of thromboembolism after capillary operations;
• primary prevention of heart pathologies.

How much to take, what is the dosage:

• In order to prevent a recurrent heart attack, only 1 tablet is required. per day in the amount of 75-150 mg;
• angina pectoris - 1 tablet. in the morning or evening;
• prevention of thromboembolism also involves 1 tablet. per day.

When Fazostabil is used simultaneously with valproic acid, narcotic analgesics, and metatrexate, their interaction increases, which increases the likelihood of toxicity. Adverse reactions are possible when used together with thrombolytic and hypoglycemic drugs, heparin and other antiplatelet medications. Alcohol should not be taken along with Fazostabil; it reduces the effect of the medication and can lead to complications. The price of the drug in Russian pharmacies is from 165 rubles. per package.

Characteristics of Cardiomagnyl

Trombital or Cardiomagnyl is best taken in combination with other cardiac medications, the pharmacology of which is aimed at strengthening the heart muscle and the walls of blood vessels.

Release form

Cardiomagnyl is an effective drug that is produced in the form of oval tablets of rich white color, closed with a protective coating with a dividing line in the center. The medication is packaged in vials made of dark brown glass. The main packaging of the drug is a cardboard box, complete with detailed instructions for its use.

The active component of the antiplatelet agent is acetylsalicylic acid at a concentration of 150 mg, as well as magnesium hydroxide, the mass fraction of which is 30.39 mg. Additional substances of Cardiomagnyl are corn and potato starch, microcrystalline cellulose, magnesium stearate, purified talc, hypromellose.

Indications and contraindications for use

Cardiomagnyl tablets are indicated for use in patients who have reached the age of 18 years.

The drug is used in the following cases:

• primary prevention of pathologies of the heart and blood vessel walls;
• therapy of heart failure and thrombosis;
• the need to reduce the risk of developing heart and vascular diseases in elderly patients, patients with obesity, diabetes mellitus, those suffering from alcohol addiction, and hypertension;
• prevention of recurrence of thrombosis of the great vessels, as well as the occurrence of myocardial infarction;
• rehabilitation period after coronary artery bypass surgery and coronary angioplasty;
• angina pectoris.

The drug is actively used to prevent thromboembolism in patients who have undergone surgery on blood vessels. Cardiomagnyl is used only as a long-term therapy medication.

At the same time, the drug is strictly contraindicated for use in the following cases:

• the body does not perceive acetylsalicylic acid, as well as other components that form the composition of Cardiomagnyl (such a reaction of the body is expressed by the manifestation of allergies);
• bronchial asthma, exacerbation of which occurs after taking salicylates;
• polyposis of the nasal canals and paranasal sinuses;

• tendency to internal bleeding;
• functional renal failure;
• hemorrhage in brain tissue;
• state of pregnancy or breastfeeding;
• the presence of ulcerative formations in the gastrointestinal tract;
• hemorrhagic diathesis;
• chronic vitamin K deficiency;
• children under 18 years of age.

Cardiomagnyl is prescribed with extreme caution to patients who have concomitant diseases of the body such as hay fever, chronic bronchitis, gout, hyperuricemia. The drug should not be taken before surgery, as this can lead to extensive blood loss.

Instructions

Regardless of the type of cardiovascular pathology, the drug Cardiomagnyl is taken 1 tablet 1 time per day, 2 hours after eating. This dosage is intended for long-term therapy, the timing of which is determined individually by the attending physician.

With a single dose, the pharmacological properties of the drug are not fully manifested, since to achieve the antithrombotic effect, a regular supply of acetylsalicylic acid is necessary.

Side effects and overdose

Most patients with diseases of the cardiovascular system tolerate the constituent components of Cardiomagnyl well.

Despite this, the following side effects cannot be ruled out:

• headache;
• hemorrhage in brain tissue;

  
  Hemorrhagic stroke

• leukopenia;
• agranulocytosis;
• thrombocytopenia;
• attacks of spasmodic pain in the abdominal cavity;
• bronchial spasm;
• ulcerative formations on the mucous membrane of the stomach and duodenum;
• hemolytic anemia;
• poor blood clotting;
• dizziness;
• insomnia at night and drowsiness during the day;
• heartburn;
• feeling of nausea and vomiting;
• perforation of an existing gastric ulcer;
• stomatitis;
• aplastic anemia;
• irritation of the intestinal mucosa;
• hives;
• swelling of the mucous membrane of the nasal canals and oral cavity;
• itching of the skin surface;
• colitis;
• violation of the filtration functions of the kidneys;
• increased activity of liver enzymes;
• internal bleeding.

The last side effect is considered the most severe and dangerous for humans, as it can lead to heavy blood loss and death. If the above symptoms occur, you should stop further therapy with Cardiomagnyl, and also consult your doctor for additional advice.

If the established rules for dosing Cardiomagnyl tablets are violated, the following signs of overdose with this drug may occur:

• headache;
• sensation of tinnitus;
• metabolic acidosis;
• swelling of the mucous membrane and tissues of the lower respiratory tract;
• respiratory depression;
• decreased visual acuity;
• vomit;
• diarrhea;
• nausea;
• respiratory alkalosis;
• migraine;
• acute renal failure;
• encephalopathy;
• dysfunction of the cerebral cortex;
• spasms of the lower extremities;
• drowsiness;
• malaise and physical weakness;
• internal bleeding;
• loss of consciousness;
• coma state;
• intoxication of the body with a risk of death.

An overdose of Cardiomagnyl is a dangerous pathological condition of the human body that requires emergency treatment measures. Patients with the above symptoms are hospitalized in the toxicology department.

The main direction of treatment is lavage of the gastrointestinal tract, removal of acetylsalicylic acid using sorbent preparations, as well as its neutralization with an alkaline solution.

Analogs

The following medications are analogues of Cardiomagnyl tablets and also contain the active substance in the form of acetylsalicylic acid:

• Thrombomag Forte;
• CardiASK-Magnesium;
• Fasostabil;
• Trombital;
• Thrombomag.

The prescription of the above medications should only be carried out by the attending physician or cardiologist after conducting a preliminary diagnosis of the cardiovascular system, as well as determining the functional state of the internal organs.

Which remedy is better according to cardiologists?

According to doctors, these 3 drugs have exclusively positive reviews. They indicate a mild effect compared to ordinary Aspirin. Most of them claim that the difference is only in the price category.

I believe that Cardiomagnyl is an effective drug against cardiovascular pathologies with a very convenient dosage.
I often prescribe it to patients prone to indigestion. Magnesium hydroxide actively neutralizes digestive juice, which is released in excess due to gastrointestinal disorders. In the treatment of thrombosis, this drug is as effective as Trombo Ass and Trombital; one can clearly say that all 3 drugs are identical. However, Thrombo Ass, according to some patients taking it, claims that it is better tolerated, even if taken for a long time. O. N. Maltseva
cardiologist

I often prescribe Cardiomagnyl to my patients, because this effective and inexpensive remedy begins to act quickly and has a long-lasting result.
It relieves unpleasant symptoms, inflammation and swelling of blood vessels and tissues. Well tolerated by elderly people and patients with diabetes. I. A. Gubarev cardiologist