Ultrasound of the salivary glands: what are the capabilities of this diagnostic method?

AUTHORS: Daniel London, Oded Nahlieli

Keywords:

sonography (ultrasound), salivary glands, parotid gland, submandibular gland, sublingual gland, stones, tumor, inflammation

Key points

• The salivary glands are superficial and can therefore be examined in detail using ultrasonography.
• It is important to scan each gland sequentially according to the protocol.
• The salivary glands can be affected by inflammatory, benign and malignant pathology, which can be detected sonographically.
• The salivary glands may have congenital anatomical abnormalities and may contain calculi, which are also detected sonographically.
• The purpose of the article is to gain in-depth knowledge about the structure of healthy glands, available sonography techniques, pathological changes and differential diagnosis of diseases.

Physical basis and equipment

Ultrasound is a high-frequency acoustic wave that uses a frequency outside the normal hearing range (20 Hz-20 kHz). Most head and neck and maxillofacial equipment are tuned to 8 MHz (8 million cycles per second) or higher. This is in contrast to ultrasound diagnostic devices used in general surgery or obstetrics, which typically operate at a frequency of 5-6 MHz, which provides greater tissue penetration but reduces image resolution. Sensors generating frequencies up to 20 MHz and, in the case of ultrasound biometry, up to 50 MHz, are now also used for imaging the salivary glands. This allows very small structures to be distinguished.

The three major salivary glands (parotid gland, submandibular gland and sublingual gland) are paired and are easily accessible due to their superficial location for sonographic diagnosis using high-frequency linear transducers (8-18 MHz).

Nowadays, the use of high-performance ultrasound devices generates a sonographic image like an anatomy book, even using smartphone ultrasound. The resolution and penetration depth of ultrasound depend on the specified frequency. The higher the frequency, the better the resolution, but the penetration is worse. For visualization of the salivary glands, linear probes with a frequency of 7.5 MHz (5.0-13.5 MHz) are most effective. Box 1 shows the scanning sequence.

Under normal conditions, the three major salivary glands have a similar homogeneous intermediate echogenicity with sharp boundaries. Small salivary glands become accessible for sonographic diagnosis only in the presence of pathological changes (for example, enlargement due to a tumor or neoplastic process). Indications for sonographic examination include swelling or increased volume in the area of ​​the salivary glands and pain. Ultrasound examination (Box 2) allows the doctor to clarify the localization, namely: whether the formation is located in the gland, or is simply adjacent to the contour of the salivary gland. This differential diagnosis often cannot be made solely on the basis of clinical examination.

HOW TO SCAN (PROTOCOLS)

Parotid gland

The parotid gland can be easily examined with the patient's head turned to the side and in a hyperextension position. A summary of the scanning procedure is provided in Box 3.

First, the gland is scanned in cross section, starting from the angle of the jaw to a point slightly above the tragus. Then the longitudinal projection is scanned. The ultrasound probe must be adequately applied to the surface of the skin, using a sufficient amount of gel, especially in the area of ​​the angle of the jaw.

Submandibular gland

If the patient's head is moderately extended, the submandibular gland can be examined ultrasonographically without any problems. First of all, along the midline of the neck, the ultrasound sensor moves in the transverse direction from the hyoid bone to the horizontal branch of the mandible. Sometimes both submandibular glands may be visible at the same time. Then, by moving the transducer sideways, parallel to the horizontal ramus of the mandible, a clear image of the corresponding submandibular gland can be obtained. Here it is necessary to ensure good contact of the gel with the sensor on the skin.

Sublingual gland

The sublingual gland examination does not have significant differences in procedure compared to the submandibular gland examination. The transducer is placed on the skin in a transverse plane in the midline just below the mandible, allowing visualization of both sublingual glands. It is important to note that all averaged structures must be within 0.2 mm of each other, and any outliers are carefully assessed and discarded and, if necessary, reanalyzed.

Symptoms of inflammation of the salivary glands

Regardless of which gland the inflammation occurs in, sialadenitis has the following symptoms:

• dry mouth associated with a decrease in the amount of saliva produced;
• shooting pain in the area of ​​the affected gland, radiating to the ear, neck and mouth;
• pain when chewing and swallowing food, as well as when opening the mouth;
• swelling and redness of the skin in the projection of the inflamed salivary gland;
• unpleasant taste in the mouth, possible appearance of pus;
• in the area of ​​inflammation you can feel a dense, painful formation;
• a feeling of fullness, pressure in the area of ​​the affected gland may indicate the accumulation of pus in it; increase in body temperature to 39 C, weakness.

A particularly dangerous form of sialadenitis is mumps, often called mumps. The disease is dangerous because the virus that causes it can affect other glands of the body (mammary, reproductive, pancreas). In addition, mumps is a contagious disease, so if signs of inflammation of the salivary glands appear, the patient should limit contact with healthy people and consult a doctor to clarify the diagnosis.

If left untreated, purulent complications of the disease may develop. When an abscess of the salivary gland occurs, the patient’s body temperature rises sharply, and the general condition worsens. It is possible that the abscess may break through either into the oral cavity, or a fistula may form on the surface of the skin.

ANATOMY

Update your anatomy knowledge

The parotid glands consist of a prismatic body and two elongated parts: the anterior part is located on the deep part of the masseter muscle, and the deeper elongated parts, which reach the lateral wall of the pharynx, pass between the prestyloid muscles and the stylomandibular ligament.

The submandibular glands are located in the submandibular space under the floor of the mouth and have a mesial extension called the “hook.” The excretory Wharton's duct arises from this expansion, which is located at the base of the frenulum of the tongue and opens into the sublingual papilla.

The sublingual glands are a group of glands located in the sublingual space, which are limited by the recess of the tongue, the floor of the mouth and the geniohyoid muscle.

NORMAL ULTRASONIC ANATOMY

Parotid glands

The parotid glands, which are the largest of the salivary glands, are enclosed in a separate fascia, which penetrates the glands, forming various lobules. In cross-section, the parotid gland is a sharply defined, homogeneous organ with intermediate echogenicity (Fig. 1).

Rice. 1. Normal parotid gland.

The gland can be clearly distinguished from subcutaneous adipose tissue. The anterior part of the gland sits on the masticatory muscle and can be differentiated from the buccal adipose tissue, which has lower echogenicity, by contraction and relaxation of the masticatory muscles. The posterior part of the gland is located in the retromandibular fossa and is clearly delimited anteriorly by the ascending ramus of the mandible, and posteriorly by the sternocleidomastoid muscle and the mastoid process. Mediocaudal to the inferior pole of the parotid gland, the posterior belly of the digastric muscle and the internal carotid artery can be distinguished. It is important to remember that a small portion of the parotid gland may be hidden by the acoustic shadow of the mandible.

In and around the gland, the internal jugular vein and the retromandibular vein can be found, which are located in the glandular parenchyma and can be visualized, especially in the longitudinal projection. In transverse views, distal to the retromandibular vein, the styloid process is projected onto the glandular parenchyma, which should not be confused with sialolithiasis. The facial nerve is usually not visible. However, with the use of modern high-resolution transducers, it is sometimes possible to obtain a sonographic image of the main outflow canal.

Submandibular gland

The submandibular gland extends cranial to the mandible and the geniohyoid muscle and has a close connection with the anterior belly of the digastric muscle. The submandibular gland forms an arch around the posterior border of the geniohyoid muscle and often reaches ventromedial to the submandibular gland. Echogenic structures with an element of acoustic shadowing are often projected in the area of ​​the gate of the submandibular gland. In this area, it is necessary to carry out differential diagnosis between the elements of the hyoid bone and the sialoliths of the submandibular gland, which may have comparable characteristics on imaging [2,7]. Sonographic imaging characteristics of the submandibular gland include an intermediate echogenic structure with a regular echo pattern corresponding to the echo pattern of the parotid gland parenchyma (Fig. 2).

Rice. 2. Normal submandibular gland.

In and around the gland, the facial artery and facial vein, which pass through the gland, are easily distinguished sonographically. The path of the efferent duct can sometimes be visualized using high-resolution ultrasound probes, even in the absence of duct obstruction. If we are talking about differentiation of the elements of the hyoid bone, then during swallowing movements its displacements are observed.

Sublingual gland

Visualization of the sublingual gland can sometimes be problematic. The sublingual gland is located under the mucous membrane in the oral cavity, lower in the projection of the tip of the tongue, next to the frenulum of the tongue. The dorsal part of the glands often touches the surface of the submandibular gland.

The gland is bounded ventrally and medially by the geniohyoid and genioglossus muscles, and caudally by the mandible. Short excretory ducts usually cannot be visualized. Accumulation of saliva may be found in and around the sublingual gland, which forms the ranula (Figure 3).

Rice. 3. Sublingual ranula.

PATHOLOGICAL RESULTS

Box 4 contains a short list of variants of salivary gland pathology.

Acute sialadenitis

Since we have to deal with paired organs, it is important to compare both glands in one picture. Characteristic findings are explained by inflammatory edema and an increase in fluid content in the parenchyma, which is transformed during inflammation. Typically we see the following:

• Diffuse expansion of the entire affected gland.
• The organ can be clearly demarcated from adjacent structures.
• The structure of the parenchyma appears loose, heterogeneous, coarsely textured and more hypoechoic.
• Limited hypoechoic formations can be detected as a concomitant inflammatory reaction of the intraglandular lymph nodes.
• Zones of liquefaction (as signs of abscess formation) are visualized as hypoechoic with a hyperechoic surrounding wall and pronounced distal signal enhancement.
• Coarsely structured hyperechoic echoes at the center of such liquefaction lesions may correspond to areas of necrotic tissue.

Chronic sialadenitis

Sonographic imaging is highly dependent on the duration and degree of inflammation of the glandular parenchyma. As in the case of acute sialadenitis, a conclusive differential diagnosis between the various pathogenic forms of chronic sialadenitis cannot be made using sonography alone. Typically we see the following:

• A clear increase in the unevenness of the echo texture.
• The internal structure has a heterogeneous pattern, most likely due to fibrotic changes in the parenchyma.
• Small cystic echo lesions are formed, which correspond to limited ductal ectasia (Fig. 4).
• Sometimes stones within the gland are identified as echogenic structures with a distal acoustic shadow.

Rice. 4. (A) Chronic sialadenitis of the parotid gland. (B) Sialocele of the parotid gland. (C) Dilatation of Stenson's duct (arrows).

Differential diagnosis is important in the following situations:

1. Patients suffering from Gougerot-Sjögren syndrome have sonographic signs of enlarged, heterogeneously structured, hypoechoic salivary glands. Numerous limited hypoechoic formations are found inside the parenchyma, which may be associated with cystic dilatation of the ducts, on the one hand, or with enlargement of intraglandular lymph nodes, on the other hand. Sonographically, the structure of the salivary glands looks like a “cloud”.
2. Sialadenitis of epithelioid cells (Heerford syndrome) is sonographically characterized by a rich echo pattern interrupted by numerous enlarged lymph nodes that appear as hypoechoic masses.
3. Kütner's tumor of the submandibular gland is visualized as a formation with an indistinct echo signal in a certain part of the submandibular gland, which is easily mistaken for an adenoma.
4. Ultrasound helps detect changes after radiation therapy. The echohomogeneous pattern disappears after irradiation, with a more hypoechoic and sometimes irregular pattern being a sign of loss of function.
5. Other secondary pathological changes (edema, infections and soft tissue tumors) around the salivary glands are easily distinguished from primary salivary gland pathology.

Parotid abscess

The evolution of the inflammatory process is characterized by a hypo-, anechoic lesion with irregular edges. Typically we see the following:

• Hypo-, anechoic lesion with irregular edges.
• Peripheral hypervascularization, which is determined by color Doppler scanning.
• In the case of partial necrotic changes, lymph nodes with anechoic areas of necrosis are identified.
• In the case of fistula formation, a fistula is defined that reaches the skin surrounded by edematous tissue.

An important initial sign of an abscess is the appearance of vessels with a linear and fairly regular direction, which subsequently changes to a more irregular one, and is characterized by numerous anastomoses, which can be determined by an increase in the intensity of the color Doppler signal. In abscesses, the color Doppler signal has a peripheral structure because in this case the vessels are intertwined along the periphery of the abscess.

Enlarged lymph nodes

Lymph nodes may be found inside the parotid gland. However, only around the submandibular gland, due to the characteristics of embryological development. In the parotid gland, a group of small lymph nodes (3-5 mm) is located along the retromandibular vein. These lymph nodes carry out lymph drainage from the Eustachian tube, external auditory canal and deep areas of the face. Intraglandular and extraglandular lymph nodes normally do not exceed 9 mm in diameter.

Ultrasound imaging of otherwise unremarkable glandular parenchyma may reveal predominantly multiple hypoechoic lesions that often lack any distal signal enhancement. Sonographically, as a rule, it is impossible to obtain reliable signs that would allow a definitive differential diagnosis between benign and malignant enlarged lymph nodes.

Reliable differential diagnosis between reactive lymphadenitis (Fig. 5), non-Hodgkin's lymphoma (Fig. 6), MALT lymphoma, or intraglandular metastatic spread is not possible on the basis of sonographic findings alone.

Rice. 5. Pathological lymph node.

Rice. 6. Primary lymphoma of the parotid gland.

Clinical signs, number, location, and sometimes texture of nodes can lead to diagnosis, but do not replace histological analysis. As with enlarged lymph nodes of the neck, some authors mention the so-called “hilus” (gate) as a sign of reactive lymphadenitis.

Cystic tumors

Congenital or acquired salivary gland cysts are usually filled with clear fluid. We usually see an echo-negative tumor with clear borders and distal signal enhancement (Fig. 7).

Rice. 7. Salivary gland cyst (arrows indicate parotid gland, arrowheads indicate cyst).

It is important to note that if cystic tumors are detected sonographically in both parotid glands, and if there is a relevant medical history, then lymphoepithelial cysts caused by HIV infection should be suspected.

Sialolithiasis

Although the sign of a distal acoustic shadow is usually detected, the signal reflection can sometimes be unclear or insufficient. This phenomenon is the result of a reflected ultrasonic component that does not reach the transducer but is scattered out of the image plane. Typically, we see an echo-opaque object with a clear sign of a distal acoustic shadow (Fig. 8) and dilatation of the excretory ducts.

Fig.8. Intraglandular sialolithiasis of the submandibular gland.

Parotid duct stones contain organic components and are visualized with great effort. Sometimes only a distinct echo-opaque object without a distal acoustic shadow may be detected. However, in many of these cases, dilatation of the efferent ducts of the salivary glands can be considered as another indirect sign of the development of sialolithiasis, if the stone cannot be clearly identified. However, dilation of the duct can also be caused by scar changes in the connective tissue (for example, the situation after an inadequately performed incision of the duct or after acute inflammation). Stones with a diameter of 1.5 to 2 mm or more, located in the area of ​​the large salivary glands, can be reliably detected during sonography.

It is important to note that the precise determination of the position of sialoliths (intraglandular, extraglandular and intraductal) is of great importance. Differential diagnosis is important both in the presence of air inside the ducts and in the case of pneumoparotitis, foreign bodies, angiolithiasis and calcified lymph nodes or arteriovenous malformations (Fig. 9).

Rice. 9. Arteriovenous malformation of the salivary glands.

Remember, because of its limited sensitivity and limited negative predictive value, sonography does not reliably exclude small salivary gland calculi. Further diagnostic studies are needed to identify stones in patients with normal sonographic findings and suspected lithiasis.

Sialadenosis (sialosis)

All large salivary glands can be simultaneously affected by sialoadenosis. Sialadenosis is a non-inflammatory condition characterized by bilateral enlargement of the salivary glands, most commonly the parotid glands. Usually we see that the glands look indistinctly enlarged, are difficult to differentiate from surrounding structures, their echo structure looks homogeneously hyperechoic, and with sialoadenosis tumor-like lesions are not detected. In some cases, the parotid gland is so enlarged that ultrasound requires a low-frequency transducer to evaluate the deep part.

Benign epithelial tumors of the salivary glands

A well-defined boundary between the surrounding salivary gland tissue and the tumor itself is a characteristic feature of a benign salivary gland tumor. Because ultrasound is unable to visualize nerves, the relationship of parotid tumors to the facial nerve cannot be reliably determined.

Pleomorphic adenomas have a homogeneous/hypoechoic texture. However, sometimes heterogeneous structures with hard and cystic inclusions may be noticeable. In these cases, a characteristic feature is distal signal enhancement (Fig. 10).

Rice. 10. Pleomorphic adenoma of the parotid gland.

Monomorphic adenomas (adenolymphomas) may also appear sonographically homogeneous and hypoechoic, as is the case with pleomorphic adenomas. If the proportion of cystic structures is high, adenolymphoma may also present completely without echo with extensive distal enhancement. Occasionally, septae may be identified within the tumor.

The remaining less common types of benign salivary gland tumors (eg, basal cell adenomas, oncocytomas, lymphoepithelial lesions) also have similar nonspecific sonomorphological features.

Definitive sonographic identification and differential diagnosis between different types of benign salivary gland tumors is currently impossible, although significant cystic portions in the mass tend to indicate adenolymphoma, and the absence of cystic areas indicates pleomorphic adenoma. To a certain extent, parotid tumors can be classified as either the "superficial" or "deep" part of the gland.

Benign nonepithelial tumors of the salivary glands

Lymphangiomas and hemangiomas (Fig. 11 and 12) have similar sonomorphological characteristics, which makes differential diagnosis between them impossible.

Rice. 11. Intraglandular lymphangioma.

Rice. 12. Submandibular hemangioma.

During the study, loosely connected alveolar structural components, consisting partly of hypoechoic and hypergeogenic areas, can be detected. Sonographic examination allows us to assess the depth of penetration and spread of this tumor into the corresponding salivary gland and into the area of ​​surrounding soft tissue.

Intraglandular and extraglandular lipomas (Fig. 13) appear as sharply demarcated, ovoid formations, with a hypoechoic and homogeneous signal reflection pattern.

Rice. 13. Well-defined lipoma.

Lipoma has a more characteristic hypoechoic reflection pattern than the rest of the salivary gland parenchyma, but its echo texture is more hyperechoic than other types of intraglandular tumors, and it also has a linear hyperechoic feathery texture.

Malignant tumors of the salivary glands

We typically see a fuzzy edge and a patchy echo texture. It is possible to describe the relationship between invasive tumor growth and surrounding tissue. It is impossible to detect involvement of the facial nerve in the malignant process. The most common malignant tumors of the salivary glands are mucoepidermoid carcinoma, adenoid cystic carcinoma, carcinoma arising in pleomorphic adenoma, and distant metastases (Fig. 14).

Rice. 14. Metastatic melanoma in the parotid gland (arrows indicate parotid glands, arrowheads indicate metastases).

Indications for sonographic examination are sometimes absent, since at the preoperative stage it is impossible to identify with complete certainty the benign or malignant nature of tumor development. If a malignant process is suspected, ultrasound-guided fine-needle aspiration biopsy can be a useful tool to more accurately classify the tumor at a preoperative stage.

It is important to note that if tumor margins cannot be accurately imaged by sonographic examination, especially when the tumor extends to osseous or deep structures, the patient's diagnostic imaging should be extended in any case to computed tomography and/or magnetic resonance imaging.

Gougerot-Sjögren syndrome

Gougerot-Sjögren syndrome occurs when lymphocytes invade and destroy the exocrine gland. It is the second most common autoimmune syndrome after rheumatoid arthritis, affecting the salivary glands in 40-80% of cases. This results in a higher incidence of parotid lymphomas and salivary stone disease. Typically we see the following:

• At an early stage, sonography is normal.
• Later, the glands become enlarged and large-scale structural damage occurs.
• The gland is heterogeneous.
• At a later stage, sonographic examination reveals sialoectasia and marked hypervascularization on color Doppler ultrasonography of the salivary glands.

Rice. 15. Minimally invasive procedures under ultrasound guidance.

Rice. 16. Therapeutic intraglandular injection of Botox.

Color Doppler ultrasonography of the salivary glands

The standard B-scan is a well-established tool for diagnosing salivary gland diseases. For tumors located in the salivary glands, there is increasing interest in non-invasive collection of clinical information such as growth and invasiveness, as well as making an accurate diagnosis before surgery. Before the benefits of sophisticated ultrasonography became available, standard testing was performed by correlating simple sonomorphological criteria, such as anechoic areas, with specific histological features. This can be easily achieved even if you buy a portable ultrasound machine .

Over the past few years, color Doppler sonography has become well established as an integral part of head and neck, ENT and maxillofacial surgery, especially as part of the preoperative evaluation of tumors and cervical lymph nodes.

Color duplex sonography

Color duplex sonography (Box 5) is a combination of B-mode sonography, pulsed Doppler sonography, and color coding of perfusion areas. The basic principle of color duplex sonography is the frequency shift of the transmitted signal, which is caused by reflection from moving red blood cells. The speed and direction in which red blood cells approach and move away from the transducer provide the information needed to perform duplex sonography.

The ability to use Doppler signal amplifiers to achieve improved visualization of tumor vascularization has provided new opportunities for tumor characterization. Analysis of microvascularization and time-dependent changes after Doppler amplifier insertion, as well as elastography, are promising new tools for identifying features that help determine whether specific changes are typical for certain types of salivary gland tumors (Fig. 17).

Rice. 17. Study of the salivary glands using power Dopplerography.

Theory and practical experience in ultrasound diagnosis of salivary gland pathology

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In domestic and foreign literature there are many works devoted to sialogy (from the Greek Sialon - saliva and logos - study) - the science of diseases and injuries of the salivary glands, methods of their diagnosis and treatment. According to various authors, diseases of the salivary glands account for up to 24% of all dental pathologies. Currently, in clinical practice, the most common are dystrophic, inflammatory diseases of the salivary glands (sialoadenoses, sialadenitis), as well as tumors and congenital malformations of the salivary glands. In addition, pathological changes in the salivary glands often accompany other diseases (diabetes mellitus, bronchiectasis, sarcoidosis, liver cirrhosis, hypertriglyceridemia, lymphogranulomatosis, etc.).

Various instrumental methods are used to diagnose diseases of the salivary glands [1]:

• radiography (if the formation of stones in the ducts of the salivary glands is suspected, but in 20% of the stones of the submandibular salivary glands and 80% of the parotid salivary glands are non-radiographically opaque);
• sialography (examination of the ducts of the salivary glands with a radiopaque substance, is rarely useful in differentiating tumors from inflammatory processes, but it can help differentiate the mass formation of the salivary glands from formations in neighboring tissues. In patients with suspected autoimmune disease of the salivary glands, a characteristic pattern of saccular expansion may be detected ductal system. In case of acute infection of the salivary glands, sialography should not be performed [2]);
• computed tomography together with sialography;
• ultrasound method (is the most accessible, safe and informative in the process of differential diagnosis of the pathological condition of the salivary glands).

Anatomy of the salivary glands [3]

There are three pairs of major salivary glands (SG) and many small ones. The large ones include paired parotid, submandibular and sublingual SGs. The parotid salivary gland (PSG) is located on the outer surface of the branch of the lower jaw at the anterior edge of the sternocleidomastoid muscle, as well as in the retromandibular fossa. Dimensions vary widely: length 48-86 mm, width 42-74 mm, thickness 22-45 mm. The OSJ is covered by the parotid fascia, which is its capsule and is tightly fused with it. Sometimes, at the anterior edge of the parotid duct, there is an additional lobule measuring 10-20 mm, which has its own duct flowing into the parotid. The parotid duct emerges from the gland at the border of its upper and middle thirds, then it passes along the outer surface of the masticatory muscle parallel to the zygomatic arch and turns 90° inward, penetrating the fatty tissue and buccal muscle. The projection of the parotid duct onto the skin of the cheek is determined on the line connecting the tragus of the auricle and the corner of the mouth. The parotid duct opens in the vestibule of the oral cavity at the level of 1-2 large molars. The diameter of the duct is on average 1.5-3.0 mm, its length is 15-40 mm. The thickness of the gland contains the branches of the external carotid artery, the facial nerve and its branches, and the auriculotemporal nerve. There are many lymph nodes around the OUSG and in its parenchyma (Fig. 1), which can serve as a primary or secondary collector for draining lymph from teeth and oral tissues.

Rice. 1.

Lymph nodes in the thickness of the parotid salivary gland.

The submandibular salivary gland (MSG) is located in the submandibular triangle between the body of the mandible and the anterior and posterior bellies of the digastric muscle. The dimensions of the gland are: anteroposterior 20-40 mm, lateral 8-23 mm, superior-inferior 13-37 mm. Posteriorly, the PNJ is separated from the OSJ by a process of the fascia propria of the neck. The medial surface of the gland in the anterior section lies on the mylohyoid muscle. The submandibular duct, bending over the posterior edge of this muscle, is located on the lateral surface of the hyoglossus muscle. Then it goes between the medial surface of the hyoid gland and the genioglossus muscle to the point of its exit in the area of ​​the hyoid papilla. The facial artery and its branches, the lingual artery and the veins of the same name pass through the gland.

The sublingual salivary gland (SSG) is located on the floor of the mouth in the sublingual region parallel to the body of the lower jaw. The dimensions of the gland are: longitudinal 15-30 mm, transverse 4-10 mm and vertical 8-12 mm. The duct of the parathyroid gland passes along its inner surface and opens in the region of the anterior section of the sublingual ridge independently or together with the submandibular duct. Sometimes the PJS duct flows into the middle section of the PJS duct.

The minor salivary glands - labial, buccal, lingual, palatine, incisive - are located in the corresponding areas of the mucous membrane. They can be a source of development of adenocarcinomas of the oral cavity.

Pathology of the salivary glands

SG malformations are rare. The most common are anomalies in the size of the glands (agenesis and aplasia, congenital hyperplasia (Fig. 2) and hypoplasia), their location (heterotopia, accessory glands), and anomalies of the excretory ducts (atresia, stenosis, ectasia, cystic transformation, ductal dystopia).

Rice. 2.

Hyperplasia of the left sublingual salivary gland.

Sialadenitis is a large group of polyetiological inflammatory diseases of the gastrointestinal tract (Fig. 3). Primary sialadenitis - sialadenitis considered as an independent disease (for example, mumps). Secondary sialadenitis is sialadenitis that is a complication or manifestation of other diseases (for example, sialadenitis with influenza). The echographic picture for different etiologies is not very specific. Etiology has clinical significance in determining treatment tactics.

Rice. 3.

Sialadenitis of the right submandibular salivary gland.

According to the etiological factor, sialadenitis is classified [4] into:

1. sialadenitis developing under the influence of physical factors (traumatic sialadenitis, radiation sialadenitis (Fig. 4) occurs during radiation therapy of malignant tumors of the head and neck);
2. sialadenitis developing under the influence of chemical factors (toxic sialadenitis);
3. infectious sialadenitis (routes of infection penetration into the fluid: stomatogenic (through ducts), contact, hematogenous and lymphogenous);
4. allergic and autoimmune sialadenitis (recurrent allergic, Sjogren's disease and syndrome, etc.);
5. myoepithelial sialadenitis caused by a pathological process, previously designated as a benign lymphoepithelial lesion. The term benign lymphoepithelial lesion was first used by JT Godwin in 1952, replacing the concept of Mikulicz disease;
6. obstructive sialadenitis, which develops when there is difficulty in the outflow of saliva due to obstruction of the excretory duct with a stone (Fig. 5-7) or thickened secretion, as well as due to cicatricial stenosis of the duct. According to the prevalence of the process, they distinguish between focal, diffuse sialadenitis and sialodochitis - inflammation of the excretory duct. The course of the process can be acute or chronic;
7. pneumosialadenitis, which develops when there is air in the gastric tissue in the absence of a bacterial gas-forming infection. Air enters the gland from the oral cavity when the pressure there increases through the duct. Pneumosialadenitis is typical for a number of professions, primarily for glassblowers and musicians playing wind instruments.

Rice. 4.

Post-radiation sialadenitis.

Rice. 5.

Stone of the duct of the submandibular salivary gland.

Rice. 6.

Stone in the parenchyma of the submandibular salivary gland.

Rice. 7.

Stone in the duct of the submandibular salivary gland.

Tumors of the salivary glands

Tumors of the salivary glands are divided into two groups: epithelial and non-epithelial. Epithelial tumors predominate in adults (95%). In children with SG, epithelial and non-epithelial tumors are equally common. In addition to true tumors, processes resembling tumors (tumor-like lesions) develop in the GS.

Among epithelial tumors of the gastrointestinal tract, benign neoplasms are distinguished, as well as malignant ones - carcinomas.

Benign epithelial neoplasms of the stomach include ductal papillomas, adenomas and benign sialoblastoma. SG adenomas are divided into two groups: polymorphic (the most common SG adenoma) and monomorphic (all other) adenomas. Tumors of different structure, origin and prognosis were artificially included in the group of monomorphic adenomas.

Pleomorphic (polymorphic) adenoma (mixed tumor of the gland) is a adenoma of the gland, built from two types of cells: ductal epithelium and myoepithelial cells. Macromorphological picture. The tumor is usually an elastic or firm nodule of lobulated grayish-white tissue, usually partially encapsulated. Typical of a pleomorphic adenoma is the so-called chondroid stroma, resembling hyaline cartilage. Variants of the echographic image of pleomorphic adenomas are presented in Figure 8.

Rice. 8.

Pleomorphic adenoma of the gastrointestinal tract.

Warthin's tumor is an adenolymphoma in which multiple cystic cavities are formed, covered with double-layered epithelium. The papillae protrude into the lumen of the cysts. A pronounced proliferation of lymphoid tissue occurs in the tumor stroma. This tumor almost exclusively develops in the parotid gland.

Other types of benign tumors are less common. These are benign oncocytoma (oxyphilic adenoma), basal cell adenoma, tubular adenoma, benign cystadenoma sialoblastoma.

Among benign primary non-epithelial tumors, the most common are hemangioma, lymphangioma, neurofibroma and lipoma.

Among malignant non-epithelial tumors, malignant lymphomas are more often found (they arise, as a rule, against the background of myoepithelial sialadenitis, Sjögren's disease and syndrome).

Tumor-like lesions of the salivary glands

Rice. 9.

Salivary gland cysts.

1. Salivary gland cysts (mucoceles). There are two types of mucocele of the gland: the retention type (retention cyst of the small gland, formed when saliva is retained in the excretory duct) and the type of interstitial secretion, when, when the wall of the duct is injured, saliva enters directly into the fibrous tissue surrounding the gland. Mucoceles in the floor of the mouth are also called ranulae.
2. Cysts of the excretory ducts of large SGs are pronounced dilatation of the excretory duct due to retention of secretions in it. Blockage of salivary outflow can be caused by various reasons: tumor, stone, thickened mucus, post-inflammatory stenosis, even cicatricial obliteration of the lumen.
3. Sialoadenosis (sialosis) is a non-tumor and non-inflammatory symmetrical increase in SF due to hyperplasia and hypertrophy of secretory cells. The outcome of sialosis is often SG lipomatosis. The process has a chronic relapsing course. Sialosis occurs in a number of diseases and conditions: diabetes mellitus, hypothyroidism, malnutrition, alcoholism, liver cirrhosis, hormonal disorders (hypoestrogenemia), reactions to medications (most often antihypertensive), neurological disorders.

Adenomatoid hyperplasia of small SGs leads to their increase to 0.5-3.0 cm in diameter. The causes of adenomatoid hyperplasia are trauma and prolonged exposure to ionizing radiation.

Oncocytosis is age-related changes in secretory cells and epithelium of the ducts of the gastrointestinal tract. In this case, the SF may slightly increase, but usually their value does not change.

To summarize, I would like to note that ultrasound using Doppler sonography in many of our observations helped to accurately determine the nature of the pathological process in the gastrointestinal tract. However, this diagnostic method does not allow one to unambiguously confirm or refute the malignant nature of the formation of the salivary glands.

Literature

1. Benign and malignant tumors of soft tissues and bones of the face. A.G. Shargorodsky, N.F. Rutsky. M.: GOU VUNMTs, 1999.
2. Topographic anatomy and operative surgery. I.I. Kagan, S.V. Chemezov. M.: GEOTAR-Media, 2011.
3. Salivary glands. Diseases and injuries. V.V. Afanasiev. M.: GEOTAR-Media, 2012.
4. Inflammatory diseases of the tissues of the maxillofacial area and neck. A.G. Shargorodsky. M.: GOU VUNMTs, 2001.

Ultrasound machine HM70A

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Summary

Ultrasonography has established itself as the primary imaging technique in the diagnosis of salivary gland diseases. Sonographic examination is usually sufficient to diagnose sialolithiasis. If chronic sialoadenitis or sialoadenosis is suspected, and sonographic data are insufficient, standard sialography may be required in some cases. A histological examination is necessary as soon as the diagnosis of a neoplasm is established. If the tumor's enlargement and connection with surrounding tissues cannot be determined sonographically, subsequent computed tomography or magnetic resonance imaging should be performed. To conduct research, we recommend using a device from GE Voluson E8 .

Preparation

Typically, an ultrasound of the salivary glands is preceded by a consultation with a general practitioner. At the initial appointment of a patient with pain symptoms in the glandular area, the doctor examines visually, collects a detailed history and diagnoses using palpation. Next, the patient will be asked to undergo laboratory tests or undergo an ultrasound scan. There is no need to specially prepare for an ultrasound of the salivary glands. It is completely painless and does not cause radiation exposure to the patient’s body. Ultrasound diagnostics are easily tolerated by people of any age. There are only a few recommendations for obtaining a more informative ultrasound examination. Before going to see a specialist, it is recommended to stop eating food 3-4 hours in advance, and to thoroughly clean the oral cavity before performing the diagnosis.