TOP 6 most inexpensive analogue drugs of Wessel Due F®

There are restrictions during pregnancy

Has restrictions when breastfeeding

Has restrictions for children

Has restrictions for older people

Has limitations for liver problems

Has limitations for kidney problems

Wessel Due F is an anticoagulant drug produced from an extract of the intestinal mucosa of pigs. If it is necessary to select similar treatment options at a lower cost, it is possible to turn to the use of other effective drugs that prevent blood clots.

Such popular analogues of Wessel Due F as Angioflux, Enixum, Fragmin and others have almost the same principle of action, but the course of treatment with them will be much cheaper. Replacement is also relevant in cases where the original drug is not suitable (for example, Angioflux is recommended for diabetes).

The drug is effective for vascular dementia and other pathologies that require the prescription of anticoagulants in order to influence hemostasis, namely the blood clotting process. The basic active substance is sulodexide, a natural mixture of glycosaminoglycans.

Definition of anticoagulant

Main scope includes:

• unspecified encephalopathy;
• retinopathy caused by diabetes;
• pathologies of arteries, arterioles or capillaries with concomitant pathologies;
• glomerular diseases in diabetes mellitus;
• peripheral vascular lesions caused by concomitant diseases.

The drug helps normalize blood viscosity and restore vascular endothelial cells. Increases the level of tissue plasminogen activator contained in the blood. Wessel Due F is not compatible with other anticoagulants due to the risk of bleeding. The drug cannot be combined in the same syringe with other medications.

Pharmacodynamics and pharmacokinetics

This substance increases prothrombin time and BOAT by activating the reaction of prothrombin with AT3 and KG2 factors. The medicine has a strong antithrombotic effect, inhibits factor Xa , and stimulates the synthesis of prostacyclin . The antithrombotic effect of taking the drug is significantly higher than the other listed effects. The substance ranks second in factor Xa activity ( heparin ). As a result of treatment with the drug, the level of fibrinogen the fibrinolytic system is stimulated .

The angioprotective properties of Sulodexide are due to the ability of this compound to restore the structural integrity and functioning of endothelial cells, the normal density of the negative charge of the pores of the basement membrane in these cells. The medicine thins the blood and inhibits the proliferation of mesangium cells .

After penetration into the systemic circulation, about 90% of the substance is absorbed by the vascular endothelium and small intestine. Metabolism of the drug occurs in the liver. desulfation reactions , remains in tissues longer, and has high antiprombotic activity . The product has high bioavailability. It is excreted from the body through the kidneys and bile; the half-life depends on the dosage taken.

Negative effects

During therapy using the drug Wessel Due F, the following negative reactions are possible:

• skin rash;
• stomach ache;
• dyspeptic symptoms;
• bruising and burning at the injection site.

If the dose is exceeded, bleeding may occur, which requires immediate discontinuation of the drug.

Wessel is a low molecular weight heparin that rarely causes side effects.

The drug is prescribed with caution for the treatment of children.

Indications for use

Sulodexide is prescribed:

• with angiopathy with an increased risk of blood clots , for example after myocardial infarction ;
• patients with cerebral circulatory disorders;
• during the period of early recovery after ischemic stroke and in the acute period;
• with dyscirculatory encephalopathy caused by atherosclerosis , high blood pressure or diabetes mellitus ;
• patients with vascular dementia ;
• with occlusive lesions of arteries along the periphery caused by atherosclerosis or diabetes ;
• as part of the complex treatment of antiphospholipid syndrome and thrombosis in combination with aspirin ;
• for deep vein thrombosis and phlebopathy ;
• patients with diabetic foot syndrome , cardiopathy , encephalopathy ;
• with thrombotic thrombocytopenia caused by taking heparin .

Analogues of Wessel Due F

The pharmacy chain offers a wide range of Wessel Due F substitutes with similar indicators for use and treatment effect. Among the presented analogues of Wessel Due F, there are cheap medicines and at a higher price in the form of:

• synonyms;
• generics;
• combined means.

Russian analogues of Wessel Due F are not inferior to foreign drug substitutes in terms of treatment effectiveness and are actively used in therapeutic practice.

Table of analogues of Wessel Due F with price and country of manufacture

The price of analogues of Wessel Due F fluctuates over a wide range. This gives the doctor the opportunity to choose a medicine with a similar mechanism of action and an equivalent effect, but much cheaper than imported drugs.

A large selection of Wessel Due F analogues allows the doctor to select the appropriate drug that is most suitable for a patient with a certain pathological condition.

What else can replace Wessel Due F, what medications? The register of the basic product will include the following drugs in different release forms:

• Enixum;
• Anfiber;
• Cibor;
• Flenox;
• Sulodexide;
• Warfarin;
• Warfarex;
• Sinkumar.

These analogues of Wessel Due F can be purchased in a pharmacy only with a doctor's prescription, since treatment of serious vascular diseases is carried out exclusively by a medical specialist.

Clexane

Manufacturer: SANOFI WINTHROP INDUSTRIE (France)
Release form: injection solution

Active ingredient: enoxaparin

Clexane is a low molecular weight heparin that normalizes the blood coagulation system and prevents the formation of blood clots. The drug is used not only to treat already formed blood clots, but also to prevent their formation during any surgical interventions.

This analogue is administered subcutaneously once a day in an amount of 20 mg. The dosage of the drug can be adjusted depending on the type of disease and its activity.

Detralex

Manufacturer: Les Laboratories Servier (France)
Release form: tablets

Active ingredients: hesperidin, diosmin

This combined analogue in tablets has the property of reducing the distensibility of veins and venous stagnation, reducing the permeability of the capillary network and increasing their resistance. The effectiveness of Detralex is especially evident in the treatment of hemorrhoids and diseases of the veins of the lower extremities, relieving their pathological symptoms (pain, cramps, heaviness in the legs).

The Wessel Due F analogue is prescribed, 1 tablet 1–3 times a day according to indications. The dosage of the drug depends on the degree of damage to the veins and the clinical manifestations of the disease.

Venoruton

Manufacturer: GlaxoSmithKline Healthcare (Russia)
Release form: capsules

Active ingredient: rutoside

Venoruton is a drug that tones the vascular wall of capillaries and reduces their fragility. This analogue of Wessel Due F restores the structure of the vascular wall, which leads to normalization of its permeability to fluid and lipids. During the treatment of deep vein thrombosis and chronic venous insufficiency with medication, tissue swelling, convulsions, and pain are relieved.

These capsules of the Wessel Due F analogue are prescribed in a dosage of 300–600 mg 2–3 times a day. It is possible to adjust the daily dose of the drug depending on the activity of the process.

Fragmin

Manufacturer: Vetter Pharma-Fertigung (Germany)
Release form: injection solution

Active ingredient: dalteparin sodium

Fragmin is a direct anticoagulant, which is a low molecular weight heparin. The Fragmin analogue is active in the treatment of deep vein thrombosis, pulmonary embolism, myocardial infarction and unstable angina.

The drug is also used as a prophylactic agent to prevent the formation of blood clots in various conditions. The medication is prescribed subcutaneously 1–2 times a day, depending on the disease and its degree of activity.

Heparin

Manufacturer: BIOK (Russia)
Release form: injection solution

Active ingredient: sodium heparin

This analogue of Wessel Due F in injection ampoules is a direct-acting anticoagulant belonging to the group of medium molecular weight heparins. Heparin reduces the risk of primary and recurrent myocardial infarction due to coronary heart disease.

The drug has a positive effect in the treatment of deep vein thrombosis and pulmonary embolism. An analogue is prescribed individually in a dosage corresponding to the form of the disease.

Fenilin

Manufacturer: ZDOROVE (Ukraine)
Release form: tablets

Active ingredient: phenindione

Phenilin is a cheap tablet similar to Wessel Due F. It is an indirect-acting anticoagulant, used for the treatment and prevention of:

• thromboembolism;
• coronary artery thrombosis;
• deep vein thrombophlebitis;
• thrombosis after surgical interventions of various locations.

Treatment with Phenilin is prescribed according to a loading dose regimen on day 1 at a dosage of 120–180 mg in 3–4 doses, on day 2 – 90–150 mg, on day 3 – 30–60 mg under the control of prothrombin levels in the blood. Cancellation of the analogue is carried out with a gradual reduction in the daily dosage.

Sulodexide, instructions for use (Method and dosage)

The dosage regimen and duration of treatment depend on the form of release and the disease and are determined by the doctor.

Sulodexide, instructions for use

The tablets are taken orally a few hours after meals or an hour before meals. Intramuscular or intravenous is also indicated .

Treatment begins with intramuscular injections of 600 LE per day for 15-20 days. Then they switch to the tablet form of the drug. Drink 250 LE twice a day. The duration of treatment is one month.

The course can be repeated after six months.

Drug interactions and special instructions

Interactions between Wessel Due F and other medications have not been established. But its simultaneous use with other anticoagulants and antiplatelet agents is contraindicated.

It is recommended to do a coagulogram before and after treatment.

Wessel is prescribed with caution and only under the supervision of a doctor during pregnancy. It is recommended for women with insulin-dependent diabetes during the last two trimesters to avoid the development of late gestosis and to prevent vascular complications.

Preparations containing (Sulodexide analogues)

Level 4 ATC code matches:
Angioflux

Hemapaxan

Fragmin

Wessel Due F

Fraxiparine

Clexane

The most common analogues of Sulodexide: capsules and solutions for injections Vesel Due F , Angioflux .

pharmachologic effect

Manufacturer: ALFA WASSERMANN (Italy)
Release form: capsules, injection solution

Active ingredient: sulodexide

Analogues: Clexan, Detralex, Angioflux

Wessel Due F is a direct-acting anticoagulant, which, by affecting the blood coagulation system, normalizes its rheological parameters (viscosity). This process leads to improved blood flow and inhibits the formation of blood clots. They often accompany heart and vascular diseases, causing serious complications.

Reviews of Sulodexide

Some reviews about Sulodexide from the Internet:

• “...I have insulin-dependent diabetes mellitus. The doctor prescribed the drug to me for problems in the blood vessels of the feet. The medicine helped, there were no exacerbations so far”;
• “... During pregnancy I had VA and APS, Sulodexide was prescribed. By week 36 I stopped drinking it on the advice of my doctor. It was difficult, but the birth went well and on time”;
• “... My mother is 74 years old. After completing the course, the blood clot in my right leg resolved. The medicine is expensive, but it justifies the cost; there were no adverse reactions during treatment.”

Who is indicated for taking the drug?

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Indications for the use of Vesel DueF tablets are extensive. This is one of the most effective and frequently prescribed drugs for the treatment of late severe complications of diabetes:

• nephropathy;
• angiopathy;
• retinopathy;
• diabetic leg lesions.

In addition, it is used in therapy:

• vascular dementia;
• deep vein thrombosis;

• antiphospholipid antibody syndrome (SAFA);
• thrombophlebitis;
• thrombotic thrombocytopenia caused by the action of heparin;
• post-infarction angiopathy with a high risk of thrombosis;
• ischemic stroke in acute conditions and during the recovery period.

For diabetic nephropathy and SAFA

the filtration and excretory function of the kidneys suffers from impaired systemic circulation and decreased pressure in the renal glomeruli. Functional deficiency leads to an increase in creatinine in the blood. Wessel Due F normalizes blood flow in the arterioles and small vessels of the kidney parenchyma, normalizing creatinine clearance.