TOP 12 inexpensive analogues of the drug Phenibut, which are sold without a prescription

Has restrictions during pregnancy

Prohibited during breastfeeding

Has restrictions for children

Has restrictions for older people

Has limitations for liver problems

Has limitations for kidney problems

Phenibut is made in tablets with the main active ingredient - aminophenylbutyric acid, or phenibut. The drug is an anti-anxiety medication that stabilizes the action of brain neurons. Phenibut is used in psychiatry and neurology. Patients who are prohibited from taking Phenibut for various reasons are prescribed its analogues.

Phenibut can be bought without a prescription in sports stores, since the drug belongs to the sports nutrition section - nutritional supplements. Follow the link: buy phenibut with delivery

Key indicators for use in Phenibut treatment:

• paranoia and anxiety;
• asthenic severe tension;
• apathy;
• psycho-emotional stress;
• anxiety and phobias;
• insomnia, depression and fear;
• nightmares at night;
• Meniere's disease;
• neurosis and tic of neurological origin;
• stuttering in children;
• deviations in autonomic functions or in the vestibular apparatus, due to which the patient experiences severe dizziness.

Pharmacological properties of Phenibut

Phenibut is also used for the development of withdrawal symptoms in alcoholics and drug addicts.

The medicine is not prescribed in case of an allergic reaction to its components, in case of severe impairment of the functioning of the kidneys and liver, as well as in children less than 3 years of age and during lactation. The drug is prescribed with extreme caution for:

• pregnancy;
• ulceration and erosion of the digestive tract.

Phenibut is taken without being tied to the procedure of eating. A single dosage per day for a child is 250 mg, and for an adult – 750 mg. Dosages directly depend on the pathology and the stage of its progression.

Drug interactions

Phenibut is well tolerated by patients, only sometimes the following negative reactions are noted:

• dizziness and fatigue;
• headache and insomnia;
• allergic reactions on the skin.

pharmachologic effect

Manufacturer: Olainfarm, Latvia
Release form: tablets

Active ingredient: aminophenylbutyric acid hydrochloride

Synonyms: Anvifen, Noofen, Noobut, Fenorabin, Nootrophen, Bifren

Phenibut is classified as a nootropic drug with an anxiolytic effect. The action of the drug is ensured by its influence on GABA receptors (GABA) in the central nervous system, facilitating the transmission of impulses in nerve synapses. Main effects when taking Phenibut:

• nootropic - stimulation of blood flow in the brain and eyes;
• tranquilizing;
• psychostimulant;
• antiplatelet;
• normalization of metabolism in nerve tissues;
• elimination of vegetative-vascular disorders - headaches, sleep disturbances, emotional instability;
• increased mental performance;
• improvement of cognitive properties - memory, speech, attention, thinking.

Phenibut is classified as a safe, low-toxic drug that does not accumulate in the body.

Meeting the main contender

Phenibut is a nootropic drug that has anxiolytic activity. Included in the group of psychostimulants. This drug is prescribed for various neuralgic and neurotic disorders.

Indications for use of the drug are based on the ability of the drug to activate metabolic and bioenergetic processes in the brain. As a result, the transmission of nerve impulses to the central nervous system from the brain is stabilized and its blood circulation is normalized.

Scope of application

The drug is used in the following cases:

• for sleep disorders, frequent nightmares, insomnia;
• during urinary retention, which is caused by myelodysplasia;
• during Meniere's disease;
• prevention of anxiety states that arise before painful diagnostic examinations and surgical interventions;
• for anxious neurotic and asthenic conditions - fear, anxiety, psychopathy, obsessive-compulsive neurosis, enuresis, for stuttering and tics in children;
• used in combination with detoxification agents during delirious and predelirious states in alcoholism;
• for dizziness caused by dysfunction of the vestibular analyzer;
• during the relief of psychopathological and somatovegetative disorders that are caused by withdrawal symptoms;
• with primary open-angle glaucoma.

Advantages and disadvantages of the product

The advantages of the drug include the following features:

• while taking the drug, blood circulation in the brain increases, which helps improve its performance;
• the product improves memory, attention, normalizes mental performance;
• increases the speed and accuracy of sensory and motor reactions;
• reduces the level of cerebral vascular tone, which reduces the risk of stroke;
• when taken, the drug has a high anticonvulsant effect;
• relieves feelings of fear and severe tension;
• eliminates sleep disorders and relieves insomnia;
• has an antioxidant effect;
• prevents various manifestations of asthenia;
• improves microcirculation in eye tissues.

However, despite the advantages, Phenibut has disadvantages, which provokes many people to look for its analogues, which do not have them. Among the disadvantages, it should be especially noted:

• the presence of contraindications - it is not recommended to take this drug if you have the following conditions - hypersensitivity to the components of the drug, with liver failure;
• should not be taken during pregnancy and breastfeeding;
• not recommended for children under 8 years of age;
• after taking there are sometimes side effects - a feeling of anxiety, agitation, headaches, increased irritability, dizziness, a feeling of drowsiness, nausea may appear at the first dose, and sometimes allergies may appear in the form of itching and irritation;
• if long-term use of the drug is required, then it is necessary to monitor the picture of peripheral blood conditions and the condition of the liver.

Before you start taking the drug, you need to study the instructions in detail, since Phenibut has numerous contraindications and a large number of side effects, and also analyze analogues of the drug available on the market.

Indications for use of Phenibut

The medicine is prescribed for the following disorders and abnormalities:

• asthenia;
• increased anxiety;
• fears;
• neuroses;
• mental disorders of various etiologies;
• delayed speech and development, especially in childhood;
• sleep disorders;
• prevention of anxiety before operations and diagnostic tests;
• Meniere's disease;
• prevention of motion sickness;
• glaucoma;
• alcoholism;
• heart rhythm disturbances.

Phenibut can be used as an independent remedy or as part of complex therapy for these diseases.

Drug substitutes for children

There are generics of Phenibut on the pharmacological market, which are often used in the treatment of children.

Noofen

Noofen is a nootropic medication that is prescribed as a psychostimulant. The main component of the medicine is phenibut.

The drug has the following properties:

• tranquilizing and stimulating neuronal activity;
• antihypoxic and antiamnestic.

Characteristics of the drug

The medication also improves the child’s intellectual ability, improves his performance, relieves mental stress and eliminates fears and anxiety.

Noofen is effectively used in the treatment of such pathologies:

• emotional overexcitation;
• decreased memory and attentiveness;
• low intellectual development;
• asthenic and neurotic anxiety state;
• neuroses;
• psychopathy;
• anxiety, causeless worry and a feeling of fear;
• childhood enuresis and stuttering;
• insomnia in old age;
• alcohol syndrome;
• dysfunction of the vestibular apparatus
• climacteric disorders in women.

Psychopathy

It is prohibited to prescribe Noofen for the following reasons:

• kidney failure;
• hypersensitivity to the composition of the drug;
• children under 8 years old;
• lactation period.

The drug can be used as part of a combination treatment with tranquilizers and antipsychotics. Adults are prescribed a dosage of 250-500 mg per day, maximum 750 mg. Children over 8 years old – no more than 500 mg per day. Therapeutic treatment continues for 3-6 weeks.

Negative effects occur infrequently in patients and are manifested by the following symptoms:

• urticaria and anaphylactic reactions;
• respiratory tract pathologies – laryngeal edema;
• dyspepsia;
• headache.

Noobut

Noobut ​​is a generic version of Phenibut with the active ingredient - phenibut. The drug belongs to the pharmacological group of nootropic medications. In terms of its properties, Noobut ​​is identical to Noofen and Phenibut, and also has the same purposes as them:

• decreased quality of sleep – insomnia;
• to increase emotional and intellectual activity;
• decreased memory and attention;
• a state of anxiety, causeless anxiety and fear;
• childhood nervous pathologies - tics, stuttering and nocturnal enuresis;
• problem of falling asleep in elderly patients.

The drug is also prescribed as part of the complex treatment of cervical osteochondrosis. Noobut ​​is used as part of preventive measures for seasickness or motion sickness in transport, for vestibular disorders.

Osteochondrosis of the cervical spine

Noobut ​​should not be prescribed to children under 3 years of age, as well as in cases of renal failure and allergies to the ingredients in the medication. During lactation, it is necessary to transfer the newborn to artificial feeding, and only then begin therapy. For pregnant women, medication can only be prescribed by a doctor based on vital signs.

For adult patients and children older than 11 years, these dosages are 250-500 mg three times a day. Children's dosages depend on the age of the children:

• 3-4 years – 2 times a day, 0.1 mg;
• 5-6 years – three times 0.1 mg;
• 7-11 years - twice 0.2 mg.

The duration of taking the tablets is 21-45 days. Preventive measures for motion sickness - take 250-500 mg of medication an hour before the trip. To relieve alcohol syndrome, the initial dosage is 750 mg, followed by a decrease. Side effects of Noobut ​​are identical to those of Noofen.

Lutsetam

Lucetam is produced in tablets and in a solution for injections based on piracetam. A Phenibut substitute is prescribed for the treatment of the following diseases:

• psychoorganic syndrome;
• disorders and behavioral disorders;
• decreased concentration and memory;
• deviations in movement coordination;
• emotional overexcitation;
• dementia and Alzheimer's disease;
• dizziness;
• alcohol syndrome;
• myoclonus of cortical etiology;
• poor learning ability of schoolchildren;
• post-traumatic period (head and brain injury).

Psychoorganic syndrome

Also prescribed after an ischemic stroke to restore the functioning of the motor and speech apparatus, as well as enhance mental and emotional activity.

Lutsetam is not prescribed under the following circumstances:

• hemorrhagic stroke;
• allergy to medicinal components in the medicine;
• kidney failure;
• breastfeeding a newborn;
• the entire period of pregnancy.

Tablets should be taken with meals - 2-4 times a day. To prevent sleep rhythm disturbances, the last intake procedure should be no later than 5 pm.

When treating intellectual disabilities, the medication is taken 2-3 times a day. Dosage per day – 2400-4800 mg. For cortical disorders - the initial dosage in therapy is 7200 mg, and there is a gradual increase by 4800 mg every 3 days until a maximum dosage of 24000 mg is reached. After achieving a therapeutic effect, it is necessary to gradually reduce the dosage by 1200 mg every 2 days.

Negative effects from taking Lucetam:

• headaches, fluctuations in blood pressure index and dizziness;
• insomnia or drowsiness;
• dyspepsia;
• epileptic seizures and impaired coordination;
• irritability and nervousness;
• weight gain;
• increased libido;
• hallucinations, depression.

Phenibut - instructions for use

The drug is taken orally. Doses are selected taking into account the disease and age of the patient:

• children 3-8 years old - ½ tablet;
• children 8-14 years old - 1 tablet;
• adults, children over 14 years old - 1-2 tablets.

Frequency of administration: 3 times/day. Duration of treatment is from 2 to 6 weeks.

The drug is well tolerated. Rarely, headaches, drowsiness, nausea, and itchy skin develop as side effects. As a rule, such symptoms appear only at the beginning of treatment.

According to the instructions for use, Phenibut is not prescribed if you are allergic to the components of the product. The medicine is used with caution in patients with liver and gastrointestinal pathologies, especially with ulcerative lesions. From the age of 60 years, the dose of the drug must be reduced.

Phenibut enhances the effectiveness of the following groups of drugs:

• sedatives;
• sleeping pills;
• analgesics;
• antiparkinsonian;
• antipsychotic.

How to take Phenibut - before or after meals

The drug should be taken before meals. Drink at least 150 ml of water. An adult should swallow the tablet whole without chewing.

Children are allowed to pre-grind a single dose and dilute it in a tablespoon of water at room temperature.

Other popular analogues for therapeutic action

Below are the most popular similar Phenibut products, which have different components with this medication, but the same therapeutic direction. The effectiveness of these analogues is no lower than that of the original product.

Cerakson

Ceraxon is produced in the form of an oral solution and for injections. The main component in the medicine is citicoline sodium. This medication is used in the treatment of stroke and pathological disorders of blood flow in the brain. The medication is also used in complications after impaired blood supply to parts of the brain.

The drug is effective in the treatment of brain and skull injuries, and neurological pathological abnormalities - vascular and degenerative etiology.

Mechanism of action of Ceraxon

The drug is not prescribed for:

• sensitivity to the ingredients of the drug;
• vagotonia;
• fructose intolerance;
• lactation.

Ceraxon is prescribed with restrictions during pregnancy. The injection solution is prescribed three times a day, 1 ml for children, 2 ml for adults. The drug can be used for children from the moment of birth. The duration of treatment is 45-60 days.

In case of a brain disorder or stroke, treatment must begin in the first hours after the attack. The dosage and duration of therapy are determined by the doctor individually for each patient, based on the pathology and the degree of its progression.

Side effects:

• heart rhythm disturbances and blood pressure fluctuations;
• headache;
• dyspepsia;
• vertigo;
• hallucinations;
• dermatological allergic reactions.

Anvifen

Anvifen is a nootropic drug that acts on GABA receptors. The drug has the following properties:

• antiplatelet and tranquilizing;
• antioxidant and anticonvulsant.

The drug is prescribed for the following patient conditions:

• insomnia in older people;
• asthenic condition;
• anxious-neurotic state;
• Meniere's pathology and vestibular disorders;
• kinetosis;
• psychopathological disorders.

Pharmacological properties of Anvifen

It is prohibited to use Anvifen in therapy if:

• manifestation of an allergy to the composition of the medication;
• GV;
• pregnancy, as well as in pediatrics up to 3 years.

Use with restrictions for:

• kidney and liver dysfunctions;
• ulcerative destruction in the digestive organs.

The medication must be taken in courses over 2-3 weeks. There are 3 procedures for taking capsules per day:

1. Patients over 14 years of age – 250-500 mg.
2. Children 3-8 years old – 50-100 mg;
3. Children 8-14 years old – 250 mg.
4. For Meniere's pathology - 250 mg for 2 weeks.

Negative reactions of the body to the drug:

• skin allergies - hives, itching and redness of the skin;
• irritability and nervousness;
• headache;
• severe drowsiness.

Biotropil

Biotropil is a nootropic medication with a psychostimulating effect. The drug is based on the main component - piracetam, which is a cyclic derivative of gamma-aminobutyric acid.

The main indicators for prescribing Biotropil are the following violations:

• cognitive;
• myoclonus of cortical origin;
• decreased mental abilities.

Myoclonus

Phenibut analogue is not prescribed for the following reasons:

• hypersensitivity to the ingredients of the drug;
• renal failure;
• hemorrhagic stroke (hemorrhage);
• Huntington's chorea;
• the patient's age is less than 18 years;
• lactation.

The medication is prescribed with caution during pregnancy due to the lack of information about the safety of the drug during this period.

Daily recommended dosages (taken in 2-3 doses during the day):

• restoration of cognitive functions and memory - initial dosage 4800 mg, maintenance therapy - 1200-2400 mg;
• myoclonus of cortical etiology – 24 g for the first 3-7 days, after which the dosage is reduced to 1200 mg per day.

Patients with renal pathologies require a downward dose adjustment.

Negative effects:

• hyperkinesia and ataxia;
• disturbance in coordination and balance;
• insomnia or severe drowsiness;
• epileptic seizures and severe headaches;
• weight gain;
• hallucinations, depression and overexcitement;
• hemorrhages;
• dermatitis and other manifestations on the epidermis;
• increased sexual activity;
• asthenia;
• dyspepsia.

Phenibut analogs

If you are looking for what can replace Phenibut for an adult or child, complete analogs with different prices and identical composition and properties will be good alternatives. The list includes the following drugs:

• Anvifen;
• Noofen;
• Phenorabine;
• Nootrophen;
• Noobut;
• Bifren.

Such products differ from manufacturer to manufacturer. Prices for Phenibut analogues in tablets differ, which makes it possible to select treatment for all categories of patients.

Analogues of action with different compositions include the following drugs:

• piracetam-based products - Lucetam, Nootropil, Piracetam;
• Glycine;
• preparations with hopantenic acid - Cognum, Pantocalcin, Pantogam;
• medications with GABA - Aminalon;
• neuropeptidase agents - Cerebrolysin, Cortexin, Actovegin, Solcoseryl;
• drugs with pyritinol - Encephabol;
• analogues based on vinpocetine - Cavinton, Vinpocetine, Bravinton;
• medications with cinnarizine - Stugeron, Cinnarizine, Vertizin, Cyrizin;
• combination drugs with cinnarizine and piracetam - Fezam, Omaron, Neuro-Norm;
• analogues based on mebicar - Adaptol, Mebicar;
• Picamilon;
• Phenibut analogs that can be bought on IHerb (USA) - California Euro Herbs “Passion Flower”, NOW foods Valerian root, KAL Magnesium L-threonate, any dietary supplements with magnesium, CALM The antistress drink mix, Onnit Alfa Brain;
• nootropic drugs with hydroxypyridine - Mexidol, Neurox, Mexiprim;
• Pramistar;
• Strezam;
• analogues with phenylpiracetam - Phenotropil;
• homeopathic medicines - Nervo-Heel, Tenoten;
• citicolines - Ceraxon, Neuroxon;
• idebenones - Noben, Celestab, Neuromet;
• herbal and sedative analogs - Persen, Sonobarboval, valerian, Novo-Passit, Donormil, Dormiplant, Alora, Sondox, Valokormid.

The following potent prescription drugs, antidepressants, tranquilizers, sleeping pills can be considered analogues:

• Fluoxetine;
• Prodep;
• Paxil;
• Emoton;
• Medopram;
• Fevarin;
• Grandaxin;
• Sonapax;
• Diazepam;
• Eglonyl;
• Gidazepam;
• Amitriptyline;
• Afobazol.

The prescription of such drugs is carried out only by a doctor if there are strict indications.

List of Phenibut analogues with prices

Similar remedies in other forms

Similar drugs Phenibut can be produced in several dosage forms - tablets, oral or injectable solutions.

Nootropil

Nootropil is produced in a solution for drip administration, capsules, a solution for injections and tablets. Nootropil contains piracetam, which provides the drug with nootropic properties.

Effect of the drug

The medication is prescribed in the following cases:

• coma of toxic or post-traumatic etiology;
• a sharp decrease in memory quality;
• severe dizziness;
• unsteadiness of gait and disturbances in coordination of movement;
• decreased attention and intellectual abilities;
• Alzheimer's disease;
• alcohol dependence in the chronic stage;
• sickle cell anemia;
• myoclonus of cortical type;
• condition after ischemic stroke.

Nootropil is not used in patients with kidney dysfunction, with hypersensitivity to the composition, as well as during lactation and children under 12 months. It is strictly forbidden to use after a cerebral hemorrhage.

Nootropil is prescribed with great caution during pregnancy.

The daily dosage of Nootropil is divided into 2-3 doses:

• psychoorganic disorders – 2400-4800 mg;
• treatment of dizziness – 2400-4800 mg;
• myoclonus - initial dosage 7200 mg and every 2-3 days increase by 4800 mg until reaching 24000 mg;
• dyslexia in a child older than 8 years – 3200 mg per day.

Adverse reactions:

• hallucinations and asthenia;
• increased irritability and overexcitement;
• manifestation of epilepsy;
• depression;
• drowsiness and lethargy;
• dyspepsia;
• skin allergies.

Cavinton

Cavinton is a vasodilator of cerebrovascular pathologies. The drug is an analogue of Phenibut based on vinpocetine and restores human brain activity. Cavinton improves the flow of blood into the cerebral arteries, which increases the delivery of oxygen to neurons.

The medication does not affect myocardial activity or blood pressure. The drug is prescribed for the treatment of the following cerebral disorders:

• memory loss and a sharp decrease in intellectual abilities;
• transient ischemic attacks;
• encephalopathy;
• cephalgia;
• tinnitus.

Properties of the drug and dosage

The drug is not prescribed to patients with the following concomitant pathologies:

• cardiac arrhythmia;
• unstable pressure index;
• severe kidney pathologies;
• lactation and pregnancy.

For treatment, 1-2 tablets are prescribed three times a day. For maintenance treatment – ​​1 tablet also 3 times a day. The first therapeutic effect can be felt 7-14 days after the start of treatment. The solution is administered only using a dropper - 1 ampoule per 0.5 liter of sodium chloride once a day, and in case of severe pathologies the frequency of procedures is increased up to 3 times.

For children, the medication is administered by drip – Cavinton is diluted in a glucose solution. Therapeutic treatment lasts 2-3 weeks, and after intravenous treatment the patient is transferred to taking tablets.

Negative actions of Cavinton:

• arrhythmia and blood pressure fluctuations;
• dizziness and severe pain in the head in different locations;
• increased body fatigue;
• dyspepsia;
• skin allergy.

Cortexin

Cortexin is a nootropic with cerebroprotective effects and anticonvulsant effect based on Cortexin.

The medication is used in the treatment of such pathologies:

• viral neuroinfection;
• insufficiency of cerebral blood flow;
• transient ischemic attacks;
• brain injury;
• encephalopathy and encephalomyelitis;
• cerebral ischemia;
• asthenic syndrome;
• epilepsy;
• encephalitis;
• Cerebral palsy and developmental disorders in children;
• decreased memory and intelligence;
• autonomic disorders;
• delayed development of the child’s speech apparatus.

Properties of Cortexin

It is not recommended to take Cortexin during pregnancy and lactation, as well as if you are allergic to the components of the medication.

Cortexin solution is administered intramuscularly every day once a day for 10-15 days. The solution is diluted with sodium chloride or lidocaine (procaine). The daily permissible dosage for an adult is 10 mg, and for children weighing less than 20 kg - 0.5 mg per kilogram of the child’s weight. After six months, the course of treatment can be repeated.

For the treatment of stroke, 10 mg of Cortexin must be administered twice a day for 10 days. If necessary, the course is repeated.

Adverse reactions to Cortexin are quite rare, and patients report allergic reactions on the skin in the form of rash, hives, itching and redness at the injection site.

Phenibut or Adaptol - which is better for anxiety, what is the difference

Manufacturer: Olaifarm, Latvia
Release form: tablets

Active ingredient: mebicar

Synonyms: Mebikar

Adaptol is a fairly close analogue of Phenibut, which can be purchased at a pharmacy without a prescription. According to doctors, this remedy is a safe “daytime” tranquilizer that eliminates anxiety, fears, and sleep disorders.

The nootropic effect is less pronounced than that of Phenibut. Both drugs do not cause drowsiness and do not have a significant effect on performance and activity.

Phenibut or Grandaxin - which is better and stronger for anxiety

Manufacturer: EGIS Pharmaceutical, Hungary
Release form: tablets

Active ingredient: tofisopam

Synonyms: Tofisopam

Grandaxin belongs to the benzodiazepine prescription tranquilizers. The structure of the active substance has been slightly changed, which has reduced the likelihood of addiction and dependence even with long-term use of this analogue.

Replacement with such a remedy is carried out only under strict indications under the supervision of a doctor. The effects of treatment with this medicine are stronger and more pronounced.

Phenibut or Atarax - which is better?

Manufacturer: UCB Pharma, Belgium
Release form: tablets

Active ingredient: hydroxyzine hydrochloride

Synonyms: Hydroxyzine

The Atarax analogue is a prescription anxiolytic and tranquilizer that is not addictive. The anxiolytic and tranquilizing effects of this analogue are more pronounced, and the nootropic properties characteristic of Phenibut are practically not manifested in the drug.

Only a doctor can choose the right remedy, since for such drugs it is important to choose the right dose and duration of treatment.

Over-the-counter analogues of Phenibut available in Russia

Many anti-anxiety medications are sold in pharmacies without a prescription from a doctor, but do not forget when purchasing over-the-counter analogues of Phenibut that self-medication is fraught with serious consequences for the patient. Before purchasing medications, you should consult a specialist.

Afobazole

Afobazole is an anti-anxiety drug based on the main component fabomotizole, an anxiolytic, which is not a drug of the benzodiazepine group.

A Phenibut substitute is prescribed for the following central nervous system conditions:

• alcohol or drug asthenic syndrome;
• generalized anxiety disorders;
• lupus erythematosus;
• myocardial ischemia or infarction;
• asthma;
• cardiac arrhythmia and hypertension;
• oncological malignant neoplasms;
• dermatological diseases of neurological etiology.

Description of the drug

Afobazol is also prescribed for:

• PMS;
• neurocirculatory dystonia, as well as during the period of smoking cessation.

Afobazole is not prescribed in pediatrics under 18 years of age, during pregnancy and lactation, as well as for those patients who are intolerant to the components of the drug and lactose.

Afobazole tablet is taken after meals. The standard dosage is 10 mg at a time, and 30 mg per day. The duration of the medication course is 14-28 days. Individually, the doctor can increase the dosage per day to 60 mg and the duration of treatment to 3 months.

Mechanism of action of Afobazole

Negative reactions of the body to treatment with Afobazole:

• weakness and fatigue of the body;
• headache;
• dermatological allergic manifestations;
• arrhythmia and shortness of breath;
• runny nose.

Phenibut or Afobazol - which is better and more effective for an adult

Manufacturer: Pharmstandard, Russia
Release form: tablets

Active ingredient: fabomotizol

Synonyms: Afobazole retard

Afobazole is a safe anxiolytic drug that has a stronger antidepressant effect. This analogue is an excellent alternative to Phenibut if replacement is necessary. In particular, Afobazole acts better and faster against stress, neuroses, depression, feelings of fear, excessive worries and other similar disorders.

Stimulation of blood flow is not typical for such a remedy. This difference requires a careful assessment of the patient's condition before prescribing the drug.

Phenibut or Anvifen - which is better, what is the difference

Manufacturer: Rapharma, Russia
Release form: capsules

Active ingredient: aminophenylbutyric acid

Synonyms: Phenibut, Noofen, Bifren, Nootrophen

Anvifen is a complete analogue of Phenibut in composition and effects. This drug is a cheaper remedy among substitutes. At the same time, such a medicine has no differences in effectiveness and safety.

According to reviews from many patients, Anvifen is not inferior to its imported counterparts for blood flow disorders, anxiety, memory impairment, speech and other disorders.

Phenibut or Teraligen - which is better?

Manufacturer: Valenta Pharm, Russia
Release form: ampoules, tablets

Active ingredient: alimemazine tartrate

Synonyms: Alimemazine

Teraligen is a strong prescription medication with pronounced sedative and antipsychotic effects. It does not have nootropic properties, unlike Phenibut.

It is used mainly for phobias, depression, neuroses, psychosomatic disorders, and severe sleep disorders.

In addition to oral administration, parenteral administration of the drug is possible.

Phenibut or Pantogam - which is better?

Manufacturer: PIK-pharma, Russia
Release form: capsules, tablets, syrup

Active ingredient: calcium hopantenate

Synonyms: Gopantam, Hopanthenic acid, Gopantomide, Pantocalcin

Pantogam is a very close analogue of Phenibut in terms of nootropic effects. The drug does not have tranquilizing and anxiolytic effects. The medicine helps improve metabolism in brain tissue and has a mild sedative effect.

Indications for Pantogam are distinguished by the ability to prescribe the drug for brain damage, epilepsy, sclerotic lesions, developmental delay in children and other pathologies. The drug cannot be considered a complete replacement for Phenibut.

Modern ideas about nootropic drugs

Drugs that affect the processes of neuroplasticity of the central nervous system occupy one of the leading positions in the treatment of vascular diseases of the brain. Currently, some researchers (E. I. Gusev, 1992, 2000, 2005; V. I. Skvortsova, 2000, 2003, 2004; N. V. Vereshchagin, 2001; Z. A. Suslina, 2003; etc.) They believe that the reorganization of neuronal processes is a combination of a number of mechanisms, including the functioning of previously inactive pathways, sprouting of fibers of surviving cells with the formation of new synapses, and activation of neuronal circuits. It is known that one of the universal components of the pathogenesis of damage to nervous tissue is trophic dysregulation, leading to biochemical and functional dedifferentiation of neurons with the initiation of a cascade of pathobiochemical reactions (V. I. Skvortsova, 2001; T. L. Deckwirth et al., 1993; RS Freeman, 1994).

Traditionally, angioneurology uses a number of drugs that affect plastic, neurotransmitter, neuroprotective and integrative processes in the brain. Among them, nootropic drugs occupy a special place.

Nootropic drugs are drugs that have an activating effect on cerebral metabolism and higher mental functions. They are characterized by a metabolic and neurotrophic effect, which determines the processes of improving redox reactions, reducing the aggressive effect of lipid peroxidation (LPO) products, and a positive effect on neurotransmission. In addition, these drugs have a vasoactive and mild antiplatelet effect - they reduce platelet aggregation, reduce the adhesion of erythrocytes to the endothelial surface, and reduce blood viscosity.

The group of drugs that nootropic drugs make up is developing very dynamically both in Russia and abroad. About 60 leading pharmaceutical companies in various countries are developing new drugs. According to the Pharmaprojects Yearbook, in 1995, 132 nootropic drugs were in various stages of research, clinical study and introduction to the market, of which 79 were in preclinical research, 34 were in various stages of clinical study, and 19 were at the stage of registration and introduction into the market. market.

The term “nootropics” (from the Greek “noos” - thinking and “tropos” - striving) was first used in 1972 by Cornelia Guirgea to describe the effect of piracetam from the Belgian company UCB.

Subsequently, this term also began to be used to refer to drugs with different chemical structures that can improve cognitive functions. The classification of these drugs is difficult due to the lack of clear criteria for dividing drugs into those that have and/or do not have a nootropic effect. Currently, there are several classes of nootropic drugs.

• Pyrrolidone derivatives (piracetam, lucetam, phenotropil).
• Dimethylaminoethanol derivatives (demanol, deanol aceglumate).
• Pyridoxine derivatives (encephabol, pyritinol).
• Derivatives of γ-aminobutyric acid (GABA) (aminalone, picamilon, phenibut, gammalon).
• Ginkgo biloba derivatives (tanakan, bilobil).
• Drugs that act on N-methyl-D-aspartate (NMDA) receptors (akatinol memantine).
• Drugs with tropism for cholinergic structures (gliatilin).
• Preparations of animal origin (Cerebrolysin, Cortexin, Actovegin).
• Mixed-action drugs (instenon).

As a result of numerous clinical and experimental studies, the main mechanisms of action of nootropic drugs have been determined.

• Accelerating the penetration of glucose through the blood-brain barrier and increasing its absorption by brain cells, especially in the cerebral cortex.
• Strengthening the conduction of cholinergic impulses in the central nervous system (CNS).
• Increased synthesis of phospholipids and proteins in nerve cells and red blood cells (stabilization of cell membranes), normalization of the liquid properties of membranes.
• Inhibition of lysosomal enzymes and scavenging of free radicals.
• Activation of cerebral microcirculation by improving the deformability of erythrocytes and preventing platelet aggregation.
• Improved cortical-subcortical interaction.
• Normalization of neurotransmitter disorders.
• Activating effect on higher mental functions (memory, learning ability, etc.).
• Improving reparative processes in case of brain damage of various origins.

Due to these properties, a group of nootropic drugs is often called neurometabolic cerebroprotectors, which indicates a common property for drugs in this group - to stimulate metabolic processes in nervous tissue, optimizing the level of metabolism. According to the severity of their effect on the central nervous system, nootropics can be arranged in the following sequence: phenibut–aminalone–pantogam–picamilon–piracetam–pyritinol–meclofenoxate.

Phenibut has the most pronounced depressive effect, meclofenoxate has the most distinct psychostimulant properties. The “pioneer” of nootropic therapy is piracetam.

Piracetam has a chemical structure similar to GABA and is considered a derivative of this amino acid, but it is not converted into GABA in the body and the GABA content in the brain does not increase after its use. But in relatively large doses and with repeated administration, the drug can enhance GABAergic inhibitory processes.

There are two main directions of action of piracetam: neuroprotective and vascular. Piracetam promotes the oxidative breakdown of glucose through the pentose phosphate shunt, increasing the metabolism of adenosine triphosphate (ATP), as well as the level of cyclic adenosine monophosphate (cAMP). The functioning of this shunt is associated with the formation of substances that neutralize free radicals and prevent membrane lipid peroxidation. The drug stimulates the activity of adenylate kinase, ensuring anaerobic metabolism without the formation of lactate. After administration of the drug in patients with acute ischemic stroke, glucose metabolism, local cerebral blood flow, extraction coefficient and local oxygen metabolism increase in the affected area and the surrounding functionally inactive zone. Piracetam interacts with the neurotransmitter system, exerting a modulating effect on cholinergic and aminacidergic (aspartate, glutamate) neurotransmission, which is especially important since disorders of synaptic transmission involving acetylcholine and glutamate cause “age-related” changes in memory and other cognitive functions. The drug also stimulates interhemispheric information exchange, which underlies the restoration of speech functions lost after a stroke. The effect of piracetam on the vestibular system is described due to its effect on the mechanisms of signal transmission from sources of visual and proprioceptive sensitivity or its effect on the vestibular nucleus in the brain stem. The vascular effect of the drug is due to a decrease in platelet aggregation, an increase in the deformability of erythrocytes, a decrease in the adhesion of erythrocytes to the endothelial surface, and a decrease in the viscosity of plasma and whole blood. Reducing vasospasm without a vasodilator effect and hypotension makes it possible to have a positive effect on cerebral circulation, not accompanied by a change in general hemodynamics. A peculiarity of piracetam is that its pharmacological effect is manifested only under conditions of prolonged repeated administration of the drug in sufficiently high doses.

Phenotropil (chemical name: N-carbamoyl-methyl-4-phenyl-2-pyrrolidone) is a derivative of pyrrolidone, has a pronounced antiamnestic effect, has an activating effect on the integrative activity of the brain, promotes memory consolidation, increases the resistance of brain tissue to hypoxia and toxic effects . It is characterized by anticonvulsant and anxiolytic effects.

Phenotropil is used with caution in patients with severe organic damage to the liver and kidneys, severe forms of arterial hypertension in patients with atherosclerosis, as well as in those who have previously suffered panic attacks, anxiety or acute psychotic states, especially with psychomotor agitation, due to the possibility of exacerbation of anxiety, panic, hallucinations and delirium.

With excessive psycho-emotional exhaustion against the background of chronic stress and fatigue, chronic insomnia, a single dose of phenotropil on the first day can cause a sharp need for sleep. Such patients on an outpatient basis should be advised to start a course of taking the drug on non-working days.

The group of neuroamino acid drugs includes a number of well-known drugs.

Aminalon 's chemical structure is GABA, which is the most important mediator of inhibition in the central nervous system and is also involved in the energy supply of the brain. In terms of clinical effectiveness, the drug is inferior to piracetam, but unlike it does not provide clear stimulating effects. Under the influence of GABA, the effectiveness of inhibitory GABAergic processes increases.

Picamilon (nicotinoyl-γ-aminobutyric acid) combines the properties of GABA and nicotinic acid, which has vasoactive properties, and affects the processes of tissue respiration. The drug is capable of exerting both neurometabolic and vascular effects: it reduces vascular resistance, increases the linear and volumetric velocity of cerebral blood flow, and improves microcirculation. Picamilon has moderate anxiolytic activity and helps restore mental and physical performance in case of overwork.

Phenibut is a derivative of GABA and phenylethylamine and has nootropic and tranquilizing activity. The drug reduces the manifestations of asthenia and vasovegetative symptoms (headache, feeling of heaviness in the head), irritability, emotional lability, and increases mental performance.

Pantogam (hopantenic acid) is the most mildly acting metabolic cerebroprotector with a minimally pronounced stimulating effect on the central nervous system. The metabolic activity of the drug is presumably due to the replacement of the p-alanine fragment in the pantothenic acid molecule with GABA. The drug improves energy metabolism in the brain, affects the oxidative processes of the tricarboxylic acid cycle, which plays a significant role in ensuring various types of metabolism in the cell, including energy.

Glycine is an inhibitory neurotransmitter and a regulator of metabolic processes in the brain; it has a sedative and antidepressant effect. The glycine site is a structural region of the NMDA receptor that is important for memory processes; its activation underlies the long-term potentiation of hippocampal neurons and, consequently, the strengthening of synaptic transmission. Glycine, as an agonist of the glycine site, has an improving effect on memory both in experiment and in humans (V. I. Skvortsova, 2000). The drug is also effective as an adjuvant for epileptic seizures.

Glutamic acid is a neurotransmitter amino acid that stimulates the transmission of excitation at synapses in the central nervous system. The drug normalizes metabolic processes, stimulates oxidative processes, promotes the neutralization and removal of ammonia from the body, and increases resistance to hypoxia.

Pyritinol consists of two pyridoxine molecules connected by a disulfide bridge. The main coenzyme form of pyridoxine is pyridoxal phosphate, which, along with various other functions, is involved in the metabolism of GABA. The only enzyme for the synthesis of GABA, glutamate decarboxylase, is a pyridoxal-dependent enzyme, which may determine the ability of the drug to stimulate the formation of GABA. The action of pyritinol ensures more economical utilization of energy substrates and the subsequent expenditure of energy for the synthesis of macromolecular compounds (ATP, ribonucleic acid). The drug enhances the transport of glucose across the blood-brain barrier, increases its utilization in conditions when oxygen consumption by tissues is reduced, accelerates the oxidation of glucose, reduces the excess formation of lactic and acetic acids in brain tissue, increases the resistance of brain tissue to hypoxia, has the ability to stabilize cell membranes and improve them functional state.

Encephabol is a pyritinol derivative that increases the density and sensitivity of receptors and normalizes neuroplasticity. The drug has a neuroprotective effect, stimulates learning processes, improves memory, memorization and concentration. Encephabol stabilizes the cell membranes of neurons by inhibiting lysosomal enzymes and preventing the formation of free radicals, improves the rheological properties of blood, increases the conformational ability of red blood cells, increasing the ATP content in their membrane. For adults, the average daily dose is 600 mg for 6–8 weeks. The drug is effective for the treatment of cognitive impairment in menopausal patients.

Choline alfoscerate (gliatilin) ​​has a cholinomimetic effect, stimulating predominantly central cholinergic receptors. In the body it is broken down into choline and glycerophosphate. Provides the synthesis of acetylcholine and phosphatidylcholine of neuronal membranes, improves the functions of receptors and membranes in cholinergic neurons. The drug activates cerebral blood flow, stimulates the metabolism of the central nervous system, and stimulates the reticular formation. Improves mood, stimulates mental activity, improves concentration, the ability to remember and reproduce received information, optimizes cognitive and behavioral reactions, and eliminates apathy.

Ginkgo biloba extract (bilobil, memoplant, tanakan) is a standardized herbal preparation that affects metabolic processes in cells, rheological properties of blood, and microcirculation. The drug improves cerebral circulation, supply the brain with oxygen and glucose, normalizes metabolic processes, has an antihypoxic effect, prevents the formation of free radicals and normalizes the LPO of cell membranes. Ginkgo biloba affects the release, reuptake, catabolism of neurotransmitters (norepinephrine, dopamine, acetylcholine) and their ability to bind to membrane receptors. The drug normalizes the vascular system, stimulates the production of endothelium-dependent relaxing factor, dilates small arteries, increases the tone of veins, reduces the permeability of the vascular wall, has an anti-edematous effect, stabilizes platelet and erythrocyte membranes, and has antiplatelet properties.

Actovegin is a modern drug that is a deproteinized extract of the blood of young calves. Its main effect is aimed at improving the utilization of oxygen and glucose. Under its influence, the diffusion of oxygen in neuronal structures significantly improves, which makes it possible to reduce the severity of secondary trophic disorders. There is also stabilization of cerebral and peripheral microcirculation against the background of improved aerobic energy exchange of vascular walls and the release of prostacyclin and nitric oxide. The resulting vasodilation and decrease in peripheral resistance are secondary to the activation of oxygen metabolism of the vascular walls (A. I. Fedin, S. A. Rumyantseva, 2002). There is evidence of the positive effect of Actovegin on patients with various forms of dementia, including vascular origin. The pace and quality of mental activity in patients may improve during treatment as the duration of drug use increases (W. Jansen, 2002).

Of significant interest are combination drugs that affect various parts of the pathogenetic process. An example of a successful combination is instenon.

Instenon is a combined drug with neuroprotective action, including a vasoactive agent from the group of purine derivatives, a substance that affects the state of the ascending reticular formation and cortical-subcortical relationships, and, finally, an activator of tissue respiration processes under hypoxic conditions (S. A. Rumyantseva, 2002; B V. Kovalchuk, 2002).

The three components of instenon (etophylline, hexobendine, etamivan) jointly affect various parts of the pathogenesis of ischemic brain damage.

Etophylline is a vasoactive component of the purine series that activates myocardial metabolism with an increase in stroke volume. The transition from a hypokinetic type of blood circulation to a normokinetic one is accompanied by an increase in cerebral blood flow. Important components of the action of etophylline are an increase in renal blood flow and, as a consequence, dehydration and diuretic effects.

Etamivan has a nootropic effect, directly affecting memory processes, attention, mental and physical performance as a result of increased activity of the reticular formation of the brain.

Hexobendine selectively stimulates metabolism by increasing the utilization of oxygen and glucose, due to increased anaerobic glycolysis and pentose cycles. At the same time, the physiological mechanisms of autoregulation of cerebral and systemic blood flow are stabilized.

The variety of drugs with combined action used in angioneurology (Cavinton, Instenon, Sermion, Vasobral, Fezam, etc.) requires clear recommendations for use by general practitioners. Taking into account the literature data and the results of our own research, additional indications for prescribing this group of drugs have been identified:

• vegetative-trophic disorders;
• concomitant peripheral circulatory disorders (retinopathy and angiopathy in diabetes mellitus, atherosclerosis, arterial hypertension);
• cochleovestibular disorders;
• asthenodepressive disorders;
• prevention of chronic cerebral ischemia after a stroke.

Nootropic drugs can be used both in patients with various pathologies of the central nervous system, and in healthy people during fatigue, natural aging, and also in extreme situations.

Indications for prescribing nootropic drugs:

• acute cerebrovascular accidents;
• traumatic brain injury;
• comatose states;
• chronic cerebral ischemia;
• vascular dementia;
• hypertensive and atherosclerotic encephalopathy;
• asthenic syndromes;
• autonomic dystonia syndrome;
• consequences of perinatal encephalopathy;
• delayed mental development in children;
• attention deficit hyperactivity disorder.

In recent years, the list of indications for the use of drugs has expanded significantly, but the complexity and multicomponent nature of cerebral metabolic disorders, as well as the limitation of extrapolation of experimental data into clinical practice, lead to ambiguity of opinions about neuroprotective and metabolically active therapy. Undoubtedly, this direction is one of the key, the most promising and at the same time the most difficult. Cerebrovascular diseases cause significant damage to the health of the population, as a result of which the percentage of disability and mortality increases. In recent decades, the arsenal of drugs used to treat these diseases has expanded significantly. Every year, new drugs with indirect nootropic effects enter the pharmacological market. Differentiated therapy for vascular diseases of the brain requires knowledge of the etiology, pathogenesis, and mechanisms of pharmacological action of certain drugs. A special place is occupied by the safety of medicines. In addition, a practicing doctor often has to decide the question: “price–quality–clinical effectiveness.” Life expectancy is constantly increasing, with the fastest growing portion of the general population being people over 65 years of age. Consequently, we can expect that the incidence of diseases associated with age, such as dementia and others, will increase significantly, and nootropic drugs will be more and more in demand. Currently, 15 drugs classified as nootropics are registered in Russia. The range of domestic nootropic drugs is significantly smaller than on the foreign medicine market; in other words, they are often not enough to meet the needs of medical practice in our country.

Understanding the mechanism of action of drugs on the body expands the range of possibilities for drug therapy for various clinical syndromes and diseases. The optimal choice of a nootropic drug is facilitated by the doctor’s correct understanding of pharmacokinetics and pharmacodynamics, which is necessary to determine a rational single and daily dose of the drug used. It should be noted that in order to determine the general patterns of treatment, an individual approach to each patient is necessary, taking into account age, gender, medical history, concomitant diseases, metabolic characteristics and hemodynamics. The effectiveness of the drug is determined from the standpoint of evidence-based medicine and is expressed in reducing the clinical manifestations of the disease and improving the patient’s quality of life. Currently, a new strategy in the use of drugs that have a neuroprotective effect is clearly visible. This is, on the one hand, optimally high doses of the drug (piracetam, Actovegin, Tanakan) and, on the other hand, the widespread introduction of forte forms (Instenon, Cavinton). However, it is necessary to observe the following rule: early initiation and long course (up to 3–4 months) of therapy. Modern medicine makes it possible to combine two or more drugs. For example, Actovegin - Instenon, Actovegin - Piracetam, Piracetam - Gliatilin, etc. The final judgment on the effectiveness of the chosen treatment and the need for its correction can be made if there is no therapeutic effect after 2-3 courses lasting at least 3 months. You should not refuse the chosen drug unless its dose has been increased to an individual maximum and well tolerated. If there is no positive response to treatment or side effects occur, it is recommended to replace the selected medication with a drug of a different class. In case of insufficient effectiveness, but good tolerability of the drug substance, a second drug belonging to a different class can be added to it. This combination can provide a more pronounced therapeutic effect with a lower likelihood of side effects, since lower doses are used during therapy.

Thus, nootropic drugs, due to various mechanisms of therapeutic action, can be used in the treatment of neurological patients. The Russian pharmaceutical market offers drugs with varying degrees of effectiveness and tolerability. Therefore, the choice of a particular drug should be based on the results of clinical studies and the personal experience of the doctor.

M. V. Putilina , Doctor of Medical Sciences, Professor of Russian State Medical University, Moscow

Phenibut or Phenazepam - which is better and stronger, what is the difference

Manufacturer: Valenta, Russia
Release form: ampoules, tablets

Active ingredient: benzodiazepine

Synonyms: Phenazef, Phenazeptin, Elzepam

Phenazepam is a strong tranquilizer that is available from pharmacies only with a prescription. Causes addiction when used for a long time. It has strong hypnotic, sedative, anticonvulsant, muscle relaxant and anxiolytic effects.

This analogue is approved for use only under strict control of dosage and duration of administration.

Phenibut or Noofen - which is better?

Manufacturer: Olaifarm, Latvia
Release form: capsules

Active ingredient: aminophenylbutyric acid

Synonyms: Phenibut, Bifren, Anvifen

Noofen is a complete substitute for Phenibut. Available from pharmacies with a prescription, it has completely identical properties and composition. The product is used internally in the form of capsules.

The differences between analogues are only in the manufacturers. Noofen is quite expensive.

Phenibut or Picamilon - which is better?

Manufacturer: Pharmstandard, Russia
Release form: ampoules, tablets

Active ingredient: GABA

Synonyms: Amylonosar

Picamilon is an inexpensive, but effective and safe analogue in action. Like Phenibut, the drug exhibits a pronounced nootropic effect, as well as moderate sedative and tranquilizing effects. There are some differences in the indications.

Picamilon is widely used in urology, sports medicine, for neuroinfections, and migraines. The drug is also prescribed for the same disorders as Phenibut.

Phenibut or Amitriptyline - which is better?

Manufacturer: Ozone, Russia
Release form: ampoules, tablets

Active ingredient: amitriptyline

Synonyms: Amitriptyline

Amitriptyline is an antidepressant with a pronounced sedative effect. The drug is used mainly for the treatment of mental disorders, depression, sleep disorders, bedwetting, pain of various etiologies, and neuralgia.

Unlike Phenibut, the medicine does not have nootropic properties. Therefore, the replacement of drugs cannot be considered complete and is carried out only when urgently necessary under the supervision of a doctor.

Why is Phenibut dangerous?

The drug rarely causes side effects:

• nausea and vomiting - at the beginning of therapy, diarrhea and stomach pain,
• dysfunction of the nervous system, which leads to headaches and dizziness, sleep disturbances,
• with long courses of treatment - hepatotoxic effect on the liver,
• allergies, which are manifested by itching and rash, swelling of the face and tongue, urticaria and erythema, angioedema.

The medication enhances the effects of drugs that include sleeping pills, narcotic analgesics, antipsychotics and psychostimulants. Medication treatment is not stopped abruptly due to “withdrawal syndrome,” which leads to a deterioration in the patient’s condition.

Phenibut or Tenoten - which is better?

Manufacturer: Materia Medica, Russia
Release form: homeopathic tablets

Active ingredient: complex of antibodies to brain-specific protein

Synonyms: Tenoten for children

Tenoten is a homeopathic and completely safe sedative and anti-anxiety medicine. This analogue, like Phenibut, is characterized by nootropic and antidepressant properties.

The effect of Tenoten on the body is very mild and less pronounced. The medicine is approved for use in children.

Phenibut or Glycine - which is better for an adult?

Manufacturer: Evalar, Russia
Release form: lozenges

Active ingredient: glycine

Glycine is a mild product based on a natural amino acid. This over-the-counter analogue, like the drug Phenibut, improves metabolism in the brain, protects against stress, calms, improves attention and memory in children and adults.

Used sublingually from 3 years of age. Possible use for epilepsy attacks. The drug is well tolerated and does not cause addiction.

The effects of taking Glycine are less pronounced than those of Phenibut.

Note!

The description of the drug Phenibut on this page is a simplified author’s version of the apteka911 website, created on the basis of the instructions for use.
Before purchasing or using the drug, you should consult your doctor and read the manufacturer's original instructions (attached to each package of the drug). Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide to prescribe the drug, as well as determine the dose and methods of its use.

Answers on questions

Is Phenibut prescription or not?

The medicine can be bought at a pharmacy without a prescription.

Is Phenibut an antidepressant or a tranquilizer?

The drug is a nootropic with minor tranquilizing properties.

Does Phenibut raise or lower blood pressure?

The medicine does not have a direct effect on blood pressure. Due to stimulation of blood flow in the vessels, a slight hypotensive effect is possible.

Is it possible to take Phenibut at night or not?

The drug can be taken at any time of the day.

Can I take Phenibut while driving or not?

Drivers should be careful when treating with the drug and its analogues, as drowsiness and dizziness may occur, especially at the beginning of treatment.

Is it possible to take Phenibut with alcohol or not?

It is not advisable to combine treatment with alcoholic beverages.

How to take Phenibut: dissolve or swallow (with a drink)?

The product is swallowed whole.

Is Phenibut addictive or not?

There is no addiction to the medicine.

Is Phenibut a sleeping pill or not?

The drug normalizes sleep without sedative and hypnotic effects.

Cost of medicines and basic analogues

The cost of Phenibut is in the high price segment, as well as its foreign analogues and generics. Domestic similar medications of Phenibut are much cheaper.