The hormonal drug Dirospan is a ready-made medicinal suspension. It can be purchased in ampoules or disposable syringes. The product is a clear solution, sometimes with a yellowish tint. It contains suspended particles that, when shaken, transform the liquid into a stable suspension.
The medicine belongs to glucosteroids. Diprospan injections, the instructions indicate this, include betamethasone. It is the main active ingredient. In the manufacture of the medicine, a complex of auxiliary components is used that enhance the effect of the medicine. A single dose of 1 ml contains 5 mg of betamethosone. The medicine is characterized by anti-inflammatory, antitoxic, antiallergic, antishock, and immunosuppressive effects. In addition, it has a pronounced effect on metabolism.
Indications
Diprospan injections, the instructions indicate this, are used for a wide range of pathologies. The effectiveness of the product has been proven in the treatment of diseases of the musculoskeletal system. It alleviates the condition of patients with rheumatoid arthritis, osteoarthritis, bursitis, etc.
Diprospan is indicated, the instructions emphasize attention, also in other situations. It is often used in therapy:
- Allergic pathologies. In particular, it is used to stabilize the condition of patients suffering from bronchial asthma and hay fever. The drug allows you to quickly remove the symptoms of rhinitis when it occurs seasonally, as well as relieve an allergic reaction to medications and insect bites.
- Dermatological diseases. The effectiveness of the product has been proven in practice against dermatitis, eczema, neurodermatitis, urticaria, etc.
- Systemic connective tissue pathologies, including lupus erythematosus and scleroderma.
- Hemoblastosis. The medicine is used in the complex therapy of leukemia and lymphomas in adults.
Diprospan, the instructions for use indicate this, can be used in severe conditions of patients. It is prescribed for toxic, traumatic, cardiogenic, surgical, burn shock. The drug is indicated for severe anaphylactoid and allergic reactions, cerebral edema that occurs during radiation therapy or after surgery, hepatic coma, thyrotoxic crisis.
Conclusions:
Today, many modern high-tech methods have been developed for the treatment of injuries and diseases of the musculoskeletal system, bones, joints, tendons and muscles. These are various arthroscopic surgical techniques that, using the most modern equipment, make it possible, using the most modern equipment, to quickly, effectively and less traumaticly eliminate the cause of pain and dysfunction of the limb, return the person to the joy of movement, and not just alleviate the symptoms for a while, postponing the solution to the problem until later or not at all. deciding, as in the case of diprospan injections. Then it may already be too late.
Contraindications
Diprospan injections, the instructions for use warn about this, have an absolute contraindication - hypersensitivity to betamethasone or any of the auxiliary components. There are many other contraindications for the use of the drug, so you need to know why diprospan is dangerous.
The drug is not prescribed for the treatment of diseases of the skeletal system in the presence of septic and infectious lesions of the joint, as well as in the presence of periarticular osteoporosis or intra-articular bone fracture. The drug cannot be used in the post-vaccination period. It is unacceptable to treat diabetes mellitus, hypothyroidism and hypertension. Before using the product, the doctor must exclude other possible risks that are associated with contraindications.
The drug can be prescribed for the treatment of severe infectious diseases only in combination with other targeted drugs in specific therapy regimens. You should stop using the medicine if you have pathologies of the digestive system, such as peptic ulcers, diverticulitis, gastritis, etc. Treatment of children with the drug is possible only after 3 years. Pregnancy and lactation are conditional contraindications, since studies of the effect of the drug on the woman’s body in such conditions have not been conducted.
pharmachologic effect
Glucocorticosteroid. The active ingredient is betamethasone . The mechanism of action is based on inhibition of the release of interleukins 1 and 2, interferon-gamma from macrophages and lymphocytes.
The drug has antiallergic, antishock, anti-inflammatory, immunosuppressive, antitoxic and desensitizing effects. Diprospan does not affect the level of circulating beta-endorphin, but suppresses the release of beta-lipotropin and ACTH from the pituitary gland .
Is Diprospan hormonal or not?
The drug is hormonal.
Side effects
Side effects when using the drug Diprospan occur when contraindications and the doctor-recommended regimen of use are violated. In this case, negative reactions can occur from various systems of the human body.
The most common side effects that occur are:
- Increased blood pressure.
- Arrhythmia.
- Headache.
- Increased sweating.
- Insomnia.
- Muscle weakness.
- Deterioration of the condition of the skin.
- Depression.
- Nervousness.
But also when taking the drug, more serious side reactions may occur that pose a threat to health. They are all given in the instructions for use of the drug. If they occur, the use of diprospan should be abandoned.
Pharmacodynamics and pharmacokinetics
The medication can inhibit the secretion of FSH and TSH. The drug Diprospan stimulates the production of erythropoietins , increases the number of red blood cells, reduces the number of eosinophils and lymphocytes, and increases the excitability of the central nervous system. When the active component interacts with specific cytoplasmic receptors, a complex is formed that is able to penetrate inside the cell, into its nucleus and stimulate the process of mRNA synthesis (it is this that induces the process of formation of lipocortin and other proteins that mediate cellular effects).
Lipocortin suppresses the process of release of arachidonic acid , inhibits phospholipase A2, suppresses the process of synthesis of leukotrienes, prostaglandins and endoperoxides, which are actively involved in inflammatory processes and in the formation of an allergic response. Under the influence of Diprospan, the amount of protein in the blood plasma decreases due to globulins, but at the same time the albumin/globulin ratio increases, the production of albumins in the tissues of the kidneys and liver increases, and protein catabolism in muscle tissue increases.
The effect of the drug Diprospan on lipid metabolism: redistribution of fat (fat deposits are localized mainly in the abdomen, face, shoulder girdle), increased synthesis of triglycerides and higher fatty acids, formation of hypercholesterolemia. The effect of the drug on carbohydrate metabolism: activation of phosphoenolpyruvate carboxylase, increased synthesis of aminotransferases (leads to activation of gluconeogenesis), increased absorption of carbohydrates from the digestive tract, increased activity of glucose-6-phosphatase (increases the flow of glucose into the blood from the liver).
The effect of the drug on water-electrolyte metabolism: stimulation of the excretion of potassium ions, retention of water and sodium ions in the body, “washing out” of calcium ions from the skeletal system, decreased absorption of calcium ions from the digestive tract, increased excretion of calcium ions by the renal system. The anti-inflammatory effect is achieved by inhibiting the release of inflammatory mediators by eosinophils; by reducing the number of mast cells (they are the ones who produce hyaluronic acid), inducing the formation of lipocortin, by stabilizing organelle membranes (lysosomal organelles are of particular importance), stabilizing cell membranes, by reducing capillary permeability.
The antiallergic effect is achieved by suppressing the secretion and synthesis of allergic mediators, inhibiting the process of antibody formation, by changing the body's immune response, reducing the sensitivity of effector cells to allergic mediators, by inhibiting the release of biologically active substances and histamine from mast cells, T-lymphocytes, B -lymphocytes.
For COPD, the drug Diprospan prevents and inhibits the development of swelling of the mucous membranes, slows down the course of inflammatory processes, slows down the deposition of circulating immune complexes in the mucous membranes of the bronchial tree, and reduces the rate of eosinophilic infiltration of the submucosal layer in the epithelia of the bronchial tree. The medication inhibits the process of desquamation and erosion of the mucous membranes. Due to the reduction in production and inhibition of mucus production, its viscosity decreases.
Antitoxic and antishock effects are achieved by increasing blood pressure through vasoconstriction, increasing the level of catecholamines circulating in the blood and restoring the sensitivity of adrenergic receptors to them. The effect is achieved through the activation of liver enzymes, which take part in the metabolism of xenobiotics and endobiotics, by reducing the permeability of vascular walls, and also due to the membrane protective effect.
The immunosuppressive effect is ensured by a decrease in the rate of release of cytokines (interferon gamma, interleukin-1,2) from macrophages and lymphocytes. The drug suppresses the secretion and synthesis of ACTH, and secondarily inhibits the process of synthesis of endogenous glucocorticosteroids. Under the influence of the medication, the likelihood of scar formation decreases due to inhibition of the speed of connective tissue reactions during inflammation. You can buy Diprospan in the form of suspensions and solution for injection.
Instructions for use
The drug is intended for intramuscular administration. It cannot be injected into a vein or subcutaneously. In this case, the injection is carried out deep into a large muscle. It is important to prevent the drug from getting into other tissues to prevent their possible atrophy. In severe conditions that require emergency measures, 2 ml of the drug is prescribed.
To the question: how often can diprospan be injected intramuscularly, the attending physician must answer in each specific case. He will also select the necessary dosage for the treatment of a particular pathology. Diprospan injections should be used based on the information provided in the instructions for use.
Uncontrolled use of a hormonal drug can lead to an overdose, which is dangerous with various negative consequences for the body. Severe vomiting, nervous agitation, and a jump in blood pressure may occur.
Reviews when the drug is prescribed correctly are always positive. Patients focus on rapid relief and elimination of painful symptoms. The affordable price of the drug is also attractive.
Diprospan ampoules should be stored at room temperature in a dark place out of reach of children. This drug has many analogues, but only a doctor should select a replacement.
Interaction
Diprospan reduces the effectiveness of anticoagulants , insulin, antihypertensive drugs, and oral hypoglycemic medications. The drug weakens the activity of vaccines and the effect of diuretics .
The use of barbiturates, phenytoin, and Rifampicin weakens the effect of the drug. The risk of side effects increases when treated with antipsychotics, estrogens, androgens, NSAIDs, immunosuppressants, ritodrine, digitalis glycosides, nitrates, tricyclic antidepressants.
Diprospan increases the severity of the hepatotoxic effects of paracetamol. Carbonic anhydrase inhibitors and Amphotericin B increase the risk of osteoporosis. The drug slows down the metabolism of Cyclosporine and increases its toxicity, enhances the metabolism of mexiletine, isoniazid, and increases the concentration of folic acid. The medication reduces the effectiveness of somatotropin .
Diprospan price, where to buy
- The price of 1 ampoule of Diprospan is about 400 rubles. You can buy the drug in Moscow for about 370 rubles.
- The price of Diprospan injections in Ukraine is 1400-1600 UAH for 5 ampoules of 1 ml.
- How much does an allergy shot cost, for example, in Kharkov? Approximately - 300 UAH. In Odessa - 330 UAH.
- Tablets of this drug are not sold.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
LuxPharma* special offer
- Diprospan amp.
No. 1 2090 rub. order
ZdravCity
- Diprospan susp. for injection 2mg+5mg/ml 1mlSchering-Plough Labo NV
RUR 438 order
Pharmacy Dialogue
- Diprospan ampoules 2mg+5mg/ml 1ml No. 1Shering-Plough
RUB 421 order
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Pharmacy24
- Diprospan 1 ml No. 5 solution Schering-Plough Labo N.V./Schering-Plough, Belgium/France
1420 UAH.order - Diprospan 1 ml No. 1 powder SENEXI HSC-EROUVILLE SAINT-CLAIR, France
297 UAH order
PaniPharmacy
- Diprospan ampoule Diprospan injection suspension ampoules 1 ml No. 5 Belgium, Schering-Plough Labo
1538 UAH. order
- Diprospan syringe Diprospan injection suspension syringe 1 ml with 2 needles No. 1 Belgium, Schering-Plough Labo
330 UAH. order
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Diprospan's analogs
Level 4 ATC code matches:
Prednisolone
Polcortolon
Dexamethasone
Cortef
Dexazone
Metipred
Cortisone
Flosteron
Depo-Medrol
Medrol
Solu-Medrol
Kenalog
Analogues in injections are:
- Betaspan Depot
- Depos
- Flosteron
Which is better: Kenalog or Diprospan?
Both drugs belong to the same pharmaceutical group of glucocorticosteroid drugs. However, based on research, Diprospan is considered a more effective remedy than Kenalog, while the price of the former is slightly higher.
