Yox 30ml spray for topical use

Compound

100 ml of topical solution contains 8.5 g of povidone-iodine and 0.1 g of allantoin . The following excipients were used: citric acid monohydrate (0.1 g), levomenthol (0.5 g), sodium citrate dihydrate (0.1 g), as well as 10 g of 96% ethanol, 15 g of propylene glycol and 50 g of purified water.
30 ml of spray contains 2.55 g of povidone-iodine and 0.03 g of allantoin . Components such as citric acid monohydrate, levomenthol, sodium citrate dihydrate, 96% ethanol, propylene glycol and purified water were also used as excipients.

Yox 30ml spray for topical use

pharmachologic effect

A drug with antimicrobial and anti-inflammatory effects for topical use in diseases of the oral cavity and in ENT practice. Releases iodine upon contact with skin. Has an antiseptic and anti-inflammatory effect. Has a wide spectrum of antimicrobial action. Active against bacteria, viruses, fungi, protozoa.

Composition and release form Yox 30ml spray for topical use

Spray - 1 ml/1 bottle:

• Active ingredients: povidone-iodine 85 mg 2.55 g, allantoin 1 mg 30 mg.
• Excipients: levomenthol - 0.3 g, citric acid monohydrate - 0.06 g, sodium citrate dihydrate - 0.06 g, ethanol 96% - 6 g, propylene glycol - 9 g, purified water - up to 30 ml.

30 ml - polyethylene bottles (1) with a mechanical sprayer, cap and applicator - cardboard packs.

30 ml - polyethylene bottles (1) with a mechanical sprayer, cap and applicator with a rotary lever - cardboard packs.

Description of the dosage form

Spray for topical use in the form of a transparent or slightly opalescent red-brown liquid, indefinitely miscible with water.

Directions for use and doses

The drug is used 2-4 times a day, one injection to the right and left into the oral cavity and pharynx. If necessary, the drug can be used more frequently, every 4 hours.

Before use, remove the protective cap and install the applicator. Press the applicator 2-3 times so that the solution enters the sprayer and sprays after pressing. After this, place the applicator tube 2-3 cm into the oral cavity, hold your breath and press the cap 2 times so that one irrigation is done to the right, and the second to the left. The applicator is washed with hot water before and after use.

Pharmacokinetics

Data on the pharmacokinetics of the drug Yox are not provided.

Indications for use Yox 30ml spray for topical use

• Infectious and inflammatory diseases of the oral cavity and pharynx, incl. tonsillitis, tonsillitis, tonsillopharyngitis, glossitis, stomatitis, aphthae;
• for treatment of the oral cavity and pharynx during surgical interventions on the respiratory tract and oral cavity and in the postoperative period;
• for the treatment of infections of the mouth and throat that occur during chemotherapy;
• for streptococcal sore throats, it is used as an additional remedy in antibiotic treatment.

Contraindications

• Thyroid dysfunction (hyperthyroidism);
• heart failure;
• Dühring's dermatitis herpetiformis;
• simultaneous use of radioactive iodine;
• children under 8 years of age;
• pregnancy;
• lactation period (breastfeeding);
• hypersensitivity to iodine and other components of the drug.

Use of Yox 30ml spray for topical use during pregnancy and breastfeeding

Contraindicated for use during pregnancy and lactation (breastfeeding).

Use in childhood

Contraindicated for use in children under 8 years of age.

special instructions

The patient should be warned about the need to stop taking the drug and consult a doctor if signs of iodism appear. This medicine is not for oral use and should not be inhaled or swallowed.

Overdose

Data on overdose of the drug Yox are not provided.

Side effects of Yox 30ml spray for topical use

In some cases: hypersensitivity reactions to the drug, local manifestations of an allergic reaction to iodine (itching, hyperemia), which may require discontinuation of the drug.

With long-term use (more than 7-10 days), phenomena of iodism are possible (including a metallic taste in the mouth, increased salivation, swelling of the eyes and larynx).

Drug interactions

The simultaneous use of Yox with other antiseptics for local use in the oral cavity and pharynx, especially those containing hydrogen peroxide, is not advisable due to inactivation of the drug.

Release form

A red-brown solution (volume 50/100 ml) is available in bottles made of dark glass with propylene caps, one in a cardboard box. To protect the integrity of the packaging, a tamper-evident control is provided, and a measuring cap is provided for ease of use.

The spray (volume - 30 ml) is available in bottles made of polyethylene terephthalate; they are equipped with mechanical sprayers and have lids to protect the sprayer. The drug is packaged in a cardboard box and equipped with an applicator with a rotary lever.

Pharmacodynamics and pharmacokinetics

Povidone-Iodine is a disinfectant that is a complex of iodine with polyvidone, a high-molecular compound that can reduce the toxic effects of iodine on the body's cells. It is characterized by a wide spectrum of antimicrobial action due to a direct effect on the proteins of microorganisms ( proteolytic properties ). It has a partially bactericidal effect on gram-positive and gram-negative cocci and bacilli , as well as on individual anaerobic bacteria, yeast , and also on protozoan viruses .

Allantoin can have an anti-inflammatory effect, which in combination with polyvidone gives a therapeutic effect.

The drug easily penetrates the epithelial of the respiratory tract mucosa and gives a quick effect in acute and chronic diseases.

Iodine in the body is converted into iodides, which are mainly accumulated in the thyroid gland. They are excreted primarily by the kidneys and in small quantities through feces, sweating and salivation.

Pharmacological properties of the drug Yox

The main active substance of the drug is povidone-iodine. This substance releases iodine upon contact with the skin or mucous membrane, which has a wide spectrum of antimicrobial action due to its direct effect on the proteins of microorganisms. The drug also contains allantoin, which has an anti-inflammatory effect. When povidone-iodine is applied topically to intact skin, iodine absorption is minimal. When used in the oral cavity, in the vagina and on damaged skin (significant burns), more pronounced systemic absorption of iodine is noted, which may result in interference with thyroid function. Iodine in the body is converted into iodides, which accumulate mainly in the thyroid gland and are excreted mainly by the kidneys, as well as in small quantities with feces, saliva, and sweat. Iodides pass through the placental barrier and enter breast milk.

Indications for use

• infectious and inflammatory processes in the oral cavity and pharynx, including tonsillitis , tonsillitis , tonsillopharyngitis , glossitis and aphthous stomatitis ;
• treatment of the oral cavity and pharynx during surgery on the airways and oral cavity, as well as in the postoperative period;
• first symptoms of flu ;
• treatment of various infections of the mouth and throat resulting from chemotherapy ;
• streptococcal tonsillitis (in combination with antibiotics ).

Use of the drug Yox

Aerosol for irrigation: remove the protective cap and put on the applicator. After this, insert the applicator 2-3 cm into the oral cavity, close your mouth, hold your breath and press the cap twice, turning the applicator so that one irrigation is directed to the right, and the second to the left. The procedure is usually repeated 2–4 times a day, if necessary, every 4 hours. The applicator is washed with hot water before and after use. To rinse, dilute the solution with water in a ratio of 1:20–1:40 (2.5–5 ml using the supplied measuring cup or 1/2 teaspoon in 100 ml of water) and rinse the mouth and throat. Rinse 2–4 times a day, possibly every 4 hours, maximum 6 times a day.

Contraindications

• dysfunction of the thyroid gland, for example hyperthyroidism ;
• decompensated heart failure ;
• renal failure;
• dermatitis (herpetiform lesions);
• simultaneous use of radioactive iodine , the interval before treatment with Yox is at least 2 weeks;
• age up to 6 years;
• pregnancy or lactation ( breastfeeding );
• hypersensitivity to the components of the drug Yox.

Side effects

Allergic reactions are possible if hypersensitivity to any of the components of the drug Yox is established, which manifest themselves in the form of itching , urticaria , dry mouth and hyperemia angioedema occurs extremely rarely . In case of these reactions, discontinuation of the drug is recommended.

Long-term use can lead to the phenomenon of iodism and the appearance of a metallic taste, increased salivation, swelling of the eyelids and larynx.

Yox overdose, symptoms and treatment

If the drug was swallowed, acute poisoning developed - a metallic taste was felt in the mouth, digestive disorders occurred - vomiting, stomach pain, diarrhea. Anuria, swelling of the glottis followed by asphyxia, aspiration pneumonia, or pulmonary edema were noted within 1–3 days. In some cases, significant circulatory disorders were noted. Treatment is symptomatic: standard measures to prevent absorption of the drug are ingestion of activated carbon and 1-5% Na-thiosulfate solution to convert iodine into iodide. Reception of milk and starch mucus is indicated. There is no specific antidote.

Instructions for use of Yox (Method and dosage)

Both the solution and the spray are used topically. It is recommended to dilute the solution with water in a ratio of 1 to 20–1 to 40, that is, 2.5 ml or 5 ml (measured with the measuring cap included in the package of the drug), or 0.5–1 teaspoon. spoons in 100 ml of water. The resulting solution should be rinsed in the mouth and pharynx 2–4 times a day; if necessary, more frequent use is permissible - up to 6 times a day with a minimum interval between rinses of 4 hours.

Instructions for using Yox spray boil down to the following algorithm:

• rinse the applicator with hot water;
• remove the cap, install the applicator, press the applicator several times so that the solution enters the sprayer and can spray after subsequent presses;
• then place the applicator tube into the oral cavity approximately 2–3 cm deep;
• holding your breath, press the irrigation cap twice, the first time on the right side, the second time on the left side of the mouth.

The spray is usually used 2-4 times a day. For more frequent use, the interval should be at least 4 hours.

The duration of treatment should be determined by the attending physician depending on the nature of the disease.

Yox 30 ml spray

Instructions for medical use of the drug YOX Trade name of the drug YOX International nonproprietary name No Dosage form Spray Composition 30 ml of solution contains active substances: povidone iodine 0.085 g, allantoin 0.001 g, excipients: levomenthol, citric acid monohydrate, sodium citrate dihydrate, ethyl alcohol 96%, propylene glycol, purified water. Description Transparent, slightly opalescent liquid of red-brown color, unlimitedly miscible with water. Pharmacotherapeutic group Drugs for the treatment of throat diseases. Antiseptics. ATC code R02AA Pharmacological properties Pharmacokinetics When polyvidone-iodine is applied topically to intact skin and mucous membranes, iodine absorption is minimal. Iodine in the body is converted into iodides, which accumulate mainly in the thyroid gland. Iodides that were not captured by the thyroid gland are excreted mainly from urine, a small amount - with feces, saliva, sweat. They pass through the placental barrier and penetrate into mother's milk. Pharmacodynamics Povido-iodine, upon contact with the skin and mucosal membranes, releases organic iodine, which has a wide spectrum of antimicrobial action against bacteria, fungi, viruses, and protozoa. The drug also contains allantoin, which has an anti-inflammatory effect. Indications for use - sore throats, pharyngitis, tonsillopharyngitis, tonsillitis, glossitis, aphthous stomatitis - when preparing a patient for surgery and in the postoperative period on the respiratory tract and oral cavity - for the treatment of oral infections arising during chemotherapy - for streptococcal sore throats it is used as an additional treatment when treated with antibiotics - for influenza conditions during the prodrome. Directions for use and dosage: Adults and children over 8 years of age. Remove the protective cap and install the applicator. Press the applicator 2-3 times so that the solution enters the sprayer and sprays after pressing. After this, place the applicator tube 2-3 cm into the oral cavity, hold your breath and press the cap 1-3 times so that one irrigation is carried out to the right, and the second to the left. It is recommended to use Yox spray 2-4 times a day, one spray to the right and left of the mouth and pharynx. The interval between individual applications of the drug should be at least 4 hours. If necessary, the drug can be used more often. Do not inhale or swallow the sprayed product! The drug can be used a maximum of 6 times per day, the course of treatment is 5-7 days. The applicator is washed with hot water before and after use. Side effects - an allergic reaction to iodine (itching, hyperemia, urticaria) - rarely: at the site of application, a burning sensation or a feeling of dryness in the mouth - the phenomenon of iodism (with long-term use): metallic taste, increased salivation, swelling of the eyes or larynx, pulmonary edema , skin rashes and gastrointestinal disorders. Contraindications - hypersensitivity to iodine or other components of the drug - hyperfunction of the thyroid gland - decompensated heart failure - pregnancy and lactation - children under 8 years of age - simultaneous use of radioactive iodine - Dühring's dermatitis herpetiformis Drug interactions It is not advisable to use the drug Yox simultaneously with other antiseptics, intended for local use in the oral cavity and pharynx. Special instructions For laryngitis, use the drug only in case of urgent need. The drug is used with caution in patients with liver failure or renal failure, since in such patients the level of transaminases may increase, so monitoring of transaminase levels in the blood plasma is necessary. The drug contains 18.6% ethanol. Features of the drug's influence on the ability to drive vehicles and potentially dangerous mechanisms Does not affect Overdose Symptoms: metallic taste in the mouth, vomiting, pain in the stomach and diarrhea. Within 1-2 days, anuria, swelling of the glottis may occur, leading to asphyxia, aspiration pneumonia or pulmonary edema. In some cases, vascular insufficiency may develop. Treatment: carry out symptomatic therapy. There is no specific antidote. Release form and packaging Spray. 30 ml of the drug in a plastic bottle equipped with a mechanical sprayer and a cap to protect the sprayer. Each bottle, along with an applicator and instructions for medical use in the state and Russian languages, is placed in a cardboard pack. Storage conditions Store at temperatures from 10 0C to 25 0C. Keep out of the reach of children! Shelf life 4 years Do not use the drug after the expiration date indicated on the package Dispensing conditions Without a prescription, Ostravska 29, 74779 Opava-Komarov, Czech Republic Registration certificate holder "Teva Czech Enterprises s.r.o.", Czech Republic Address of the receiving organization on the territory of the Republic of Kazakhstan, claims from consumers regarding the quality of products (products) Representative office in the Republic of Kazakhstan 050000 Republic of Kazakhstan Almaty, Al-Farabi Avenue 13, Nurly Tau Business Center 1b, office 305, 306 Telephone, fax; 311-10-68 Director of the Pharmacological Center Kuzdenbaeva R.S. Scientific secretary Mirmanov R.K. Expert Head of Representative Office Sabirov M.K.

Interaction

It is not advisable to use with antiseptics containing hydrogen peroxide , since there is a high probability of inactivation of the active substances.

Concomitant use with lithium causes an additional hypothyroid effect .

It is not advisable to use with chlorheximide , silver sulfadiazine , alkaloid salts and mercury .

Iodine is not compatible with:

• iron salts;
• bismuth;
• copper;
• lead;
• potassium chlorate and other oxidizing agents;
• mineral acids;
• strychnine hydrochloride ;
• quinine sulfate and other alkaloid salts.

special instructions

The drug should not be taken orally, including inhaled or swallowed, as it causes nausea , vomiting , diarrhea of acute poisoning is possible .

When applied topically to entire integuments, iodine absorption is minimal, while the use of Yox spray in the oral cavity leads to more pronounced and systemic absorption of iodine, as a result of which interference with thyroid functions may occur.

Contains approximately 18.6% ethanol .

Special instructions for the use of the drug Yox

The drug contains ethanol and is not intended for oral administration. Use with caution in patients with liver failure due to possible changes in the level of transaminases in the blood serum (laboratory monitoring of their content is required). For laryngitis, the drug is used in exceptional cases. If within 3 days the patient’s general condition does not improve or adverse reactions or unusual sensations are observed, a second consultation with a doctor is necessary. The use of the drug does not affect the ability to drive vehicles and machinery.

Analogs

Level 4 ATX code matches:
Falimint

Suprima-ENT

Ingalipt-N

Strepsils Plus

Strepsils

Ingalipt

TheraFlu LAR

Hexoral Tabs

Lisak

Efizol

Angilex

Kameton

Anzibel

Agisept

Lugol's solution with glycerin

Lugol

Laripront

Stopangin 2A

Stopangin

Septolete Neo

• Agisept;
• Aqua Maris;
• Angilex-Health.

Reviews about Yox

The drug is popular today, many note its effectiveness and always keep it in their home medicine cabinet.

Patients leave positive reviews about Yox, pointing out the convenience and ease of use of the aerosol and the speed of onset of the therapeutic effect (within 24 hours). Of course, there are patients who prefer traditional rinses, where Yox, thanks to its active substances, is effective in various inflammatory and infectious processes of the oral cavity and larynx.

You can find a few negative reviews about the drug associated with adverse allergic reactions: itching, burning, lacrimation.

Yox price, where to buy

The price of Yox spray (30 ml) is 265-325 rubles, solution (50 ml) – 165-205 rubles.

• Online pharmacies in RussiaRussia
• Online pharmacies in UkraineUkraine
• Online pharmacies in KazakhstanKazakhstan

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