Nosological classification (ICD-10)
- A60 Anogenital herpetic viral infection [herpes simplex]
- A63.0 Anogenital (venereal) warts
- B00 Infections caused by herpes simplex virus
- B02 Herpes zoster
- B25.9 Cytomegalovirus disease, unspecified
- B37.3 Candidiasis of the vulva and vagina (N77.1*)
- B97.7 Papillomaviruses
- L29.2 Itching of the vulva
- L29.3 Anogenital itching, unspecified
- N76 Other inflammatory diseases of the vagina and vulva
Reviews about Epigen
Reviews of Epigen Intim spray characterize the pharmaceutical drug on the positive side. Patients with various infectious diseases of viral etiology recommend the drug on thematic forums and Internet resources, because the spray allows you to eliminate the pathological focus of the nosological unit and normalize the functioning of the genital organs and skin. For thrush, the medicine allows you not only to get rid of unpleasant discomfort and odor, but also to avoid this problem in the future, since the intimate gel effectively prevents this disease.
The anti-condylomas spray, in combination with surgical treatment, completely neutralizes the human papillomavirus, which ensures rapid healing of the skin defect and the fight against further relapses. The spray for HPV activates the humoral and cellular immunity, allowing you to further recognize the structure of the pathological agent and eliminate possible re-infection.
The pharmaceutical drug also helps with bacterial and nonspecific inflammatory diseases of the genital organs. An intimate spray allows you to maintain a physiological level of acidity, providing a feeling of cleanliness and freshness. Thanks to the drug Epigen intimate, the genital area of both partners is protected from unpleasant consequences in the form of irritation, redness or other natural reactions.
Reviews from doctors are based primarily on the pharmacological effects and duration of the course of conservative therapy. Both indicators of a drug in the form of a spray allow us to give professional and qualified preference, based on reliable clinical studies, to this drug. On thematic resources, some medical professionals even openly admit about the independent use of Epigen Intim, which cannot but tip the scales in favor of the medicinal spray.
Separately, it should be noted reviews of Epigen Intim gel, which is often used incorrectly. The cream is designed to keep the genitals clean during daily intimate hygiene, unlike a spray. Of course, both pharmaceutical forms of the drug are based on licorice root extract, but the gel has a milder effect. The absence of soap and some other auxiliary components allows the gel to be used exclusively for cosmetic purposes.
This dosage form receives good recommendations from women who are carrying a child. Gel during pregnancy allows you to avoid a large number of aesthetic consequences of this physiological process, caused by changes in hormonal levels and some other features of the female body. The chemical formula of Epigen cream is specially designed for daily care, which in practice is manifested by the absence of dryness and various types of irritation after its use.
The price of the intimate gel is indicated below, but it is worth noting that among hygiene products it is the best, because it contains a plant with therapeutic properties. Licorice root has long been used for medicinal and cosmetic purposes, which creates a certain level of trust in this pharmaceutical drug, which is why women tend to choose an experienced method of daily intimate hygiene.
Pharmacodynamics
The active ingredient of Epigen Intim is activated glycyrrhizic acid, obtained by extraction from plant materials (licorice root).
Activated glycyrrhizic acid has a complex effect, including immunostimulating, antiviral, anti-inflammatory, antipruritic and regenerating.
Activated glycyrrhizic acid induces the production of its own interferons.
The immunostimulating effect is manifested by an increase in the number and activity of T-lymphocytes, a decrease in the concentration of IgG and an increase in the concentration of IgA and IgM.
Activated glycyrrhizic acid has an antiviral effect on various types of DNA and RNA viruses in vitro and in vivo (Varicella zoster; herpes simplex virus types 1 and 2; CMV, various types of human papillomavirus, including oncogenic ones). Activated glycyrrhizic acid interrupts the replication of viruses in the early stages, causes the virion to exit the capsid, thereby preventing its penetration into cells. Activated glycyrrhizic acid inactivates these viruses in concentrations that are non-toxic for normally functioning cells. Mutant strains of viruses resistant to acyclovir and iodouridine are also highly sensitive to glycyrrhizic acid, like non-mutant strains.
The anti-inflammatory activity of activated glycyrrhizic acid is combined with a stimulating effect on humoral and cellular immunity factors. Activated glycyrrhizic acid significantly inhibits the release of kinins and the synthesis of PG by connective tissue cells in the area of inflammation. The regenerating effect is due to improved repair of the skin and mucous membranes.
Release form
- Epigen intimate spray is presented in the form of a medicinal solution from light yellow to light brown in color, which has a characteristic odor. In pharmacy kiosks, the pharmaceutical drug can be found in 15 or 60 ml spray bottles with a nozzle for vaginal administration and an annotation.
- Epigen Intim gel (sometimes called cream in pharmacy kiosks or on thematic resources) with a concentration of the active component of 0.1%. Sold in a 250 ml container with a special dispenser for rational use.
- Epigen Labial is a cream for external local use (used primarily as a lip cream). A plastic tube with a medicine in an amount of 5 g or a sachet (a bag or pad with dry flavorings) weighing 2.5 g is placed in a cardboard package.
Indications for Epigen Intim
treatment of a viral infection caused by the human papillomavirus, incl. asymptomatic isolation of human papillomavirus of high oncogenic risk, as part of combination and complex therapy;
treatment of a viral infection caused by herpes simplex virus types 1 and 2 as part of complex therapy;
treatment of a viral infection caused by the Varicella Zoster virus (shingles) as part of complex therapy;
treatment of viral infection caused by cytomegalovirus as part of complex therapy;
prevention of relapses of viral infections caused by herpes simplex virus types 1 and 2, Varicella Zoster virus, human papillomavirus, cytomegalovirus;
prevention and treatment of genital warts and cervical pathology caused by human papillomavirus, cytomegalovirus;
prevention and treatment of conditions accompanied by a decrease in local immunity, incl. nonspecific vulvovaginitis, candidal vulvovaginitis and bacterial vaginosis, as part of complex therapy;
phenomena of discomfort in the genital area, accompanied by itching, burning and dryness, incl. after sexual intercourse;
phenomena of discomfort in the genital area, accompanied by itching, burning and dryness of the mucous membranes, with insufficient ovarian function.
Epigen analogs
Level 4 ATX code matches:
Aldara
Viru-Merz Serol
Zovirax Duo-Active
Acyclovir
Fenistil Pencivir
Bonafton
Zovirax
Atsik
Alpizarin
Herpferon
Lysozyme
Gerpevir
Kondilin
Virolex
Gevisosh
Analogs of Epigen Intim spray are presented in various pharmaceutical forms from tablets for oral use to granules for preparing a medicinal solution. If there are contraindications to Epigen spray, Glyciram , Glycyrrhizic acid or Epigen Labial are prescribed. The price of analogues of the Epigen intimate spray at licensed points of sale is, as a rule, lower, but the effectiveness of such therapeutic agents is relative, because they realize their beneficial properties indirectly, unlike a spray that acts directly on the pathological focus of the disease.
Epigen intimate gel also has its analogues on the pharmaceutical market, but the proven therapeutic properties of the licorice root extract and effects such as normalizing acidity and maintaining the physiological level of microflora of the genital organs predispose you to choose Epigen gel.
Directions for use and doses
Externally, intravaginally, intraurethrally.
Shake the container before use. When using, keep the container in an upright position. For external use, the drug is applied to the entire affected surface of the skin from a distance of 4–5 cm with 1–2 valve presses, which is the optimal therapeutic dose.
For intravaginal use of the drug, a special nozzle with a sprayer is included. Remove the valve from the spray bottle and put on the nozzle valve. Then insert the nozzle into the vagina and inject using 1-2 presses of the nozzle, which is the optimal therapeutic dose.
When used by men, in addition to external application, the drug is injected into the external opening of the urethra with 1-2 presses of the spray valve.
For herpesvirus infection type 1, herpes zoster, the drug is recommended to be used 6 times a day, on the affected area, for 5 days. If the infectious process persists, the treatment period is extended until the symptoms of the disease completely disappear.
For herpesvirus infection type 2 (genital herpes), CMV infection is recommended to be used 5 times a day for 14 days externally and intravaginally, after stopping the relapse - externally and intravaginally 3 times a day for 10 days.
In order to prevent relapses of genital herpes and CMV infection, the drug is recommended to be used externally and intravaginally from the 18th to 20th day of the menstrual cycle until the end of menstruation, 2 times a day, morning and evening.
For human papillomavirus infection, the drug is recommended to be used:
- before removal of condylomas - 3 times a day during the entire period of etiotropic therapy;
- against the background of destruction - 5 times a day for 10 days or more until complete healing;
- for the prevention of immediate relapses 3 times a day for 1 month.
To prevent the progression of human papillomavirus infection, it is recommended to use it before and after sexual intercourse, as well as in the event of provoking factors (stress, fatigue, respiratory viral infections, microflora disturbances, taking antibiotics, cytostatics) - 3 times a day intravaginally and externally during the entire period of exposure to provoking agents. factors.
For bacterial vaginosis, nonspecific vulvovaginitis and vulvovaginal candidiasis, the drug is recommended to be used intravaginally 3-4 times a day for 7-10 days. If necessary, repeat the course of treatment after 10 days. If provoking factors occur (respiratory viral infections, taking antibiotics, cytostatics) - 3 times a day intravaginally and externally during the entire period of exposure to provoking factors.
For symptoms of discomfort in the genital area, accompanied by itching, burning and dryness of the mucous membranes - 2 times a day (morning and evening) for 2-3 weeks. To prevent discomfort, use regularly after sexual intercourse.
As a prophylactic antiviral agent, the drug is recommended to be used before and after sexual intercourse.
Compound
100 ml spray for topical use contains:
- glycyrrhizic acid – 0.1 g (the amount of the active component is equivalent to ammonium glycyrrhizinate);
- malic acid;
- fumaric acid;
- ascorbic acid;
- folic acid;
- propylene glycol;
- Tween 80 (polysorbate 80);
- purified water.
Composition of Epigen Labial (corresponds to gel for external use):
- ammonium glycyrrhizinate – 100 mg per 100 ml (active component concentration – 0.1%);
- Apple acid;
- fumaric acid;
- ascorbic acid;
- Polavax GP 200 (cetearyl alcohol-Peg-20 stearate);
- phenonip;
- butylated hydroxytoluene;
- flavor 195 AG;
- distilled water.
special instructions
The nozzle is washed with boiled water and soap and stored in the supplied PE packaging.
The design of the nozzle allows you to maintain the effect of uniform irrigation of the cervix and vaginal walls.
For use in a hospital setting, intravaginal irrigation with the drug in speculums can be performed without a nozzle.
To be effective, no prior rinsing of the application area is required.
If signs of intolerance appear, stop using the drug.
Interaction
Glycyrrhizic acid has synergistic pharmacological effects with other pharmaceutical antiviral drugs , in particular with derivatives of Acyclovir , Iodouridine , Interferon and some immunomodulators.
Drug interactions with basic medications used to treat these pathological conditions and nosological units (for example, antibiotics , antiseptics or painkillers) were not identified during clinical studies.
