Buy Codelac Broncho elixir with thyme 100ml in pharmacies

Dosage forms and composition

The drug is produced in two forms for oral administration:

• tablets: yellowish in color with visible small inclusions, flat-cylindrical, have a separating score, packaged in foil plates of 10 pieces, the package contains 1 or 2 blisters;
• liquid elixir with thyme: light brown syrup with a characteristic balsamic aroma, in glass bottles with screw caps from 50 to 200 ml, cardboard packaging equipped with a measuring spoon.

Codelac Broncho is a combination drug. It contains several active substances:

• ambroxol: 200 mg in tablets and 100 mg in syrup;
• extracted thermopsis: 100 mg;
• sodium glycyrrhizinate: 300 mg;
• in tablets - sodium bicarbonate: 200 mg;
• in syrup - extracted thyme: 500 mg.

Auxiliary compounds of tablets: starch, MCC, stearic acid, talc and others. The elixir also contains sorbitol, distilled water, napazole and nipagin. When storing in liquid medicine, slight sedimentation may occur. This does not affect the therapeutic properties.

Compound

What kind of cough do Codelac Broncho tablets and elixir help with?

The effect of both dosage forms of the drug is similar. These are mucolytics with a moderate anti-inflammatory effect. Designed to liquefy mucous secretions, improve the passage of accumulated clots from the bronchi and lungs. Increases cough productivity and helps cleanse the respiratory system.

Ambroxol in combination with thermopsis extract reduces the viscosity of mucus, stimulating its elimination. Sodium bicarbonate improves the motility of bronchioles and epithelial villi on the walls of the bronchi. Glycyrrhizinate has an antimicrobial effect and neutralizes the damaging effects of oxidation products. Thyme complements the activity of other components of the elixir, helps to expectorate mucus more easily, helps relieve microspasms and makes breathing easier.

Positive dynamics are usually observed from the second day of therapy. The effect of the medicine increases gradually: the cough becomes less intrusive, the mucus leaves in a larger volume, and relief comes faster.

Pharmacodynamics

A combined drug for the treatment of cough, it has a mucolytic and expectorant effect, and also has anti-inflammatory activity. The effect of the Codelac® Broncho elixir with thyme is due to the pharmacological properties of its components.

Ambroxol has a secretomotor, secretolytic and expectorant effect, normalizes the disturbed ratio of serous and mucous components of sputum, and increases the secretion of surfactant in the alveoli. Reduces the viscosity of sputum and promotes its removal.

Glycyrrhat (glycyrrhizic acid and its salts) has anti-inflammatory and antiviral effects. It has a cytoprotective effect due to its antioxidant and membrane-stabilizing activity. Potentiates the effect of endogenous corticosteroids, providing anti-inflammatory and antiallergic effects. Due to its pronounced anti-inflammatory activity, it helps reduce the inflammatory process in the respiratory tract.

Thyme herb extract contains a mixture of essential oils that have an expectorant and anti-inflammatory effect. In addition, thyme herb extract has weak antispasmodic and reparative properties.

When to take Codelac Broncho

The drug is taken when signs of respiratory inflammation or symptoms of exacerbation of chronic conditions develop. It is recommended to start the course of treatment from the first minutes of discomfort: sore throat, hoarseness and coughing.

General indications:

• accumulation of sputum in acute and chronic forms of bronchitis;
• chronic pulmonary obstruction;
• bronchiectasis;
• viral or bacterial pneumonia;
• signs of ARVI, accompanied by cough.

How to take Codelac Broncho elixir

The liquid preparation is approved for children from 2 years of age. It should also be drunk with food: 3-4 times a day. If necessary, wash down the product with warm water. For kids, you can first dilute the mixture in some familiar drink.

Recommended doses:

• children 2–6 years old: 1–1.5 tsp. twice or thrice a day;
• from 7 to 12 years: 1–1.5 tbsp. l. 2–4 times depending on the intensity of the disease;
• adolescents over 12 years of age and adults: 2–2.5 tbsp. l. 3–4 times a day.

The maximum treatment time without additional medical supervision is 5 days.

Elixir Codelac Broncho with thyme: instructions for use

Where can I buy

Registration number: LSR-006772/09

Trade name: CODELAC® BRONCHO WITH THYME

Dosage form : elixir

Composition per 5 ml of elixir:

Active ingredients:

• ambroxol hydrochloride – 10 mg,
• sodium glycyrrhizinate (trisodium salt of glycyrrhizic acid) – 30 mg,
• creeping thyme herb extract (thyme liquid extract) – 500 mg.

Excipients:

• methyl parahydroxybenzoate – 3.75 mg,
• propyl parahydroxybenzoate – 1.25 mg,
• sorbitol (sorbitol) – 3000 mg,
• purified water - up to 5 ml.

Description: transparent liquid from light brown to brown. During storage, sediment may form.

Pharmacotherapeutic group: combined expectorant.

ATX code : [R05CA10]

Pharmacological properties

Pharmacodynamics

A combined drug for the treatment of cough, it has a mucolytic and expectorant effect, and also has anti-inflammatory activity. The effect of the elixir CODELAC® BRONCHO WITH THYME is due to the pharmacological properties of its components:

• Ambroxol has a secretomotor, secretolytic and expectorant effect, normalizes the disturbed ratio of serous and mucous components of sputum, and increases the secretion of surfactant in the alveoli. Reduces the viscosity of sputum and promotes its removal. On average, when taken orally, the effect of ambroxol occurs within 30 minutes, the duration of action is 6–12 hours, depending on the dose taken.
• Sodium glycyrrhizinate (trisodium salt of glycyrrhizic acid) has anti-inflammatory and antiviral effects. It has a cytoprotective effect due to its antioxidant and membrane-stabilizing activity. Enhances the effect of endogenous glucocorticosteroids, providing anti-inflammatory and antiallergic effects. Due to its pronounced anti-inflammatory activity, it helps reduce the inflammatory process in the respiratory tract.
• Creeping thyme (thyme) herb extract contains a complex of biologically active substances that have expectorant, anti-inflammatory, and antimicrobial effects. In addition, the extract of the herb creeping thyme (thyme) has weak antispasmodic and reparative properties.

Pharmacokinetics

Ambroxol

After oral administration, ambroxol is quickly and almost completely absorbed from the gastrointestinal tract. The maximum concentration (Cmax) in blood plasma after oral administration is reached after 1–3 hours. The volume of distribution is 552 l. In the therapeutic concentration range, binding to plasma proteins is 80-90%. The highest concentrations of the active component of the drug are observed in the lungs. Ambroxol penetrates the placental and blood-brain barriers and is excreted in breast milk. Approximately 30% of an oral dose is subject to first pass effects through the liver. Studies on human liver microsomes have shown that CYP3A4 is the predominant isoform responsible for the metabolism of ambroxol to dibromoantranilic acid. The remainder of ambroxol is metabolized in the liver by conjugation to form pharmacologically inactive metabolites. The terminal half-life (T1/2) of ambroxol from blood plasma is 10 hours. The total half-life of ambroxol and its metabolites is about 22 hours. Excreted by the kidneys: 90% in the form of metabolites, 10% unchanged. No clinically significant effect of age and gender on the pharmacokinetics of ambroxol was found, so there is no basis for selecting the dosage based on these characteristics.

Sodium glycyrrhizinate (trisodium salt of glycyrrhizic acid)

After oral administration, in the intestine, under the influence of the enzyme β-glucuronidase, produced by bacteria of normal microflora, the active metabolite β-glycyrrhetic acid is formed from glycyrrhizic acid, which is absorbed into the systemic circulation. In the blood, β-glycyrrhetic acid binds to albumin and is almost completely transported to the liver. The excretion of β-glycyrrhetic acid occurs predominantly in bile, with residual amounts in urine.

Creeping thyme herb extract (thyme)

The effect of the drug is the result of the combined action of the active substances of the creeping thyme herb extract (thyme), so pharmacokinetic studies are not possible; Collectively, the components cannot be traced using markers or bioassays.

Indications for use

Diseases of the respiratory tract with the formation of viscous sputum:

• acute and chronic bronchitis,
• pneumonia,
• chronic obstructive pulmonary disease (COPD),
• bronchiectasis.

Contraindications

Hypersensitivity to the components of the drug, children under 2 years of age, pregnancy, breastfeeding.

Carefully

For liver and/or kidney failure, gastric and duodenal ulcers, bronchial asthma, diabetes mellitus. For liver diseases, alcoholism, traumatic brain injury, brain diseases, children over 2 years of age.

Use during pregnancy and breastfeeding

The use of ELIXIR KODELAK® BRONCHO WITH THYME is contraindicated during pregnancy. If it is necessary to take the drug during breastfeeding, breastfeeding should be discontinued.

Directions for use and doses

Inside, during meals, with a small amount of water.

• adults and children over 12 years old: 10 ml 4 times a day;
• children from 2 to 6 years old are prescribed 2.5 ml of elixir 3 times a day;
• children from 6 to 12 years old: 5 ml 3 times a day.

The maximum duration of treatment without consulting a doctor is 5 days.

If there is no improvement during treatment, or symptoms worsen, or new symptoms appear, you should consult your doctor.

Use the drug only according to the indications, method of administration and in the doses indicated in the instructions.

Side effect

Allergic reactions. Rarely - weakness, headache, diarrhea, dry mouth and respiratory tract, exanthema, rhinorrhea, constipation, dysuria. With long-term use in high doses - gastralgia, nausea, vomiting.

If you experience the side effects indicated in the instructions, or they get worse, or you notice any other side effects not listed in the instructions. Tell your doctor about this.

Overdose

Symptoms: nausea, vomiting, diarrhea, dyspepsia.

Treatment: artificial vomiting, gastric lavage in the first 1-2 hours after taking the drug.

Interaction with other drugs

Combined use with antitussive drugs leads to difficulty in sputum discharge.

special instructions

Do not combine with antitussives. Patients with diabetes can use the drug, taking into account the sorbitol content in the amount of 0.18 XE per 5 ml of elixir.

The content of absolute ethyl alcohol in the maximum single dose of the drug is 0.24 grams, in the maximum daily dose of the drug – 0.96 grams.

Impact on the ability to drive vehicles and machinery

During the period of use of the drug, care must be taken when performing potentially hazardous activities that require increased concentration and speed of psychomotor reactions (driving vehicles, working with moving mechanisms, working as a dispatcher, operator).

Release form

Elixir. 50, 100, 125 and 200 ml in dark glass bottles. One bottle with instructions for use and a measuring spoon is placed in a cardboard pack.

Storage conditions

At a temperature not higher than 25 °C. Keep out of the reach of children.

Best before date

3 years. Do not use after the expiration date.

Vacation conditions

Available without a prescription.

Marketing authorization holder/organization receiving consumer complaints:

PJSC OTCPharm, Russia, 123317, Moscow, st. Testovskaya, 10

Tel.

Fax

www.otcpharm.ru

, 305022, Russia, Kursk, st. 2nd Aggregatnaya, 1a/18, tel./fax, www.pharmstd.ru

Side effects

During treatment, the following are rarely possible:

• the appearance of physical weakness, dizziness;
• dryness, unpleasant taste in the mouth, loss of appetite;
• abdominal cramps, stool upset, constipation;
• irritation of the mucous membrane of the nasopharynx, trachea;
• the appearance of a runny nose.

After taking large doses, intoxication may occur. Possible vomiting, severe abdominal pain, diarrhea. In such cases, it is necessary to lavage the stomach and take enterosorbents.

Contraindications

The drug in tablets is prohibited for use by children under 12 years of age. Elixir - for infants and children up to 2 years old. Contraindications also include:

• pregnancy, breastfeeding period;
• individual intolerance to the active or auxiliary components of the drug;
• period of exacerbation of stomach ulcers, duodenal ulcers, and some forms of gastritis;
• diseases with a high risk of internal bleeding;
• severe renal failure or liver dysfunction.

Patients with diabetes should be careful when treating with the elixir, as it contains the carbohydrate sorbitol. Those suffering from bronchial asthma, chronic liver and kidney diseases also need to monitor their well-being while using the drug.