Pharmacological properties of the drug Coldact flu plus
Combined drug with prolonged action. Chlorphenamine maleate is an H1 receptor blocker. Helps reduce vascular permeability of the mucous membrane of the upper respiratory tract, eliminates lacrimation and rhinorrhea. Paracetamol has analgesic, antipyretic and anti-inflammatory effects. Phenylephrine hydrochloride reduces the severity of hyperemia and swelling of the mucous membrane of the upper respiratory tract and paranasal sinuses. Chlorphenamine after oral administration is slowly absorbed from the digestive tract, the maximum concentration in the blood plasma is reached within 2.5–6 hours, the degree of absorption is about 80%. The level of binding to blood plasma proteins is 45%. It is largely metabolized in the body. It is excreted mainly in the urine, the half-life is 30 hours. Phenylephrine is easily absorbed after oral administration, the maximum concentration in the blood plasma is reached after 1–2 hours; the degree of absorption is 70%, the average half-life is 2–3 hours. Phenylephrine is largely metabolized in the body and is excreted mainly in the urine. Paracetamol is quickly and almost completely (95%) absorbed after oral administration, the maximum concentration in the blood plasma is reached after 15 minutes–2 hours. Bioavailability - 80%, binding to plasma proteins - 20%, half-life - 2-3 hours. Paracetamol metabolized in the body and excreted primarily in the urine.
Coldact Flu + extended-release capsules No. 10
A country
India
Country of manufacture may vary depending on the batch of goods. Please check with the operator for detailed information when confirming your order.
Active substance
Paracetamol + Chlorpheniramine + Phenylephrine
pharmachologic effect
Combined drug with prolonged action. Chlorphenamine has an antiallergic effect, eliminates lacrimation, itching in the eyes and nose. Paracetamol has an antipyretic and analgesic effect: reduces the pain syndrome observed during colds - sore throat, headache, muscle and joint pain, reduces high temperature. Phenylephrine has a vasoconstrictor effect - reduces swelling and hyperemia of the mucous membranes of the upper respiratory tract and paranasal sinuses .
Indications for use
- symptomatic treatment of colds, flu, acute respiratory viral infections (fever, pain, rhinorrhea).
Mode of application
Adults and children over 12 years old - 1 capsule every 12 hours for 3-5 days. Duration of use as an antipyretic - no more than 3 days; as a pain reliever - no more than 5 days. Coldact Flu Plus capsules are not recommended for use during pregnancy and lactation. Contraindicated in children under 12 years of age.
Interaction
The risk of developing hematotoxic effects of paracetamol increases with simultaneous use of barbiturates, diphenine, carbamazepine, rifampicin, zidovudine and other inducers of microsomal liver enzymes. Enhances the effects of sedative drugs, ethanol, MAO inhibitors. Antidepressants, phenothiazine derivatives, antiparkinsonian and antipsychotic drugs increase the risk of developing urinary retention, dry mouth, and constipation. GCS increase the risk of developing glaucoma. Paracetamol reduces the effectiveness of uricosuric drugs. Chlorphenamine combined with furazolidone can lead to hypertensive crisis, agitation, and hyperrexia. Tricyclic antidepressants enhance the adrenomimetic effect of phenylephrine; simultaneous administration of halothane increases the risk of developing ventricular arrhythmia. Reduces the hypotensive effect of guanethidine, which in turn enhances the alpha-adrenergic stimulating activity of phenylephrine.
Side effect
Increased blood pressure, tachycardia, drowsiness, difficulty falling asleep, dizziness, increased excitability, dry mucous membranes, mydriasis, accommodation paresis, increased intraocular pressure, loss of appetite, nausea, epigastric pain, anemia. Very rare: urinary retention, allergic reactions (skin rash, itching, urticaria, angioedema). Rarely: anemia, thrombocytopenia, leukemia, agranulocytosis. With long-term use in high doses, hepatotoxic and nephrotic effects are possible.
Contraindications
- hypersensitivity to any of the components included in the composition; - severe atherosclerosis of the coronary arteries; - arterial hypertension; - diabetes mellitus; - thyrotoxicosis; - angle-closure glaucoma; - severe diseases of the liver, kidneys, heart, bladder; - peptic ulcer of the stomach and duodenum intestines; - diseases of the pancreas; - difficulty urinating with prostate adenoma; - diseases of the blood system; - deficiency of glucose-6-phosphate dehydrogenase; - children under 12 years of age. With caution: congenital hyperbilirubinemia (Gilbert, Dubin-Johnson and Rotor syndromes) , bronchial asthma and chronic obstructive pulmonary disease.
Overdose
Symptoms caused by paracetamol appear after taking more than 10-15 g: pallor of the skin, decreased appetite, nausea, vomiting, hepatonecrosis, increased activity of liver transaminases, increased prothrombin time. Treatment: gastric lavage in the first 6 hours, administration of SH-group donors and precursors for the synthesis of glutathione-methionine 8-9 hours after an overdose and N-acetylcysteine after 12 hours. In case of accidental overdose, you should immediately consult a doctor, regardless of whether any symptoms of overdose are noted or not.
special instructions
Without a doctor's instructions, the drug should not be used by patients undergoing treatment with other medications, in particular MAO inhibitors. If, despite taking the drug, the disease is accompanied by ongoing fever or repeated increases in temperature are observed, you should consult a doctor. Do not take with alcohol or combine with other drugs containing paracetamol. When using Coldact Flu Plus, it is undesirable to use sleeping pills, tranquilizers and other psychotropic drugs. It distorts laboratory test results in the quantitative determination of glucose and uric acid in plasma. In case of long-term treatment, peripheral blood parameters and the functional state of the liver are monitored. Impact on the ability to drive vehicles and operate machinery During the treatment period, it is necessary to refrain from driving vehicles and engaging in potentially hazardous activities that require increased concentration and speed of psychomotor reactions.
Side effects
Doesn't happen often:
- drowsiness, headache, overexcitation and excessive irritability;
- hepa- and nephrotoxic effects;
- dry mouth, diarrhea, nausea, loss of appetite;
- increased blood pressure , vision problems;
- chest pain, dysuria ;
- pain in the epigastric region , loss of appetite.
Instructions for Koldakt (Method and dosage)
The duration of administration and dosage should be prescribed by a doctor.
According to the instructions for use of Koldakt, adults are prescribed 2 capsules per day, divided into 2 doses.
The course of treatment is from 1-3 ( flu, ARVI ) to 30 days.
Instructions for use Coldact Flu Plus
According to the instructions for Coldact Flu Plus, two capsules are prescribed per day, at regular intervals.
The syrup should be shaken well before use.
Adults are prescribed 30-40 ml per day, in 3-4 doses. Children from six years old – 15-20 ml, in 3-4 doses.
The course of treatment, as a rule, is no more than five days.
Composition of Koldakt
The composition of the drug Koldakt includes the active ingredients phenylpropanolamine hydrochloride - 0.5 g + chlorpheniramine maleate - 0.08 g and additional substances that make up the gelatin shell.
Coldact Flu Plus contains capsules of active ingredients: paracetamol – 0.2 g; chlorphenamine maleate – 8 mg; phenylephrine hydrochloride – 25 mg and excipients ( hypromellose, MCC, talc, ethylcellulose, povidone, diethyl phthalate, isopropanol, dyes, sucrose, water, sodium disulfite, starch syrup, disodium edetate, granulated sugar ).
Flu Plus suspension contains active ingredients: chlorphenamine maleate – 2 mg; paracetamol – 0.125 g; phenylephrine hydrochloride - 5 mg + sodium carmellose, propyl parahydroxybenzoate, disodium edetate, methyl parahydroxybenzoate, sodium saccharinate, sodium chloride, MCC, glycerin, sucrose, xanthan gum, silicon dioxide, flavorings, polysorbate 20, sodium citrate, water, citric acid .
Analogs
Level 4 ATC code matches:
Phenacetin
Combiflu
Chlorphenamine
Coldflu
Calpol
Fervex
Panadol Extra
Panadol for children
Panadol
Solpadeine
Efferalgan
Milistan
Coldrex Maxgripp
Coldrex Hotrem
Coldrex
AntiGrippin
Unispaz
Pentalgin Plus
Rapidol
Maxicold
The most common analogues are: angisept, rinza, Angilex, Aqua Maris, anginal, anti-angin, vokasept, hexaliz, hexoral, gripcold, decatylene, cameflu, flu effect, antiflu, coldfree, coldrex, teraflu, pharmacotron, fervex .
Interaction
Use with caution in combination with MAO inhibitors, tricyclic antidepressants, halothane, guanethidine, furazolidone .
The drug does not combine with ethanol .
Do not take with paracetamol - barbiturates, carbamazepine, zidovudine, diphenin and rifampicin . The effectiveness of uricosuric drugs is reduced.
Contraindications
Taking the drug in capsules is not recommended for children under 12 years of age if they have a drug allergy to any of the components.
The suspension can be taken by children from 6 years of age.
Flu Plus has a number of additional contraindications:
- atherosclerosis of the coronary arteries;
- thyrotoxicosis;
- severe forms of kidney, liver, heart, gall bladder diseases;
- diabetes mellitus and glaucoma ;
- stomach ulcer.
