Pharmacodynamics and pharmacokinetics
The effect is achieved due to irritation of cold sensitive receptors located in the oral mucosa. Irritation of nerve receptors has a calming effect on the nervous system. of opioid peptides increases , under the influence of which the permeability of the vascular wall is normalized, the severity of pain is reduced, and the functioning of the nervous and cardiovascular systems is regulated.
Corvalment stimulates the production of kinins , histamine and other physiologically active substances. The antispasmodic, sedative effect is caused by the action of isovaleric acid , which is part of the drug Corvalment.
When administered sublingually, the drug is absorbed from the oral mucosa. The effective effect of the drug appears after 5 minutes. Biotransformation of the drug occurs in the hepatic system, metabolites are excreted in the form of glucuronides through the urinary system.
Pharmacological properties
Pharmacodynamics.
the drug exhibits a calming effect on the central nervous system, and also has a moderate reflex vasodilator (coronary lytic) effect through reflex irritation of sensitive nerve (“cold”) receptors of the oral mucosa. stimulation of receptors is accompanied by the induction of the release of endorphins, enkephalins, dynorphins and other peptides, histamine, kinins, which play an important role in reducing pain sensitivity, normalizing vascular permeability and regulating other important mechanisms of functioning of the cardiovascular and nervous systems. Pharmacokinetics. When administered sublingually, Corvalment is absorbed from the oral mucosa. The therapeutic effect occurs in approximately 5 minutes. After absorption, it is biotransformed in the liver and excreted in the urine in the form of glucuronides.
Side effects
Dyspeptic disorders , lacrimation, nausea, and dizziness are rarely observed Long-term use of the drug is manifested by increased drowsiness and arterial hypotension. Symptoms disappear on their own after stopping use of the drug.
If you are allergic to the components, itching, Quincke's edema and other allergic reactions are noted.
Corvalment, instructions for use (Method and dosage)
According to the instructions for use, the Corvalment capsule is placed under the tongue and held until completely dissolved. When crushing the capsule with your teeth, the effect is achieved faster.
The frequency of administration depends on the frequency and duration of angina attacks.
For heart failure, it is recommended to take one capsule sublingually.
The daily dosage can reach up to 6 capsules for the treatment of angina pectoris in combination with other conditions.
The course of treatment should not exceed a week if the drug is taken regularly.
Corvalment
Name: Corvalmentum Pharmacological action: The effect of the drug is mainly due to the action of menthol included in its composition. In the oral cavity, menthol irritates the nerve endings of the mucous membrane. In response to this, a reflex expansion of the coronary vessels occurs. In addition, the production of endorphins, kinins, enkephalins, histamine and other vasoactive peptides increases. The antianginal effect of the drug is weak. The sedative effect is due to the presence of isovaleric acid. For sea and air sickness, Corvalment acts as an antiemetic drug. The effect after taking Corvalment develops after 1-3 minutes and lasts 15-30 minutes.
Indications for use: - Angina pectoris (mild attacks); - cardialgia; - neurosis; - motion sickness syndrome; - hysteria.
Directions for use: For pain, Corvalment is taken sublingually. To speed up the effect, it is recommended to crush the capsule with your teeth. During an attack, use 1 capsule. The lack of effect requires a transition to taking organic nitrates. Daily dose – up to six capsules.
Side effects: Dizziness, lacrimation, mild nausea.
Contraindications: - Hypersensitivity; - stroke; - arterial hypotension; - age up to six years.
Pregnancy: No information on contraindications.
Interaction with other drugs: Corvalment improves the tolerability of nitroglycerin, preventing or reducing the headaches it causes. When taken simultaneously with sedatives, it enhances their effect.
Release form: Soft capsules containing 0.1 g of the drug, No. 10 and 30.
Storage conditions: Temperature 5-20 degrees Celsius. Avoid exposure to moisture.
Synonyms: Validol.
Ingredients: 25% menthol solution. The solvent is isovaleric acid menthyl ester.
Additionally: In severe attacks of angina, use is not justified.
Attention! The description of the drug " Corvalment " on this page is a simplified and expanded version of the official instructions for use. Before purchasing or using the drug, you should consult your doctor and read the instructions approved by the manufacturer. Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide to prescribe the drug, as well as determine the dose and methods of its use.
Interaction
Corvalment can be used simultaneously with riboxin , asparkam , vitamin complexes and other drugs that improve metabolic processes in the body.
Corvalment enhances the effective effect of antihypertensive drugs, opioid analgesics, psychotropic drugs, anesthetics, and alcohol.
Combined use with neurotropics leads to depression of the nervous system and increased drowsiness.
Note!
Description of the drug Corvalment caps. soft 0.1g No. 30 on this page is a simplified author’s version of the apteka911 website, created on the basis of the instructions for use.
Before purchasing or using the drug, you should consult your doctor and read the manufacturer's original instructions (attached to each package of the drug). Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide to prescribe the drug, as well as determine the dose and methods of its use.
special instructions
Corvalment does not relieve attacks of severe angina. The drug is approved for use in patients with diabetes and does not contain sugar.
During breastfeeding and pregnancy, taking Corvalment is allowed only in situations where the therapeutic effect is more important than the possible negative effect of the drug components on the fetus (child).
There is no experience in using the drug in pediatrics.
In the first hours of use, dizziness and drowsiness are possible, so it is recommended to refrain from operating complex mechanisms, driving vehicles, or activities that require concentration or increased concentration.
Corvalment soft capsules 0.1g No. 10x3
Name
Corvalment caps 100 mg in blister pack No. 10x3
Description
Soft gelatin capsules of spherical or spherical shape, with a seam, colorless or from slightly yellow to light brownish-yellow, filled with a transparent, colorless or yellowish-tinged oily liquid with a menthol odor;
Main active ingredient
solution of menthol in menthyl ester of isovaleric acid
Dosage
100mg
Compound
Active ingredient: solution of menthol in menthyl ester of isovaleric acid; 1 capsule contains a solution of menthol in menthyl ester of isovaleric acid 100 mg; excipients: gelatin, glycerin.
Pharmacotherapeutic group
Other combinations of drugs for the treatment of heart diseases.
Pharmacological properties
It has a sedative effect and has a moderate reflex vasodilator effect due to irritation of sensitive nerve endings.
Indications
Used in complex therapy for neurasthenia and functional cardialgia. Use for these purposes is based only on experience of long-term use.
Contraindications
Hypersensitivity to the components of the drug; severe arterial hypotension; acute myocardial infarction; children under 18 years of age; patients with epilepsy and a history of seizures (including febrile seizures). With caution: gastroesophageal reflux, hiatal hernia, inflammatory and ulcerative diseases of the gastrointestinal tract, bronchial asthma, tendency to bronchospasm and laryngospasm.
Drug interactions
No studies have been conducted to evaluate the interaction. If you are taking other medications at the same time, you should consult your doctor.
Features of application
Before starting treatment, consult your doctor! If symptoms persist or worsen while taking the drug, you should consult a doctor. If the pain in the heart area does not go away after taking the drug, it is necessary to exclude acute coronary syndrome. Immediate medical attention is needed if pain occurs in the heart area radiating to the arm, upper abdomen, neck, or if respiratory failure develops (for example, shortness of breath).
Use during pregnancy or breastfeeding
Use during pregnancy and breastfeeding is not recommended due to the lack of sufficient data.
The ability to influence the reaction rate when driving vehicles or other mechanisms
When taking the drug, care must be taken when performing potentially hazardous activities that require increased concentration and speed of psychomotor reactions (driving vehicles, working with moving mechanisms, working as a dispatcher, operator).
Use in pediatrics
Use in children under 18 years of age is not recommended due to the lack of sufficient data.
Directions for use and doses
The drug is prescribed under the tongue. The capsule should be kept in the mouth until completely absorbed. Take 1 capsule 2-3 times a day. The daily frequency and duration of administration is determined depending on the effectiveness of treatment. If the therapeutic effect is absent or insufficiently expressed in the next 5-10 minutes after taking the drug, you should consult a doctor to prescribe another therapy.
Overdose
In case of overdose, headache, nausea, diarrhea, formation of rectal ulcers, gastrointestinal disorders, decreased blood pressure, respiratory disorders, cardiac arrhythmias, ataxia, agitation, epileptic convulsions, loss of consciousness and other disorders of the central nervous system are possible. In case of overdose, the drug must be discontinued. Treatment is symptomatic.
Side effects
Allergic reactions may develop (rash, itching, urticaria, angioedema), nausea, heartburn, lacrimation, dizziness, drowsiness, and decreased blood pressure. Contact allergy to menthol can be accompanied by the appearance of burning and ulceration in the oral cavity, lichenoid rashes. Allergic reactions to menthol may be accompanied by headache, bradycardia, muscle tremors, ataxia, anaphylactic shock, and erythematous skin rash. Frequency unknown. If any adverse reactions occur, including those not listed in this instruction, you must stop taking the medicine and consult a doctor.
Storage conditions
Store to protect from moisture and light in the original packaging at a temperature not exceeding 25 C. Keep out of the reach of children.
Buy Corvalment caps 100 mg in blister pack No. 10x3 in the pharmacy
Price for Corvalment caps 100 mg in blister pack No. 10x3
Instructions for use for Corvalment caps 100 mg in blister pack No. 10x3
Analogues of Corvalment
Level 4 ATC code matches: Eltacin
Validol
Tonginal
Tricardin
Instenon
Pumpan
Barboval
It has no structural analogues.
Corvalment price, where to buy
The price of Corvalment in Ukraine is approximately 60 UAH per pack of 30 pieces.
Tablets are not available in Russia at this time.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
LuxPharma* special offer
- Corvalment 0.1 g N80 capsules
RUB 1,490 order
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Pharmacy24
- Corvalment 0.1 g N10 capsules PAT "Kiev Vitamin Plant", Kiev, Ukraine
9 UAH. order - Corvalment 0.1 g N30 capsules PAT "Kiev Vitamin Plant", Kiev, Ukraine
25 UAH order
- Corvalment 0.1 g N80 capsules PAT "Kiev Vitamin Plant", Kiev, Ukraine
69 UAH order
