The benefits and harms of Panangin. Instructions for use, indications, price, reviews and analogues

Composition of Panangin

The tablets contain active substances: magnesium aspartate (280 mg) and potassium aspartate (316 mg).
Additional substances: silicon dioxide, corn and potato starch, talc, povidone, magnesium stearate. The shell consists of talc, macrogol 6000, titanium dioxide, methacrylic acid copolymer. The concentrate for Panangin IV solution includes magnesium aspartate (40 mg) and potassium aspartate (45.2 mg), as well as water for injection.

Description of the drug

The medicine Panangin is produced in two dosage forms. The tablets are round, biconvex, film-coated, white or grayish in color, without a noticeable odor. The drug in this release form is intended for oral use. Tablets of 50 pieces are produced in jars or blisters placed in cardboard packaging.

The injection solution is available in ampoules, has a white or slightly greenish tint, transparent, without visible chemical and mechanical additives. The solution is packaged in 5 ampoules in a cardboard box, one ampoule – 10 ml.

International name (INN) Potassium aspartate + Magnesium aspartate.

Pharmacological group - a medicine that replenishes the deficiency of magnesium and potassium in the body.

pharmachologic effect

What is the medicine for? It is a source of potassium and magnesium. The drug helps restore electrolyte balance, regulates metabolic reactions and processes, and has a pronounced antiarrhythmic effect.

Potassium takes an active part in synaptic transmission, in the conduction of nerve impulses along fibers, in muscle contractions, and supports the normal functioning of the heart. When potassium metabolism is disturbed, the excitability of muscle tissue and nerves changes. Active ion transport maintains a high potassium gradient across the plasma membrane. Small dosages of potassium contribute to the expansion of the coronary arteries, and in large dosages the microelement narrows their lumen. Potassium has a moderate diuretic effect, negative bathmotropic and chronotropic effects.

Magnesium is a cofactor in three hundred enzyme reactions. Magnesium is an essential element during processes and reactions that provide energy intake and expenditure. Magnesium is part of the pentose phosphate structure of DNA, takes part in the process of cell division and growth, the structure of heredity, and RNA synthesis; is a natural BMCA, prevents the release of free fatty acids and catecholamines during stress, and promotes the penetration of potassium ions into the cell. The drug has a stimulating effect on intercellular phosphate synthesis.

Patient reviews

Maria, Ufa “I have already taken this remedy several times in courses of 3 weeks. The doctor prescribed me Panangin in tablet form. I took the product in combination with other medications, so I can’t say that the improvement in my well-being is solely due to it. At least I didn’t notice any negative effects, my condition returned to normal.”

Anastasia, Surgut “I have suffered from arrhythmia since my youth. After the examination, it turned out that this condition arose against the background of an imbalance in metabolic processes. After a course of treatment with Panangin, I feel much lighter, palpitations and shortness of breath occur less frequently. The drug is relatively inexpensive, and I’m also satisfied with the quality.”

Anton, Moscow “I took medicine after a heart attack. The doctor said that it is necessary to nourish the heart and restore metabolic processes. Six months after completing the course, I was again prescribed this drug for prevention. I was satisfied with the treatment."

Indications for use of Panangin

Indications for the use of Panangin are as follows; the drug is prescribed:

for hypomagnesemia , hypokalemia ;
when taking laxatives and diuretics, glucocorticosteroids;
for diarrhea, persistent vomiting, taking saluretics;
for myocardial infarction, heart failure , digitalis intoxication, ventricular extrasystole , atrial extrasystole , supraventricular tachycardia , paroxysmal tachycardia .

Example of a recipe in Latin: Rp.: Dragee “Panangin” N. 20

Analogues of the product

In the RLS drug directory you can find the following analogues of Panangin:

Plus vitamin B6 Panangin is a drug used as a dietary supplement when there is a lack of potassium, magnesium, and vitamin B in the body;
Aspirin Cardio - used for the treatment and prevention of coronary heart disease, angina pectoris, in the period after heart surgery, after myocardial infarction;
Riboxin is a complex drug that is prescribed to patients for the treatment of coronary artery disease, heart defects, arrhythmias of various origins, atherosclerosis and other heart diseases. Riboxin contains inosine, which has a positive effect on the functioning of the heart muscle, helps to establish metabolic processes, causes the necessary relaxation of the heart, and normalizes the frequency of contractions of the organ;
Neocardil - has indications such as neurocirculatory dystonia, coronary heart disease, arterial hypertension, arrhythmias, angina pectoris and other diseases of the cardiovascular system.

It is strictly not recommended to take drugs that are similar in composition and action at the same time; this can only be done as prescribed by a doctor.

Contraindications for Panangin

The drug is not used for:

intolerance to fructose, sorbitol ;
impaired amino acid metabolism;
chronic pathology of the renal system;
hemolysis;
exicosis;
dehydration;
arterial hypotension;
myasthenia gravis;
atrioventricular block;
hypermagnesemia;
hyperkalemia;
metabolic acidosis;
Addison's disease.

Panangin is used with caution during pregnancy.

Side effects

Side effects are the following:

ulceration of the mucous wall of the digestive tract;
epigastric pain;
diarrhea;
bleeding from the digestive system;
drop in blood pressure;
bradycardia;
paradoxical reaction in the form of an increase in the number of extrasystoles;
dry mouth, nausea, flatulence ;
hyporeflexia;
itchy skin;
dyspnea;
thrombosis;
phlebitis;
paresthesia;
dizziness;
increased sweating;
asthenia;
myasthenia gravis.

With rapid intravenous infusion, hypermagnesemia and hyperkalemia .

Instructions for use of Panangin (Method and dosage)

Panangin tablets, instructions for use

How to take the medicine? The drug is taken orally three times a day, 2 tablets. Maintenance and preventive therapy: 1 tablet three times a day, course for 3-4 weeks. In some situations, a repetition of the course of therapy is required.

Instructions for intravenous use

Panangin solution is injected intravenously, slowly. The drug is administered at a rate of 20-30 drops per minute, 1-2 times a day, 300 ml. Dosing of the drug Panangin during pregnancy is carried out according to the standard regimen of medication use.

Children can take the medicine from birth.

How to take Panangin for prevention?

If you ask the question of the benefits and harms of Panangin, you should realize that this is a drug that has its own side effects, so you should not use it for prevention. Firstly, in this way you accustom the body to a high content of magnesium and potassium, and secondly, you can provoke an overabundance of these substances, which in turn can cause a lot of negative reactions.

Buy Panangin forte tablets 316mg+280mg No. 60 in pharmacies

Instructions for use Panangin forte tab. 316mg+280mg No. 60 Dosage forms tablets 316mg+280mg Synonyms Asparkam Potassium and magnesium aspartate Berlin-Chemie Panangin Group Drugs regulating water-electrolyte balance International nonproprietary name Potassium and magnesium aspartate Manufacturers Gedeon Richter (Hungary) Composition per tablet: Tablet core Active substances: potassium aspartate 316.00 mg (in the form of potassium aspartate hemihydrate 332.60 mg), magnesium aspartate 280.00 mg (in the form of magnesium aspartate tetrahydrate 350.00 mg); Excipients: corn starch 172.20 mg, talc 20.00 mg, magnesium stearate 8.00 mg, potato starch 6.60 mg, povidone K30 6.60 mg, colloidal silicon dioxide 4.00 mg; Tablet shell: talc 7.30 mg, butyl methacrylate copolymer 6.00 mg, titanium dioxide (color index: CI 77891, E171) 5.30 mg, macrogol-6000 1.40 mg. Description Oval, biconvex, film-coated tablets, white or almost white, with a slightly glossy surface, engraved “A83” on one side, almost odorless. On a cross section it is white or almost white in color. Pharmacotherapeutic group: potassium and magnesium preparation. ATC code: A12СХ Pharmacological properties Pharmacodynamics The most important intracellular cations of potassium (K) and magnesium (Mg++) play a key role in the functioning of numerous enzymes, in the formation of connections between macromolecules and intracellular structures and in the mechanism of muscle contractility. The intra- and extracellular ratio of potassium, calcium, sodium and magnesium ions affects myocardial contractility. Endogenous aspartate acts as a conductor of ions: it has a high affinity for cells, due to the slight dissociation of its salts, ions in the form of complex compounds penetrate into the cell. Magnesium aspartate and potassium aspartate improve myocardial metabolism. Lack of magnesium/potassium predisposes to the development of arterial hypertension, atherosclerosis of the coronary arteries, arrhythmias and metabolic changes in the myocardium. Each tablet of the drug Panangin® Forte contains 280 mg of magnesium aspartate and 316 mg of potassium aspartate, which is 2 times higher than the content of active ingredients in the drug Panangin®, film-coated tablets. The daily dose of the drug Panangin® Forte: 1 tablet 3 times a day, corresponds to the daily dose of the drug Panangin®: 2 tablets 3 times a day. Taking a single dose of Panangin® Forte in the form of one tablet makes treatment more convenient for the patient. Pharmacokinetics Potassium and magnesium aspartates are intensively absorbed in the intestine, mainly in the small intestine. Excreted by the kidneys. Indications for use To eliminate potassium and magnesium deficiency as part of combination therapy for various manifestations of coronary heart disease (including acute myocardial infarction); chronic heart failure; heart rhythm disturbances (including arrhythmias caused by an overdose of cardiac glycosides). Contraindications Hypersensitivity to any of the components of the drug, acute and chronic renal failure, hyperkalemia, hypermagnesemia, Addison's disease, atrioventricular block I-III degree, shock (including cardiogenic) (blood pressure less than 90 mm Hg), metabolic disorders amino acids, myasthenia gravis, hemolysis, acute metabolic acidosis, dehydration state, age under 18 years (efficacy and safety have not been established). With caution Pregnancy (especially in the first trimester of pregnancy) and the period of breastfeeding. Use during pregnancy and breastfeeding Use is possible if the potential benefit to the mother outweighs the possible risk to the fetus. Potassium and magnesium aspartate pass into breast milk. If it is necessary to take the drug during breastfeeding, breastfeeding should be stopped. Directions for use and dosage: Before use, you should consult your doctor. Take orally, without chewing and with plenty of water. Panangin® Forte should be taken after meals, because... the acidic environment of the stomach reduces its effectiveness. Recommended daily dose: 1 tablet 3 times a day. Maximum daily dose: 1 tablet 3 times a day. Side effects Possible nausea, vomiting, diarrhea, discomfort or burning sensation in the epigastric region (in patients with anacid gastritis or cholecystitis), atrioventricular block, paradoxical reaction (increased number of extrasystoles), hyperkalemia (nausea, vomiting, diarrhea, paresthesia), hypermagnesemia ( facial flushing, thirst, decreased blood pressure, hyporeflexia, respiratory depression, convulsions). If any of these adverse reactions become serious, or you notice the occurrence of adverse reactions not listed in these instructions, you should consult a doctor. Overdose The risk of symptoms of hyperkalemia and hypermagnesemia increases. Symptoms of hyperkalemia: increased fatigue, myasthenia gravis, paresthesia, confusion, cardiac arrhythmia (bradycardia, atrioventricular block, arrhythmias, cardiac arrest). Symptoms of hypermagnesemia: decreased neuromuscular excitability, nausea, vomiting, lethargy, decreased blood pressure. With a sharp increase in the content of magnesium ions in the blood: inhibition of deep tendon reflexes, respiratory paralysis, coma. Treatment: symptomatic therapy - intravenous administration of calcium chloride at a dose of 100 mg/min, if necessary - hemodialysis. Interaction with other drugs Pharmacodynamic interaction When used together with potassium-sparing diuretics (triamterene, spironolactone), beta-blockers, cyclosporine, heparin, angiotensin-converting enzyme (ACE) inhibitors, non-steroidal anti-inflammatory drugs, the risk of developing hyperkalemia up to the development of arrhythmia and asystole increases. The simultaneous use of potassium supplements with glucocorticosteroids eliminates hypokalemia caused by the latter. Potassium reduces the undesirable effects of cardiac glycosides. Panangin® Forte enhances the negative dromo- and bathmotropic effects of antiarrhythmic drugs. Magnesium reduces the effects of neomycin, polymyxin B, tetracycline and streptomycin. Anesthetics increase the inhibitory effect of magnesium preparations on the central nervous system; when used simultaneously with atracuronium, decamethonium, succinyl chloride and suxamethonium, neuromuscular blockade may be enhanced. Calcitriol increases the content of magnesium in the blood plasma, calcium supplements reduce the effects of magnesium supplements. Pharmacokinetic interaction Drugs with an astringent and enveloping effect reduce the absorption of magnesium aspartate and potassium aspartate in the gastrointestinal tract, therefore it is necessary to maintain a three-hour interval between oral administration of Panangin® Forte with the above medications. Storage conditions : At a temperature not exceeding 30 °C. Keep out of the reach of children! Shelf life: 2 years. Do not use after the expiration date stated on the package.

Interaction

Panangin is able to enhance the negative bathmotropic, dromotropic effects of antiarrhythmic drugs.

The medication eliminates hypokalemia, which develops against the background of long-term use of diuretics, glucocorticosteroids, and MCS.

NSAIDs, ACE inhibitors, Heparin , potassium-sparing diuretics, Cyclosporine , beta-blockers - increase the risk of developing hyperkalemia.

When using general anesthetics, the inhibitory effect of Panangin on the nervous system increases.

Succinyl chloride, decamethonium, atracuronium, suxamethonium enhance neuromuscular blockade.

The use of enveloping and astringent medications reduces the absorption of potassium and magnesium in the digestive tract.

In combination with insulin , dextrose as part of a polarizing mixture, the heart rate is normalized in case of an overdose of cardiac glycosides, in case of ectopic arrhythmias, myocardial infarction .

Panangin improves the tolerability of cardiac glycosides and is pharmaceutically compatible with their solutions.

Overdose

It is not recommended to exceed the prescribed dose. An overdose of the drug is possible, manifested by the following symptoms:

excessive levels of potassium and magnesium ions in the blood;
muscle hypotonicity;
problems with the functioning of the heart, even to the point of cardiac arrest;
arrhythmia;
changes on the electrodiogram.

If such signs appear, you should immediately inject a solution of dextrose and sodium chloride intravenously. Depending on the patient's condition, peritoneal dialysis may be required.

Panangina price, where to buy

The price of Panangin in tablets is about 150 rubles per package No. 50, the price in ampoules is about 160 rubles.

The price of Panangin in Ukraine is 110 and 140 UAH. for tablets and solution, respectively.

Online pharmacies in RussiaRussia
Online pharmacies in UkraineUkraine
Online pharmacies in KazakhstanKazakhstan

ZdravCity

Panangin Forte tablets p.p.o.
316mg+280mg 60 pcs. JSC Gedeon Richter RUB 294 order
Panangin tab. p/o captivity. 158 mg + 140 mg No. 100 JSC "Gedeon Richter-RUS" RU
RUB 265 order
Panangin tab. p/o captivity. No. 50 JSC "Gedeon Richter-RUS" RU
RUB 157 order
Panangin conc. ready solution d/inf 45.2 mg mg/ml + 0.04 g/ml 10 ml 5 pcs CJSC PharmFirma Sotex
RUB 156 order

Pharmacy Dialogue

Panangin (tab.p.pl/rev. No. 50)Gedeon-Richter/Gedeon-Richter-RUS ZAO
RUB 168 order
Panangin (amp. 10ml No. 5) Gedeon-Richter
160 rub. order
Panangin (tab.p.pl.vol. 158 mg + 140 mg No. 100) Gedeon-Richter/Gedeon Richter-RUS JSC
RUB 301 order
Panangin forte (tab.pl/vol. 316mg+280mg No. 60)Gedeon-Richter
RUB 322 order
Panangin (concentrated solution 10ml No. 5) Gedeon-Richter
162 RUR order

Pharmacy24

Panangin N50 tablets VAT "Gedeon Richter", Ugorshchina
110 UAH. order
Panangin 10 ml No. 5 concentrate for the preparation of solution for infusion VAT "Gedeon Richter", Ugorshchina
142 UAH order

PaniPharmacy

Panangin solution d/in. 10ml No. 5 Hungary, Gedeon Richter
142 UAH order
Panangin tablet p/captivity about. No. 50 Hungary, Gedeon Richter
115 UAH order