Pharmacological effects, pharmacodynamics and pharmacokinetics
According to the annotation, the drug has the following therapeutic effect:
- Cinnarizine dilates blood vessels without changing blood pressure levels.
- Improves blood supply to brain structures and peripheral organs.
- Shows moderate antihistamine activity.
- Somewhat suppresses the sensitivity of the vestibular apparatus (the organ responsible for coordination and balance).
- Helps reduce blood viscosity.
- Increases the elasticity of the cell membrane of red blood cells, facilitating their passage through small capillaries.
Absorption of the drug from the gastrointestinal tract into the systemic bloodstream and the onset of its action occurs within 1 to 3 hours, depending on the characteristics of metabolism. Most of the drug is excreted during the day with feces, about 25-30% leaves the body during urination.
What does Cinnarizine help with?
The drug is prescribed for prophylactic and therapeutic purposes for a number of diseases and pathological conditions:
- The recovery period after an ischemic stroke.
- Disculatory encephalopathy.
- Raynaud's syndrome (vasospastic pathology).
- Minière's disease.
- Kinetoses of various origins.
- Condition after suffering traumatic injuries to the head and central nervous system.
- Obliterating atherosclerosis of cerebral vessels.
- Thromboangiitis and thrombophlebitis.
- Sea and mountain sickness.
Any condition accompanied by impaired blood circulation and nutrition of organs can cause the preventive or therapeutic use of Cinnarizine.
Contraindications, side effects and overdose
The drug has a minimal number of contraindications for use, but they still exist. Cinnarizine is strictly prohibited during pregnancy and breastfeeding. It should also not be prescribed to children under 12 years of age.
A relative contraindication is Parkinson's disease. In this case, Cinnarizine can be used, but under the strict supervision of the attending physician.
Undesirable side reactions develop extremely rarely. Most often they are associated with individual intolerance to the main or auxiliary components of the drug. Some patients may experience weakness, fatigue, headaches, increased drowsiness, nausea, vomiting, stool disorders and dry mouth. It is extremely rare that taking Cinnarizine leads to hypotension and the development of depressive states.
The symptoms of overdose are similar to the manifestations of adverse reactions. If this condition develops, it is recommended to discontinue the drug, thoroughly rinse the stomach with clean water and take adsorbents (activated carbon or filtrum). There is currently no specific antidote.
CINNARIZINE (tablets)
mg of the active substance cinnarizine plus excipients.
The package contains 50 tablets on one blister. The tablets are small, round, white, not too bitter, and easy to swallow. Cinnarizine is used for the treatment and prevention of cerebral circulatory disorders. It is also used for the treatment of cervical osteochondrosis, post-stroke changes, vestibular disorders, decreased concentration and memory, headaches, prevention of seasickness, and to eliminate the symptoms of menopause. Cinnarizine tablets should be taken after meals, without crushing them, and washed down with plenty of water. When I was diagnosed, I was prescribed to take 1 tablet 3 times a day for one month. Treatment with Cinnarizine by your attending physician can last up to 2 - 3 months. Only with long-term treatment is it necessary to take a blood test. Cinnarizine is often prescribed for treatment together with Piracetam; these two drugs complement each other well and can be prescribed in combination. The doctor also prescribed me to take Cennarizine along with Piracetam. In the first two days when taking the pills, I always feel a little drowsy, but then it all goes away. But your night's sleep still remains of better quality; you fall asleep faster and wake up less often. You greet the morning feeling good. In general, I really like the effect of this drug. Headaches stop bothering you, debilitating dizziness goes away, memory and overall well-being improve.
Like all drugs, Cinnorizine has contraindications and side effects. Contraindications include: pregnancy, breastfeeding and children under 12 years of age. This drug should be taken with caution by those who drive a car. Side effects can occur in both the nervous system and the digestive tract. I have been using Cinnorizine for 3 years now and have not encountered any side effects, which is good. A neurologist recommends taking the drug in courses twice a year - in spring and autumn. Now the drug Phezam has appeared, it already contains Piracetam and Cinnorizine together. These capsules are probably more convenient to use, but also much more expensive, the active ingredients are the same. Therefore, I think there is no point in overpaying for this drug. I continue to buy Piracetam and Cinnarizine separately, which suits me.
I have been buying Cinnarizine tablets for three years now, I had Ozonovskie, Avexima and Sopharma. I didn’t feel any difference in the effect obtained from any of the tablets; they differ only in price, and even then not significantly. For side effects, I will still remove one star from the drug. I wish everyone health and do not self-medicate under any circumstances. Be sure to consult your doctor before using Cinnarizine. Thank you for your attention and see you for new reviews.
Cinnarizine: instructions for use
The drug tablets are taken orally with a sufficient amount of water. The daily dosage and frequency depend on the type of underlying pathology:
- For ischemic stroke, it is recommended to take 1-2 tablets 3 times a day.
- For disorders of nutrition and blood supply to the peripheral parts - 2-3 tablets three times a day.
- For disorders of the vestibular apparatus - 1 tablet with the same dosage.
- To prevent various pathologies described in the “Indications” section, Cinnarizine is taken 1 tablet every 24 hours.
The maximum daily dose is 200-225 mg of the drug for adults and 100-125 mg for children aged 12 to 18 years.
To achieve a lasting therapeutic effect, continuous and long-term use of the drug is necessary. The duration of treatment is determined by a specialist.
Vascular drug Cinnarizine - reviews
Leonid
https://www.otzyvua.net/tsinnarizin/review-104779
I took Cinnarizine as prescribed by a doctor after a traumatic brain injury that impaired cerebral circulation. I did not feel any particular effect from its use. Headaches either did not decrease at all, or for a very short time. Therefore, I had to refuse further use and ask the doctor to prescribe another drug.
Katerina
https://med-otzyv.ru/lekarstva/165-c/33518-tsinnarizin#scomment-392441
For vegetative-vascular dystonia, Cinnarizine is one of the drugs that really works. I did not feel well until a competent doctor prescribed this medicine to me. I've been taking it for a month and finally feel quite tolerable. Headaches, dizziness, the feeling of “pins and needles”, weakness and fatigue are gone. I calmed down and even gained 3 kg in weight, which I had not been able to achieve for a long time.
Varvara
https://med-otzyv.ru/lekarstva/165-c/33518-tsinnarizin#scomment-392433
My mother had a mini-stroke 2.5 years ago. Now she feels more or less tolerable, but, of course, her memory is failing her and her head is, as her mother puts it, “not quite right.” Today she finished taking Cinnarizine tablets. I took two tablets three times a day for 3 months. During this time we saw a clear improvement. Now once a year my mother will definitely take this course. The medicine is really effective.
Lily
https://www.medcentre.com.ua/review/73499-tsinnarizin
An effective, proven drug.
I have problems with the blood vessels of the brain, I often feel dizzy, and I constantly feel tinnitus. I visited a neurologist more than once. After the examination, I was prescribed medications such as Tanakan, Sermion. These drugs are effective, but very expensive. And since I have to use them often due to my condition, it costs too much. Therefore, I was advised to take Cinnarizine, which is inexpensive and effective, as I was convinced of. I’ve been taking one tablet at night for a month now, my health has noticeably improved, my head is less dizzy, the ringing in my ears has gradually stopped, and therefore my sleep and blood pressure have returned to normal. So there is no point in buying expensive similar drugs. Good health to everyone!
filyaa1971
https://otzovik.com/review_3260270.html
Advantages:
pills are not expensive
Flaws:
No
A very good vascular drug, I suffer from vegetative-vascular dystonia. There are frequent headaches, pressure, numbness of the limbs. The doctor prescribed this drug to me, it helps me a lot, two tablets, three times a day. I am a weather-dependent person and I react to weather phenomena with these tablets, I tolerate such weather well. It solves problems with cerebral circulation disorders. It is also taken for strokes, atherosclerosis, memory problems and thinking disorders. Side effects include drowsiness, dry mouth, dyspeptic symptoms, and allergies in the form of skin rashes. I trust this drug.
striker762
https://otzovik.com/review_1444852.html
Advantages:
Helps with intracranial pressure and insomnia.
Flaws:
Have not found
My grandmother advised me to take the drug when I had a headache. The drug really helped after the first dose. But in addition to relieving headaches, another effect was discovered - drowsiness. After it you want to sleep very much and the sleep is very sound. In general, I slept better than I had slept for a long time - in the morning I was just super energetic. In general, you shouldn’t take it in the morning (although not everyone may have such an effect), I take it 2 times a day after 6, 1 tablet - I feel just great.
Ursula Buffay
https://irecommend.ru/content/tsinnarizin-instruktsii-po-primeneniyu-preparat-s-massoi-dostoinstv-no-esli-ne-eti-sny-i-pro
Today I’ll tell you about another drug that makes my life easier. During my life I have tried a lot of vascular and neurotropic drugs, what can I do, such is the everyday life of a neurasthenic. I have been familiar with Cinnarizine for a very long time; I remember when I was a child that I was prescribed Cinnarizine for constant headaches. But childhood is long gone, the drug has somehow become forgotten.
I have a very light sleep, I wake up from any rustle. If I wake up at 3-4 am, then everything is gone, I don’t close my eyes until the morning. Then you walk around all day like a sleepwalker, you can’t hear well, you can’t see well, and in general you can’t quite understand what’s going on around you. It’s good if after such a day you come home and go to bed until the morning, but sometimes such nights repeat one after another. And it can be difficult to break this ill-fated circle. Then we have to turn to pharmaceutical products.
This is exactly how I recently remembered Cinnarizine.
pharmachologic effect
Cinnarizine is a calcium channel blocker with a pronounced effect on cerebral vessels. Improves cerebral, as well as coronary and peripheral blood circulation. It disrupts the flow of calcium ions into vascular smooth muscle cells. Reduces the tone of smooth muscles of arterioles, reduces reactions to biogenic vasoconstrictors (adrenaline, norepinephrine, bradykinin). In patients with peripheral circulatory disorders, it improves blood supply. Increases tissue resistance to hypoxia. Reduces the excitability of the vestibular apparatus.
Indications
- cerebrovascular accidents (vasospasm, atherosclerosis, traumatic brain injury, stroke); - labyrinthine disorders (including for maintenance therapy for dizziness, tinnitus, nystagmus, nausea and vomiting of labyrinthine origin); — motion sickness (as a preventive measure); - prevention of migraine attacks; - Meniere's disease; - prevention and treatment of peripheral circulatory disorders: atherosclerosis obliterans, thromboangiitis obliterans, Raynaud's disease, diabetic angiopathy, acrocyanosis. - as part of complex therapy for rapid mental fatigue, irritability, low mood, memory impairment and the ability to concentrate.
Compound
1 tablet contains 25 mg of cinnarizine
Price: about 30-60 rubles depending on the pharmacy and manufacturer. It is Cinnarizine from Sopharma, Bulgaria that costs the most, about 55-60 rubles.
Directions for use and dosage:
For cerebrovascular accidents, the drug is prescribed 25 mg 3 times a day. For peripheral circulation disorders, Cinnarizine is used at a dose of 50-75 mg 3 times a day. For motion sickness, 25 mg of Cinnarizine is taken as a prophylactic measure. The maximum daily dose is 225 mg (9 tablets). Children aged 6-12 years are prescribed half the adult dose. The drug should be taken after meals.
I’ll say right away that on the first day of treatment I didn’t feel any better. I fell asleep only in the morning. But in the morning it was still easier, I thought faster, and most importantly, there was no annoying headache, which so often accompanies insomnia. And most importantly, when I came home, I fell into a deep sleep and slept until the alarm clock rang. And so, continuing to drink it, my sleep was restored and became perfectly sound. I take 2-3 tablets a day. I don’t hear noise from the street, I don’t hear my neighbors, I don’t even hear my husband leaving for work in the morning. I sleep soundly until my alarm rings and sometimes wake up in the middle of the ringing.
Also, while taking it, I have migraine attacks much less often, and they pass easier and faster, in this more erased form.
And in general, while taking it, I feel a so-called increase in cognitive qualities, I think faster, remember better, am more creative and, which is very pleasant, I have an even good mood.
Side effects
Possible: drowsiness, dry mouth, dyspeptic symptoms, allergic reactions in the form of skin rash.
And now about a side effect that is not written about in the instructions and which I myself realized, but not right away. Sleeping against the background of Cinnarizine is sound, but getting up in the morning is incredibly difficult. It was so difficult that it was such that I would snooze the alarm clock for half an hour, and then run to work with an armful of makeup and food, and I had to put on makeup and have breakfast at work. And this is me, who is generally quite disciplined in life. This sleepy state does not go away for another 3 hours after waking up and it can be quite difficult to connect to the work process.
The second side effect that is quite significant for me is very vivid dreams, sometimes bordering on delirium. I already have pretty funny dreams, but on Cinnarizina it’s basically just whole trips into the land of the subconscious. Moreover, the number of nightmares prevails, so this is just a side effect.
All other listed side effects passed me by. There were no allergies, no rash, and everything was OK in the digestive system.
Pros:
- normalization of sleep,
- reduction of headaches
- improvement of cognitive functions
Minuses:
- hard to get up in the morning
- weakness, drowsiness and lethargy in the morning if you take the drug at night.
- nightmares.
In general, I can say that the drug suited me. And I still recommend it.
