Sinekod - cheap analogues (list), instructions, reviews

The appearance of a cough forces patients to look for ways to eliminate it. First of all, cough is a symptom, and does not always indicate inflammation of the lower parts of the respiratory system.

It happens that a patient starts taking expectorants because of a severe dry cough that deprives him of sleep, but the drug turns out to be ineffective.

During a consultation with a doctor, it is discovered that the patient, for example, has atrophic pharyngitis, which has nothing to do with inflammation of the bronchi. Therefore, in order to fight a cough, the primary task remains to find the cause of its occurrence.

If, after diagnosis, it is determined that the patient has an objectively determined inflammatory process in the bronchopulmonary system, then antitussives of various actions are used to treat such pathologies.

Cough treatment drugs occupy a strong position in the pharmaceutical market. One of these representatives is the Swiss centrally acting antitussive drug Sinecode, ATC code: R05DB13. The main active ingredient of the drug is butamirate citrate.

pharmachologic effect

Manufacturer: GSK CONSUMER HEALTHCARE S. A. (Switzerland)
Release form: syrup, drops, dragees

Active ingredient: butamirate

Analogues: Codelac neo, Rengalin, ACC

Sinekod is an antitussive drug that can suppress the cough reflex by acting on certain areas of the medulla oblongata. The medication is not an opium alkaloid and does not form dependence on the drug. Sinekod effectively relieves bronchospasm, improves spirometric parameters and increases blood oxygen saturation.

Sinekod - instructions for use

According to the instructions for use of Sinecode, the medication is prescribed:

• In the form of drops for children - from 2 months to 1 year, 10 drops 4 times a day;

from 1 year to 3 years, 15 drops 4 times a day;

from 3 years and older, 25 drops 4 times a day.

• In the form of syrup for children - from 3 to 6 years, 5 ml 3 times a day;

from 6 to 12 years, 10 ml 3 times a day;

from 12 to 18 years, 15 ml 3 times a day.

• In the form of tablets for children - from 6 to 12 years old, 1 tablet 2 times a day;

from 12 to 18 years, 1 tablet 3 times a day.

Adults are prescribed 15 ml syrup 4 times a day, and 2 tablets 3 times a day. The duration of treatment is determined by the doctor and does not exceed 7 days, but according to indications, the course of therapy can be increased or shortened.

How to take Sinekod: before or after meals

It is necessary to drink Sinekod before meals. The syrup package is equipped with a measuring cap, which is used to measure the medicine. After each use it must be rinsed and dried. Sinekod drops are available in a glass bottle equipped with a dropper.

Depending on the age of the child, a certain number of drops are measured into a spoon, which is given to the baby to drink without diluting the medicine with water or other liquid.

Sinekod for dry cough, syrup 1.5 mg/ml 100 ml

A country

Switzerland
The country of production may vary depending on the batch of goods. Please check with the operator for detailed information when confirming your order.

Active substance

Butamirat

Description

Sinekod syrup for dry coughs with a pleasant vanilla flavor. • Helps cope with dry coughs and reduce the intensity of night coughs from the first use*. • Butamirate, the active substance of the drug "Sinekod", is a centrally acting antitussive agent. It is not classified as an opium alkaloid either chemically or pharmacologically. Does not form dependence or addiction. • Sinekod facilitates breathing, selectively affecting the cough center • Suppresses cough, having a direct effect on the cough center • Has a bronchodilator effect (dilates the bronchi).** • Duration of the antitussive effect is up to 6 hours.* * Materazzi F. et al. Gatz. honey. It. Arch.S.Med. 1984; 143: 229-232. ** Instructions for medical use, RU P N011631/01 dated 04/01/2011

Compound

(weight-volume percentage): Active substance – butamirate citrate – 0.150 (1.5 mg/ml). Excipients: sorbitol solution 70% m/m 40.50, glycerol 29.00, sodium saccharinate 0.06, benzoic acid 0.115, vanillin 0.06, ethanol 96% v/v. 0.25, sodium hydroxide 30% m/m 0.031, water up to 100 ml.

Product description

Colorless transparent liquid with a vanilla odor.

pharmachologic effect

Butamirate, the active substance of the drug Sinecod®, is a centrally acting antitussive agent. It is not classified as an opium alkaloid either chemically or pharmacologically. Does not form dependence or addiction. Suppresses cough, having a direct effect on the cough center. Has a bronchodilator effect (expands the bronchi). Helps make breathing easier by improving spirometry (reduces airway resistance) and blood oxygenation (saturates the blood with oxygen). Absorption Based on available data, it is assumed that butamirate ester is rapidly and completely absorbed and hydrolyzed in plasma to 2-phenylbutyric acid and diethylaminoethoxyethanol. The effect of food on absorption has not been studied. The change in the concentration of 2-phenylbutyric acid and diethylaminoethoxyethanol occurs in proportion to the dose taken in the range of 22.5 mg - 90 mg. Butamirate is rapidly and completely absorbed when taken orally, measured concentrations are detected in the blood 5 to 10 minutes after taking doses of 22.5 mg, 45 mg, 67.5 mg and 90 mg. Maximum plasma concentrations are achieved within 1 hour when taking dosages at all 4 levels, the average is 16.1 ng/ml when taking an oral dose of 90 mg. Average plasma concentrations of 2-phenylbutyric acid are achieved within 1.5 hours; the maximum concentration was observed after a dose of 90 mg (3052 ng/ml); average plasma concentrations of diethylaminoethoxyethanol are reached within 0.67 hours; Cmax is observed after taking a dose of 90 mg (160 ng/ml). Distribution Butamirate has a large volume of distribution in the range of 81 – 112 l (adjusted for body weight in kg), as well as a high degree of binding to plasma proteins. 2-phenylbutyric acid has a high degree of binding to plasma proteins at all dosage levels (22.5 - 90 mg), averaging 89.3% - 91.6%. The ability of diethylaminoethoxyethanol to bind to plasma proteins is also detected, the average values ​​vary between 28.8% and 45.7%. It is unknown whether butamirate crosses the placenta or is excreted in breast milk. Metabolism Hydrolysis of butamirate, which results in the formation of 2-phenylbutyric acid and diethylaminoethoxyethanol, which have an antitussive effect, occurs very quickly. 2-phenylbutyric acid undergoes further partial metabolism by hydroxylation in the para position. Excretion Excretion of the three metabolites occurs primarily through the kidneys; After conjugation in the liver, the acidic metabolites are largely bound to glucuronic acid. Conjugates of 2-phenylbutyric acid are determined in urine in significantly higher concentrations than in blood plasma. Butamirate is detectable in urine within 48 hours, and butamirate excreted in urine during the 96-hour sampling period accounts for approximately 0.02, 0.02, 0.03, and 0.03% of 22.5 mg doses. , 45 mg, 67.5 mg and 90 mg, respectively. As a percentage, butamirate is excreted in the urine in greater quantities in the form of diethylaminoethoxyethanol than unchanged butamirate or unconjugated 2-phenylbutyric acid. The measured half-lives of 2-phenylbutyric acid, butamirate, and diethylaminoethoxyethanol are 23.26–24.42, 1.48–1.93, and 2.72–2.90 hours, respectively.

Indications for use

Symptomatic treatment of dry cough of various etiologies: cough in the preoperative and postoperative period, during surgical interventions, bronchoscopy, and whooping cough.

Contraindications

Hypersensitivity to the components of the drug, children under 3 years of age (for children under 3 years of age, you can use Sinekod® oral drops for children), pregnancy (first trimester), lactation period, fructose intolerance (the drug contains sorbitol).

Carefully

Pregnancy (II and III trimesters). Due to the presence of ethyl alcohol in the drug, use with caution in patients with a tendency to develop drug dependence, with liver diseases, alcoholism, epilepsy, brain diseases, pregnant women and children.

Use during pregnancy and lactation

In animal studies, no adverse effects on the fetus were observed. There have been no controlled studies in pregnant women. In this regard, Sinekod® should not be used in the first trimester of pregnancy. In the second and third trimesters, the use of Sinecod® is possible, taking into account the benefits for the mother and the potential risk for the fetus. Given the lack of data on the excretion of butamirate in breast milk, the use of Sinecod® during lactation is not recommended.

Directions for use and doses

Inside, before meals. Children from 3 to 6 years old – 5 ml 3 times a day; from 6 to 12 years – 10 ml 3 times a day; 12 years and older – 15 ml 3 times a day; adults – 15 ml 4 times a day. Use the measuring cap (supplied). The measuring cap should be washed and dried after each use. If the cough persists for more than 7 days, you should consult a doctor.

Side effect

Classification of the frequency of occurrence of adverse reactions: very often (≥1/10); often (≥1/100, Overdose Symptoms: drowsiness, nausea, vomiting, diarrhea, dizziness and decreased blood pressure. Treatment: gastric lavage, taking activated charcoal, maintaining vital body functions. There is no special antidote.

Interaction with other drugs

No drug interactions have been reported for butamirate. Due to the fact that butamirate suppresses the cough reflex, the simultaneous use of expectorants should be avoided to avoid the accumulation of sputum in the respiratory tract with the risk of developing bronchospasm and respiratory tract infection.

special instructions

The syrup contains saccharinate and sorbitol as sweeteners, so it can be prescribed to patients with diabetes. The drug contains a small amount of ethyl alcohol (11.73 mg/5 ml), less than 100 mg per dose. Due to the presence of ethyl alcohol in the drug, use with caution in patients with a tendency to develop drug dependence, with liver diseases, alcoholism, epilepsy, brain diseases, pregnant women and children.

Release form

Syrup (vanilla) 1.5 mg/ml. 100 ml in a bottle made of dark glass, with a lid made of polyethylene and polypropylene, equipped with a child-proof system, and with a measuring cap made of polypropylene. The bottle along with instructions for use is placed in a cardboard box.

Storage conditions

At a temperature not exceeding 30 C. Keep out of the reach of children.

Best before date

3 years. Do not use after expiration date

Analogues of Sinecode

The pharmaceutical market is represented in sufficient quantities by analogues of Sinecode from Russian and foreign manufacturers. These medications not only have similar indications and therapeutic results. Some substitutes for Sinecode also have an equivalent effect due to the same active substances. They are sold in pharmacies under the guise of:

• generics;
• synonyms;
• combined means.

Among the wide variety of drugs, there are analogs of Sinekod that are cheaper and more expensive, but with the same effect.

List of Sinecode analogues with prices.

Prices for Sinecode analogues depend on the manufacturer, the original ingredients and the degree of their purification.

Sinecode or Omnitus - which is better for an adult?

Manufacturer: HEMOFARM (Serbia)
Release form: tablets, syrup

Active ingredient: butamirate

Both medications have the same active substance, so their mechanisms of action will be equivalent. The difference between the drugs lies in the form of release of the drugs and the concentration of the active substance. Sinecode is presented in drops, syrup and dragees, while Omnitus is available only in tablets and syrup, which contains almost 2 times less active ingredient compared to Sinecode.

Syrup for children can only be used from 3 years old, and tablets - from 6 years old. For a child from 2 months of age, Sinekod drops are the best.

For dry cough in adults, Sinekod will be an advantage, since the dosage in the medicine is higher and the activity of the medicine will be more effective.

Erespal or Sinekod

Erespal is a French-made drug that is not an exact structural analogue of Sinecod, but is similar in some indications for use. The drug is presented in the form of tablets and syrup.

Instructions for use of the drug Erespal:

The drugs differ in their mechanism of action, the list of indications and the range of pharmacological effects of Erespal are wider: the medicine will help cope with otitis and sinusitis, manifestations of allergic reactions, and will additionally have an antispasmodic effect.

Such medications should not be used together due to the risk of developing unwanted reactions in the body.

Sinecode or Codelac Neo - which is better?

Manufacturer: PHARMSTANDARD-LEKSREDSTVA (Russia)
Release form: tablets, syrup, drops

Active ingredient: butamirate

Sinecode and Codelac Neo are equivalent in action, since both medications contain the same active substance. An analogue of Sinecode for children with dry cough in the form of syrup can be used from 3 years, tablets - from 6 years, in the form of drops - from 2 months. Codelac Broncho has more side effects in adults.

Therefore, a Swiss drug, the effect of which has been tested by many years of pediatric practice, is better suited for a child. For an adult with a dry cough, the analogue of Sinekod will be cheaper, but with the same effectiveness of the medicine.

Sinekod or Rengalin - which is better?

Manufacturer: NPF MATERIA MEDICA HOLDING LLC (Russia)
Release form: lozenges, oral solution

Active ingredient: affinity purified antibodies to bradykinin, morphine, histamine

Both medications have the same indications and treatment results, but differ in their mechanism of action. The Rengalin analogue is a combination drug that reduces the excitability of the cough center and inhibits pain sensitivity centers in the central nervous system.

Rengalin will be the best, thanks to the ingredients included in the medicine; the drug has anti-inflammatory, anti-edematous, anti-allergic and antispasmodic effects. The drug does not cause addiction, does not cause respiratory depression, actively relieves cough and alleviates the symptoms of diseases of the respiratory system.

Sinecode or ACC - which is better for dry cough

Manufacturer: HERMES ARTSNAIMITTEL GMBH (Germany)
Release form: effervescent tablets, granules for solution preparation

Active ingredient: acetylcysteine

Both drugs are used in therapeutic practice to eliminate cough, but have different active substances and mechanisms of action. An analogue of Sinekoda tablets, the drug ACC will be the best for diseases of the respiratory system, accompanied by the formation of viscous mucopurulent sputum and a productive cough.

For a dry cough, Sinekod is better suited, since the medication directly affects the cough center of the central nervous system, eliminates the cough reflex due to irritation of the bronchial tree and facilitates breathing, improving spirometry.

Pharmacological action and indications for use

The active substance is an antitussive that does not belong to the opioid alkaloids.

Butamirate inhibits cough centers, eliminates paroxysmal coughs provoked by infectious and inflammatory diseases, without affecting the activity of the respiratory center.

Taking drops or syrup does not cause addiction or drug dependence.

The following pharmacological effects are observed:

• Suppression of cough.
• Providing a direct effect on cough centers.
• Normalization of breathing.
• Improving indicators such as oxygen supply to the blood and reducing airway resistance.
• Providing a bronchodilator effect.

The latter allows you to relieve spasms of the bronchi, increase their lumen, and remove phlegm and pathogenic microorganisms. The drug reduces swelling of the mucous membranes and normalizes the functional state of the bronchial glands.

Thanks to the Sinecode effect, the inner surface of the bronchi is moisturized, which helps relieve coughing and improve general condition.

After taking the medicine, the maximum concentration of the active component is observed after 90 minutes.

Butamirate does not accumulate in tissues and internal organs; the half-life takes up to 5-6.5 hours. The component is excreted by the kidneys.

Sinekod is used in the complex treatment of dry cough of various origins:

• To suppress cough reflexes caused by diagnostic tests (bronchoscopy).
• For acute and chronic bronchitis.
• To eliminate coughing attacks caused by whooping cough.
• For smoker's cough.

The drug is not intended for self-medication; consultation with a doctor is required before starting use.

Sinekod or Stoptussin - which is better for children with dry cough

Manufacturer: TEVA CZECH ENTERPRISES S. R. O. (Czech Republic)
Release form: tablets, drops, syrup

Active ingredient: guaifenesin, butamirate

An analogue of Sinekod cough syrup for children and the Swiss drug Stoptussin contain the same active substance. The latter is a combination product containing one more active ingredient that stimulates the glands that produce mucus in the bronchi.

Under the influence of the medicine, viscous sputum is liquefied and evacuated out. The cough then becomes wet, that is, productive. For children with a dry cough, the best option would be Sinekod, which causes fewer side effects and can be used from 2 months. For very severe coughs, it is more advisable to use Stoptussin, since the drug is more effective due to the combination of active substances.

Stoptussin or Sinekod

Stoptussin is a combination drug, a substitute for Sinecod, which, in addition to butamirate, also contains guaifenesin.

The medicine has a wider spectrum of pharmacological activity: thanks to the additional substance, there is an increase in the secretion of the bronchial glands and a decrease in the viscosity of mucus.

With this composition, tablets and drops for internal use are available on the pharmaceutical market. There is another dosage form - Stoptussin phyto syrup, which contains extracts of plantain and thyme as active substances.

The analogue is recommended for use in acute and chronic bronchitis and tracheitis, bronchial asthma, bronchopneumonia, whooping cough. You should refrain from using the medicine during the 1st trimester of pregnancy and breastfeeding, with myasthenia gravis, intolerance to the active components.

It is worth considering the age restrictions for the use of one or another dosage form:

• tablets are approved for use by patients over 12 years of age;
• drops – from 6 months;
• syrup – from 12 months.

Unlike Stoptussin, Sinekod does not exhibit mucolytic properties; the active substance directly affects the cough centers and suppresses the reflex.

As for the safety of use in childhood, Sinekod is approved from 2 months, while the use of Stoptussin drops should be avoided for up to six months. Pregnant women (especially in the first trimester) and breastfeeding women should avoid using both drugs.

Sinekod or Ascoril - which is better for a dry cough for an adult

Manufacturer: GLENMARK (India)
Release form: tablets

Active ingredients: bromhexine, guaifenesin, salbutamol

Both medications are prescribed to relieve cough, but have different mechanisms of action. Ascoril is a combination medicine that has a bronchodilator, expectorant and mucolytic effect. The analogue is prescribed for productive cough accompanying respiratory tract diseases with bronchial obstruction.

For dry coughs in adults and children, the best option is Sinekod, which suppresses the unwanted reflex by directly influencing the cough center of the brain. The release of the medicine in the form of dragees or syrup allows an adult to choose the most convenient form for use.

How does the syncode work?

Sinekod has nothing to do with narcotic substances, because...
dubious sources claim. The action of sodium butamirate is based only on blocking the cough center, but no depression occurs in the brain. According to research, in addition to its suppressive effect on cough, sinekod is able to dilate the bronchi and relieve minor inflammation.

If you diagnose forced expiration using special equipment, you can clearly see that this indicator improves in patients, and the numbers at the level of small, medium and large bronchi are normalized.

In simple terms, it becomes easier for the patient to breathe and the obsessive cough decreases.

Sinekod or Lazolvan

Manufacturer: DELPHARM Rheims (France)
Release form: tablets, lozenges, syrup, solution for oral administration and inhalation

Active ingredient: ambroxol

Medicines Lazolvan and Sinekod have different active substances and mechanisms of action. The drugs belong to different pharmacological groups. Sinekod is an antitussive drug and is mainly used for dry cough.

Lazolvan acts as a mucolytic agent that stimulates the secretory function of the respiratory tract and thins sputum. That is, it is prescribed and will be best for wet or productive cough.

The indication for prescribing Sinekod or its analogue will be the clinical picture of the disease and the type of cough.

When is the syncode shown?

In order to choose cheaper analogues, you need to know that the main criterion for using synecode is a dry cough. It is he who “presses” the patient and deprives him of all the joy of life. Sometimes this cough occurs in attacks, often in the evening and at night.

A painful dry cough occurs with the following diseases and medical interventions:

• whooping cough (more often in children, adults rarely suffer from this pathology);
• bronchitis (all forms);
• laryngitis;
• smokers' cough (usually experienced smokers);
• bronchial asthma;
• residual manifestations of cough;
• performing bronchoscopy;
• surgical operations.

Sinecode or Bromhexine - which is better?

Manufacturer: JSC BIOSINTEZ (Russia)
Release form: tablets, syrup

Active ingredient: bromhexine

Both drugs are prescribed for the treatment of diseases of the respiratory system accompanied by cough. Medicines have a positive therapeutic effect, but have a different mechanism of action and different pharmacological groups. The best for dry cough would be Sinekod, which actively relieves cough and is a centrally acting antitussive.

Its analog Bromhexine has mucolytic and expectorant effects. It will be best for diseases accompanied by a wet cough. The medication actively dilutes mucus and promotes its rapid evacuation from the bronchi, facilitating breathing and improving the general condition of the patient.

Comparative assessment of synecode and its analogues

When choosing one of the analogues, patients try to determine the drug that will be most effective and will bring a quick recovery. Unfortunately, many people have chronic diseases, which may be a contraindication to the use of Sinecode and its analogues.

Therefore, this issue should be approached scrupulously, studying in detail the official instructions for the drugs of interest. Of course, the doctor should select the drug, taking into account all the patient’s expectations.

Some specialists offer the patient several drugs to choose from, allowing the patient to make their own preference. This is not entirely correct, because... Patients may have some doubts. The doctor must clearly prescribe the drug and, if necessary, describe a detailed treatment regimen.

Gerbion

Manufacturer: KRKA (Slovenia)
Release form: syrup

Active ingredient: liquid extract of plantain leaves (primrose), mallow flowers, ascorbic acid

Herbion is a natural medicine that belongs to the group of expectorants of plant origin. The analogue is a combined agent that has an expectorant, anti-inflammatory and antimicrobial effect. The medication helps to liquefy mucus and remove it from the bronchi.

Ambroxol

Manufacturer: OZON LLC (Russia)
Release form: tablets, capsules, solution for injection and internal use

Active ingredient: ambroxol

Ambroxol is a stimulant for respiratory motility, which has a mucolytic and expectorant effect. Increases the formation of bronchial secretions with reduced sputum viscosity and stimulates the motor activity of the ciliated epithelium. This effect of the drug facilitates the removal of secretions from the respiratory tract, alleviating the patient’s condition.

Bronholitin

Manufacturer: SOPHARMA JSC (Bulgaria)
Release form: syrup

Active ingredient: glaucine, ephedrine

Broncholitin is a combination drug with antitussive and bronchodilator effects. This analogue of Sinekod cough syrup helps to dilate the bronchi, relieve spasm of the respiratory tract and suppress the cough reflex. In addition, the medication has a mild sedative and antimicrobial effect. The effect of using the product occurs 1.5 hours after its use.

What else can replace Sinekod, what cough remedies for adults and children? You can add the following drugs to the list of analogues:

• Erespal;
• Panatus;
• Fluifort;
• Ambrobene;
• Gedelix;
• Mukaltin;
• Doctor Mom;
• Stodal;
• Fluditek;
• Bronchipret;
• overslept;
• Linkas.

Such a variety of cough analogues allows them to be used in pediatric and therapeutic practice with maximum therapeutic effect, taking into account the characteristics of the child and adult body.

A correctly selected analogue, which maximally relieves the manifestations of cough in case of respiratory tract disease, will quickly suppress the cough reflex, reduce the manifestations of the inflammatory process and prevent unwanted complications.

Answers on questions

Sinekod drops or syrup - which is better for children?

For children from 2 months to 3 years old, drops are the best, and from 3 to 6 years old - syrup, which is taken 3 times a day.

Sinekod for what kind of cough: dry or wet (moist)?

The medication is prescribed for dry cough.

Sinecode syrup or tablets - which is better?

For children, syrup is best, and for adults, tablets.

Contraindications and side effects

Taking Sinecode is prohibited if:

• Individual intolerance to the components of the drug.
• Pulmonary hemorrhages.
• Drops should not be used for up to 2 months.
• Syrup – up to 3 years.
• During the 1st trimester of pregnancy.
• During lactation.
• Fructose intolerance.

Particular care is required in the treatment of women during the 2nd and 3rd trimester of pregnancy, patients with a history of alcohol and drug addiction, epilepsy, liver and brain diseases.

In rare cases, the drug causes the development of undesirable side reactions such as drowsiness, nausea, diarrhea, and urticaria.