Modern approaches to the prescription of progesterone in the practice of an obstetrician-gynecologist

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Progesterone (Progesteronum)

The dosage regimen is individual.
The dose, frequency and duration of treatment are determined according to the regimen depending on the indications and clinical situation.

The progestogenic effect of 20-25 mg of progesterone when administered intramuscularly is equivalent to intravaginal administration (in the form of a suppository) of 100 mg of progesterone.

Secondary amenorrhea

(caused by hormonal imbalance, in the absence of organic pathology).

Orally at a dose of 400 mg 1 time per day (in the evening) for 10 days.

Intramuscularly 5-10 mg/day for 6-10 consecutive days.

Intramuscularly in a single dose of 100-150 mg.

Intramuscularly for adults, the highest single dose is 0.025 g (2.5 ml of 1% or 1 ml of 2.5% solution).

Intravaginally (in the form of a vaginal gel) at a dose of 45 mg (one applicator of 4% gel) every other day in 6 doses. You can increase the dose to 90 mg (one applicator of 8% gel) every other day up to 6 injections (8% vaginal gel is used only if 4% gel is ineffective).

With full ovarian activity or previous treatment with estrogen within 2 weeks before the administration of progesterone, withdrawal bleeding develops within 48-72 hours after the last injection. If menstrual bleeding occurs during treatment, stop using progesterone. Spontaneous normal menstruation may then develop.

Increasing the dose to 90 mg through the use of 4% vaginal gel does not provide the necessary absorption of the substance: the use of 8% gel is necessary.

With secondary amenorrhea of ​​4 and 8%, vaginal progesterone gel more often causes progestogenic changes in 92 and 100% of patients, respectively, and withdrawal bleeding in 81 and 82% of patients, respectively, in the absence of serious side effects and the associated need to discontinue treatment (2%).

Dysfunctional uterine bleeding

(for parenteral use).

Intramuscularly 5-10 mg/day (15 mg/day) for 6-8 consecutive days.

Orally 400 mg/day for 10 days.

The bleeding should stop within 6 days. When combined with estrogens, treatment with progesterone begins 2 weeks after taking them. If menstruation develops during treatment, the use of progesterone is discontinued.

Induction of menstruation

(for parenteral use): before prescribing a progestin, adequate stimulation of the secretory phase of the endometrium with estrogens is necessary. Withdrawal bleeding in women with an intact uterus usually develops within 3-7 days after stopping the progestin.

Intramuscularly 5-10 mg/day for 5-10 consecutive days, stopping 2 days before the expected menstruation.

Orally at a dose of 400 mg/day for 10 days.

Intravaginally (in the form of a gel) at a dose of 45 mg every other day, on the 15-25th day of the menstrual cycle.

Reproductive technologies:

maintaining the luteal phase in women.

Intravaginally (in the form of a gel) at a dose of 90 mg (one applicator of 8% gel) 1 time per day. For in vitro fertilization, treatment begins within 24 hours after embryo transfer and continues for 30 days. When pregnancy occurs, therapy is continued until the placenta becomes independent (10-12 weeks of pregnancy).

Partial or complete ovarian failure: intravaginally (in the form of a gel) at a dose of 90 mg (one applicator of 8% gel) 2 times a day before the transfer of a donor oocyte; when pregnancy occurs, treatment is continued until the placenta becomes independent (10-12 weeks of pregnancy).

When donating eggs

(against the background of estrogen therapy): intravaginally (in the form of capsules) at a dose of 100 mg/day on the 13th and 14th days of the cycle, then 100 mg 2 times a day from the 15th to the 25th day of the cycle. From the 26th day and if pregnancy is detected, the dose is increased by 100 mg/day every week, reaching a maximum (600 mg in 3 doses for 60 days).

To maintain the luteal phase during the in vitro fertilization cycle: intravaginally (in capsule form) 400-600 mg/day, starting from the day of human chorionic gonadotropin injection and until the 12th week of pregnancy.

Intravaginally (in the form of suppositories) 25-100 mg 1-2 times a day, starting a few days before ovulation. If pregnancy occurs, treatment is continued until the 11th week.

Corpus luteum deficiency

(maintaining the luteal phase in women).

Intramuscularly at least 12.5 mg/day, starting a few days before ovulation. The duration of treatment is about 2 weeks, but if necessary, therapy is continued until the 11th week of gestation.

Intravaginally (in the form of a gel) at a dose of 90 mg (one applicator of 8% gel) 1 time per day. When pregnancy occurs, treatment is continued until placental autonomy is achieved (10-12th week of gestation).

Intravaginally (in capsule form) 200-300 mg/day, starting from the 17th day of the menstrual cycle for 10 days. If menstruation is delayed and pregnancy occurs, treatment must be continued.

Intravaginally (in the form of suppositories) at a dose of 25-100 mg 1-2 times a day, starting a few days before ovulation. If pregnancy occurs, treatment is continued until the 11th week of gestation.

In case of corpus luteum insufficiency, intravaginal use of micronized progesterone in the first trimester of pregnancy is superior to its intramuscular administration in terms of the likelihood of continuing pregnancy (30.5 versus 19.1%; p <0.05).

Assessment of endogenous estrogen production

: for parenteral use - diagnosis of menopause by measuring the concentration of estrogen in the absence of menstruation after discontinuation of progestin. The standard method for verifying menopause is measuring the levels of gonadotropins in the blood.

Intramuscularly in a single dose of 100 mg.

Prevention of endometrial hyperplasia

in postmenopausal patients who receive estrogens in the form of hormone replacement therapy.

Orally at a dose of 200 mg 1 time per day before bedtime for 14 days (from the 8th to the 21st day of a 28-day cycle or from the 12th to the 25th day of a 30-day cycle).

Intravaginally (in the form of a gel) at a dose of 45 mg every other day for 12 days of a 28-day cycle.

The dose is adjusted based on the desired uterine response (regular withdrawal bleeding or amenorrhea). In many treatment regimens, hormones are not taken at all during the last 5-7 days of each month.

Premature menopause.

Prevention of habitual and threatened miscarriage

, caused by gestagenic insufficiency of the corpus luteum.

Intravaginally (in capsule form) 100-200 mg 2 times a day daily (until the 12th week of pregnancy).

Intramuscularly at a dose of 10-25 mg daily or every other day until the symptoms of a possible miscarriage completely disappear. With a routine abortion, treatment is continued until the 4th month of pregnancy.

Intramuscularly at a dose of 25-100 mg daily, starting from the 15th day and continuing until the 8-16th week of pregnancy.

Intravaginally (in the form of a gel) 90 mg/day, continuing for 30 days after laboratory confirmation of pregnancy.

Threat of miscarriage:

there is no evidence of the effectiveness of the use of progestins for threatened abortion, with the exception of the administration of progesterone to patients with its deficiency.

Intravaginally (in capsule form) 100-200 mg 2 times a day daily until the 12th week of pregnancy.

Intramuscularly at a dose of 10-25 mg daily or every other day until the symptoms of a possible miscarriage completely disappear. With a routine abortion, treatment is continued until the 4th month of pregnancy.

If there is a threat of miscarriage

caused by insufficiency of the corpus luteum, the use of progesterone (in the form of 8% vaginal gel) for 5 days significantly reduces the severity of pain, the frequency of uterine contractions (p <0.005) and the likelihood of miscarriage within 60 days (p <0.05) compared with placebo ).

Prevention of uterine fibroids.

Endometriosis.

Oligomenorrhea and algomenorrhea

caused by hypogenitalism.

Orally at a dose of 200-300 mg for 10 days (from the 17th to the 26th day of the cycle).

Hypogenitalism and amenorrhea:

after using estrogens - IM at a dose of 5 mg daily or 10 mg every other day for 6-8 days.

Algodismenorrhea:

treatment begins 6-8 days before menstruation. The drug is administered intramuscularly at a dose of 5-10 mg daily for 6-8 days. For algodismenorrhea caused by underdevelopment of the uterus, it is combined with estrogens at a rate of 10 thousand units every other day for 2-3 weeks, then progesterone is administered for 6 days.

Fibrocystic breast disease, mastodynia.

Orally at a dose of 200-300 mg for 10 days (from the 17th to the 26th day of the cycle).

Externally (in the form of a gel). One dose of gel (2.5 g) 2 times a day is applied to the skin of the mammary gland until completely absorbed (including on menstruation days).

Use in children

Efficacy and safety have not been studied. There are descriptions of severe side effects in children who accidentally took high doses of oral contraceptives.

Pharmacodynamics and pharmacokinetics

Progestogen is a steroid hormone that is produced in the body by the corpus luteum of the ovaries .

The mechanism of action of progesterone drugs is associated with their ability to interact with specific progestin receptors, which are located on the surface of target cells.

By binding to them, the substance penetrates the cell nucleus, activates deoxyribonucleic acid and stimulates the synthesis of ribonucleic acid.

The effect on a woman’s body is that the drug:

  • stimulates the transition of the endometrium (the mucous layer of the inner mucous membrane that lines the body of the uterus) from the proliferative phase, which coincides with the ovulatory and follicular phases of the ovarian cycle, to the secretory phase;
  • creates optimal conditions for embryo , reduces the sensitivity of the uterus and fallopian tubes to the action of oxytocin and has a tocolytic effect;
  • stimulates lipoprotein lipases ;
  • increases body fat reserves;
  • helps increase the level of induced and basal (background) insulin glucose utilization ;
  • enhances the accumulation of glycogen in the liver;
  • stimulates the synthesis by the adrenal cortex of the mineralocorticosteroid hormone aldosterone ;
  • provokes hypoazotemia ;
  • increases the excretion of nitrogen-containing metabolic products in the urine;
  • suppresses the production of a number of hypothalamic factors for the release of luteotropin (LH) and follicle-stimulating hormone (FSH) and, accordingly, the biosynthesis of pituitary gonadotropic hormones ;
  • reduces the permeability of the capillary wall in the tissues of the mammary glands;
  • reduces swelling of the connective tissue framework, depending on the phase of the menstrual cycle ;
  • suppresses the proliferative and mitotic activity of ductal epithelial tissue (in the case when progesterone is used in the form of a gel).

When taken orally, intravaginally using the drug in capsules, or injecting an injection solution under the skin and into the muscle, the substance is quickly absorbed. When applied to the skin in gel form, it is almost not absorbed and does not enter the systemic circulation.

The maximum plasma concentration when taking the tablet orally is observed after 1-3 hours; with intravaginal application, this figure is achieved after 2-6 hours.

protein binding (mainly albumin (approximately 50–54%) and 43–48% corticosteroid binding globulin ).

In the liver, the substance is biotransformed into inactive metabolites (mainly pregnanediol and pregnanolone ).

From 50 to 60% of the substance is eliminated by the kidneys , more than 10% - with bile ; Progesterone metabolization products excreted in bile intestinal and can undergo enterohepatic recirculation .

Contraindications

All dosage forms of Progesterone are contraindicated:

  • in case of hypersensitivity to the components of the drug;
  • in the presence of serious impairment of renal function and/or hepatic function ;
  • if the patient is diagnosed with hepatitis ;
  • in the acute form of inflammation of the venous walls , as well as in acute thromboembolic diseases ;
  • patients who have an increased risk of blood clots ;
  • vaginal (vaginal) bleeding of unknown origin;
  • missed miscarriage;
  • incomplete abortion;
  • porphyrin disease.

Additional contraindications to the use of an oil solution are:

  • the presence of a malignant tumor of the mammary gland or genital organs (for breast carcinoma, exceptions are cases when progesterone is prescribed as part of complex therapy);
  • pregnancy (starting from 14 weeks).

Side effects

Treatment with progesterone drugs can cause the development of allergic reactions.

The effect on a woman’s body of the drug in capsule form is in some cases accompanied by:

  • increased drowsiness;
  • dizziness that occurs 1-3 hours after taking the tablet;
  • various types of menstrual cycle disorders (for example, a reduction in its duration or the appearance of intermediate bleeding).

The most common side effects of injections:

  • acute blockage of the lumen of blood vessels by a thrombus;
  • thrombophlebitis (thrombosis accompanied by inflammation of the venous wall);
  • thrombosis of retinal blood vessels;
  • increased blood pressure ;
  • the appearance of edema ;
  • chronic cholecystitis , characterized by the formation of stones in the gallbladder (calculous cholecystitis);
  • increased drowsiness ;
  • headache;
  • apathy;
  • visual impairment;
  • hair loss ( alopecia );
  • decreased libido ;
  • hirsutism (male pattern hair growth in women);
  • attacks of nausea and vomiting;
  • deterioration of appetite and, as a result, loss of body weight;
  • menstrual irregularities;
  • cholestatic hepatitis;
  • depression;
  • dysphoria (gender identity disorder);
  • release of milk from the mammary glands not associated with breastfeeding ( galactorrhea );
  • enlargement, tenderness and tension of the mammary glands;
  • local reactions (redness of the skin and pain at the injection site).

Analogs

Matches by level 4 ATX code:
Iprozhin

Utrozhestan

Crinon

Prajeesan

Progestogel

Progesterone-containing drugs are Utrozhestan , Iprozhin , Crinon , Prajisan , Progestogel , Endometrin . A multicomponent analogue of the drug - vaginal capsules Triozhinal .

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