Vaccine prevention of influenza. New domestic vaccine Ultrix®


Lakhta Clinic offers seasonal flu vaccinations for children and adults, as well as corporate clients. For private patients, vaccinations are carried out in all three branches in St. Petersburg - on the street. Savushkina, 73, Kovensky lane, 5 and Lakhta Junior. For corporate clients, we offer vaccination of employees with on-site visits to the office or enterprise. All prices include the cost of a pre-vaccination examination. We remind you that an appointment is required. The seasonal flu vaccination campaign begins every fall. Many people underestimate the danger of this infection, but it can cause a lot of problems.

ULTRIX QUADRI (Fort, Russia) (EXPECTED TO DELIVERY)

It is a vaccine against all four circulating seasonal influenza virus strains. The composition includes inactivated influenza viruses split into individual small antigens. Ultrix Quadri does not contain adjuvants, since the concentration of viral antigens in the drug is sufficient to form an immune response.

Age restrictions:

for children from 6 months and adults up to 60 years.

Price:

3,500 rubles , including examination by a doctor before vaccination.

Early 20th century: Spanish flu

The most famous flu pandemic that everyone hears is the Spanish flu. It is not known for certain where the pandemic began. It is believed that China was among the first countries. A little later - America and France, and only a few months later - Spain, Italy, Switzerland and then the whole world.

The Spanish flu is a flu, its pandemic lasted two years (1918-1920), about 30% of the planet's population (about 550 million people) became infected, and up to 50-100 million people died.

A distinctive feature of the disease was the rapid development of severe pneumonia. The Spanish flu claimed the lives of the younger generation, almost without affecting people 50-60 years old. Later, medicine will explain this mystery by the fact that the older generation had already developed immunity due to previously suffering from influenza with similar strains.

In those days, doctors were almost powerless. They looked for various methods of treatment, but the only thing that somehow helped was blood transfusions from those who had already been ill and recovered.

FLU-M (SPbNIIVS, Russia)

A proven vaccine against three of the four circulating seasonal influenza virus strains. The vaccine contains inactivated influenza viruses that have been split into individual small antigens. FLU-M does not contain adjuvants, since the concentration of viral antigens in the vaccine is sufficient to generate an immune response.

Age restrictions:

for children from 6 years old with no age limit.

Price:

2,000 rubles , including examination by a doctor before vaccination.

1st half of the 20th century: discovery of the cause of the disease

Oddly enough, such disasters also entail important discoveries in the development of science. In 1933, research by British scientists: Patrick Laidlaw, Wilson Smith and Christopher Andrews led to the discovery of the virus. They conducted experiments on laboratory ferrets (and later mice) and proved that the culprit of the disease was not a bacterium, but a virus.

Sheffield professor Charles Stewart-Harris (author of classic textbooks on virology) took part in the development of the first vaccine.

In the USSR, virus research was led by the head. Department of Bacteriology at the Leningrad Institute of Epidemiology and Bacteriology named after Louis Pasteur - Anatoly Smorodintsev. He developed the first monovalent vaccine in 1936-1938. It contained only 1 strain of influenza, it was of the “live” type, i.e. contained a weakened virus, not fragments of it. In those days it was not possible to avoid frequent side effects, but nevertheless, even such a vaccine was a breakthrough step.

Another difficulty was that the virus mutates quickly, but scientists did not know this yet and the flu returned again and again.

FLU-M TETRA (SPbNIIVS, Russia)

Vaccine for the prevention of influenza (tetravalent inactivated split). Forms immunity to all four that are relevant in 2021/2022. strains of influenza types A and B. Immunity is developed up to two weeks after vaccination and lasts up to a year. Prompt vaccination is possible at the beginning of the epidemiological rise in the incidence of influenza. The vaccine is administered once. It can be used simultaneously with inactivated and live vaccines of the vaccination schedule, vaccination during pregnancy is possible - the final decision on the possibility of vaccination is made only by a doctor during an individual examination, taking into account the risk of contracting influenza and its possible complications.

Age restrictions:

from 18 to 60 years old.

Price:

2000 rubles , including examination by a doctor before vaccination.

Reviews from parents

Negative opinions about the Ultrix vaccine are quite common; people write that after this vaccine the temperature rose, signs of acute respiratory infections began, even to the point of catching the same notorious flu. The description of the drug states that it contains viruses cultured on chicken embryos. That is, the split vaccine is included in the second group in terms of protection and contraindications.

In addition to negative reviews, there are, of course, positive ones.

An excerpt of opinions was taken from forums, comments and personal interviews with parents. Write your comments under the article - we need the TRUTH!!!

“My daughter was given Ultrix at school, but they didn’t give me a refusal because I was sick all last year. So the school nurse praised this vaccine to us, and after 1-2 days all the symptoms appeared - the temperature rose, the child just lay there. Because of this, they decided not to vaccinate their son and husband; as a result, the whole family got sick in February, except for their daughter. So Ultrix works, but at the beginning it can have a serious impact on the immune system.”

“After Ultrix, I fell ill in the same way in the winter. Maybe now I’ll install the French one, they say at least they don’t give any side effects.”

“This is just horror, not a vaccine. I installed Ultrix, almost immediately my cough and throat began to hurt, my performance decreased, I almost failed the session, I walked around half asleep. I will never stage this crap again.”

“I do Ultrix every year, there are no complications, I don’t get sick at all, although I work with people, and my colleagues constantly take sick leave. It’s a normal vaccine, I’ve been on it for 3 years now, and besides, we get paid at work. It’s better to do it once, so you don’t have to go to hospitals later and get even more infected.”

“When my son was 4 years old, he was diagnosed with Ultrix, and he was sick for almost two weeks. The doctor said that maybe there was already a hidden cold somewhere, which is why it had such an effect. This year they didn’t install it, they just took it out of kindergarten for the winter months.”

“I put Ultrix in early pregnancy (I didn’t yet know that I was pregnant), the child was born healthy, I didn’t have the flu, although I worked with people before the maternity leave. The vaccination was painless and I didn’t find any side effects.”

“My son was given Ultrix Forte at school, and as a result, he was the only one in the family who did not get sick. We had a very hard time with the flu this year, we just lay there.”

“I am for vaccinations. It was done for my youngest daughter in kindergarten, for my eldest daughter at school, and my husband and I had it done at the local doctor’s office for free. It’s a good vaccine, there weren’t even any acute respiratory infections this year.”

Which flu vaccine to choose

All flu vaccines contain strains of influenza viruses that are relevant for the coming season. The vaccine contains antigens from three or four of the expected four strains - such vaccines are called trivalent or quadrivalent .

What are the pros and cons? Vaccines containing antigens from all four strains provide more complete protection. Trivalent vaccines are less likely to cause any negative reactions to the vaccine.

Reviews from doctors

A few reviews from honest doctors are approximately the following:

“All over the world, people at risk are vaccinated against influenza. The elderly, over 65 years old, children who have chronic illnesses, schoolchildren, sellers and even doctors themselves. Ultrix is ​​a regular split vaccine against 3 main strains. There are complications from it, doctors are trained for this, there are many situations when vaccination is prohibited. Practice shows that Ultrix works, but everyone’s body is different, so some people may sneeze and cough for several days, even leading to more serious symptoms of ARVI. Then it goes away, immunity arises. But, if a doctor vaccinates an already sick child, or one whose immunity has been reduced to zero, then the consequences will be the saddest. A child for vaccination must be assessed individually, especially for Ultrix. If you don’t want complications, then it’s better to get a subunit European vaccine, for example, Influvac or Russian Grippol-Plus. But they protect a little worse than split vaccinations, that is, Ultrix.”

“Doctors hear a lot of negative reviews about flu vaccinations; there are also colleagues who refrain from vaccination and do not give it to their children. Even in the medical community, opinions differ. But still, the Ministry of Health is testing the effect of vaccines, and there are already positive dynamics with Ultrix, proving that this vaccine is relatively safe and works well.”

“Every doctor has a vaccination plan, there’s no getting around it. Ultrix itself is not a bad vaccine, at least from experience I can say that it causes fewer adverse reactions than vaccinations used 5-7 years ago, and even more so, compared to live vaccines, it is practically harmless. However, complications do happen. If the child’s immunity is weak, he has recently received other vaccinations and there have been complications, or the body is susceptible to allergies, he does not need Ultrix, like any other flu vaccine. Another point is that vaccination begins in the fall, when children are already suffering from acute respiratory infections. “Many doctors simply don’t take the temperature or examine children as instructed, hence the problems.”

“After Ultrix, I recommend using absorbents like Enterosgel, drinking more fluids, and eating fruits and fiber. A week before vaccination, take vitamins. There are fewer side effects, fewer signs of intoxication, nausea, loss of strength and headaches after Ultrix.”

“Approximately 85-90% of those vaccinated do not complain about the vaccine. And this is a very good indicator. We looked at the statistics for the district and individual educational institutions - the incidence rate dropped over the past year. Not a bad domestic vaccine.”

As you can see, in general, Ultrix doctors approve, but do not remain silent about the problems. If a child may have allergies or simply low immunity, it is better to refuse the injection.

Flu vaccination by risk group

It is especially undesirable for children of preschool and school age, pregnant women, the elderly, people with a weakened immune system and chronic diseases of the heart and lungs, central nervous system, and diabetes to get sick.
In these people, the flu can be extremely severe, with complications and a high probability of death. That is why they are vaccinated first. It is also important for their relatives and immediate circle to undergo preventive vaccination in order to reduce the risk of encountering an infection within the family. Please register and ask all questions by phone: +7.

Mid-20th century: the secret of the virus revealed

By this time, scientists had already identified 3 types of influenza virus. They are designated A, B and C.

1957 American virologist, Maurice Hilleman and his colleagues, when discovering the next type of influenza virus, discovered that people who survived the 1889-1890 pandemic were resistant to the new virus. Scientists have identified which proteins are responsible for the formation of immunity and have developed a suitable vaccine.

It turned out that the influenza virus consists of surface

and
internal
antigens. Surface antigens are variable, but internal antigens are constant.

Surface antigens

– this is:
hemagglutinin
(in the name of the strain it is designated H) – ensures the ability of the virus to attach to the cell;
neuraminidase
(denoted N) - is responsible for the ability of a viral particle to penetrate the host cell and for the ability of viral particles to exit the cell after reproduction.

Both hemagglutinin and neuraminidase have varieties that are usually numbered: H1, H2, H3..., N1, N2, N3... The high variability of the influenza virus type “A” is due to two properties: A) the possibility of gene exchange between different viruses during simultaneous infection of the same and the same cells, and B) gradual variability in the structure of N and H as a result of mutations (antigenic drift).

Combinations of different surface antigens determine different strains of the same A virus (H1N5, H1N1, etc.). One of the most recently identified H18N11 strains was found in 2013 in bats in Central America.

Internal antigens

make up the core (genome) of the virus in the form of
a ribonucleoprotein complex (nucleoprotein in complex with viral RNA)
and determine the type of virus (A, B or C).

When the secret of the virus was revealed, 40 million doses were produced, which helped reduce the number of deaths in the United States tenfold. In 1968, Hilleman was given another strain, the Hong Kong flu, and four months later another new vaccine was produced.

However, countries without a vaccine continued to suffer from the return of the virus, with outbreaks recorded in late 1969, 1970 and 1972. However, there were no such devastating consequences, because by this time there were antibiotics that saved from secondary infections; there was vaccination in a number of states; and many who have recovered have developed immunity.

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