Aquadetrim: instructions for using drops

Aquadetrim is a medication that is responsible for the normal metabolism of phosphorus and calcium.

Pharmacology and pharmacodynamics
Why do they drink Aquadetrim?
How to take Aquadetrim drops correctly
Contraindications and adverse reactions
How to give Akvadetrim to a child
How to give Akvadetrim to a baby correctly
Can pregnant women take Aquadetrim?
Where should Aquadetrim be stored?
What is the best replacement for Aquadetrim?
special instructions
How much does Aquadetrim cost?

Pharmacology and pharmacodynamics

The medicine allows you to stabilize the metabolism of phosphorus and calcium in the body.

Vitamin D3 is known to everyone as an antirachitic element. It plays one of the main roles - it takes part in the metabolism of calcium and phosphates, which improves skeletal growth.

This vitamin is very important in the absorption of phosphates and calcium in the digestive system and the transport of salts.

If the child’s body receives an insufficient amount of the vitamin, its absorption will be impaired, and if the person is exposed to sunlight for a short time, this can lead to rickets in the child, and bone tissue can soften in an adult.

Aquadetrim - instructions for use

Pharmacological properties

Pharmacodynamics

Vitamin D3 is a natural form of vitamin D that is formed in humans in the skin under the influence of sunlight. Compared to vitamin D2, it is characterized by 25% higher activity.

Vitamin D binds to the specific vitamin D receptor (VDR), which regulates the expression of many genes, including the ion channel genes TRPV6 (ensures the absorption of calcium in the intestine), CALB1 (calbindin; ensures the transport of calcium into the bloodstream), BGLAP (osteocalcin; ensures bone mineralization tissue and calcium homeostasis), SPP1 (osteopontin; regulates osteoclast migration), REN (renin; ensures regulation of blood pressure, being a key element of the renin-angiotensin-aldosterone regulation system), IGFBP (insulin-like growth factor binding protein; enhances the action of insulin-like growth factor) , FGF23 and FGFR23 (fibroblast growth factor 23; regulate the levels of calcium, phosphate anion, processes of cell division of fibroblasts), TGFB1 (transforming growth factor beta-1; regulates the processes of cell division and differentiation of osteocytes, chondrocytes, fibroblasts and keratinocytes), LRP2 ( LDL receptor-related protein 2; mediates endocytosis of low-density lipoproteins), INSR (insulin receptor; ensures the effects of insulin on any cell type).

Vitamin D3 is an active antirachitic factor. The most important function of vitamin D3 is to regulate calcium and phosphate metabolism, which promotes proper mineralization and skeletal growth.

Colecalciferol plays a significant role in the absorption of calcium and phosphates in the intestine, in the transport of mineral salts and in the process of bone calcification, and also regulates the excretion of calcium and phosphates by the kidneys. The concentration of calcium ions in the blood determines the maintenance of muscle tone of skeletal muscles, myocardial function, promotes nervous stimulation, and regulates the process of blood clotting.

Lack of vitamin D in food, impaired absorption, calcium deficiency, as well as insufficient exposure to the sun during the period of rapid growth of a child leads to rickets, in adults - to osteomalacia, pregnant women may experience symptoms of tetany, disruption of the calcification processes of the bones of newborns.

An increased need for vitamin D occurs in women during menopause, as they often develop osteoporosis due to hormonal imbalances. Vitamin D has a number of so-called. extraskeletal effects.

Vitamin D is involved in the functioning of the immune system by modulating cytokine levels and regulating the division of T-helper lymphocytes and the differentiation of B-lymphocytes. A number of studies have noted a decrease in the incidence of respiratory tract infections with vitamin D supplementation.

It has been shown that vitamin D is an important part of the homeostasis of the immune system: it prevents autoimmune diseases (type 1 diabetes, multiple sclerosis, rheumatoid arthritis, inflammatory bowel diseases, etc.)

Vitamin D has antiproliferative and prodifferentiating effects, which determine the oncoprotective effect of vitamin D. It has been noted that the incidence of certain tumors (breast cancer, colon cancer) increases against the background of low levels of vitamin D in the blood.

Vitamin D is involved in the regulation of carbohydrate and fat metabolism by influencing the synthesis of IRS1 (insulin receptor substrate 1; participates in the intracellular pathways of the insulin receptor signal), IGF (insulin-like growth factor; regulates the balance of adipose and muscle tissue), PPAR-δ (activated receptor peroxisome proliferators, type δ; helps process excess cholesterol).

Low levels of vitamin D in humans are associated with unfavorable risk factors for cardiovascular pathology, such as diabetes mellitus, dyslipidemia, arterial hypertension, and are associated with the risk of cardiovascular accidents, incl. strokes.

Studies in experimental models of Alzheimer's disease showed that vitamin D3 reduced amyloid accumulation in the brain and improved cognitive function.

Non-interventional human studies have shown that the incidence of dementia and Alzheimer's disease increases with low vitamin D levels and low dietary intake of vitamin D. Cognitive function and the incidence of Alzheimer's disease have been impaired with low vitamin D levels.

Pharmacokinetics

An aqueous solution of vitamin D3 is absorbed better than an oil solution. In premature babies, there is insufficient formation and flow of bile into the intestines, which interferes with the absorption of vitamins in the form of oil solutions.

After oral administration, colecalciferol is absorbed in the small intestine. Metabolized in the liver and kidneys. The half-life of colecalciferol from the blood is several days and may be prolonged in cases of renal failure.

The drug penetrates the placental barrier and into mother's milk.

Excreted by the kidneys in small quantities, most of it is excreted in bile.

Vitamin D3 has the property of cumulation.

How to take Aquadetrim drops correctly

The dosage of the drug is determined for each patient individually, taking into account his condition. The required amount of solution must be combined with 1 spoon of water.

In order to prevent rickets in healthy and full-term babies, from 28 days of life to 3 years, you can take 1-2 drops every day. Premature babies and twins are prescribed 3 drops every day. In summer, the dosage should be reduced to 1 drop per day.

Pregnant women are prescribed 1 drop per day throughout pregnancy or 2 drops from the 3rd trimester. Postmenopausal women can take 2 drops per day.

To treat rickets, the medication is prescribed to be taken every day, 6-10 drops for 30 days, taking into account the severity of the condition and the clinical picture. In addition, you regularly need to monitor the patient’s condition and maintain normal levels of calcium and phosphorus in the body.

In the first 5 days you need to take 4 drops per day. When the patient is sure that the drug is well tolerated by the body, the dosage can be gradually increased. With significant changes in bone tissue, the dose can reach its maximum value of 10 drops.

If necessary, you can take a break and resume the therapeutic course again, but only after examination by a specialist and his appointment. Treatment should continue until significant results are achieved. After this, you can switch to taking a prophylactic dose.

Aquadetrim soluble tablets 500ME No. 90

Compound

Active substance: colecalciferol - 500 IU. Excipients: D,L-α-tocopherol, modified starch, sucrose, crystalline sodium ascorbate, medium chain triglycerides, silicon dioxide, mannitol, sodium benzoate.

Pharmacokinetics

Excreted by the kidneys in small quantities, most of it is excreted in bile. Vitamin D3 has the property of cumulation.

Indications for use

Prevention and treatment of vitamin D deficiency.
Prevention and treatment of rickets.
In the complex treatment of osteoporosis, including postmenopausal.

Contraindications

Hypersensitivity to the components of the drug. Hypervitaminosis D, increased concentration of calcium in the blood (hypercalcemia), increased excretion of calcium in the urine (hypercalciuria), urolithiasis (formation of calcium oxalate stones), sarcoidosis, acute and chronic diseases of the liver and kidneys, renal failure, active form of pulmonary tuberculosis, pseudohypoparathyroidism, sucrose/isomaltase deficiency, fructose intolerance, glucose-galactose malabsorption.

Carefully:

State of immobilization, atherosclerosis, during pregnancy and breastfeeding.
In patients taking thiazide diuretics, as well as in patients with cardiovascular diseases taking cardiac glycosides.
In infants with a predisposition to early overgrowth of fontanelles (when the size of the anterior crown is small from birth).

Directions for use and doses

Inside.

Dissolve the tablet in water at room temperature (the amount of water is at least 15 ml - 1 tablespoon). Dissolution of the tablet takes some time (about 1-2 minutes). Unless otherwise prescribed by the doctor, the drug is used in the following dosages:

Prophylactic doses:

Full-term newborns from 4 weeks of life to 2-3 years with proper care and sufficient exposure to fresh air: 500 IU (1 tablet) per day.
Premature babies from 4 weeks of life, twins, infants in poor living conditions: 1000-1500 ME (2-3 tablets) per day.

In the summer, you can limit the dose to 500 IU (1 tablet) per day.

In healthy adults without malabsorption: 500 IU (1 tablet) per day, in adult patients with malabsorption syndrome: 3000-5000 IU (6-10 tablets) per day (except for patients with glucose-galactose malabsorption).
Pregnant women: a daily dose of 500 IU (1 tablet) of vitamin D3 for the entire period of pregnancy, or take 1000 IU (2 tablets) per day, starting from the 28th week of pregnancy.

In the postmenopausal period, 500-1000 ME (1-2 tablets) per day.

Therapeutic doses:

For rickets: daily 1000-5000 IU (2-10 tablets), depending on the severity of rickets (I, II, or III) and the course of the disease, for 4-6 weeks, under close monitoring of the clinical condition and the study of biochemical parameters (calcium, phosphorus, alkaline phosphatase) blood and urine. You should start with 1000 IU for 3-5 days. Then, if well tolerated, the dose is increased to an individual therapeutic dose (most often 3000 IU). A dose of 5000 IU is prescribed only for pronounced bone changes.

If necessary, after a one-week break, you can repeat the course of treatment. Treatment is carried out until a clear therapeutic effect is obtained, followed by a transition to a prophylactic dose of 500-1500 IU per day.

For complex treatment of postmenopausal osteoporosis: 500-1000 ME (1-2 tablets) per day.
To maintain an adequate level of vitamin D concentration in the blood (> 30 ng/ml 25(OH)D) - 2000 IU (4 tablets) per day.

The dosage is usually prescribed based on the amount of vitamin D obtained from food.

Storage conditions

At a temperature not exceeding 25 °C, in the original packaging. Keep out of the reach of children.

Best before date

2 years. Do not use after expiration date.

special instructions

Avoid overdose.

Individual provision of a specific need must take into account all possible sources of this vitamin.

Too high doses of vitamin D3, used over a long period of time or in shock doses, can cause chronic hypervitaminosis D3.

The determination of a child’s daily need for vitamin D and the method of its use should be determined by a doctor individually and each time subject to correction during periodic examinations, especially in the first months of life.

When an adequate level of vitamin D concentration in the blood is achieved (> 30 ng/ml 25(OH)D) in adults, maintenance therapy with Aquadetrim can be continued at a dose of 1500-2000 IU (3-4 tablets) per day.

If water is not available, the tablet can be dissolved in the mouth.

Do not use high doses of calcium at the same time as vitamin D3.

During treatment, periodic monitoring of phosphate concentrations in the blood and urine is necessary.

With long-term use of colecalciferol, it is necessary to regularly determine the level of calcium in the blood serum and urine, and also evaluate renal function by measuring serum creatinine levels. If necessary, the dose of colecalciferol should be adjusted depending on the level of calcium in the blood serum.

Description

Calcium-phosphorus metabolism regulator.

Pharmacodynamics

Vitamin D3 is a natural form of vitamin D that is formed in humans in the skin under the influence of sunlight. Compared to vitamin D2, it is characterized by 25% higher activity.

Vitamin D3 is an active antirachitic factor. The most important function of vitamin D3 is to regulate calcium and phosphate metabolism, which promotes proper mineralization and skeletal growth.

The concentration of calcium ions in the blood determines the maintenance of muscle tone of skeletal muscles, myocardial function, promotes nervous stimulation, and regulates the process of blood clotting.

An increased need for vitamin D occurs in women during menopause, as they often develop osteoporosis due to hormonal imbalances. Vitamin D has a number of so-called. extraskeletal effects.

Vitamin D is involved in the regulation of carbohydrate and fat metabolism by influencing the synthesis of IRS1 (insulin receptor substrate 1; participates in the intracellular pathways of the insulin receptor signal), IGF (insulin-like growth factor; regulates the balance of adipose and muscle tissue), PPAR-5 (activated receptor peroxisome proliferators, type 5; helps process excess cholesterol).

According to epidemiological studies, vitamin D deficiency is associated with the risk of metabolic disorders (metabolic syndrome and type 2 diabetes mellitus). Vitamin D receptors and metabolizing enzymes are expressed in arterial vessels, the heart, and virtually all cells and tissues relevant to the pathogenesis of cardiovascular disease. Animal models show anti-atherosclerotic effects, renin suppression and prevention of myocardial damage, etc. Low levels of vitamin D in humans are associated with unfavorable risk factors for cardiovascular pathology, such as diabetes mellitus, dyslipidemia, arterial hypertension, and are associated with the risk of cardiovascular accidents , incl. strokes. Studies in experimental models of Alzheimer's disease showed that vitamin D3 reduced amyloid accumulation in the brain and improved cognitive function. Non-interventional human studies have shown that the incidence of dementia and Alzheimer's disease increases with low vitamin D levels and low dietary intake of vitamin D. Cognitive function and the incidence of Alzheimer's disease have been impaired with low vitamin D levels.

Side effects

Hypersensitivity to the components of the drug, hypervitaminosis D (symptoms of hypervitaminosis: loss of appetite, nausea, vomiting; headaches, muscle and joint pain; constipation; dry mouth; polyuria; weakness; mental disorders, including depression; weight loss; disorder sleep; increased temperature; protein, leukocytes, hyaline casts appear in the urine; increased calcium levels in the blood and its excretion in the urine; possible calcification of the kidneys, blood vessels, lungs).

If signs of hypervitaminosis D appear, it is necessary to discontinue the drug, limit the intake of calcium, and prescribe vitamins A, C and B.

Use during pregnancy and breastfeeding

During pregnancy, vitamin D3 should not be used in high doses due to the possibility of teratogenic effects in case of overdose. During pregnancy, you should avoid exceeding recommended doses of vitamin D3, as hypercalcemia may develop, which can lead to delayed mental and physical development of the fetus.

Vitamin D3 should be prescribed with caution to women breastfeeding - the drug taken in high doses by the mother can cause overdose symptoms in the child.

Interaction

Antiepileptic drugs, rifampicin, cholestyramine reduce the reabsorption of vitamin D3.

Use simultaneously with thiazide diuretics increases the risk of hypercalcemia.

Concomitant therapy with cardiac glycosides (digitalis) may increase their toxic potential due to hypercalcemia. In such patients, it is necessary to monitor ECG indicators and calcium levels in the blood plasma and urine, and adjust the doses of cardiac glycosides. And also, it is necessary to monitor the levels of digoxin and digitoxin in the blood plasma if indicated.

Concomitant therapy with glucocorticosteroids may reduce the effectiveness of vitamin D3.

Overdose

In severe cases, clouding of the cornea may occur, less commonly swelling of the optic nerve papilla, inflammation of the iris, and even the development of cataracts.

Kidney stones may form and calcification of soft tissues, including blood vessels, heart, lungs and skin, occurs.

Cholestatic jaundice rarely develops.

Treatment

Stop using the drug. Contact your doctor. Take plenty of fluids. If necessary, hospitalization may be required.

Contraindications and adverse reactions

Taking the drug is contraindicated in the following cases:

excessive presence of calcium in the body;
excess vitamin D;
kidney diseases;
urolithiasis;
age up to 1 month;
pulmonary tuberculosis;
increased susceptibility to constituent elements.

The medicine should be used with caution by people who are immobilized, as well as during pregnancy and breastfeeding.

Excessive presence of vitamin D is manifested by the following symptoms: vomiting, nausea, lack of appetite, constipation, dry mouth, malaise, mental problems, weight loss, insomnia, high body temperature, high levels of calcium in the blood.

As soon as adverse reactions are detected, you should immediately stop taking the medication and, if possible, limit the intake of the mineral into the body. You also need to start taking vitamins A, B, C.

Allergies may also appear in the form of a skin rash.

If you constantly exceed the dose, an overdose may occur, which is manifested by increased adverse reactions. The most common symptoms are pain in the joints, muscles and head.

Aquadetrim Vitamin D3, drops 15000 IU/ml, 10 ml

Vitamin D3 is a natural form of vitamin D, which is formed in humans in the skin under the influence of sunlight. Compared to vitamin D2, it is characterized by 25% higher activity.

Vitamin D binds to the specific vitamin D receptor (VDR), which regulates the expression of many genes, including the ion channel genes TRPV6 (ensures the absorption of calcium in the intestine), CALB1 (calbindin; ensures the transport of calcium into the bloodstream), BGLAP (osteocalcin; ensures bone mineralization tissue and calcium homeostasis), SPP1 (osteopontin; regulates osteoclast migration), REN (renin; regulates blood pressure, being a key element in the regulation of the RAAS), IGFBP (IGF binding protein; enhances the effect of IGF), FGF23 and FGFR23 (fibroblast growth factor 23; regulate the levels of calcium, phosphate anion, processes of cell division of fibroblasts), TGFB1 (transforming growth factor beta-1; regulates the processes of cell division and differentiation of osteocytes, chondrocytes, fibroblasts and keratinocytes), LRP2 (LDL receptor-related protein 2; mediates LDL endocytosis ), INSR (insulin receptor; mediates the effects of insulin on all cell types).

Vitamin D3 is an active antirachitic factor. The most important function of vitamin D3 is to regulate calcium and phosphate metabolism, which promotes proper mineralization and skeletal growth. Colecalciferol plays a significant role in the absorption of calcium and phosphates in the intestine, the transport of mineral salts and the process of bone calcification, and also regulates the excretion of calcium and phosphates by the kidneys.

An increased need for vitamin D occurs in women during menopause, as they often develop osteoporosis due to hormonal imbalances.

Vitamin D has a number of so-called. extraskeletal effects.

It has been shown that vitamin D is an important part of the homeostasis of the immune system: it prevents autoimmune diseases (including type 1 diabetes, multiple sclerosis, rheumatoid arthritis, inflammatory bowel diseases). Vitamin D has antiproliferative and prodifferentiating effects, which determine the oncoprotective effect of vitamin D. It has been noted that the incidence of certain tumors (breast cancer, colon cancer) increases against the background of low levels of vitamin D in the blood.

Vitamin D is involved in the regulation of carbohydrate and fat metabolism by influencing the synthesis of IRS1 (insulin receptor substrate 1; participates in the intracellular pathways of the insulin receptor signal), IGF (IGF; regulates the balance of adipose and muscle tissue), PPAR-δ (activated peroxisome proliferator receptor , type δ; promotes the processing of excess Xc).

According to epidemiological studies, vitamin D deficiency is associated with the risk of developing metabolic disorders (metabolic syndrome and type 2 diabetes mellitus). Vitamin D receptors and metabolizing enzymes are expressed in arterial vessels, the heart, and virtually all cells and tissues relevant to the pathogenesis of cardiovascular disease.

Antiatherosclerotic effects, renin suppression, and prevention of myocardial damage have been demonstrated in animal models.

Low levels of vitamin D in humans are associated with unfavorable risk factors for the development of cardiovascular pathology, such as diabetes mellitus, dyslipidemia, arterial hypertension, and are associated with the risk of developing cardiovascular accidents, incl. strokes.

Studies in experimental models of Alzheimer's disease showed that vitamin D3 reduced amyloid accumulation in the brain and improved cognitive function. Non-interventional human studies have shown that the incidence of dementia and Alzheimer's disease increases with low levels and low dietary intake of vitamin D.

There has been a decline in cognitive function and the incidence of Alzheimer's disease with low vitamin D levels.

Aquadetrim 10ml drops for oral administration

pharmachologic effect

Calcium-phosphorus metabolism regulator.

Composition and release form Aquadetrim 10ml drops for oral administration

Drops - 1 ml:

active ingredient: colecalciferol (vitamin D3) - 15,000 IU;
excipients: macrogol glyceryl ricinoleate, sucrose, sodium hydrogen phosphate dodecahydrate, citric acid monohydrate, anise flavor, benzyl alcohol, purified water.

10 ml in dark glass bottles with a polyethylene dropper stopper and a screw-on polyethylene cap with a “first opening” guarantee ring. 1 bottle along with instructions for use is placed in a cardboard box.

Description of the dosage form

Colorless, transparent or slightly opalescent liquid with an anise odor.

Directions for use and doses

Orally.

Take the drug in a spoonful of liquid.

1 drop contains about 500 IU of vitamin D3.

Unless otherwise prescribed by the doctor, the drug is used in the following dosages:

Prophylactic doses:

full-term newborns from 4 weeks of life, up to 2-3 years with proper care and sufficient exposure to fresh air: 500 - 1000 IU (1-2 drops) per day;
premature babies, from 4 weeks of life, twins, infants in poor living conditions: 1000 - 1500 IU (2-3 drops) per day. In the summer, you can limit the dose to 500 IU (1 drop) per day;
pregnant women: a daily dose of 500 IU (1 drop) of vitamin D3 for the entire period of pregnancy, or take 1000 IU (2 drops) per day, starting from the 28th week of pregnancy;
in the postmenopausal period 500 - 1000 ME (1-2 drops) per day.

Therapeutic doses:

for rickets: daily 2000 - 5000 IU (4-10 drops), depending on the severity of rickets (I, II, or III) and the course of the disease, for 4-6 weeks, under close monitoring of the clinical condition and the study of biochemical parameters (calcium, phosphorus, alkaline phosphatase) blood and urine. You should start with 2000 IU for 3-5 days. Then, if well tolerated, the dose is increased to an individual therapeutic dose (most often 3000 IU). A dose of 5000 IU is prescribed only for pronounced bone changes. If necessary, after a one-week break, you can repeat the course of treatment. Treatment is carried out until a clear therapeutic effect is obtained, followed by a transition to a prophylactic dose of 500 - 1500 IU per day.
in the treatment of rickets-like diseases: 20,000 - 30,000 IU per day (40 - 60 drops), depending on age, weight and severity of the disease, under the control of biochemical blood parameters and urine analysis. The course of treatment is 4-6 weeks. Treatment is carried out under the supervision of a doctor.
for complex treatment of postmenopausal osteoporosis: 500 - 1000 IU (1-2 drops) per day.

The dosage is usually prescribed based on the amount of vitamin D obtained from food.

Pharmacodynamics

Vitamin D3 is an active antirachitic factor. The most important function of vitamin D3 is to regulate calcium and phosphate metabolism, which promotes proper mineralization and skeletal growth.

Vitamin D3 is a natural form of vitamin D that is formed in humans in the skin under the influence of sunlight. Compared to vitamin D2, it is characterized by 25% higher activity. Colecalciferol plays a significant role in the absorption of calcium and phosphates from the intestine, in the transport of mineral salts and in the process of bone calcification, and also regulates the excretion of calcium and phosphates by the kidneys. The concentration of calcium ions in the blood determines the maintenance of muscle tone of skeletal muscles, myocardial function, promotes nervous stimulation, and regulates the process of blood clotting. Vitamin D is necessary for the normal function of the parathyroid glands and is also involved in the functioning of the immune system, influencing the production of lymphokines.

Lack of vitamin D in food, impaired absorption, calcium deficiency, as well as insufficient exposure to sunlight, during the period of intensive growth of the child, leads to rickets, in adults to osteomalacia, pregnant women may experience symptoms of tetany, disruption of the processes of calcification of bone tissue in newborns . An increased need for vitamin D occurs in women during menopause, as they often develop osteoporosis due to hormonal imbalances.

Pharmacokinetics

Excreted by the kidneys in small quantities, most of it is excreted in bile. Vitamin D3 has the property of cumulation.

Indications for use Aquadetrim 10ml drops for oral administration

Prevention and treatment of vitamin D deficiency.

Prevention and treatment of rickets, rickets-like diseases, hypocalcemic tetany, osteomalacia and metabolic-based bone diseases (such as hypoparathyroidism and pseudohypoparathyroidism).

In the complex treatment of osteoporosis, including postmenopausal.

Contraindications

Hypersensitivity to the components of the drug, especially to gasoline alcohol. Hypervitaminosis D, increased concentration of calcium in the blood (hypercalcemia), increased excretion of calcium in the urine (hypercalciuria), urolithiasis (formation of calcium oxalate stones), sarcoidosis, acute and chronic diseases of the liver and kidneys, renal failure, active form of pulmonary tuberculosis. Children up to 4 weeks of age.

Carefully:

State of immobilization, when taking thiazides, cardiac glycosides (especially digitalis glycosides); during pregnancy and breastfeeding.

In infants with a predisposition to early overgrowth of fontanelles (when the size of the anterior crown is small from birth).

Application of Aquadetrim 10ml drops for oral administration during pregnancy and breastfeeding

During pregnancy, vitamin D3 should not be used in high doses due to the possibility of teratogenic effects in case of overdose.

Vitamin D3 should be prescribed with caution to women breastfeeding - the drug taken in high doses by the mother can cause overdose symptoms in the child.

During pregnancy and breastfeeding, the dose of vitamin D3 should not exceed 600 IU per day.

special instructions

Avoid overdose.

Individual provision of a specific need must take into account all possible sources of this vitamin.

Too high doses of vitamin D3, used over a long period of time or in shock doses, can cause chronic hypervitaminosis D3.

Do not use high doses of calcium at the same time as vitamin D3.

During treatment, periodic monitoring of the concentration of calcium and phosphate in the blood and urine is necessary.

Overdose

Symptoms of overdose: loss of appetite, nausea, vomiting, constipation, anxiety, thirst, polyuria, diarrhea, intestinal colic. Frequent symptoms are headache, muscle and joint pain, mental disorders, including depression, stupor, ataxia and progressive weight loss. Renal dysfunction develops with albinuria, erythrocyturia and polyuria, increased potassium loss, hyposthenuria, nocturia and increased blood pressure. In severe cases, clouding of the cornea may occur, less commonly swelling of the optic nerve papilla, inflammation of the iris, and even the development of cataracts. Kidney stones may form and calcification of soft tissues, including blood vessels, heart, lungs and skin, occurs. Cholestatic jaundice rarely develops.

Treatment

Stop using the drug. Contact your doctor. Take plenty of fluids. If necessary, hospitalization may be required.

Side effects of Aquadetrim 10ml drops for oral administration

If signs of hypervitaminosis D appear, it is necessary to discontinue the drug, limit the intake of calcium, and prescribe vitamins A, C and B.

Drug interactions

Antiepileptic drugs, rifampicin, cholestyramine reduce the reabsorption of vitamin D3.

Use simultaneously with thiazide diuretics increases the risk of hypercalcemia.

Simultaneous use with cardiac glycosides may enhance their toxic effect (increases the risk of heart rhythm disturbances).