Eating dry food, snacking on the run - this has become commonplace in the modern world. Unfortunately, every year the number of patients with gastritis, as well as gastric and duodenal ulcers, is steadily increasing. Today, there are many drugs available to treat these diseases. One of the drugs - De-Nol - is effective and safe, which will help cope with gastritis and ulcers.
pharmachologic effect
The drug has an astringent effect, due to which a film forms on the surface of the mucous membrane of the stomach and duodenum at the site of the lesion. Thus, the affected areas are protected from the aggressive action of gastric juice, which means that the progression of the process is suspended. The presence of a protective film promotes scarring of ulcerative lesions.
De-Nol is harmful to Helicobacter pylori, which is the main culprit in the formation of ulcers on the gastrointestinal mucosa. Not a single strain of this pathogenic bacterium is resistant to this drug.
In addition, taking the drug has a beneficial effect on the digestion process in the stomach due to the fact that it improves microcirculation in the mucous membrane of its antrum.
Indications and contraindications
De-Nol protects the mucous membrane from the effects of hydrochloric acid, active enzymes and other aggressive factors, thereby promoting the healing of erosive and ulcerative lesions. All this determines the indications for prescribing the drug:
- Gastritis, gastroduodenitis, duodenitis and other inflammatory diseases of the gastrointestinal tract.
- Peptic ulcer of the stomach and duodenum. In this situation, the drug is used not only to treat exacerbations, but also to reduce the risk of their occurrence.
- Irritable bowel syndrome, which is accompanied by stool upset, dyspeptic syndrome and abdominal pain.
- Gastropathy caused by taking medications or alcohol.
- The need for eradication of Helicobacter pylori infection. De-Nol penetrates into the deep layers of the gastric mucosa and blocks the metabolism of the bacterium.
- It can be used for chronic cholecystitis or pancreatitis if the transport function of the gastrointestinal tract is impaired.
Contraindications to the use of the drug:
- Age under 4 years.
- Pregnancy (the active substance causes mutations in the fetus, leading to congenital diseases of the nervous system).
- Lactation period.
- Chronic renal failure.
- Individual intolerance to bismuth tripotassium dicitrate or auxiliary components of drugs.
What do De-Nol tablets help with?
Taking this medicine is indicated for:
- Acute and chronic gastritis and gastroduodenitis;
- Exacerbations of gastric and duodenal ulcers;
- Gastropathy that developed as a result of taking NSAIDs or alcohol;
- Functional dyspepsia.
In addition, a gastroenterologist may prescribe De-Nol for pancreatitis. In this case, the drug helps eliminate intestinal dyskinesia, which often accompanies a chronic inflammatory process in the pancreas.
De-Nol during pregnancy and lactation
Doctors unanimously prohibit pregnant and lactating women from taking De-Nol. The drug poses a particular danger to the fetus, starting from 5-6 weeks. It is during this period that the formation of all the systems and organs of the future baby occurs. The use of De-Nol during pregnancy can lead to spontaneous abortion, mutations and the occurrence of a number of congenital disabilities.
During lactation, the main substance of the drug, bismuth tripotassium dicitrate, passes into breast milk through the bloodstream. If it is consumed, a newborn may develop kidney and nervous system diseases.
In this regard, the use of De-Nol in pregnant women is strictly prohibited; when breastfeeding, taking the drug is possible only when the baby is transferred to artificial feeding.
How to drink De-Nol
Adults and children over 12 years of age can take 4 tablets per day. They can be divided into 4 or 2 doses.
It is recommended to take the tablets half an hour before meals with water.
The drug is also used for diseases of the stomach and duodenum that are associated with the bacterium Helicobacter pylori. De-Nol is included in schemes for destroying this microbe along with antibacterial drugs.
According to experts, this drug increases the effectiveness of the Helicobacter pylori eradication (destruction) regimen. In addition, taking De-Nol is not accompanied by the risk of developing unnecessary adverse reactions, which is also important when using such a serious treatment regimen.
De-nol tablets p/o 120 mg No. 8x14
Name
De-Nol Astellas.
Release forms
Pills.
INN
Bismuth tripotassium dicitrate.
FTG
Antiseptic intestinal and astringent.
Compound
Each tablet contains: Active substance: bismuth tripotassium dicitrate - 304.6 mg, in terms of bismuth oxide Bi2O3 - 120 mg. Excipients: corn starch, povidone K3O, potassium polyacrylate, macrogol 6000, magnesium stearate. Shell: Opadry OY-S-7366, consists of: hypromellose and macrogol 6000.
Description
Round, biconvex, creamy white film-coated tablets with "gbr 152" embossed on one side and a square graphic with broken sides and rounded corners embossed on the other, odorless or with a slight ammonia odor.
Pharmacotherapeutic group
Other antiulcer agents and agents for the treatment of gastroesophageal reflux disease (GERD). ATX code: A02ВХ05
Pharmacological properties
Pharmacodynamics
Antiulcer agent with bactericidal activity against Helicobacter pylori. It also has anti-inflammatory and astringent effects. In the acidic environment of the stomach, insoluble bismuth oxychloride and citrate are precipitated, and chelate compounds are formed with the protein substrate in the form of a protective film on the surface of ulcers and erosions. By increasing the synthesis of prostaglandin E, mucus formation and bicarbonate secretion, it stimulates the activity of cytoprotective mechanisms, increases the resistance of the gastrointestinal mucosa to the effects of pepsin, hydrochloric acid, enzymes and bile salts. Leads to the accumulation of epidermal growth factor in the defect area. Reduces the activity of pepsin and pepsinogen.
Pharmacokinetics
Absorption Bismuth subcitrate is practically not absorbed from the gastrointestinal tract, the drug acts locally. A minimal amount of bismuth is absorbed (less than 0.2% of the dose taken). Distribution Bismuth is mainly found in the kidneys. In other organs trace amounts of bismuth are determined. Metabolism Insoluble bismuth compounds precipitate in the stomach, in particular bismuth oxychloride and bismuth citrate. Excretion Most of the drug is excreted primarily in the feces. Renal clearance of small amounts of absorbed bismuth is approximately 50 ml/min. The half-life of most absorbed bismuth is 5 to 11 days.
Indications for use
Peptic ulcer of the stomach and duodenum. Gastritis accompanied by complaints of dyspepsia, in which eradication of Helicobacter pylori is recommended.
Contraindications
Severe renal dysfunction, pregnancy, lactation, individual intolerance to the drug, children under 6 years of age.
Directions for use and doses
For adults and children over 12 years of age, the drug is prescribed 1 tablet of 120 mg 4 times a day 30 minutes before meals and at night or 2 tablets of 120 mg 2 times a day. For children from 6 to 12 years old, the drug is prescribed at the rate of 8 mg/kg/day. Depending on the weight of the child, 1-3 tablets are prescribed per day (respectively, in 1-3 doses per day). In this case, the daily dose should be as close as possible to the calculated dose (8 mg/kg/day). The tablets are taken 30 minutes before meals with a small amount of water. The duration of treatment is 4-8 weeks. For the next 8 weeks, you should not use medications containing bismuth. To eradicate Helicobacter pylori, it is advisable to use De-Nol in combination with other antibacterial agents that have anti-Helicobacter activity.
Side effect
From the digestive system Very often (≥1/10): when using De-Nol, stool may turn dark due to the formation of bismuth sulfide. Discoloration of stool can be easily distinguished from melena. Rarely (≥1/1000,
Drug overdose
Symptoms of intoxication: acute massive overdose can lead to renal failure with a delayed onset of up to 10 days. Treatment of intoxication: after a single dose of a very high dose, treatment should include gastric lavage, followed by therapy with activated charcoal and osmotic laxatives. This reduces the absorption of bismuth, so additional therapeutic measures are not required. Bismuth concentrations in the blood and urine should be determined in cases of acute and chronic intoxication to determine whether symptoms are related to increased bismuth exposure. Chelation therapy with dimercaptosuccinic acid (DMSA) or dimercaptopropane sulfonic acid (DMPS) is used if symptoms are known to be caused by acute or chronic bismuth overdose. In severe renal failure, hemodialysis should be performed after chelation therapy. Interaction with other medications For half an hour before and after taking De-Nol, it is not recommended to take other medications internally, as well as take food and liquids, in particular antacids, milk, fruits and fruit juices. This is due to the fact that when taken orally simultaneously, they can affect the effectiveness of De-Nol.
special instructions
The drug should not be used for more than 8 weeks. It is also not recommended to exceed the established daily doses for adults and children during treatment. During treatment with De-Nol, you should not use other drugs containing bismuth. At the end of a course of treatment with the drug in recommended doses, the concentration of the active substance in the blood plasma does not exceed 3-58 mcg/l, and intoxication is observed only at concentrations above 100 mcg/l. When using De-Nol, stool may turn dark due to the formation of bismuth sulfide. Sometimes there is a slight darkening of the tongue. Prolonged use of large doses of bismuth-containing compounds is not recommended, since, in some cases, this can lead to reversible encephalopathy. The risk of encephalopathy, however, is minimal if De-Nol is used as recommended.
Pregnancy and lactation
The use of De-Nol during pregnancy and lactation is contraindicated.
Impact on the ability to drive a car and operate machinery
There is no data on the effect of De-Nol on the ability to drive vehicles and operate machinery.
Release form
8 tablets in an aluminum foil blister, 7 or 14 blisters along with instructions for use in a cardboard box.
Storage conditions
Store at a temperature not exceeding 25°C. Keep out of the reach of children.
Best before date
4 years. Do not use after the expiration date stated on the package.
Conditions for dispensing from pharmacies
By doctor's prescription.
Buy De-nol tablet p/o 120 mg in bl. in pack No. 8x14 in the pharmacy
Price for De-nol tablet p/o 120 mg per bl. in pack №8x14
Instructions for use for De-nol tablet p/o 120 mg per bl. in pack №8x14
Is De-Nol an antibiotic?
Despite the fact that the drug is capable of destroying Helicobacter pylori, it does not belong to the group of antibacterial agents. Consequently, its use is not associated with the appearance of such unpleasant side symptoms as diarrhea and mucosal candidiasis.
Bacteria cannot develop resistance to De-Nol due to the peculiarities of its pharmacological action. That is why the inclusion of this drug to destroy the pathogenic bacteria helps to completely get rid of the infection.
Is it possible to use De-Nol as a prophylactic agent?
Gastritis and gastric ulcers have a chronic, often relapsing course. Periods of exacerbations are followed by remissions. More often, the deterioration of the health status of patients occurs in spring and autumn, which is associated with weakened immunity and massive hypo- and avitaminosis. Patients also note increased pain during emotional stress, heavy physical labor and deviations from the diet.
The prophylactic use of De-Nol can prevent the occurrence of an exacerbation of the disease. Persons suffering from ulcers and gastritis are recommended to take the drug in early autumn or spring, without waiting for their health to worsen. It has a moderate antacid effect and reduces the aggressive influence of factors from the external and internal environment of the body.
Side effects of the drug De-Nol
Taking the drug may be accompanied by the following side effects:
- Nausea and vomiting, frequent bowel movements or constipation.
- On the part of the central nervous system – the development of encephalopathy. This phenomenon is observed only with long-term use of the drug in high doses.
- Skin itching and rashes in case of hypersensitivity to the components of the drug.
The development of adverse symptoms when taking De-Nol is rare. Usually, if all the rules for taking this medicine are followed, patients do not encounter such problems.
Basic rules for using the drug
To minimize the unwanted side effects of De-Nol, it is important to choose its optimal dosage and organize the correct intake.
The drug is produced exclusively in the form of tablets with a fixed content of the active substance, so the only possible way to administer the drug into the body is orally. If swallowed, De-Nol should be taken with a small amount of water.
Basic rules for using De-Nol that increase its effectiveness:
- You should not use sweet drinks, tea or coffee to wash down the drug.
- During treatment with this drug, it is necessary to limit the consumption of dairy products, as they reduce the activity of the active substance.
- The consumption of alcohol and alcoholic drugs is prohibited.
- You should not take other medications containing bismuth salts at the same time as De-Nol.
The dosage is selected and prescribed only by a doctor. It is necessary to strictly adhere to the prescribed regimen to minimize the likelihood of adverse reactions.
While taking De-Nol, stool turns black and darkens the mucous membrane of the mouth and tongue. This is explained by the fact that as a result of taking the drug, a compound is formed in the body - bismuth sulfide, which enters the oral cavity and intestines, and therefore the discharge becomes darker in color.
Attention! It is important to remember that taking De-Nol alone without combining it with other drugs and a special diet will not eliminate the exacerbation of the disease.
Health professionals recommend taking the medicine 30 minutes before meals. Half an hour is enough for a protective film to form on the surface of the gastric mucosa, so that food enters the prepared environment and does not have an aggressive effect.
The maximum daily dose for adults and children over 12 years of age is 500 mg or 4 tablets.
It is prohibited to use the drug under 4 years of age. For children aged 4-8 years, the daily dose is calculated by weight, 8 mg per 1 kg of body weight, and for children aged 8-12 years, it is recommended to take 1 tablet 2 times a day.
Overdose symptoms
An overdose of De-Nol is accompanied by impaired functional activity of the kidneys. These changes are reversible: after discontinuation of the drug, kidney function is completely normalized.
In case of overdose, saline laxatives and enterosorbents are used. Gastric lavage is also recommended.
In rare cases, if the dose is repeatedly exceeded, renal failure may develop. In this case, renal dysfunction can only be compensated for by hemodialysis.
