Ecdisten in bodybuilding[edit | edit code]
Ekdisten
(synonyms: Ecdysterone, ectysterone, 20 Beta-Hydroxyecdysterone, turkesterone, ponasterone, ecdysone, ecdystene) is a naturally occurring phytoecdysteroid.
Ecdisthene is produced from the plants Leuza rhaptonticum sp., Rhaponticum carthamoides, or Cyanotis vaga. They can also be found in high concentrations in the plant Pfaffia paniculata (also known as “Brazilian ginseng” or “suma”).
Research conducted over the past 30 years in Russia and Czechoslovakia has shown that ecdisthene may have beneficial effects on physiological processes in insects and animals.[1][2][3][4][5][6] However, most of the data on ecdysterones has been published in unknown publications, and the research results are difficult to interpret. Wilborn et al[7] supplemented 20-hydroxyecdysone (200 mg daily) with resistance-trained adult men for 8 weeks.
It was noted that taking 20-hydroxyecdysone had no effect on the growth of lean muscle mass, as well as on the processes of anabolism and catabolism. Thus, based on this well-controlled study, ecdisthene 200 mg/day does not appear to be effective in increasing lean muscle mass.
Perhaps future studies will reveal the ergogenic properties of ecdisthene, but at this stage it is too early to say that phytoecdysteroids are an effective and safe nutritional supplement for athletes.
Read the main article:
ecdysterone
ECDISTEN[edit | edit code]
Source:
"Handbook of Sports Pharmacology".
Publisher
: Soviet Sport, 2014
Composition and release form[edit | edit code]
Natural compound with steroid structure.
In tablets of 0.005 g (5 mg), in a package - 30 pieces.
Pharmacological action[edit | edit code]
A tonic that enhances protein biosynthesis in the body. The drug weakens the effect of sleeping pills and increases physical performance. Unlike anabolic steroids, Ecdisten does not have an androgenic, antigonadotropic, thymolytic effect, and does not affect the functionality of the adrenal cortex.
Recommendations for use in sports[edit | edit code]
Asthenic and asthenodepressive conditions associated with weakening of protein synthesis processes, prolonged intoxication, infections, neurasthenia, neuroses, hypotension in athletes during intense training, dysfunction of the cardiovascular system, especially with pronounced signs of myocardial overstrain and increased protein catabolism, as well as as a remedy , which increases speed and strength qualities during preparation for competitions.
Method of administration and dosage[edit | edit code]
Orally 0.005-0.01 g 3 times a day, before meals. The course of treatment is 15-20 days; if necessary, it can be repeated after a 1-2 week break.
In sports medicine, the drug is used at a dose of 0.01-0.02 g 3 times a day for 2-3 weeks.
Higher doses for adults orally: single - 0.025 g (25 mg), daily - 0.1 g (100 mg).
Contraindications[edit | edit code]
Nervous excitement, insomnia, hypertension, epilepsy and hyperkinesis.
Side effects[edit | edit code]
In patients with a labile nervous system, the following are possible: insomnia, increased blood pressure. In these cases, reduce the dose or stop taking the drug in the evening.
Special instructions[edit | edit code]
To achieve the effect simultaneously with the use of Ecdisten, it is necessary to use adequate amounts of proteins, fats, vitamins and minerals.
Pharmacies in Moscow where you can buy Ecdisten, compare prices and make a pre-order
Natural compound of steroid structure from the roots and rhizomes of Leuzea safflower; has a tonic effect, helps to enhance the processes of protein synthesis in the body. Increases mental and physical performance.
Compound:
Active ingredient: ecdisthene.
Excipients: sugar (sucrose), potato starch, calcium stearate.
Indications:
- Asthenic syndrome associated with weakening of protein synthesizing processes;
- with prolonged intoxication, infections;
- mental and physical fatigue;
- in athletes, as a medicine that increases speed and strength qualities during preparation for competitions.
Application:
Orally 0.005-0.01 g (1-2 tablets) 3 times a day after meals. The course of treatment is 15-20 days. On the recommendation of a doctor, it is possible to carry out a second course of treatment after 1-2 weeks.
In sports medicine, use 0.01 g (2 tablets) 3 times a day for 2-3 weeks. The maximum single dose is 0.01 g (2 tablets), the maximum permissible daily dose is 0.03 g (6 tablets).
Side effect:
Insomnia, increased blood pressure, and pain in the epigastric region are possible.
If any of the side effects indicated in the instructions get worse, or you notice any other side effects not listed in the instructions, tell your doctor immediately.
Contraindications for use:
- nervous excitement;
- insomnia;
- arterial hypertension;
- epilepsy;
- hyperkinesis;
- peptic ulcer of the stomach and duodenum (in the acute stage);
- congenital fructose intolerance;
- glucose-galactose malabsorption;
- sucrase/isomaltase deficiency;
- pregnancy;
- lactation period;
- age under 18 years;
- increased individual sensitivity to the components of the drug.
If you have at least one of the listed diseases, be sure to consult your doctor before taking the drug.
Use with caution in patients with diabetes and those on a low-carbohydrate diet.
Use during pregnancy and breastfeeding:
The drug is contraindicated during pregnancy and lactation.
Use in children:
Contraindicated in children under 18 years of age.
Special instructions:
To achieve the effect, simultaneously with the use of the drug, it is necessary to receive adequate amounts of proteins, fats, carbohydrates, vitamins and minerals from food.
In case of side effects, incl. To avoid sleep disturbances, it is advisable to reduce the dose or stop taking the drug in the evening.
Patients with diabetes should take into account that one tablet of the drug contains about 0.094 g of carbohydrates (0.008 XE).
Impact on the ability to drive vehicles and operate machinery:
The use of the drug does not affect the ability to drive vehicles or engage in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.
Overdose:
Symptoms:
Dose-dependent adverse reactions may increase.
Treatment:
Symptomatic.
Interaction with other drugs and preparations:
With simultaneous use, it is possible to enhance the effect of stimulants and analeptics (caffeine, camphor, phenamine).
The drug is an antagonist of drugs that depress the central nervous system (including antipsychotics, barbiturates, tranquilizers, anticonvulsants).
The online pharmacy help from the Pharmindex website will help you find and buy Ecdisten in pharmacies at the best price.
Information from the book “Sports Pharmacology”[edit | edit code]
The drug ecdysterone or ecdisten (registered as a dietary supplement in Ukraine) is a natural compound with a steroid structure; it is obtained from plants widely used in folk medicine - Rhaponticum carthamoidis (Wild) Jilin (synonym: Leuzea carthamoidis DC) and Turkestan tenacious - Ajuga turkestanica (Rgl.) Brig, growing in Central Asia. The chemical properties and pharmacological action of ec-disthene have been studied by Japanese, Uzbek and Russian scientists. The chemical structure of the drug resembles the molting hormone of insects. Available in tablets of 5 mg (the content of the active substance is 98%, in addition they contain turkesterone and cyasterone, which enhances the effect of the main active ingredient).
Experimental studies have shown that the drug is low-toxic and has a wide range of biological effects. When it is introduced into the body of animals, a pronounced tonic and restorative effect is noted. Increases the adaptive capabilities of the animal body in relation to stressful environmental factors, improves their dynamic performance. Comparative studies indicate that in terms of general tonic effects, ecdisthene is superior to the drug saparal (a sum of triterpene glycosides from Manchurian aralia) widely used for these purposes.
An essential point in the mechanism of action of ecdisthene is its ability to activate the processes of protein biosynthesis in various organs and tissues, similarly to the well-known steroidal anabolic drugs (Nerobol, Retabolil). However, having a fundamentally different mechanism of anabolic action, this drug, unlike anabolic androgenic steroids, does not have their inherent hormonal effects (androgenic, thymolytic, antigonadotropic, etc.), which often complicate the use of these drugs, especially in women and children. In addition to protein metabolism, ecdisthene also has a positive effect on carbohydrate-phosphorus and lipid metabolism. Under its influence, accumulation of glycogen and high-energy phosphorus compounds (ATP and creatine phosphate) is observed in organs and tissues, and a clear hypocholesterolemic hypotriacylglycerolemic effect is noted.
Ecdysterone significantly improves the well-being of patients, increases general tone, enhances performance, increases body weight with reduced nutrition as a result of disruption of protein-synthesizing processes of various etiologies. Has a positive effect on the metabolic parameters of the heart muscle. Ecdisthene was found to have a hypoglycemic effect in patients with severe forms of diabetes, which made it possible to reduce the dose of insulin. Good results were observed in the treatment of patients with gastric and duodenal ulcers, hepatitis of various etiologies.
In all cases of use of the drug, no side effects were noted, and no negative effects on the functions of the adrenal cortex and other endocrine glands were observed. Studies have noted a fairly pronounced general tonic effect on the body, especially in athletes during intense training loads. Moreover, when tested on athletes, 89% of those examined who received ecdisten noted a faster passing of the feeling of fatigue, apathy, improved exercise tolerance in sports such as athletics (jumping, middle-distance running), swimming, figure skating, speed running skating, cross-country skiing. It should be noted that in these sports, a similar effect when using saparal was observed in only 9% of athletes. When there was a need for a significant increase in the dose of ecdisten (observation of athletes - throwers and weightlifters, where the drug was used at a dose of up to 100 mg per day), the positive specific effect was not accompanied by any toxic phenomena.
The anabolic manifestations of ecdisthene in all cases were confirmed by clinical and laboratory studies (increase in body weight, hemoglobin and erythrocyte content, total protein in the blood serum, decrease in urea concentration). Anthropometric studies of individuals who repeatedly took ecdisten showed an increase in muscle mass with a slight decrease in the amount of total and subcutaneous fat. As a result of testing ecdisten in the practice of clinical and sports medicine, it has been established that it is advisable to prescribe it to patients who have neurotic conditions, hypotension, general weakness, vegetative-vascular dystonia, as well as somatic patients with asthenic and asthenodepressive conditions associated with a weakening of protein synthesizing processes in body. The use of ecdisthene for certain disorders of carbohydrate and lipid metabolism has proven promising.
The drug is indicated for athletes specializing in many sports where it is necessary to improve speed and strength qualities and increase the functional state of the muscular system.
Actively influencing metabolic processes in organs and tissues, ecdisten is an effective means for preventing and eliminating myocardial overstrain syndrome after intense physical activity and promotes rapid recovery between competitions. It is advisable to use ecdisten by practically healthy people to prevent excessive mental and physical fatigue, as well as to correct the figure, especially in the complex of sports and recreational activities.
Thus, based on the results of the study of ecdisthene, the following conclusions can be drawn.
- Ecdisten is an original herbal preparation that has no analogue among approved drugs; recommended as a general tonic with a simultaneous anabolic effect.
- The therapeutic effect of ecdisten is most clearly manifested in asthenic and asthenodepressive conditions associated with a weakening of protein-synthesizing processes in the body, with reduced mental and physical performance, as well as with neurasthenia, neuroses, hypotension, increased fatigue, reduced adaptive capabilities of the body, impaired metabolic processes in organs, deterioration of adaptation and recovery processes after maximum and submaximal physical activity. The drug is well tolerated by patients, including the elderly. It is usually used 5-10 mg (1-2 tablets) 3 times a day. The course of treatment is 15-20 days, if necessary it can be repeated after a 1-2 week break. It is advisable to combine the intake of ecdisten with the consumption of protein preparations and B vitamins.
- Ecdisten is also effective in the practice of medical and biological correction of sports activity, especially in those cases where it is necessary to improve speed and strength qualities and increase the functional state of the muscular system. Its use by athletes does not contradict the requirements of anti-doping control.
- In terms of general tonic effects on the body, ecdisten is superior to saparal and (unlike the latter) has pronounced anabolic activity.
- Unlike anabolic steroid drugs (methylandrostenediol, nerobol, nerobolil, etc.), ecdisten, while providing an anabolic effect, does not exhibit their characteristic hormonal effects (primarily androgenic) and can be recommended in cases where the administration of steranobols is undesirable.
Based on the above, the Pharmacological Committee of the USSR Ministry of Health, by its Resolution dated July 5, 1984 (protocol No. 15), recommended ecdisten for medical use. By order of the USSR Ministry of Health No. 848 dated June 30, 1987, ecdisten is approved for widespread use (registration certificate of the USSR Ministry of Health No. 87/848/2). In 1998, the drug was re-registered in the Main Directorate for Quality Control of Medicines and Medical Equipment of the Ministry of Health of the Republic of Uzbekistan under the same number 87/848/2. In Ukraine, ecdisten is registered as a dietary supplement and is therefore available today to Ukrainian athletes.
Ekdisten
Name: Ecdistenum Pharmacological action: Has a tonic effect, helps enhance protein biosynthesis in the body. The drug weakens the effect of sleeping pills and increases physical performance. Unlike anabolic steroids (hormones that stimulate metabolism), ecdisthene does not have an androgenic (similar to the action of male sex hormones), antigonadotropic (aimed at reducing the function of the gonads) effect, and does not affect the function of the thymus and adrenal cortex.
Indications for use: As a tonic for asthenic and asthenodepressive conditions (weakness, depression), associated with weakening of protein-synthesizing processes, with prolonged intoxication (poisoning), neurasthenia, neuroses, hypotension (low blood pressure), in athletes during intense training with dysfunctions of the cardiovascular system, especially with pronounced signs of myocardial (heart muscle) overstrain and increased protein catabolism (decomposition), as well as a means of increasing speed and strength qualities during preparation for competitions.
Directions for use: Take 0.005-0.01 g orally before meals 3 times a day. The course of treatment (15-20 days), if necessary, can be repeated after a 1-2 week break. In sports medicine, the drug is used at a dose of 0.01-0.02 g 3 times a day for 2-3 weeks. Higher doses for adults orally: single 0.025 g (25 mg), daily 0.1 g (100 mg). To achieve the effect, simultaneously with the use of ecdisten, the patient must receive adequate amounts of proteins, fats, carbohydrates, vitamins and minerals from food.
Side effects: In patients with a labile (unstable) nervous system, insomnia and increased blood pressure are possible. In these cases, reduce the dose or stop taking the drug in the evening.
Contraindications: Nervous agitation, insomnia, hypertension (persistent rise in blood pressure), epilepsy and hyperkinesis (violent automatic movements due to involuntary muscle contractions).
Release form: Tablets of 0.005 g (5 mg).
Storage conditions: List B. In a dry place, protected from light.
Additionally: Natural compound with steroid structure.
Attention! The description of the drug " Ecdisten " on this page is a simplified and expanded version of the official instructions for use. Before purchasing or using the drug, you should consult your doctor and read the instructions approved by the manufacturer. Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide to prescribe the drug, as well as determine the dose and methods of its use.
Sources[edit | edit code]
- Slama K, Koudela K, Tenora J, Mathova A: Insect hormones in vertebrates: anabolic effects of 20-hydroxyecdysone in Japanese quail. Experientia 1996, 52(7):702-6.
- Slama K, Kodkoua M: Insect hormones and bioanalogues: their effect on respiratory metabolism in Dermestes vulpinus L. (Coleoptera). Biol Bull 1975, 148(2):320-32.
- Tashmukhamedova MA, Almatov KT, Syrov VN, Sultanov MB, Abidov AA: . Nauchnye Doki Vyss Shkoly Biol Nauki 1985(9):37-9.
- Syrov VN: . Nauchnye Doki Vyss Shkoly Biol Nauki 1984(11):16-20.
- Kholodova Y: Phytoecdysteroids: biological effects, application in agriculture and complementary medicine (as presented at the 14th Ecdysone Workshop, July, 2000, Rapperswil, Switzerland). Ukr Biokhim Zh 2001, 73(3):21-9.
- Toth N, Szabo A, Kacsala P, Heger J, Zador E: 20-Hydroxyecdysone increases fiber size in a muscle-specific fashion in rat. Phytomedicine 2008, 15(9):691-8.
- Wilborn C, Taylor L, Campbell B, Kerksick C, Rasmussen C, Greenwood M, Kreider R: Effects of methoxyisoflavone, ecdysterone, and sulfo-polysaccharide supplementation on training adaptations in resistance-trained males. Journal of the International Society of Sports Nutrition 2006., 3(2).
