Nosological classification (ICD-10)
- B37.0 Candidal stomatitis
- K00.7 Teething syndrome
- K05 Gingivitis and periodontal diseases
- K12 Stomatitis and related lesions
- K13.0 Diseases of the lips
- K13.7 Other and unspecified lesions of the oral mucosa
- L43.9 Lichen planus, unspecified
- L51.9 Erythema multiforme, unspecified
- Z100* CLASS XXII Surgical practice
- Z97.2 Presence of dental prosthetic device (complete) (partial)
How to use Cholisal gel
The instructions indicate that the ointment is for external use only. It should be applied exclusively to the affected area of the mouth.
The product should be applied 20 minutes before or after meals. You can also rub the ointment in before going to bed. The procedure can be repeated up to 3 times a day. It will be enough for a child to use 0.5 cm, and for an adult – 1 cm.
If a person suffers from periodontal disease, then the ointment can be placed in the gum pockets that appear or effective compresses can be made.
Pharmacodynamics
Choline salicylate has analgesic, anti-inflammatory and antipyretic effects. It inhibits the activity of cyclooxygenase, the functions of macrophages and neutrophils, the production of interleukin-1 and inhibits the synthesis of PG. It also has antimicrobial and antifungal effects (in acidic and alkaline environments).
The analgesic effect appears within 2–3 minutes and lasts 2–8 hours.
Cetalkonium chloride has an antiseptic effect on bacteria, fungi and viruses.
Cholisal does not contain sugar, does not have a local irritating effect and is well tolerated by patients.
Pharmacology and pharmacodynamics
The medication has an antimicrobial effect and also has anti-inflammatory and analgesic effects.
The active ingredient choline salicylate relieves pain and inflammation at the site of application of the gel. The analgesic effect lasts for an average of 4-7 hours.
The second active element has a powerful antiseptic effect. Effectively copes with harmful bacteria.
The structure of the ointment promotes its rapid absorption into tissues, reaches the nerve endings in a short time and remains on the oral mucosa for a long time. Almost does not enter the blood.
Indications for the drug Cholisal®
Infectious-inflammatory, ulcerative-necrotic, trophic diseases of the oral mucosa: stomatitis of various etiologies, gingivitis, periodontitis, damage to the mucous membrane when wearing dentures, trauma to the oral mucosa, pain during teething in children, glandular cheilitis, thrush, small surgical interventions, lichen planus, exudative erythema multiforme (including Stevens-Johnson syndrome) - as part of complex therapy.
Adverse reactions and overdose
In some cases, after direct contact of the oral mucosa and the ointment, undesirable reactions may occur in the form of a burning sensation and tingling sensation. Such reactions are normal and disappear on their own after a few minutes. In rare cases, allergies may occur.
If serious side effects occur, you should stop using the gel and tell your doctor.
There are no cases of drug overdose. The ointment should not be swallowed; it is intended for external use only. If part of the medicine gets inside, then you need to rinse the stomach and, if necessary, begin symptomatic treatment.
When to use
The gel is prescribed in the following cases:
- stomatitis;
- cheilitis;
- damage to the integrity of the mucosa due to the use of prostheses or as a result of mechanical impact;
- pain relief after dental surgery;
- when teething in babies;
- other damage and inflammatory processes in the oral mucosa.
Cholisal dental gel 10g aluminum tube
Registration Certificate Holder
VALEANT (Russia)
Dosage form
Medicine - Cholisal® (Cholisal)
Description
Dental gel
in the form of a colorless, transparent, homogeneous mass with the smell of anise oil.
1 g
choline salicylate 87.1 mg cetalkonium chloride 0.1 mg
Excipients
: hyaetellose - 20 mg, methyl parahydroxybenzoate - 1.5 mg, propyl parahydroxybenzoate - 0.8 mg, glycerol - 50 mg, anise seed oil - 1.61 mg, ethanol 96% - 390 mg, water - up to 1000 mg.
15 g - aluminum tubes (1) - cardboard packs.
Indications
For local use on the mucous membranes of the oral cavity as an analgesic and anti-inflammatory agent in the treatment of periodontal diseases, damage to the oral mucosa, diseases that occur with an inflammatory reaction and pain, including:
- stomatitis of various etiologies;
- gingivitis;
- periodontitis;
- damage to the oral mucosa when wearing dentures;
- trauma to the oral mucosa;
- pain during teething in children;
- cheilitis;
- candidiasis of the oral mucosa;
- minor surgical interventions in the oral cavity;
- lichen planus when localized on the oral mucosa;
- damage to the oral mucosa in Stevens-Johnson syndrome (as part of complex therapy).
Contraindications for use
- hypersensitivity to salicylates and other components of the drug.
Carefully
The drug should be used during pregnancy, during breastfeeding and in children under 1 year of age.
pharmachologic effect
When applied topically, choline salicylate
quickly absorbed by the oral mucosa, providing local analgesic, anti-inflammatory and antipyretic effects. It inhibits the activity of COX, the functions of macrophages and neutrophils, the production of interleukin-1 and inhibits the synthesis of prostaglandins. It also has antimicrobial and antifungal effects in acidic and alkaline environments.
Cetalkonium chloride
- antiseptic, acts on bacteria, fungi and viruses.
The gel ethanol-containing adhesive base ensures rapid development of the effect and retains the active substances on the mucous membrane for a long time.
The analgesic effect occurs within 2-3 minutes, while its duration is 2-8 hours.
Drug interactions
When using the drug Cholisal®, it is possible to enhance the effect of other simultaneously used anti-inflammatory, antipyretic and analgesic drugs.
Dosage regimen
Cholisal® is used topically 2-3 times a day before meals (for pain relief) or after meals and before bedtime. 1 cm long gel strip for adults
and 0.5 cm for
children
is squeezed onto a clean finger and rubbed with light massaging movements into the affected area of the oral mucosa.
For periodontal diseases
The gel should be placed in the gum pockets or applied as compresses, or gently rubbed into the gums 1-2 times a day.
Overdose
No cases of overdose of the drug Cholisal® have been identified.
Side effect
Local reactions:
a short-term burning sensation at the site of application of the drug, which goes away on its own.
Other:
allergic reactions.
special instructions
When the first signs of a side effect appear, the patient should immediately contact their doctor.
The drug should be used only topically.
Cholisal® does not contain sugar.
Effect on the ability to drive vehicles and operate machinery
The drug does not limit psychophysical activity, the ability to drive vehicles and operate moving mechanisms.
Storage conditions
The drug should be stored out of the reach of children at a temperature not exceeding 25°C; do not freeze.
Best before date
Shelf life: 3 years. Do not use after the expiration date stated on the packaging.
Use during pregnancy and breastfeeding
Restrictions during pregnancy - With caution. Restrictions when breastfeeding - With caution.
Cholisal® should be used with caution during pregnancy and breastfeeding.
Use in children
Restrictions for children - With caution.
Carefully _
The drug should be used in children under 1 year of age.
Terms of sale
The drug is available without a prescription.
Contacts for inquiries
Bausch Health LLC (Russia)
115162 Moscow, st. Shabolovka, 31, building 5 Tel.
special instructions
Despite the many advantages and high safety of the drug, dentists all recommend adhering to several rules:
- Gel in large doses can enhance the effect of antipyretics, analgesics and anti-inflammatory drugs, so it is especially important to monitor the dose of the gel used if you take such drugs.
- Women during lactation and pregnancy, as well as children under 1 year of age, are advised to use the gel with caution.
Reviews about Cholisal
Most reviews about the use of the drug by adults and children are positive. The gel is able to quickly and effectively eliminate pain and inflammation and cools the affected area. If you use the medicine at night, the effect will last almost until the morning. Also has an antipyretic effect. For many, the advantage is that the composition does not contain lidocaine, to which many have adverse reactions and allergies.
There are many rave reviews from patients who had stomatitis. Within 3-5 minutes after application, you can notice a significant improvement in the condition, pain disappears, and after 15-20 minutes the inflammation is relieved. If you apply compresses before bed, then after a couple of days the signs of stomatitis will almost completely disappear.
The gel is sold in pharmacies. It can be bought without a doctor's prescription.
Holisal: reviews from specialists and patients
What can you say about Holisal?
Only good. All specialists from the dental industry speak only positively about the drug. Negative reviews are extremely rare, and, as a rule, they are from patients who made mistakes in trying to self-medicate. For example, some patients begin to use the product without first consulting a dentist, completely forgetting that inflammation in the mouth always has a cause. In such cases, using Cholisal alone is not enough, since the treatment will be ineffective and short-term. Therefore, it is necessary to discover the cause and carry out full therapy to avoid relapse of the disease.
What benefits do doctors and patients notice?
- Versatility of use. Cholisal is available in one form, which allows it to be used by both adults and children. There are no age restrictions, the gel is safe and effective for everyone.
- In normal doses, the drug is inert and does not react with other drugs, which makes it possible to include it in combination therapy.
- No risk of overdose.
- No sugar in the composition.
- The drug penetrates deeply into tissues, providing a stronger and longer-lasting therapeutic effect.
- Quickly relieves pain.
- Cholisal gel does not affect the psychomotor state of the patient, so it can be used while driving a vehicle or when working with complex mechanisms.
- The gel is applied topically, which eliminates a number of side effects that can usually occur with oral medications.
- Availability and popularity. Cholisal is sold without a prescription, so you can easily purchase it at any pharmacy.
Cholisal: composition, release form
Cholisal is a modern dental drug with a pronounced analgesic, anti-inflammatory and antibacterial effect. The gel acquires its unique healing properties thanks to a combination of the following active ingredients:
- Anise oil (1.6 mg per 1 g of gel) is a natural oil that has a calming effect on inflammation and kills pathogenic microorganisms;
- cetalkonium chloride (87.1 mg per 1 g of gel) – a broad-spectrum antiseptic;
- Choline salicylate (100 mcg per 1 g of gel) is an analgesic that also relieves inflammation.
Auxiliary components: 50 mg of glycerin, up to 1 g of water, 390 mg of ethyl alcohol, 20 mg of hyaetellose, 1.5 mg of methyloxybenzoate, 0.8 mg of propyl parahydroxybenzoate.
Why is this composition so good?
When most dental preparations that are used topically differ only in their superficial effect, Cholisal gel penetrates into the deep layers of the oral mucosa. This property is given to the gel by the active substance choline salicylate. The component formed from salicylic acid acts on the site of inflammation, blocking inflammatory mediators in the oral mucosa. The analgesic component has a light structure, so it penetrates quite deeply into the layers of the mucous membrane.
Cholisal gel acts simultaneously on bacteria, fungi and viruses; this universal property is given to it by a broad-spectrum antiseptic - cetalkonium chloride.
The product is available in gel form, 10 g in aluminum tubes, sealed cardboard packs.
