Flucinar N Ointment, tube, 15 g, for topical use, for skin, from 2 years

Pharmacodynamics and pharmacokinetics

Flucinar ointment, like the gel, has antiexudative, antipruritic, antiallergic and anti-inflammatory effects.

Its effect is achieved by inhibiting phospholipase A2, reducing PG synthesis and releasing macrophage chemotactic factor.

This ensures the migration of macrophages and lymphocytes to the area of ​​inflammation, stabilization of the lysosome membrane, prevention of the release of lysosomal enzymes , blocking the release of biologically active components from sensitized mast cells, histamine basophils, and so on.

It has been established that the activity of this drug is 40 times hydrocortisone

Indications for use

Flucinar gel and ointment are used for external lesions. Therefore, the main indications for the use of ointment and gel are the treatment of severe inflammatory and allergic diseases of the skin and mucous membranes:

• neurodermatitis;
• seborrheic dermatitis;
• eczema;
• psoriasis;
• lichen planus.

Fluocinolone acetonide (Fluocinoloni acetonidum)

Local reactions:

burning, skin itching, acne, post-steroid vascular purpura, inhibition of epidermal growth, skin atrophy and telangiectasia, dry skin, perioral dermatitis, stretch marks, folliculitis, increased hair growth or baldness, melasma or skin discoloration, secondary infected skin lesions (tendency to develop pyoderma and candidiasis, ecchymosis).

From the gastrointestinal tract:

vomiting, pancreatitis, bleeding and perforation of the gastrointestinal tract, flatulence, hiccups, nausea, steroid ulcers of the stomach and duodenum, esophagitis, increased or decreased appetite, increased activity of liver enzymes.

From the endocrine system:

suppression of adrenal function, suppression of the function of the pituitary-adrenal system, steroid diabetes or manifestation of latent diabetes mellitus, delayed sexual development in children, menstrual irregularities, Itsenko-Cushing syndrome, decreased tolerance to carbohydrates, slowed growth in children.

From the side of metabolism:

negative nitrogen balance due to protein catabolism, hypocalcemia, weight gain, sweating.

From the musculoskeletal system:

slowing of growth and ossification processes in children (premature closure of the epiphyseal growth zones), rupture of muscle tendons, muscle weakness, steroid myopathy, osteoporosis (very rarely - pathological fractures, aseptic necrosis of the head of the humerus and femur), decrease in muscle mass (atrophy).

From the cardiovascular system:

potassium loss, arrhythmia, arterial hypertension, steroid myopathy, heart failure (development or intensification of symptoms) characteristic of hypokalemia, hypercoagulation, hypokalemic alkalosis, bradycardia (up to cardiac arrest), ECG changes, increased blood pressure, thrombosis. In patients with acute myocardial infarction - slowing down the formation of scar tissue, spreading of necrosis, rupture of the heart muscle.

From the nervous system:

headache, delirium, disorientation, hallucinations, depression, insomnia, vertigo, seizures, increased intracranial pressure, euphoria, manic-depressive psychosis, nervousness or restlessness, dizziness, pseudotumor of the cerebellum.

From the point of view:

posterior subcapsular cataract, trophic changes in the cornea, exophthalmos, increased intraocular pressure (with possible damage to the optic nerve), tendency to develop a secondary infection (bacterial, fungal, viral).

Other:

with long-term use and/or application to large surfaces of the body: peripheral edema, slowdown of regeneration processes, secondary immunodeficiency (exacerbation of chronic infectious diseases, decreased resistance to infections - generalization of the infectious process, development of opportunistic infections), allergic reactions (urticaria, maculopapular rash).

Instructions for use of Flucinar (Method and dosage)

Flucinar ointment instructions for use recommend applying it externally. In this case, the area of ​​application of the ointment is determined by the degree of damage.

Flucinar gel instructions for use also recommend applying to the affected area, gently rubbing, up to 2 times a day, no more than 2 g.

For psoriasis, Flucinar N ointment is often used, which can be applied under an occlusive dressing. The duration of treatment with the drug on the skin on the face should not exceed 1 week, on other places - up to 2 weeks.

Treatment of children over 2 years of age should be carried out with extreme caution, no more than once a day, on small areas of the skin.

Interactions of the drug Flucinar

No interactions were observed with external use of GCS. However, it should be noted that during treatment with the drug it is not recommended to vaccinate against smallpox, as well as carry out other types of immunization (especially with prolonged use on large areas of the skin) due to the possible lack of an adequate immunological response in the form of the production of appropriate antibodies. Flucinar may enhance the effect of immunosuppressive drugs and weaken the effect of immunostimulating drugs.

Analogs

Level 4 ATC code matches:
Gistan-N

Sinalar

Avecourt

Mesoderm

Momederm

Betazon

Silkaren

Elokom

Sinaflan

Celestoderm

Cutivate

Advantan

Betamethasone

Beloderm

Mometasone Furoate

Uniderm

Momat

The main ointment analogues: Akriderm, Metipred, Dermovate and Lokoid .

Reviews of Flucinar

There are often reviews of Flucinar ointment on the Internet, but opinions about its effectiveness are very ambiguous. Patients often report that the drug helps well at the initial stage of treatment, but further effects may be unexpected.

If for some people this remedy helps to quickly get rid of the symptoms of psoriasis - for which Flucinar ointment is used most often - then others note a significant weakening of the effect or its complete disappearance.

In addition, you can come across reports that the drug helps eliminate unwanted symptoms well, but after stopping its use they arise with renewed vigor. When the ointment is not used for a while, itching, flaking and redness begin to appear again.

Sometimes patients suffering from psoriasis use Flucinar N to treat new plaques. They say that applying the ointment under the bandages helps get rid of spots and other manifestations of the disease. At the same time, other users clarify whether Flucinar ointment is hormonal or not, and how often it can be used.

Unfortunately, often users, even without knowing exactly what Flucinar ointment is intended for, apply it to the skin for a variety of skin lesions: itching, redness, peeling and irritation.

The use of this drug without a doctor’s prescription for serious disorders does not help solve the problem, but, on the contrary, complicates the course of the disease. Moreover, this ointment is not a completely safe product, and its uncontrolled use can cause numerous side effects. This can be avoided by timely contacting a specialist and mandatory compliance with all his appointments.

Pharmacological properties of the drug Flucinar

Framacodynamics. Fluocinolone acetonide is a synthetic fluorinated corticosteroid for external use. When used as an ointment at a concentration of 0.025%, it has a pronounced anti-inflammatory, antipruritic, antiallergic and vasoconstrictor effect. It has lipophilic properties and is well absorbed through the skin. Already after applying 2 g of ointment, the production of ACTH by the pituitary gland may decrease as a result of inhibition of the adrenal-pituitary gland system. The mechanism of the anti-inflammatory effect of fluocinolone acetonide has not been fully studied and suggests that this drug affects the inflammation process by inhibiting the production of prostaglandins and leukotrienes as a result of a decrease in the activity of phospholipase A2 and the release of arachoidonic acid from cell membrane phospholipids. The antiallergic effect is manifested by inhibiting the development of local hypersensitivity reactions. As a result of local vasoconstrictive action, it reduces the risk of developing exudative reactions. Reduces protein synthesis and collagen deposition. Accelerates the breakdown of proteins in the skin and weakens proliferative processes. Pharmacokinetics. Fluocinolone acetonide penetrates well through the stratum corneum of the epidermis, where it gradually accumulates and is detected even 15 days after application. Does not biotransform in the skin. After absorption, it is systemically biotransformed, mainly in the liver. It is excreted in the urine and in smaller quantities in bile, mainly in the form of a compound with glucuronic acid, and also in a small amount unchanged. Absorption of fluocinolone acetonide through the skin is enhanced when applied to sensitive skin - areas of anatomical folds of the body and face, as well as to skin with damaged epidermis or inflammation. The use of an occlusive dressing causes an increase in skin temperature and humidity, which also leads to increased absorption of fluocinolone acetonide. In addition, absorption increases with frequent use of the drug and over large areas of the skin. Absorption through the skin occurs faster in adolescents than in adults.

Flucinar price, where to buy

The price of Flucinar ointment is 216-250 rubles.

The price of Flucinar gel varies between 220-260 rubles.

You can buy the drug in almost any Russian pharmacy without a prescription.

• Online pharmacies in RussiaRussia
• Online pharmacies in UkraineUkraine
• Online pharmacies in KazakhstanKazakhstan

ZdravCity

• Flucinar gel 0.025% 15gJelfa SA
  RUR 313 order
• Flucinar ointment 0.025% 15gJelfa SA

  RUB 316 order

• Flucinar N ointment d/nar. approx. tube 15gJelfa SA

  RUB 227 order

Pharmacy Dialogue

• Flucinar ointment (tube 0.025% 15g)Jelfa

  RUB 323 order

• Flucinar N ointment (tube 15g)Jelfa SA
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• Flucinar gel (tube 15g)Jelfa

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Pharmacy24

• Flucinar 0.025% 15 g gel Elfa A.T. Pharmaceutical Plant, Poland
  106 UAH order
• Flucinar 0.25 mg/1 g 15 g ointment Elfa A.T. Pharmaceutical Plant, Poland

  104 UAH order

• Flucinar N 15 g ointment Farmzavod Elfa A.T., Poland

  111 UAH order

PaniPharmacy

• Flucinar N ointment Flucinar N ointment 15g Poland, Jelfa

  115 UAH order

• Flucinar gel Flucinar gel 0.025% 15g Poland, Jelfa

  116 UAH order

• Flucinar ointment Flucinar ointment 0.025% 15g Poland, Jelfa

  116 UAH order

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Composition and release form

in tubes of 15 g; in a cardboard pack 1 tube.

in tubes of 15 g, in a cardboard pack 1 tube.