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Cartan 1 g/10 ml No. 10 solution for oral administration bottle.

Instructions for medical use of the drug CARTAN Trade name Cartan International nonproprietary name Levocarnitine Dosage form Oral solution, 1 g/10 ml Composition 1 ml of the drug contains the active substance - levocarnitine 100 mg, excipients: sorbitol solution 70%, methylparaben E-218 (methylhydroxybenzoate), sodium saccharin, sodium citrate dihydrate (equivalent to sodium citrate anhydrous), orange flavor, hydrochloric acid and/or sodium hydroxide, water for injection Description A clear, colorless or light yellow solution with an orange odor. Pharmacotherapeutic group Other drugs for the treatment of gastrointestinal diseases and metabolic disorders. Amino acids and their derivatives. ATC code A16AA01 Pharmacological properties Pharmacokinetics When taken orally, it is well absorbed from the gastrointestinal tract (80%). Swipe. is achieved after 3 hours, the therapeutic concentration is maintained for 9 hours. From the blood plasma it penetrates into the liver, myocardium, and skeletal muscles. Excreted by the kidneys, mainly in the form of acyl esters. Pharmacodynamics L-carnitine is a natural substance related to B vitamins. It participates in metabolic processes as a carrier of fatty acids through cell membranes from the cytoplasm to the mitochondria, where they undergo the process of beta-oxidation with the formation of a large amount of metabolic energy in the form of ATP. With a lack of carnitine in the body, lipids are deposited in muscle tissue (skeletal muscles, myocardium), which disrupts their contractile activity. Normalizes protein and fat metabolism, increased basal metabolism in hyperthyroidism, being a partial antagonist of thyroxine, restores the alkaline reserve of the blood, inhibits the formation of keto acids and anaerobic glycolysis, reduces the degree of lactic acidosis, and also increases physical activity and increases exercise tolerance, while promoting economical consumption of glycogen and an increase in its reserves in the liver and muscles. Cartan has an anabolic effect, stimulates the secretion of gastric juice, slows down the breakdown of protein and carbohydrate molecules. Reduces excess body weight and reduces fat content in muscles. It has a neurotrophic effect, inhibits the development of apoptosis, limits the affected area and restores the structure of nervous tissue. Indications for use - consequences of birth trauma and asphyxia of newborns - malnutrition and hypotension of newborns - respiratory distress syndrome in newborns - nursing of premature newborns on parenteral nutrition and children undergoing hemodialysis - underweight in children and adolescents under 16 years of age - primary or secondary carnitine deficiency in adults, children and newborns - secondary carnitine deficiency in patients receiving long-term hemodialysis and having the following symptoms: severe persistent muscle spasms, skeletal muscle weakness, myopathies, loss of muscle mass, symptoms of hypotension, anemia that does not respond to treatment or requiring large doses of erythropoietin, cardiomyopathy - myocardial metabolic disorders due to ischemic heart disease (stable angina, acute myocardial infarction, post-infarction cardiosclerosis) - chronic heart failure - acute and chronic cerebrovascular accident (stroke, encephalopathy of various origins) - physical exhaustion, intense physical activity in athletes (as an anabolic and adaptogen) Method of administration and dose Used orally. Before use, dilute in 100 ml of chilled boiled water. Treatment must be carried out under monitoring the level of free and acyl L-carnitine in plasma and urine to determine an adequate dosage. The concentration of carnitine in plasma is 35 to 60 μmol/l. The ratio of acyl and free L-carnitine in plasma is normal 0.35. The daily dose depends on age and body weight: Up to 2 years – 150 mg/kg body weight 2 – 6 years – 100 mg/kg body weight 6 – 12 years – 75 mg/kg body weight of the child. Children over 12 years of age and adults - 2 - 3 years. In case of primary or secondary carnitine deficiency, the dosage depends on the congenital abnormalities in metabolism and the severity during the treatment period. In most cases, the recommended oral dose is 100 to 200 mg/kg/day, divided into 2 to 4 divided doses. If clinical and biochemical parameters do not improve, the dose may be increased on a short-term basis. High doses up to 400 mg/kg/day are necessary for acute metabolic decompensation. For secondary carnitine deficiency in patients with end-stage chronic renal failure, maintenance therapy is prescribed 1 g per day orally. Side effects - pain in the epigastric region, dyspeptic symptoms - nausea, vomiting - muscle weakness Contraindications - hypersensitivity to the components of the drug Drug interactions Before taking the drug, you should inform your doctor about taking other drugs. Glucocorticoids increase carnitine levels in many tissues (except the liver). Excessive doses of choline inhibit the synthesis and activity of carnitine. Carnitine can be combined with various anabolic agents; with drugs that have antioxidant and/or antihypoxic activity. Special instructions It is recommended to monitor therapy by measuring the level of free and acyl L-carnitine in plasma and urine to determine an adequate dosage. L-carnitine is not addictive, as it is a natural solution for the human body. Administration of L-carnitine to diabetic patients receiving insulin or oral hypoglycemic treatment may cause hypoglycemia. Plasma glucose levels in such patients should be continuously monitored to adjust hypoglycemic treatment. Long-term oral administration of high doses of L-carnitine in patients with severe renal impairment may cause increased concentrations of the potentially toxic metabolites, trimethylamine (TMA) and trimethylamine-N-oxide (TMAO), since these metabolites are usually excreted in the urine. In this case, urine, breath and sweat have an unpleasant odor. Pregnancy and lactation Prescribed during pregnancy or lactation only if absolutely necessary, if the benefit to the mother outweighs the potential risk to the sex or the child. Peculiarities of the drug's influence on the ability to drive a vehicle or operate potentially dangerous mechanisms. No effect. Overdose There are no data on toxicity in case of overdose of L-carnitine. Tolerability of the drug is monitored during the first week of use and after each increase in the dose taken. Symptoms: high doses of the drug cause diarrhea. Treatment: reducing the dose of the drug and replacement therapy. Release form and packaging 10 ml of the drug in polypropylene ampoules. 5 ampoules are placed in thermoplastic blister packs, sealed with aluminum foil. 2 contour packages together with instructions for medical use in the state and Russian languages are placed in a cardboard box. Storage conditions Store at a temperature not exceeding 25 ° C, in a place protected from light. Keep out of the reach of children! Shelf life: 4 years Do not use the drug after the expiration date indicated on the package. Conditions for dispensing from pharmacies By prescription Manufacturer DEMO SA Pharmaceutical Industry, 21 Km National Road Athens-Lamia, 14568 Athens. Greece, tel.: + 30 210 8161802 fax: + 30 210 8161802 Owner of the registration certificate DEMO SA Pharmaceutical Industry, Greece, Address of the organization that accepts claims from consumers on the quality of products (products) in the territory of the Republic of Kazakhstan KFK Medservice Plus LLP RK, Almaty, st. Mametova, 54 tel.

Dosage form

Oral solution, 1 g/10 ml

Compound

1 ml of the drug contains

active substance - levocarnitine 100 mg,

excipients: sorbitol solution 70%, methylparaben E-218 (methylhydroxybenzoate), sodium saccharin, sodium citrate dihydrate (equivalent to anhydrous sodium citrate), orange flavor, hydrochloric acid and/or sodium hydroxide, water for injection

Description

A clear, colorless or light yellow solution with an orange odor.

Pharmacological properties

Pharmacokinetics

When taken orally, it is well absorbed from the gastrointestinal tract (80%). Swipe. is achieved after 3 hours, the therapeutic concentration is maintained for 9 hours. From the blood plasma it penetrates into the liver, myocardium, and skeletal muscles. Excreted by the kidneys, mainly in the form of acyl esters.

Pharmacodynamics

L-carnitine is a natural substance related to B vitamins. It participates in metabolic processes as a carrier of fatty acids through cell membranes from the cytoplasm to the mitochondria, where they undergo the process of beta-oxidation with the formation of a large amount of metabolic energy in the form of ATP. With a lack of carnitine in the body, lipids are deposited in muscle tissue (skeletal muscles, myocardium), which disrupts their contractile activity. Normalizes protein and fat metabolism, increased basal metabolism in hyperthyroidism, being a partial antagonist of thyroxine, restores the alkaline reserve of the blood, inhibits the formation of keto acids and anaerobic glycolysis, reduces the degree of lactic acidosis, and also increases physical activity and increases exercise tolerance, while promoting economical consumption of glycogen and an increase in its reserves in the liver and muscles.

Cartan has an anabolic effect, stimulates the secretion of gastric juice, slows down the breakdown of protein and carbohydrate molecules. Reduces excess body weight and reduces fat content in muscles. Has a neurotrophic effect, inhibits the development of apoptosis, limits the affected area and restores the structure of nervous tissue

Indications for use

consequences of birth trauma and asphyxia of newborns
malnutrition and hypotension of newborns
respiratory distress syndrome in newborns
nursing of premature newborns on parenteral nutrition and children undergoing hemodialysis
underweight in children and adolescents under 16 years of age
primary or secondary carnitine deficiency in adults, children and newborns
secondary carnitine deficiency in patients receiving long-term hemodialysis and having the following symptoms: severe persistent muscle spasms, skeletal muscle weakness, myopathy, loss of muscle mass, symptoms of hypotension, anemia that does not respond to treatment or requires large doses of erythropoietin, cardiomyopathy
disorders of myocardial metabolism due to ischemic heart disease (stable angina, acute myocardial infarction, post-infarction cardiosclerosis)
chronic heart failure
acute and chronic cerebrovascular accident (stroke, encephalopathy of various origins)
physical exhaustion, intense physical activity in athletes (as an anabolic and adaptogen)

Directions for use and doses

Used internally. Before use, dilute in 100 ml of chilled boiled water.

Treatment must be carried out under monitoring the level of free and acyl L-carnitine in plasma and urine to determine an adequate dosage. The concentration of carnitine in plasma is 35 to 60 μmol/l. The ratio of acyl and free L-carnitine in plasma is normal 0.35.

The daily dose depends on age and body weight:

Up to 2 years – 150 mg/kg body weight

2 – 6 years – 100 mg/kg body weight

6 – 12 years – 75 mg/kg child’s body weight.

Children over 12 years old and adults - 2 - 3 years old.

In case of primary or secondary carnitine deficiency, the dosage depends on the congenital abnormalities in metabolism and the severity during the treatment period. In most cases, the recommended oral dose is 100 to 200 mg/kg/day, divided into 2 to 4 divided doses. If clinical and biochemical parameters do not improve, the dose may be increased on a short-term basis. High doses up to 400 mg/kg/day are necessary for acute metabolic decompensation.

For secondary carnitine deficiency in patients with end-stage chronic renal failure, maintenance therapy is prescribed 1 g per day orally.

Side effects

pain in the epigastric region, dyspeptic symptoms
nausea, vomiting
muscle weakness

Contraindications

- hypersensitivity to the components of the drug

Drug interactions

Before taking the drug, you should inform your doctor about taking other drugs.

Glucocorticoids increase carnitine levels in many tissues (except the liver). Excessive doses of choline inhibit the synthesis and activity of carnitine. Carnitine can be combined with various anabolic agents; with drugs that have antioxidant and/or antihypoxic activity.

special instructions

It is recommended to monitor therapy by measuring the level of free and acyl L-carnitine in plasma and urine to determine adequate dosage.

L-carnitine is not addictive, as it is a natural solution for the human body. Administration of L-carnitine to diabetic patients receiving insulin or oral hypoglycemic treatment may cause hypoglycemia. Plasma glucose levels in such patients should be continuously monitored to adjust hypoglycemic treatment.

Long-term oral administration of high doses of L-carnitine in patients with severe renal impairment may cause increased concentrations of the potentially toxic metabolites, trimethylamine (TMA) and trimethylamine-N-oxide (TMAO), since these metabolites are usually excreted in the urine. In this case, urine, breath and sweat have an unpleasant odor.

Pregnancy and lactation

Prescribed during pregnancy or breastfeeding only if absolutely necessary, if the benefit to the mother outweighs the potential risk to the sex or child.

Features of the effect of the drug on the ability to drive a vehicle or potentially dangerous mechanisms

Does not affect.

Overdose

There are no data on toxicity in case of overdose of L-carnitine. Tolerability of the drug is monitored during the first week of use and after each increase in the dose taken.

Symptoms: high doses of the drug cause diarrhea.

Treatment: reducing the dose of the drug and replacement therapy.

Release form and packaging

10 ml of the drug in polypropylene ampoules.

5 ampoules are placed in thermoplastic blister packs, sealed with aluminum foil.

2 contour packages together with instructions for medical use in the state and Russian languages are placed in a cardboard box.

Storage conditions

Store at a temperature not exceeding 25 °C, in a place protected from light.

Keep out of the reach of children!

Shelf life

4 years

Do not use the drug after the expiration date indicated on the package.

Vacation conditions

from pharmacies

According to the recipe
Attention! The description of the drug on this page is simplified. Before purchasing and using the drug, consult your doctor or pharmacist, and also read the instructions approved by the manufacturer. Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. ATTENTION! This section is provided for informational purposes only and is not a catalog or price list of our company. To obtain information about the availability of drugs, call + 99871 202 0999 Pharmacy Network Helpline 999.