The problem of combating pathological changes in the digestive system is very acute today. A huge number of people suffer from stomach ulcers and gastritis. Currently, these diseases affect not only the body of adults; more and more children are among the patients of gastroenterologists.
Basically, diseases associated with impaired secretory function of stomach cells are treated with effective drugs based on the biologically active proton pump inhibitor - omeprozole. In recent years, a whole line of new generation drugs has appeared that use isomers of this substance. One such drug is Nexium.
Indications for use
Nexium and Nolpaza are prescribed when symptoms are observed:
- gastroesophageal reflux disease;
- erosive reflux esophagitis, for long-term treatment, relief of symptoms, prevention of exacerbations;
- stomach ulcer; in a complex therapeutic course for the treatment of duodenal and gastric ulcers;
- peptic ulcer with bleeding, the medicine is used to destroy Helicobacter pylori bacteria when taken together with antibiotics;
- long-term use of non-steroidal drugs NSAIDs, with the healing of stomach and duodenal ulcers, for the prevention of ulcers;
- pathologies with increased hypersecretion in the form of Zollinger-Ellison syndrome.
Nexium
Nexium belongs to the group of inhibitor medications that inhibit the production of HCl in the gastric glands. By inhibiting the secretory activity of the glands, Nexium effectively lowers the acidity level of digestive juice. Therefore, it is often used in complex drug therapy regimens for gastroesophageal reflux disease, gastric or duodenal ulcers, and disorders of the structure of the mucous membranes of the gastrointestinal tract.
Nexium contains esomeprazole, an isomer of omeprazole, which has similar pharmacodynamic activity. Since esomeprazole exhibits weakly basic properties, it begins to act actively in the acidic environment of the secretory tubules of parietal cells. As a result, the basal secretion of hydrochloric acid is inhibited.
Be sure to discuss whether Esomeprazole or Omeprazole is better and what the difference is between them.
The biologically active substance of the medicine begins to act effectively within one hour after taking the tablet. Just 20 mg per day can reduce the amount of hydrochloric acid in the stomach by 15-20%. And during a course of therapy lasting 6 days, its concentration decreases by 80-90%.
Taking medications
The active ingredients of these drugs (pantoprazole and esomeprazole) are in enteric-coated tablets or capsules. If the membrane is damaged, the active substance may damage the mucous wall of the mouth or esophagus. The tablet should be swallowed without crushing or chewing. Drink with still drinking water.
The usual dosage prescribed by the doctor is one tablet in the morning, before meals; Can be taken twice a day (one tablet in the morning and evening). Additional dosage adjustments are prescribed by a specialist after a complete examination of the patient’s body and for certain symptoms.
When a patient has problems swallowing, the tablet must first be dissolved in water (one tablet in half a glass of water) and given to the patient to drink immediately or within thirty minutes. If the powder remains at the bottom of the glass, add more water, stir well and give the patient a drink again.
For more serious problems with swallowing and eating, the medicine should be administered through a nasogastric tube, after dissolving the tablet or capsule in water.
Comparison of addiction between Nexium and Omez
Like safety, addiction also involves many factors that must be considered when evaluating a drug.
So, the totality of the values of such parameters as “o syndrome” in Nexium is quite similar to the similar values in Omez. Withdrawal syndrome is a pathological condition that occurs after the cessation of intake of addictive or dependent substances into the body. And resistance is understood as initial immunity to a drug; in this it differs from addiction, when immunity to a drug develops over a certain period of time. The presence of resistance can only be stated if an attempt has been made to increase the dose of the drug to the maximum possible. At the same time, Nexium has quite a small amount of “syndrome”, however, the same as Omez.
Similarities between Nolpaza and Nexium
- With different active ingredients, medications have the same pharmacological effect on internal organs and are used for similar diseases of the gastrointestinal tract, including those associated with increased synthesis of hydrochloric acid and increased gastric secretion.
- The drugs are produced in the form of enteric tablets and capsules, with the active substance inside, with the same dosage: 20 and 40 milligrams. At the pharmacy you can also purchase injection solutions with the same dose in a bottle - 40 mg.
- Both drugs are available in pharmacies with a doctor's prescription.
- The shelf life is the same and is 36 months. Medicines should be kept away from children in a dark place.
- The contraindications for Nolpaza and Nexium are identical. First of all, these include children under eighteen years of age. For the treatment of GERD (gastroesophageal reflux disease), Nexium can be taken by adolescents over twelve years of age.
- Inherited fructose intolerance and individual intolerance to drug components are also contraindications to their use.
Regardless of the course of treatment and the dose taken, all medications have side effects specified in the instructions. Both drugs can cause:
- headache and dizziness;
- colic and abdominal pain;
- blurred vision and depression;
- interstitial nephritis;
- flatulence accompanied by nausea, vomiting, constipation or diarrhea;
- allergic reactions such as itching, burning, skin rashes, peripheral edema, rarely - anaphylactic shock;
- leukopenia and thrombocytopenia;
- photosensitivity;
- increased activity of liver enzymes;
- arthralgia and myalgia;
- Stevens-Johnson syndrome.
Nexium may additionally cause bronchospasm, taste disturbance, stomatitis, aggressive behavior and hallucinations, confusion, sweating, and gastrointestinal candidiasis.
Introduction
Proton pump inhibitors (PPIs) are drugs that block the H+-K+-ATPase (proton pump) on the apical membrane of the parietal cells of the gastric mucosa, thereby inhibiting the formation of hydrochloric acid and, consequently, its secretion. All PPIs are relatives, representing the same pharmacological group, but close or distant ones are a matter of debate. PPIs are leaders in pharmacology and practical medicine in terms of effectiveness and safety. If we count by international nonproprietary name, then 6 PPIs are registered in the Russian Federation: omeprazole, esomeprazole, pantoprazole, lansoprazole, dexlansoprazole, rabeprazole. In clinical practice, doctors and patients often deal with trade names, of which there are many more.
Difference between drugs
Esomeprazole in Nekium in a lower dosage gives a similar positive result. If the patient has impaired liver function or a lack of liver enzymes, the maximum dosage of Nexium should be 20 mg per day.
In case of renal failure, the medicine should be used with caution and under medical supervision.
For Nolpaza, the dosage can be doubled and be 40 mg per day for patients suffering from renal or liver failure. There is no need to adjust the dosage.
- Nolpaza begins to exert its effect on the body after 2 hours, Nexium - after one hour. The speed of action of Nexium not only reduces the concentration of hydrochloric acid in the stomach, but also controls and maintains the acidic environment in a normal state for a long period of time.
- The course of taking Nexium is usually four weeks until complete recovery, Nolpaza gives its effect in a month to a month and a half.
However, the bioavailability of esomeprazole is lower and with continuous use gradually increases to 68%. The level of absorption from the intestine of pantoprazole remains constant throughout the course of therapy and is 77%.
- Nolpaza is cheaper than Nexium. A newer product is always more expensive than the previous analogue.
- One of Nolpaza's strong advantages over Nexium is its ability to interact with other medications. The first reacts more calmly to additionally taken substances, without changing their effect on the body.
- Concurrent use of anti-elliptic drugs with Nexium or Nolpaza may change the concentration of antidepressants in the blood. Nexium should not be taken concomitantly with nelfinavir and atazanavir to avoid increased saquinavir serum concentrations.
- Pantoprazole can be used by people who have a deficiency of vitamin B12: the medicine reduces the absorption of cyanocobalamin into the body.
- Esomeprazole reduces acidity in the stomach, which can alter the absorption of drugs that are absorbed into the body due to acid levels, such as itraconazole and ketoconazole.
When taking esomeprazole at a dosage of 40 mg, the concentration of phenytoin in the blood plasma should be monitored at the beginning and at the end of the treatment course.
The instructions note the interaction of Nexium with antiretroviral medications.
Taking Nexium and clarithromycin together leads to a 2-fold increase in esomeprazole concentrations. The consequences of such medication use are fraught for patients with severe abnormalities and liver dysfunction, especially with long-term course therapy.
An overdose of Nexium (up to 280 mg orally) may cause indigestion and weakness of the entire body. To relieve symptoms, symptomatic therapy should be carried out.
Comparison of the effectiveness of Nexium and Omez
The effectiveness of Nexium is quite similar to Omez - this means that the ability of the drug substance to provide the maximum possible effect is similar.
For example, if the therapeutic effect of Nexium is more pronounced, then using Omez even in large doses will not achieve this effect.
Also, the speed of therapy - an indicator of the speed of therapeutic action - is approximately the same for Nexium and Omez. And bioavailability, that is, the amount of a drug reaching its site of action in the body, is similar. The higher the bioavailability, the less it will be lost during absorption and use by the body.
Additional tips and tricks
The combined use of drugs belonging to the same group is impossible. The result can be a sharp increase in the concentration of biologically active substances inside the body, and there will be a severe disruption in the functioning of organs and entire systems: digestive, nervous, circulatory and urinary. Allergies are inevitable.
To take inhibitor medications, you should consult a specialist. He will suggest a medication regimen, combination, and determine the duration of course therapy depending on the disease and severity.
During pregnancy and lactation, only a doctor can prescribe any medication, with caution, under close supervision, if the mother’s health is in greater danger.
This is due to the lack of data and laboratory studies regarding the effect of these medications on the health and development of the unborn or newborn baby.
If a driver is using Nexium or Nolpaza, they should drive with caution. Medicines may have adverse effects on the body such as blurred vision, dizziness, drowsiness, and fatigue.
Comparing the safety of Nexium and Omez
The safety of a drug includes many factors.
At the same time, with Nexium it is quite similar to Omez. It is important where the drug is metabolized: drugs are excreted from the body either unchanged or in the form of products of their biochemical transformations. Metabolism occurs spontaneously, but most often involves major organs such as the liver, kidneys, lungs, skin, brain and others. When assessing metabolism in Nexium, as well as in Omez, we look at which organ is the metabolizing organ and how critical the effect on it is.
The risk-benefit ratio is when the prescription of a drug is undesirable, but justified under certain conditions and circumstances, with the obligatory observance of caution in use. At the same time, Nexium does not have any risks when used, just like Omez.
Also, when calculating safety, it is taken into account whether only allergic reactions occur or possible dysfunction of the main organs. In other matters, as well as the reversibility of the consequences of using Nexium and Omez.
Comparison of side effects of Nexium and Omez
Side effects or adverse events are any adverse medical event that occurs in a subject after administration of a drug.
Nexium has almost the same level of adverse events as Omez. They both have few side effects. This implies that the frequency of their occurrence is low, that is, the indicator of how many cases of an undesirable effect of treatment are possible and registered is low. The undesirable effect on the body, the strength of influence and the toxic effect of Nexium are similar to Omez: how quickly the body recovers after taking it and whether it recovers at all.
