Omitox Gastro®
Orally, with a small amount of water (the contents of the capsule must not be chewed).
If you have difficulty swallowing a whole capsule, you can swallow its contents after opening or dissolving the capsule, or you can mix the contents of the capsule with a slightly acidified liquid (juice or yogurt) and use the resulting suspension within 30 minutes. Do not use with milk or sparkling water. Adults
Duodenal ulcer
Patients with an active duodenal ulcer are recommended to take Omitox Gastro® 20 mg once daily. The drug provides rapid relief of symptoms. In most patients, ulcer healing occurs within 2 weeks. In cases where complete healing of the ulcer does not occur within 2 weeks, healing is achieved with a subsequent 2-week intake of Omitox Gastro®. Patients with duodenal ulcers that are poorly responsive to treatment are usually prescribed Omitox Gastro® 40 mg once a day; Ulcer healing usually occurs within 4 weeks.
To prevent relapses, patients with duodenal ulcers are recommended to take Omitox Gastro® 10 mg once a day. If necessary, the dose can be increased to 20-40 mg 1 time per day.
Stomach ulcer
The recommended dose of Omitox Gastro® is 20 mg once a day. The drug provides rapid relief of symptoms. For most patients, cure occurs within 4 weeks. In cases where complete healing does not occur after the first course of taking the drug, a repeated 4-week course of treatment is usually prescribed, during which healing is achieved.
Patients with stomach ulcers that are poorly responsive to treatment are usually prescribed Omitox Gastro® 40 mg 1 time per day; healing is usually achieved within 8 weeks.
To prevent relapses, patients with gastric ulcers are recommended to take Omitox Gastro® 20 mg once a day. If necessary, the dose can be increased to 40 mg 1 time per day.
NSAID-associated ulcers and erosions of the stomach and duodenum
In the presence of NSAID-associated gastric, duodenal ulcers or gastroduodenal erosions in patients with ongoing NSAID therapy or after its cessation, the recommended dose of Omitox Gastro® is 20 mg 1 time per day. The drug provides rapid relief of symptoms; in most patients, cure occurs within 4 weeks. In those patients who do not heal during the initial period of therapy, healing is usually achieved with a repeat dose of the drug for 4 weeks.
For the prevention of ulcers and erosions of the stomach and duodenum and symptoms of dyspepsia associated with taking NSAIDs, the recommended dose of Omitox Gastro® is 20 mg 1 time per day.
Helicobacter pylori eradication in peptic ulcer disease (in combination with appropriate antibacterial therapy)
Helicobacter pylori eradication regimens in peptic ulcer disease
Three-component treatment regimen:
Omitox Gastro® 20 mg, amoxicillin 1 g and clarithromycin 500 mg. Take all medications 2 times a day for one week
or
Omitox Gastro® 20 mg, metronidazole 400 mg (or tinidazole 500 mg) and clarithromycin 250 mg. Take all medications 2 times a day for one week
or
Omitox Gastro® 40 mg once a day, as well as amoxicillin 500 mg and metronidazole 400 mg 3 times a day for one week.
Two-component treatment regimen:
Omitox Gastro® 40-80 mg daily and amoxicillin 1.5 g daily (dose should be divided into parts) for two weeks. During clinical trials, amoxicillin was used at a daily dose of 1.5-3 g, omeprazole 40 mg once a day and clarithromycin 500 mg 3 times a day for two weeks.
To ensure complete healing, further treatment should be carried out in accordance with the recommendations in the sections “Duodenal Ulcer” and “Gastric Ulcer”.
In cases where, after completing a course of treatment, the test for Helicobacter
pylori
remains positive, the course of treatment can be repeated.
Reflux esophagitis
The recommended dose is one capsule of Omitox Gastro® 20 mg 1 time per day. The drug provides rapid relief of symptoms. For most patients, cure occurs within 4 weeks. In cases where complete cure does not occur after the first course of taking the drug, a repeated 4-week course of treatment is usually prescribed, during which a cure is achieved.
For patients with severe reflux esophagitis, it is recommended to take Omitox Gastro® 40 mg once a day; cure usually occurs within 8 weeks. Patients with reflux esophagitis in remission are prescribed Omitox Gastro® 10 mg 1 time per day as long-term courses of maintenance therapy. If necessary, the dose can be increased to 20-40 mg.
Symptomatic gastroesophageal reflux disease
The recommended dose is Omitox Gastro® 20 mg once a day. The drug provides rapid relief of symptoms. The therapeutic effect can be achieved with a daily dose of 10 mg, so individual dose selection cannot be ruled out. If after 4 weeks of treatment (Omitox Gastro® 20 mg 1 time per day) symptoms do not disappear, additional examination of the patient is recommended.
Dyspepsia
associated
with high acidity
To relieve pain and/or eliminate discomfort in the epigastric region, with or without heartburn, prescribe Omitox Gastro® 20 mg 1 time per day. The therapeutic effect can be achieved with a dose of 10 mg 1 time per day, so treatment can be started with this dose. If after 4 weeks of treatment (Omitox Gastro® 20 mg 1 time per day) symptoms do not disappear, additional examination of the patient is recommended.
Zollinger-Ellison syndrome
For patients with Zollinger-Ellison syndrome, the drug is prescribed in an individual dosage. Treatment is continued according to clinical indications for as long as necessary. The recommended starting dose is Omitox Gastro® 60 mg daily. In all patients with a severe form of the disease, as well as in cases where other therapeutic methods did not lead to the desired result, the use of the drug was effective in more than 90% of patients when taking 20-120 mg of Omitox Gastro® daily. In cases where the daily dose of the drug exceeds 80 mg, the dose should be divided into two parts and taken 2 times a day.
Children and teenagers
Reflux esophagitis and symptomatic gastroesophageal reflux disease
Children over 2 years of age with a body weight of more than 20 kg are prescribed Omitox Gastro® at a dose of 20 mg once a day. If necessary, the dose can be increased to 40 mg once a day. The recommended duration of treatment in case of reflux esophagitis is 4-8 weeks. The recommended duration of treatment for symptomatic gastroesophageal reflux disease is 2-4 weeks.
If after 2-4 weeks of treatment control of the symptoms of the disease has not been achieved, additional examination of the patient is recommended.
Duodenal ulcer caused by
Helicobacter pylori
When choosing a treatment regimen, one should take into account official national, regional and local recommendations regarding the resistance of microorganisms to antibacterial agents, the duration of therapy (most often - 7 days, but in some cases - up to 14 days) and the correct use of antibacterial drugs drugs. Therapy must be carried out under the supervision of a specialist.
For children over 4 years of age, the following treatment regimen is recommended:
| Body mass | Treatment regimen |
| 15-30 kg | Omitox Gastro® 10 mg, amoxicillin 25 mg/kg and clarithromycin 7.5 mg/kg. Take all medications 2 times a day for a week. |
| 31-40 kg | Omitox Gastro® 20 mg, amoxicillin 750 mg and clarithromycin 7.5 mg/kg. Take all medications 2 times a day for a week. |
| > 40 kg | Omitox Gastro® 20 mg, amoxicillin 1 g and clarithromycin 500 mg. Take all medications 2 times a day for a week. |
Special patient groups
Renal dysfunction
For patients with impaired renal function, no dose adjustment is required.
Liver dysfunction
In patients with impaired liver function, the bioavailability and plasma half-life of omeprazole are increased. In this regard, a dose of 10-20 mg per day is sufficient.
Elderly patients
For elderly patients, no dose adjustment is required.
Instructions for use OMEPRAZOLE
- Omeprazole 20 mg + clarithromycin 500 mg + amoxicillin 1000 mg, each taken 2 times a day for one week, or
Omeprazole 20 mg + clarithromycin 250 mg or 500 mg + metronidazole 400 mg (or 500 mg or tinidazole 500 mg), each taken 2 times a day for one week, or
Omeprazole 40 mg + amoxicillin 500 mg + metronidazole 400 mg (or 500 mg or tinidazole 500 mg), each taken 3 times a day for one week.
After eradication of Helicobacter pylori, further treatment of gastric ulcer in the acute phase should be carried out according to the standard treatment regimen. In cases where, after therapy, the test for Helicobacter pylori remains positive, the course of treatment can be repeated.
Treatment of NSAID-related gastric and duodenal ulcers
The recommended dose is 20 mg/day. For most patients, healing occurs within four weeks. In cases where, after the first course of treatment, the ulcer has not healed completely, a repeat 4-week course is usually prescribed.
To prevent NSAID-related gastric and duodenal ulcers in patients at risk
(age over 60 years, history of stomach and duodenum, history of gastrointestinal bleeding) the recommended dose is 20 mg/day.
Treatment of reflux esophagitis
The recommended dose is 20 mg/day. In most patients, healing occurs within 4 weeks. In cases where, after the first course of treatment, the ulcer has not healed completely, a repeat 4-week course is usually prescribed. In patients with severe reflux esophagitis, a dose of 40 mg/day is recommended, the course of treatment averages 8 weeks.
For long-term treatment of patients with healed reflux esophagitis (in remission), 10 mg/day is prescribed in the form of long courses of maintenance therapy. If necessary, the dose can be increased to 20-40 mg.
For the symptomatic treatment of gastroesophageal reflux disease, the dosage regimen is set individually. Prescribe 10-20 mg/day. The course of treatment is 4 weeks. If symptoms do not disappear after completion of therapy, it is recommended to change the treatment regimen.
Treatment of Zollinger-Ellison syndrome
For Zollinger-Ellison syndrome, the dosage regimen is selected individually and treatment continues according to clinical indications for as long as necessary. The recommended starting dose is 60 mg/day. All patients with severe disease, as well as in cases where other therapeutic methods have not led to the desired result, should be effectively monitored and more than 90% of patients are maintained on a dose of 20-120 mg/day. In cases where the daily dose of omeprazole exceeds 80 mg, the dose should be divided into two doses per day.
Dosage in children
Clinical experience with omeprazole in children is limited . Treatment should be carried out under the supervision of a specialist.
In case of severe reflux esophagitis
resistant to other types of therapy, children over 2 years of age weighing more than 20 kg are prescribed 20 mg/day (equivalent to approximately 1 mg/kg/day). The duration of treatment is 4-8 weeks. Children aged 1 to 2 years are prescribed a dose of 10 mg/day. In this case, the contents of the capsule are poured into 50 ml of drinking water, after mixing, half of this volume of liquid is measured and given to the child to drink. The dose can be increased to 40 mg 1 time/day if necessary.
For the treatment of duodenal ulcer caused by Helicobacter pylori
, children and adolescents, the choice of treatment regimen should be in accordance with national, regional and local guidelines regarding bacterial resistance, duration of treatment (usually 7 days, but sometimes up to 14 days) and appropriate use of antibacterial agents.
Children weighing 15-30 kg:
omeprazole 10 mg + amoxicillin 25 mg/kg + clarithromycin 7.5 mg/kg body weight, each drug 2 times a day for one week.
