Instructions
The instructions contain useful information about side effects, release form, indications, composition, contraindications, storage conditions, expiration date. In addition, in the article you can also find data on the price range, analogues and reviews of patients who have encountered this product. The same information is necessary to obtain complete information about the drug.
Pharmacology
After taking the medicine orally, the effect of the active substance begins after half an hour and continues throughout the day, the maximum effect is observed after a few hours.
The active substance of the drug is absorbed from the gastrointestinal tract, its bioavailability ranges from 30 to 45%.
Indications
For any disease of the gastrointestinal tract, following a diet is mandatory. This medicine may be prescribed to treat conditions such as:
- Reflux esophagitis;
- Any form of ulcer that is caused by Helicobacter pylori (used as an adjuvant);
- Zollinger-Ellison syndrome.
Erosive and ulcerative lesion, which was caused by taking NSAIDs.
Method of administration
The drug should be taken orally with water (capsules should never be chewed or crushed).
- For ulcers, the drug is prescribed at a dosage of 20 mg per day. Treatment lasts 14-28 days;
- For ulcers that are in the acute stage, as well as erosive-ulcerative esophagitis, a medicine is prescribed in a dosage of 20 mg per day. In severe cases, the dosage can be increased to 40 mg. Treatment lasts 14-28 days;
- For ulcers caused by taking NSAIDs, the drug is prescribed at a dose of 20 mg per day. Therapy lasts an average of 7 weeks.
- When eradicating Helicobacter pylori, the drug is prescribed at a dosage of 20 mg 2 times a day. Treatment should be continued for 1-2 weeks (depending on the therapy regimen used). This medicine should be taken together with other antibacterial drugs;
- For the treatment of reflux esophagitis, the drug is prescribed at a dosage of 20 mg per day. Treatment lasts a long time (up to six months). The medicine is taken to relieve existing symptoms;
- For Zollinger-Ellison syndrome, the dose is individualized based on many factors, such as the severity of the disease, but typically starts at 60 mg per day. If required, the dosage is increased to 120 mg. If this has been done, then it should be divided into 2 doses.
If the patient has mild or moderate liver damage, the dosage should not exceed 20 mg. However, if a person has severe liver damage, then the drug is strictly contraindicated.
Compound
One of the most effective means for the prevention and treatment of gastrointestinal diseases. The drug is available in the form of capsules that have a gray cap. The contents of the capsules are granules that are covered with a white shell.
The medicine contains the active substance omeprazole, as well as polysorbate 80, sucrose, hypromellose, calcium carbonate, mannitol, propylene glycol, sodium laryl sulfate, starch, sodium dihydrogen phosphate, diethyl phthalate, lactose, alcohol, methacrylic acid, sodium hydroxide, alcohol.
The shell contains carmosine, gelatin, methyl parahydroxybenzoate, propyl parahydroxybenzoate, titanium dioxide, yellow and blue oxide.
Interaction
Important! Before you start taking Omizak, it is important to inform your doctor if you are taking other medications. This must be done so that the doctor can adjust your treatment.
As a result of taking Omizak, the absorption of other drugs, the absorption of which depends on the pH of gastric juice, may increase or decrease.
The drug increases the absorption of digoxin. Simultaneous administration of the active substance of the drug Omizak with digoxin increases the bioavailability of the latter by approximately 10%.
Omeprazole, when taken simultaneously with certain antiretroviral drugs, interacts with them. When omeprazole is taken together with antiretroviral drugs such as nelfinavir, as well as atazanavir, the concentration of the latter in the blood decreases. Given this fact, it is not recommended to take these drugs at the same time.
Omeprazole Omizac
Composition and release form
1 capsule contains the active substance: omeprazole 20 mg.
There are 30 pieces in a package.
Description of the dosage form
Capsules, hard gelatin, No. 2, with a gray cap and a white body, with the inscription “OMIZAC” and a monogram (logo) on the capsule shell, the contents of the capsules are enteric-coated granules, white or almost white.
pharmachologic effect
H+-K+-ATPase inhibitor. It inhibits the activity of H+-K+-ATPase in the parietal cells of the stomach and thereby blocks the final stage of hydrochloric acid secretion. This leads to a decrease in the level of basal and stimulated secretion, regardless of the nature of the stimulus. Due to a decrease in acid secretion, it reduces or normalizes the effect of acid on the esophagus in patients with reflux esophagitis.
Omeprazole has a bactericidal effect on Helicobacter pylori. Eradication of H. pylori with the simultaneous use of omeprazole and antibiotics allows you to quickly relieve the symptoms of the disease, achieve a high degree of healing of damaged mucosa and stable long-term remission and reduce the likelihood of bleeding from the gastrointestinal tract.
Pharmacokinetics
When taken orally, it is quickly absorbed from the gastrointestinal tract. Penetrates the parietal cells of the gastric mucosa. Plasma protein binding is about 95%, mainly with albumin. Biotransformed in the liver. Excreted by the kidneys - 72-80%, with feces - about 20%. T1/2 0.5-1 hour. In patients with chronic liver diseases, T1/2 increases to 3 hours.
Clinical pharmacology
H+-K+-ATPase inhibitor. Antiulcer drug.
Indications for use
Peptic ulcer of the stomach and duodenum in the acute phase (including those associated with Helicobacter pylori), reflux esophagitis, Zollinger-Ellison syndrome, erosive and ulcerative lesions of the stomach and duodenum associated with taking NSAIDs.
Contraindications for use
Chronic liver diseases (including a history), childhood, hypersensitivity to omeprazole.
Use during pregnancy and children
Due to the lack of clinical experience, omeprazole is not recommended for use during pregnancy. If it is necessary to use it during lactation, the issue of stopping breastfeeding should be decided.
Use in children
Due to the lack of experience in clinical use, omeprazole is not recommended for use in children.
Side effects
From the digestive system: rarely - nausea, diarrhea, constipation, abdominal pain, flatulence.
From the side of the central nervous system: rarely - headache, dizziness, weakness.
From the hematopoietic system: in some cases - anemia, eosinopenia, neutropenia, thrombocytopenia.
From the urinary system: in some cases - hematuria, proteinuria.
From the musculoskeletal system: in some cases - arthralgia, muscle weakness, myalgia.
Allergic reactions: rarely - skin rash.
Drug interactions
With simultaneous use, cases of the development of symptoms of the toxic effects of benzodiazepines have been described, which is associated with inhibition of the activity of CYP3A isoenzymes and, apparently, CYP2C9.
When used simultaneously with atracurium besylate, the effects of atracurium besylate are prolonged.
When used concomitantly with bismuth tripotassium dicitrate, an undesirable increase in the absorption of bismuth may occur.
When used simultaneously with digoxin, a slight increase in the concentration of omeprazole in the blood plasma is possible.
When used simultaneously with disulfiram, a case of impaired consciousness and catatonia has been described; with indinavir, a decrease in the concentration of indinavir in the blood plasma is possible; with ketoconazole, a decrease in the absorption of ketoconazole is possible.
With prolonged simultaneous use with clarithromycin, the concentrations of omeprazole and clarithromycin in the blood plasma increase.
Cases of decreased excretion of methotrexate from the body in patients receiving omeprazole have been described.
When used simultaneously with theophylline, a slight increase in the clearance of theophylline is possible.
It is believed that with the simultaneous use of omeprazole in high doses and phenytoin, an increase in the concentration of phenytoin in the blood plasma is possible.
Cases of increased concentrations of cyclosporine in blood plasma have been described when used simultaneously with cyclosporine.
When used simultaneously with erythromycin, a case of increased concentration of omeprazole in the blood plasma was described, while the effectiveness of omeprazole decreased.
Dosage
Individual. When taken orally, a single dose is 20-40 mg. Daily dose - 20-80 mg, frequency of use - 1-2 times/day. Duration of treatment is 2-8 weeks.
Precautionary measures
Before starting therapy, it is necessary to exclude the possibility of a malignant process (especially with a stomach ulcer), because Treatment with omeprazole may mask symptoms and delay correct diagnosis.
The use of omeprazole may distort the results of laboratory tests of liver function and gastrin concentrations in the blood plasma.
Side effects
In isolated cases, the patient exhibits such effects as:
- Constipation, diarrhea, flatulence, nausea, abdominal pain, stomatitis, vomiting, taste disturbance, liver dysfunction;
- Dizziness, drowsiness, depression, pain in the head, agitation, encephalopathy, paresthesia;
- Myalgia or arthralgia;
- Thrombocytopenia, eosinopenia, pancytopenia, as well as agranulocytosis, anemia, neutropenia;
- Alopecia, photosensitivity, erythema;
- Increased sweating, gynecomastia, and visual impairment;
- Bronchospasm, urticaria, nephritis, swelling, fever.
Symptoms of overdose are drowsiness, headache, tachycardia, confusion, arrhythmia, nausea, dry mouth. Treatment should be symptomatic.
Peptic ulcer in the stomach is a complex pathological process. It develops due to an imbalance between local factors of protection and aggression, when infected with Helicobacter pylori.
What to do in case of overdose?
In the event of an overdose, a person may experience the following symptoms:
- Dizziness;
- Abdominal pain, flatulence, bloating;
- Diarrhea, as well as constipation;
- Vomiting, nausea;
- Tachycardia, increased blood pressure, arrhythmia;
- Visual impairment, appearance of black spots before the eyes;
- Dry mouth, increased sweating, drowsiness.
There is no special antidote. In case of negative consequences, symptomatic therapy must be carried out.
Contraindications
Important! Before starting treatment, the doctor must exclude the possibility of a malignant process.
Doctors do not advise taking the medicine if the patient has concomitant conditions or diseases such as:
- Allergy to certain substances;
- Severe liver diseases;
- Childhood.
During pregnancy
At this time, it is better to refrain from taking medications, because... use may adversely affect the patient's condition. If the appointment is vital, then the appointment is allowed, but the doctor must carefully monitor not only the condition of the patient, but also her fetus.
At the slightest deviation from the norm, treatment should be stopped . During breastfeeding, it is also better to refrain from taking Omizak.
What to do if you have heartburn?
If you are worried about heartburn, then first of all you should get rid of all the factors that contribute to its occurrence. Eat 3-4 times a day, limit your consumption of too fatty and fried foods, smoked foods, and sour foods. Get rid of bad habits (smoking, alcohol), and also eliminate coffee and carbonated drinks from your diet.
If, despite changing your lifestyle, heartburn still bothers you, then medications will come to the rescue. Currently, two main groups of drugs are used for heartburn:
- Antacids (from the Greek “anti” - against; from the Latin “acidus” - acid). These are drugs that neutralize hydrochloric acid in the stomach4. In other words, antacids treat the symptom but not the cause of heartburn. The duration of the neutralizing effect of antacids is several hours while they are in the stomach. For this reason, antacids must be taken several times a day.
- Proton pump inhibitors (PPIs). As mentioned above, the production of hydrochloric acid in the stomach is carried out by special (parietal) cells of the gastric glands. The central link in the synthesis of hydrochloric acid is the proton (or hydrogen) pump, which ensures the transfer of hydrogen ions H+ through the membrane into the gastric space. PPIs inhibit the activity of the proton pump, resulting in decreased production of hydrochloric acid5.
What else do you need to remember?
Some important points are covered here.
Driving
The product may cause drowsiness, abdominal pain, blurred vision, and diarrhea. This is why doctors strongly discourage drivers from driving.
Pregnancy
At the beginning of pregnancy, the stomach may hurt due to the onset of hormonal changes in the body. Before conceiving a child, you should stop taking any medications, including Omizak, for several months. The fact is that the active substance of the drug can have a negative effect on the fetus, causing the development of serious deviations from the norm.
If there is an urgent need, the drug can be prescribed, but in the last month of pregnancy.
It is highly undesirable to take the drug during breastfeeding.
Childhood
No information was provided on taking the drug in childhood.
For kidney problems
If kidney function is impaired, dosage adjustment may be required. In addition, you should also constantly monitor the condition of your kidneys.
With impaired liver function
If a person has liver dysfunction, no dosage adjustment is required.
Release from pharmacy
A prescription from a doctor is required for release.
What are the causes of heartburn?
If heartburn bothers you frequently, this may indicate the following diseases of the gastrointestinal tract:
- Gastroesophageal reflux disease (GERD) - develops when the esophageal sphincter is insufficient1.
- Gastritis with high acidity is also accompanied by pain in the epigastric region.
- Peptic ulcer of the stomach and duodenum.
Most often, attacks of heartburn bother a person 15-30 minutes after eating.
Heartburn can also occur in healthy people under certain circumstances, namely:
- Unhealthy eating . Heartburn can occur with excessive consumption of fatty, fried and smoked foods, since such food promotes excessive secretion of gastric juice. Citrus fruits, sour fruits and berries also contribute to heartburn.
- Coffee, tea and carbonated drinks . Caffeine contained in coffee and tea has a relaxing effect on the esophageal sphincter muscles, which promotes the upward flow of acid. As for carbonated drinks, it's all about carbon dioxide, which puts pressure on the intestines.
- Bad habits . Smoking and excessive alcohol consumption increase the likelihood of heartburn2. It has been established that nicotine increases the acidity of gastric juice and disrupts the process of salivation, which contributes to the appearance of heartburn. As for alcoholic drinks, on the one hand, they contribute to the appearance of inflammation of the mucous membranes of the esophagus, and also increase the production of hydrochloric acid in the stomach.
- Stress . Under stress, contraction of the walls of the esophagus increases, which disrupts the functioning of the esophageal sphincter.
Analogs
The drug Omizak has a large number of possible drugs that can replace it.
Among such drugs we can highlight drugs such as: Omeprazole, Gastrozol, Zhelkizol, Omez, Omitos, Omecaps, Ortanol, Ultop, Promez, Losek Maps, Omefez, Zerotsid, Ulkozol, Pepticum, Cisagast, Romesec, Otsid.
Among the analogues presented, you can choose a cheaper product, however, the selection can only be made by a specialist, but not by the patient.
Reviews
Among the obvious advantages are the minimum number of contraindications, as well as the low cost of the drug.
In addition, many patients note the high effectiveness of the drug and its convenient release form. Pregnant girls like that they can take this medicine in extreme cases.
Among the disadvantages are a large number of side effects. You can also find reports on the Internet that the drug did not have the desired therapeutic effect.
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