Hepatoprotective activity of Remaxol in chronic liver damage

Compound

Active ingredients:

succinic acid – 5.280 g; meglumine (N-methylglucamine) – 8.725 g; inosine (riboxin) – 2.0 g; methionine – 0.75 g; nicotinamide – 0.25 g.

Excipients:

sodium chloride – 6.0 g; potassium chloride – 0.30 g; magnesium chloride hexahydrate (in terms of anhydrous) – 0.12 g; sodium hydroxide – 1.788 g; water for injections up to – 1.0 l.

Description:

transparent colorless liquid with a weak characteristic odor.

Pharmacotherapeutic group:

metabolic agent

ATX code: A05VA

Combination of Remaxol with other drugs

A significant advantage is that the active substances of the drug are perfectly combined with cardiac glycosides. Due to this interaction, the duration of the medication increases and better results can be achieved.

It is strictly forbidden to use the medicine with alkaloids.

This combination forms insoluble compounds, as a result of which significant harm will be caused to the patient’s body.

The product combines negatively with tannin. A precipitate appears, and this substance also neutralizes the properties of Remaxol. While taking the medication, it is recommended to stop smoking and completely avoid drinking alcohol.

PHARMACOLOGICAL PROPERTIES

Pharmacodynamics

REMAXOL® is a balanced infusion solution with a hepatoprotective effect. Under the influence of the drug, the transition of anaerobic processes to aerobic ones is accelerated, the energy supply of hepatocytes is improved, the synthesis of macroergs increases, the resistance of hepatocyte membranes to lipid peroxidation increases, and the activity of antioxidant enzymes is restored. REMAXOL® reduces cytolysis, which is manifested in a decrease in indicator enzymes: aspartate aminotransferases, alanine aminotransferases. REMAXOL® helps reduce bilirubin and its fractions, improves the excretion of direct bilirubin into bile. Reduces the activity of excretory enzymes of hepatocytes - alkaline phosphatase and gamma-glutamyl transpeptidase, promotes the oxidation of cholesterol into bile acids.

Hepatoprotective activity of Remaxol in chronic liver damage

Home•Clinician School•Algorithm•Hepatoprotective activity of Remaxol...

26.01.2010

00:00

1: T.V.
Sologub, L.G. Goryacheva, D.S. Sukhanov, M.G. Romantsov, V.G. Radchenko, 2: A.A. Shuldyakov, V.N. Rechnik, 3: A.A. Suzdaltsev, E.V. Esaulenko, 4: S.L. Maksimov, 5: T.V. Antonova, 6: A.A. Yakovlev 7: I.P. Baranova 1: Academy named after. I. I. Mechnikova; 2: Saratov State Medical University; 3: Samara State Medical University Influenza Research Institute of the Russian Academy of Medical Sciences; 4: MGMSU 5: St. Petersburg State Medical University named after. acad. I. P. Pavlova 6: Infectious Diseases Hospital named after. S. P. Botkina; 7: Penza GIUV

The paper presents the results of multicenter randomized clinical trials, evaluating the effectiveness of the remaxol infusion solution as a hepatoprotective agent for chronic liver damage, conducted at 7 clinical sites. 494 patients suffering from chronic hepatitis B and C were observed. 294 people received Remaxol, 200 people received active placebo. Randomization was carried out using the “envelope” method. The article describes in detail the clinical and laboratory characteristics of the manifestations of the disease. The effect of the drug in comparison with an active placebo on the functional activity of the liver of patients with chronic liver damage is presented. Based on the obtained laboratory and clinical data, the mechanism of action of the drug is described, including hepatoprotective activity, antioxidant effect and anticholestatic effect.

Key words: hepatitis, remaxol, cytolysis, cholestasis, active placebo, cholesterol, alkaline phosphatase, bilirubin

This milticentre randomized clinical study of the effectiveness of remaxol infusion solution (hepatoprotective medicine for chronic liver dysfunction) included 494 patients with chronic hepatitis B and C. 294 of them staying in 7 clinics were given remaxol and 200 ones received placebo. Randomization was achieved by the envelope method. A detailed description of clinical and laboratory characteristics of the diseases is presented. Effects of remaxol vs placebo on the functional activity of affected liver are discussed. Results of laboratory and

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CONTRAINDICATIONS

Individual intolerance to the components of the drug, pregnancy, breastfeeding, childhood. With caution - For nephrolithiasis, gout, hyperuricemia. Use during pregnancy and breastfeeding Preclinical studies have not shown direct or indirect effects on pregnancy, embryo/fetal development, childbirth or postnatal development. Controlled studies of the use of the drug during pregnancy have not been conducted. REMAXOL® should not be prescribed during pregnancy. You should refrain from breastfeeding when prescribing REMAXOL® to a woman.

Instructions for use

Remaxol should only be administered intravenously using a dropper. The daily dosage should not exceed 400-800 ml.

Remaxol is administered at a rate of 40-65 drops per minute. The volume will be 2-3 ml per minute.

The course of therapy cannot exceed 3-12 days, taking into account the severity of the disease. The duration of treatment depends on whether the patient shows improvement.

Side effect

According to the World Health Organization, adverse reactions are classified according to the frequency of their development as follows: – very common (≥ 1/10); – common (≥ 1/100 – – uncommon (≥ 1/1000 – – rare (≥ 1/10000 – – very rare ( – frequency unknown (cannot be determined from available data). General disorders and administration site conditions: very rarely - sensation of heat. Disorders of the skin and subcutaneous tissues: very rarely - allergic rash, itching, urticaria. Disorders of the respiratory system, chest and mediastinal organs: very rarely - sore throat. Vascular disorders: very rarely - hyperemia of the skin of varying severity. Gastrointestinal tract disorders: very rare - dry mouth, nausea. Nervous system disorders: very rare - headache, dizziness. Metabolic and nutritional disorders: very rare - hypoglycemia, hyperuricemia.In order to avoid the occurrence of undesirable reactions, it is recommended to follow the dosage regimen and the rate of administration of the drug. If undesirable reactions occur, it is recommended to reduce the rate of administration of the drug. If any of the adverse reactions indicated in the instructions worsen or you notice any other adverse reactions not listed in the instructions, notify your doctor.

General description of the medicine

Liver problems can occur suddenly. If measures are not taken in a timely manner, a slight illness can have serious consequences. Remaxol is a special substance that allows you to achieve significant results in the treatment of pathology.

Remaxol is a drug available in different forms. The composition of the medicine is as balanced as possible. When used, the product has a hepatoprotective effect. Immediately before taking the medicine, you should consult a specialist, as side effects may occur.

To get a complete picture of the drug, special instructions are included in each package. All the characteristics and properties of the drug are indicated in detail there. Here, patients can read about the procedure for taking the drug.

Release form

Solution for infusion. 400 ml in glass bottles with a capacity of 500 ml, sealed with rubber stoppers, crimped with caps combined from aluminum and plastic. Each bottle, along with instructions for medical use, is placed in a cardboard pack, on which a tamper evident label can be applied. 400 ml in containers made of multilayer polyolefin film. 5 containers along with instructions for medical use are placed in a group container made of corrugated cardboard.

Remaxol price, where to buy

The price of Remaxol is about 280 rubles. The product is sold in 400 ml glass bottles. The indicated price of Remaxol is considered very affordable.

• Online pharmacies in RussiaRussia
• Online pharmacies in UkraineUkraine

Pharmacy Dialogue

• Remaxol (400ml bottle) Polisan NTFF
  RUR 421 order

show more

Pharmacy24

• Remaxol 400 ml No. 1 solution for infusion TOV NTFF Polisan, Russian Federation
  190 UAH order

Remaxol's analogs

Several effective drugs can be distinguished from drug analogues. If you focus on the structure, then you won’t be able to find such a replacement for Remaxol. Medicines have a similar mechanism of action:

It is necessary that the attending physician select a similar drug, since it is important to take into account the combination of the drug with other drugs.

Cost and conditions of dispensing from a pharmacy

Accurate information about the cost of the medicine is available only in pharmacies in a specific locality. Prices may vary depending on the region of sale, so it is worth checking this information in advance.

The medicine is dispensed strictly according to the prescription of the attending physician, since patients should take the drug only under the supervision of a specialist.

In Russia, the average price of Remaxol is 465 rubles and above. What matters is where the medicine is purchased and the volume.

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Opinions from patients and experts

To get a complete picture of the drug Remaxol, you should pay attention to studying reviews. Comments about the drug can be found on the Internet. Very often people indicate that Remaxol helps with discomfort in the liver area in a short time.

The attending physicians emphasize that the drug quickly eliminates the symptoms of the disease, but recommend prescribing the drug in combination with other drugs. The reviews are mostly positive, since the drug is taken under the strict guidance of specialists.

The presented material will allow readers to get a complete understanding of the actions of a drug such as Remaxol. It can be noted that the substance is very effective, but it is better to use it for symptomatic treatment. The solution can only be sold with a doctor's prescription, since it has some contraindications for use.