Miramistin is an unremarkable bottle with a spray nozzle. But he can do so many things! If you look at the list of indications, we can say that the drug helps with literally everything. From anything that is infectious in nature. Or is about to become one. Burns, wounds, viruses, operations and much more are the scope of application of Miramistin. It relieves inflammation and has an antimicrobial effect. It is especially pleasant that the simple composition is characterized by a virtual absence of contraindications or adverse reactions, and the drug can be prescribed from birth.
Miramistin copes well with burns
What does Miramistin protect against?
The effect of the drug is detrimental to:
- Many aerobic and anaerobic gram-positive and gram-negative microorganisms.
- A number of pathogenic fungi, including yeast and yeast-like fungi.
- Some viruses, in particular the herpes virus.
- Most pathogens that cause sexually transmitted infections: chlamydia, trichomonas, gonococci, etc.
Among other things, the drug also affects hospital strains of pathogenic bacteria that are highly resistant to antimicrobial therapy. Therefore, Miramistin in such cases helps to increase the effectiveness of antibiotic therapy.
Local therapy of infectious and inflammatory diseases of the respiratory system
As an advertisement
Miramistin® (benzyldimethyl [3-(myristoylamino)propyl]ammonium chloride monohydrate) is a drug from the group of cationic surfactants. Numerous studies have confirmed that Miramistin has a pronounced antimicrobial effect against gram-positive and gram-negative bacteria, fungi, complex viruses, protozoa, aerobic, anaerobic flora, found in the form of monocultures and microbial associations, including strains multidrug-resistant. Miramistin is a drug with low toxicity and does not have a local irritant, allergenic, mutagenic, carcinogenic or embryotoxic effect. Its immunoadjuvant effect was revealed. The biological action of Miramistin is based on its direct effect on the cell membranes of microorganisms. The predominant mechanism is the hydrophobic interaction of its molecule with lipid membranes, leading to fragmentation and destruction of the microbial membrane. In this case, part of the Miramistin molecule is immersed in the hydrophobic region of the microbial cell membrane and destroys the supra-membrane layer, loosens the membrane and increases its permeability to large molecular substances. In addition, the Miramistin molecule changes the enzymatic activity of the cell, inhibiting the enzymatic systems of membranes, which leads to the suppression of the vital activity of the microbial cell. Miramistin has a much weaker effect on human cell membranes, since they have longer lipid radicals and the hydrophobic effect with the drug molecules is very weak.
Antiviral activity of Miramistin
The virucidal properties of Miramistin were studied in relation to laboratory strains of influenza virus (H3N2), adenoviruses, herpesviruses type I and II, coronaviruses OC43, hepatitis, ECHO type 6, polioviruses type 2, Coxsackie B1 and B6, coliphage T2, as well as human immunodeficiency virus (HIV). Antiviral activity was determined in comparison with the antiviral activity of a number of well-known antiseptics: Aurisan, Chlorhexidine, Etonium, Dioxidine, Rokkala, Nonoxynol, TVIN-20. The data obtained showed that Miramistin is superior in its virucidal activity to other antiseptic drugs and antimicrobial compounds. Moreover, complex viruses that have a supercapsid shell are highly sensitive to Miramistin, that is, influenza viruses, herpes, coronoviruses, HIV, etc. The minimum inhibitory concentrations (MIC) of some surface-active antiseptics for viruses are presented in Table. 1.
Antibacterial and fungicidal properties of Miramistin
The antimicrobial activity of Miramistin has been studied in relation to various types of pneumotropic microflora. When determining the MIC of growth of pathogenic flora, it was found that Miramistin inhibits the growth of a number of microorganisms (Table 2).
The effect of Miramistin on mucociliary clearance and the restructuring of the ciliated epithelium of the upper respiratory tract
The transport function of the ciliated epithelium of the upper respiratory tract is one of the important components of systemic immunity in patients with diseases of the respiratory system. The effect of Miramistin on the transport function of the ciliated epithelium of the upper respiratory tract was studied. The experiment was carried out in healthy patients (volunteers) using a saccharin test, using a polymer film with methylene blue, and also by studying a radionuclide label. All methods used revealed a complete absence of the inhibitory effect of Miramistin on mucociliary clearance of the upper respiratory tract.
The results obtained allowed us to conduct a similar study in patients with sinusitis, who received Miramistin and a traditional antiseptic - 0.02% Chlorhexidine solution as local therapy. At the beginning of treatment, all patients experienced a decrease or cessation of the transport function of the ciliated epithelium. During therapy, there was a tendency to normalize the rate of mucociliary clearance. Moreover, it was stated that a long “experience” of the disease or a long period of use of vasoconstrictor drops had a negative effect on the rate of normalization or improvement of mucociliary clearance. The results of the study showed that the speed of the transport function of the ciliated epithelium of the nasal cavity in patients with sinusitis in the dynamics of treatment with Miramistin is significantly higher than during treatment with Chlorhexidine solution. Moreover, when using chlorhexidine, in half of the observations there was inhibition of the transport function of the ciliated epithelium.
The influence of Miramistin on the immunological status of patients with diseases of the respiratory system
The effect of Miramistin on immunological parameters was studied in patients with acute and chronic sinusitis, nonspecific endobronchitis, as well as in patients suffering from bronchial asthma. To assess the immunomodulatory effect of Miramistin, indicators of specific and nonspecific protection in patients with various forms of sinusitis were studied. The levels of immunoglobulins A, G, M, E, lysozyme, properdin, glycogen, alkaline and acid phosphatases, the phagocytic index and phagocytic number of macrophages in the blood and lavage fluid of the maxillary sinuses, and the levels of CD-lymphocytes in the blood were studied.
As a result of the study, positive changes were noted in all studied indicators. The degree of changes varied and depended on the form and duration of the disease. The best results were obtained with catarrhal and allergic forms.
In a comparative assessment, it turned out that Miramistin contributes to a more pronounced normalization of immunity parameters than Chlorhexidine solution. For example, in chronic allergic sinusitis, the effect on the level of eosinophilia was more pronounced than that of Chlorhexidine solution.
Due to the fact that, according to the scientific literature, Miramistin has certain properties of an extra-immune corrector, in vitro studies of the effect of this drug on the functional activity of phagocytes obtained during bronchoscopy from bronchoalveolar lavages (BAS) in patients with nonspecific endobronchitis were conducted. The phagocytic number, phagocytic index, NCT - test with neutrophils and alveolar macrophages were studied.
The results of the experiment showed that Miramistin is able to stimulate both the phagocytic activity of neutrophils and the realization of reserves of oxygen-dependent bactericidal activity of phagocytes. To confirm clinical effectiveness, similar tests were carried out after a course of local therapy in patients with endobronchitis. It was found that the phagocytic activity of neutrophils isolated from ALS patients treated with endobronchial administration of Miramistin was significantly higher than in patients treated locally with conventional antiseptics.
To assess the immunological status of patients with bronchial asthma, indicators of systemic and regional immunity were studied: the total number of peripheral blood lymphocytes, the absolute and relative number of T-lymphocytes (E-ROC), the reaction of blast transformation of lymphocytes (RBTL) to phytohemagglutinin (PHA), concanavalin-A (con-A), lipopolysaccharides (LPS), subpopulation composition of T cells, absolute and relative number of B cells (EAC-ROC), content of immunoglobulins M, G, A, level of circulating immune complexes, as well as absorption capacity and NBT- test of macrophages isolated from ALS.
As a result of treatment in the form of endotracheal administration of Miramistin, an increase in the indicators of the T-link of immunity was noted, which was manifested in an increase in the absolute and relative number of T-lymphocytes, improvement in the functional activity of T-cells, as evidenced by an increase in RBTL indicators on PHA and Con-A, as well as in normalizing the number of theophylline-sensitive and reducing theophylline-resistant lymphocytes. Less significant changes were noted on the part of the B-link of immunity. They consisted only of an increase in the level of IgG and a decrease in IgE.
Methods of using the drug Miramistin
Miramistin in the treatment of laryngitis
For superficial laryngitis, Miramistin is administered by inhalation. Rinsing with Miramistin is also possible. In this case, the antiseptic effect of the drug plays an important role, as it eliminates inflammation, relieves swelling, dry throat, reduces dry cough, and also ensures that the patient’s voice is preserved.
Miramistin in the treatment of nasopharyngitis
The technique is based on the inhalation administration of Miramistin intranasally, using inhalers that form particles of about 10 microns in size, which predominantly settle in the nasopharynx. Also effective is instilling Miramistin (in each nasal passage) 2-3 drops, 3-4 times a day, for 7 days.
Miramistin in the treatment of tonsillitis
Treatment of patients with acute tonsillitis is carried out by gargling with Miramistin 3-4 times a day or by aerosol irrigation of the tonsils from a special bottle with a spray nozzle. The data obtained showed that the most pronounced therapeutic effect is observed in patients within 5–7 days.
Miramistin in the treatment of sinusitis
To carry out the manipulation, the usual 0.01% Miramistin solution is used. For purulent forms of sinusitis, therapeutic manipulation is carried out according to the following method. After local application anesthesia and anemization of the nasal passages, a puncture of the medial wall of the maxillary sinus is performed through the lower nasal passage. Then the sinus contents are removed by rinsing with a 0.9% sodium chloride solution. After washing, 10.0 ml of Miramistin is injected into the maxillary sinus. The manipulation is carried out daily. In case of an acute purulent process, the number of manipulations is 3-4, in case of exacerbation of a chronic process - 5-6. In parallel, drug and physiotherapeutic therapy indicated for this pathology is carried out. For exudative forms of sinusitis, vasoconstrictor drops are additionally administered intranasally (2-3 drops 3 times a day).
The use of Miramistin for other forms of sinusitis (catarrhal, acute and chronic, allergic, purulent polyposis) differs in the dose of the drug administered and the number of punctures per course of treatment. For this reason, only the distinctive characteristics of the techniques used in these forms are given below.
For catarrhal sinusitis, Miramistin is used in a dose of 7–10 ml. The drug is administered 1–2 times per course of treatment daily, 1 time per day. With exacerbation of chronic catarrhal sinusitis, the number of injections increases to 2–4 in the same dose of the drug and frequency.
For chronic allergic sinusitis, Miramistin is used in a dose of 7–10 ml. The drug is administered using a similar method. The course of therapy is 4–5 procedures.
For chronic purulent polyposis sinusitis, Miramistin is used in a dose of 10 ml. The drug is administered daily. The course of treatment is 5–7 procedures.
The effectiveness of using these techniques in treatment regimens for various sinusitis is confirmed by the results of clinical trials conducted in 430 patients with paranasal sinusitis of various etiologies. It has been clinically proven that when Miramistin is used in the treatment of catarrhal and allergic sinusitis, recovery occurs 3-4 days earlier than when using a 0.02% chlorhexidine solution. The use of Miramistin in the treatment of purulent and purulent-polyposis sinusitis allows one to achieve sanitization of the sinuses 2-3 days faster than when using a 0.02% chlorhexidine solution. The use of Miramistin for purulent sinusitis allows in some cases to avoid surgical intervention, thereby preserving the anatomical structures of the nasal cavity and paranasal sinuses. Its use effectively restores respiratory function and mucociliary clearance, without causing allergic reactions from the nasal mucosa. Confirmation of the effectiveness of Miramistin in clinical trials allows us to recommend the use of the proposed methods in treatment regimens for various forms of sinusitis.
Miramistin in the treatment of bronchitis and bronchopneumonia
Miramistin is administered by inhalation. The amount of the drug for one inhalation is 5 ml. Inhalations are carried out daily or every other day. The course of treatment consists of 8–10 inhalations, i.e. the course amount of Miramistin is 40–50 ml. When carrying out aerosol therapy, all types of inhalers are used. Each patient is instructed on the rules for taking inhalation therapy, highlighting the value of the frequency of respiratory movements and preventing the possibility of hyperventilation. After completing the procedure, a 15-30 minute rest is required.
Recently, nebulizers and metered dose inhalers, including those with spacers, have been widely used. Patients inhale medications using a mask or mouthpiece. The working gas is air or, which is preferable for bronchial asthma, oxygen. The average gas flow is 6–8 liters per minute. When using a mask, the patient must breathe through the mouth, since the nose is a good filter and can interfere with the delivery of drugs into the respiratory tract. An analysis of the dynamics of clinical parameters before and after the use of Miramistin was carried out in 120 patients with bronchitis against the background of concomitant bronchial asthma. The results showed that the most pronounced clinical effect was present in the group of patients who, in parallel with traditional therapy, received a course of aerosol therapy with Miramistin solution, while the duration of remission increased by an average of 21.8%.
Literature
- Khan M.A. Use of the drug Miramistin® in the treatment of children with acute nasopharyngitis // Treating Doctor. 2014. No. 6. Page. 93–95.
- Malanicheva T. G. //Journal of International Medicine. 2013. No. 4.
- Petrenko V. M., Dmitrieva I. A., Kirichenko I. M. Evaluation of the integral effect of using Miramistin® for the treatment of patients suffering from chronic tonsillitis / II World Asthma & COPD Forum Saint Petersburg, Russia, April 25–28, 2009.
- Krivoshein Yu. S., Rudko A. P., Sistov V. V. Miramistin is an antiseptic with immunomodulatory and regeneration-enhancing properties / Abstract. report VIII Russia national congr. "Man and Medicine." M., 2000. P. 509.
- Meshkov V.V., Bogdanov N.N., Chirkov A.V. Miramistin electrophoresis in complex treatment, medical rehabilitation and secondary prevention of chronic bronchitis and pathology accompanying or complicating their course: Methodological. recommendations. Simferopol, 1997. 18 p.
- Grishin M.N. Use of the antiseptic miramistin in the complex therapy of nonspecific suppurative lung diseases // Probl. tuberculosis. 1998. No. 1. P. 40–41.
- Kuznetsova L.V. The influence of the cationic surfactant miramistin on the immune status of patients with bronchial asthma in the dynamics of treatment // GRM of the Ministry of Health of Ukraine. 1996. 1 section. No. 87. P. 28.
- Balabantsev A.G., Zavaliy M.A. The influence of miramistin on the phagocytic activity of neutrophilic granulocytes of the mucous membrane of the upper maxillary sinuses in patients with sinusitis // Current problems of otorhinolaryngology. Dnepropetrovsk, 1997. pp. 21–22.
- Grishin M.N. Antiseptic miramistin in the complex treatment of nonspecific endobronchitis // Bulletin of physiotherapy and balneology. 1998. No. 4. pp. 33–36.
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- Vintserskaya G. A. Functional activity of nonspecific T-helpers and suppressors in patients with pyoderma and its correction with Miramistin // Dermatology and Venereology. 1997. No. 2 (4). pp. 59–62.
- Krivoshein Yu. S., Tyshkevich L. V., Sarachan T. A. Determination of the antimicrobial activity of emulsions and aerosols containing different concentrations of miramistin / Proc. report IX All-Union. symp. on the targeted search for medicinal substances. Riga, 1991. P. 115.
- Zavaliy M.A., Balabantsev A.G., Svistov V.V. Application of miramistin for the treatment of patients with sinusitis / Proc. report VIII Russia national congr. "Man and Medicine." M., 2000. pp. 133–134.
- Irtuganova O. A., Smirnova N. S., Krivoshein Yu. S., Sistov V. V., Smirnov I. V., Grishin M. N. Activity of the antiseptic agent “Miramistin” against mycobacteria in an in vitro experiment. In the book: Miramistin: Collection of works / Ed. Yu. S. Krivosheina. M.: Medical Information Agency LLC, 2004. pp. 48–53.
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A. M. Dunaevsky I. M. Kirichenko1
LLC "Infamed", Moscow
1 Contact information
What is Miramistin used for?
The drug is widely used by doctors of several specialties:
- Traumatologists and surgeons use the solution to prevent the suppurative process, as well as to treat purulent wounds.
- Obstetricians and gynecologists prescribe Miramistin for the treatment of postpartum and postoperative sutures, as well as as part of the treatment of inflammatory diseases of the female genital organs.
- Dermatovenerologists use the product for the auxiliary treatment of fungal diseases such as dermatomycosis and mucosal candidiasis.
- Urologists treat acute and chronic urethritis and urethroprostatitis with Miramistin.
- ENT doctors prescribe the drug as part of complex therapy for tonsillitis, laryngitis, otitis, and inflammatory diseases of the sinuses.
- Dentists use the solution to treat stomatitis, gingivitis, and periodontitis. Miramistin is also a means of preventing inflammatory diseases of the oral cavity.
The drug is also used to treat burns and for antiseptic treatment of wounds before dermatoplasty.
Finally, Miramistin is a popular and very effective means for individual prevention of sexually transmitted diseases.
Description
Miramistin is a domestic broad-spectrum antiseptic drug that is used for the prevention and treatment of bacterial, fungal and viral infections. Initially, the drug was intended to disinfect compartments on Soviet spaceships and stations. And now Miramistin has shown itself to be excellent in the prevention and therapeutic treatment of wounds, purulent-septic processes, the appearance of which accompanies surgery and traumatology. Miramistin effectively fights pathogenic microorganisms, therefore it is applicable in gynecology, urology, dentistry, otolaryngology and other branches of medicine.
But you should not think that Miramistin simply has an antimicrobial effect; it is quite strong and fights even those strains that are insensitive to other antibiotics. Miramistin interacts with ascomycetes, yeast and yeast-like fungi, dermatophytes, and some other pathogenic fungi. And what is especially important, Miramistin is able to influence human immunodeficiency viruses, herpes, etc. That is, demonstrate an antiviral effect. The medicine is also quite active against pathogens that cause sexually transmitted diseases (STDs).
Miramistin prevents infection of burns and wounds, as it accelerates the absorption of purulent secretions, stimulates the process of tissue regeneration and the manifestation of the body's protective reactions.
And all these wonderful properties practically do not cause allergic reactions or irritation to the skin. This is what it means that the product was developed for the space industry.
How to take Miramistin
Before you start using the drug, you must carefully read the instructions for use. If the package contains a sprayer, then first remove the cap from the bottle, then install the spray nozzle and perform 1-2 control presses. After this, the product is ready for use.
Miramistin has certain features of use for each type of pathology. Thus, when treating wound surfaces, including burns, this product can be used to treat both the wound itself and tampons for dressings.
For the treatment of ENT diseases, in particular, sore throat and pharyngitis, Miramistin is used both for irrigation and for gargling. The frequency and duration of use is indicated by the doctor based on the severity of the pathological process. Another method of treating diseases of the ENT organs is inhalation with Miramistin.
For diseases of the oral cavity, in particular for stomatitis, rinse with Miramistin 3-4 times a day.
Application in ENT practice
Miramistin is widely used for diseases of the ear, nose and throat. It treats inflammation of the inner and outer ear. It is also used in the form of drops for sinusitis and sinusitis. They help with allergic swelling of the mucous membrane.
This is important, because some nasal drops, for example Nazivin, cause swelling of the nasal mucosa. Miramistin is also administered as a puncture, sometimes for inflammation of the nasal sinuses.
Miramistin is also used for pharyngitis, laryngitis, sore throat, and tonsillitis. This remedy does not cause irritation to the mucous membranes as, for example, from Chlorhexidine. All ENT diseases must be treated comprehensively, alternating with other medications, for example, throat lozenges such as Strepsils. Miramistin in the form of lozenges is not yet available.
Why is Miramistin prescribed in gynecology?
In gynecology, the drug can be used for:
- Impregnation of vaginal tampons. This method of administering an antiseptic shows good results in the treatment of cervical erosion, metritis, and endometritis.
- Douching. The method is widely used for the treatment and prevention of sexually transmitted diseases.
- Introduction into the genitourinary canal using a catheter is a method of treating urethritis and cystitis. The manipulation can only be performed by a person with medical education.
- Electrophoresis sessions. Physiotherapeutic procedures using Miramistin help cure pelvic pathologies such as salpingitis, oophoritis, etc.
The method of treatment and duration of therapy are selected by the attending physician in each specific case.
How to understand that inflammation has begun?
Gum inflammation is difficult to confuse with any other disease. The main symptoms of the process are:
- bleeding gums;
- sore gums;
- discomfort (pain) while eating;
- bad breath;
- inflammation after braces.
Sometimes gum inflammation is accompanied by an increase in body temperature. In such cases, you need to contact your dentist as soon as possible to identify the causes of the pathology and determine its proper treatment.
How to use Miramistin in venereology
The solution effectively prevents sexually transmitted diseases. However, it should be remembered that Miramistin will provide the expected result only if it is applied within two hours after sexual intercourse.
To prevent sexually transmitted diseases, a bottle with a special urological attachment is used. It is recommended for men to inject 2-3 ml of solution into the urethra, for women - 1-2 ml. Additionally, the drug is administered into the vagina in a volume of 5-10 ml using a gynecological applicator. The skin of the external genitalia is also treated with the solution. After treatment, it is recommended to refrain from urinating for 2 hours.
Nosological classification (ICD-10)
- A53.9 Syphilis, unspecified
- A54 Gonococcal infection
- A56 Other chlamydial sexually transmitted diseases
- A59 Trichomoniasis
- A60 Anogenital herpetic viral infection [herpes simplex]
- B35.3 Mycosis of the feet
- B36.9 Superficial mycosis, unspecified
- B37.0 Candidal stomatitis
- B37.2 Candidiasis of the skin and nails
- B37.3 Candidiasis of the vulva and vagina (N77.1*)
- B37.4 Candidiasis of other urogenital sites
- H60.8 Other external otitis
- J01 Acute sinusitis
- J02.9 Acute pharyngitis, unspecified
- J03.9 Acute tonsillitis, unspecified (angina agranulocytic)
- J04.0 Acute laryngitis
- J31.2 Chronic pharyngitis
- J32.0 Chronic maxillary sinusitis
- J35.0 Chronic tonsillitis
- J37.0 Chronic laryngitis
- K05.6 Periodontal disease, unspecified
- K12 Stomatitis and related lesions
- N34.1 Nonspecific urethritis
- N41.9 Inflammatory disease of the prostate, unspecified
- N71 Inflammatory diseases of the uterus, except the cervix
- N76 Other inflammatory diseases of the vagina and vulva
- O86.1 Other genital tract infections after childbirth
- P15.9 Birth injury, unspecified
- T30 Thermal and chemical burns of unspecified location
- T79.3 Post-traumatic wound infection, not elsewhere classified
- Z100* CLASS XXII Surgical practice
- Z97.2 Presence of dental prosthetic device (complete) (partial)
At what age can Miramistin be used for children?
According to the instructions, the solution is prescribed for the treatment of pharyngitis and tonsillitis for children over 3 years of age. As a rule, in childhood, the throat is irrigated with Miramistin using a spray. The dosage of the drug increases in proportion to the age of the child. Duration of use is from 4 to 10 days, the period depends on the severity of the disease.
Do not drop the solution into the child’s nose - this can lead to irritation of the mucous membranes.
Many parents are interested in the question of whether infants can be treated with this drug. The list of contraindications for Miramistin does not include infancy, so the use of the drug is possible. However, you should not self-medicate: before use, you must consult a pediatrician.
Pharmacodynamics
Miramistin® has a wide spectrum of antimicrobial action, including hospital strains resistant to antibiotics.
The drug has a pronounced bactericidal effect against gram-positive (Staphylococcus spp., Streptococcus spp., Streptococcus pneumoniae, etc.), gram-negative (Pseudomonas aeruginosa, Escherichia coli, Klebsiella spp., etc.), aerobic and anaerobic bacteria, determined in the form of monocultures and microbial associations, including hospital strains with multiresistance to antibiotics.
It has an antifungal effect on ascomycetes of the genus Aspergillus and the genus Penicillium, yeast (Rhodotorula rubra, Torulopsis glabrata, etc.) and yeast-like fungi (Candida albicans, Candida tropicalis, Candida krusei, Pityrosporum orbiculare (Malassezia furfur), etc.), dermatophytes (Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton verrucosum, Trichophyton schoenleini, Trichophyton violacent, Epidermophyton Kaufman-Wolf, Epidermophyton floccosum, Microsporum gypseum, Microsporum canis, etc.), as well as other pathogenic fungi in the form of monocultures and microbial associations, including fungal microflora with resistance to chemotherapy drugs.
It has an antiviral effect and is active against complex viruses (herpes viruses, human immunodeficiency virus, etc.).
Miramistin® acts on pathogens of sexually transmitted diseases (Chlamydia spp., Treponema spp., Trichomonas vaginalis, Neisseria gonorrhoeae, etc.).
Effectively prevents infection of wounds and burns. Activates regeneration processes. Stimulates protective reactions at the site of application due to the activation of the absorption and digestive functions of phagocytes, potentiates the activity of the monocyte-macrophage system. It has pronounced hyperosmolar activity, as a result of which it stops wound and perifocal inflammation, absorbs purulent exudate, promoting the formation of a dry scab. Does not damage granulations and viable skin cells, does not inhibit marginal epithelialization.
Does not have a local irritant effect or allergenic properties.
Can Miramistin be used during pregnancy?
According to the results of numerous studies, this drug does not have an embryotoxic effect. However, its use in the first trimester of pregnancy is not advisable. Treatment with Miramistin at this time can lead to dermatitis and allergic reactions in the child.
The use of Miramistin by pregnant women is possible, but only if the drug was prescribed by a specialist. A woman must strictly follow the doctor’s instructions: follow the dosage and adhere to the recommended method of use.
Composition of the drug
The drug contains a complex chemical substance that has a long name. Miramistin is an aqueous solution of the substance 0.01 percent. It is completely transparent, but sometimes there is sediment.
The solution is available in the form:
- drops in the nose and ears;
- throat spray;
- gargling solution;
- bottles with attachments for douching in gynecology;
- bottles with sprayers for use in urology, surgery, dentistry;
- sterile eye drops.
Miramistin is also produced in the form of 0.5 percent ointments used in dermatology. The uniqueness of the active substance is that it recognizes diseased cells without affecting healthy ones.
Consumer Reviews
Olga: With the help of Miramistin, I completely got rid of bacterial conjunctivitis. Moreover, no side effects were observed during treatment. There was a burning sensation in the eye only after the first instillation of the drug. Visual acuity did not decrease.
Andrey: Miramistin helped get rid of the purulent inflammation of the eyes that arose after hypothermia. I instilled the drug for 5 days. During this time, the manifestations of inflammation completely disappeared. There were no side effects during the treatment.
Contraindications
- Individual hypersensitivity.
- Pregnancy, lactation.
- Children under 3 years old.
Information on the use of the drug during pregnancy and lactation is not provided, which does not allow us to predict whether Miramistin will have any effect on the fetus. If indicated, the use of the drug may be justified if the potential benefit to the mother outweighs the possible risk to the fetus. In this case, the drug is prescribed by a doctor. Since Miramistin is practically not absorbed and does not enter the bloodstream, the risk of negative effects on the fetus is minimal. However, due to the lack of any reliable data and studies on the use of Miramistin in pregnant women, it is not recommended to instill the solution without a doctor’s prescription.
special instructions
Before instilling the solution, contact lenses must be removed. You can put them on again approximately 15 minutes after the procedure. Most ophthalmologists recommend not wearing soft lenses for the entire duration of treatment with Miramistin.
After using eye drops, you do not need to drive for half an hour. This is due to a temporary decrease in visual acuity.
After surgery and eye drops, you should not touch or rub your eyes with your hands.
Self-administration of the drug is prohibited: before starting treatment, consultation with a specialist is necessary.
Composition and form of Miramistin
The drug owes its antiseptic activity to the main chemical compound in its composition - an unsaturated hydrocarbon with a substituted radical. The chemical formula looks like this: C26H47ClN2O. The substance is supplemented only by pure water. The product is odorless and tasteless, which makes it easy to use when treating children.
The solution is packaged in plastic containers of different capacities. Depending on the type of use, you can buy Miramistin with different attachments on the bottle:
- with urological spout;
- with a spray bottle;
- with gynecological attachment.
The products are sold in three volumes: 50 ml, 150 ml and 500 ml. Travelers are advised to take a compact bottle of Miramistin with them, which will not take up much space in your bag and will protect the whole family from infections. It comes with a convenient spray bottle that makes it easy to use.
Bottles with a volume of 150 ml vary in shape: round and flat. Both types have additional attachments.
Indications for use
The scope of the medicine is quite extensive. It is used in the following medical areas:
- traumatology;
- otolaryngology;
- surgery;
- dentistry;
- obstetrics;
- dermatology;
- venereology;
- gynecology.
Diseases for which Miramistin is used:
- gonorrhea;
- genital candidiasis;
- sinusitis;
- genital herpes;
- tonsillitis;
- trichomoniasis;
- otitis;
- mycoses;
- laryngitis;
- syphilis;
- infections after childbirth;
- staphyloderma and streptoderma;
- urethroprostatitis;
- bedsores;
- urethritis;
- trophic ulcers;
- wounds;
- frostbite;
- fistulas;
- second and third degree burns.
Miramistin ointment is prescribed for the treatment of mycoses of the mucous membranes and skin, staphyloderma, streptoderma. It is also used as one of the drugs in the treatment of skin lesions, burns and wounds.
Many people are interested in whether Miramistin is an antibiotic or an antiseptic. Let's figure it out.
Treatment of children under one year of age with Miramistin
Is it allowed to buy a product for a child aged one year? Since the drug does not have an unpleasant taste or odor, it is allowed even for infants. The medicine in the form of a spray is sprayed onto the tonsils of children from six months of age, but this requires permission from the pediatrician.
It must be remembered that the antiseptic is injected into children no more than three times a day. During the procedure, breathing is held to prevent spasms in the airways.
An antibacterial compound in children can cause dysbiosis of the mucous membrane, due to which beneficial microflora is inhibited and pathological ones develop.
Doctors prescribe the solution to newborns up to one year old, because it is not absorbed into the systemic circulation. Its effect extends only to the epithelial and secretory cover. If the throat is treated correctly, there are no negative consequences in children.
When it comes to rinsing the throat, such a manipulation cannot be used in the treatment of a one-year-old baby, since there is a high probability that he will choke on the solution or swallow it. Spraying may cause spasm of the bronchi and trachea.
Is Miramistin an antibiotic or not?
"Miramistin" is one of the antiseptic drugs that are dispensed from pharmacies without a prescription.
An antiseptic differs from an antibiotic in that it does not cause addiction to bacterial infections, microorganisms and microbes. However, like an antibiotic, the drug eliminates microbes, the source of pathogenic spread. The antibiotic eliminates various microorganisms inside human tissues and organs during the development of inflammatory processes.
Why are people interested in whether Miramistin is an antibiotic or not?
The medication has a similar effect. The product is effective only in contact with the area of inflammation. The drug does not penetrate the organs and tissues of the human body. The product essentially has a disinfectant effect. Therefore, it is impossible to use this antiseptic internally, and this is stated in the instructions for the drug.
Shelf life and storage
The total shelf life of the drug is 3 years. After opening, it is recommended to use this product within a month.
Miramistin is an effective drop for the treatment of eye infections. They quickly have a therapeutic effect and prevent the spread of the infectious process. The drug is usually well tolerated by patients and rarely causes side effects.
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