TOP 10 cheap and effective analogues of the drug Noopept

Noopept is a neurometabolic stimulant that has a positive effect on psychophysiological processes. It is used to eliminate complications of head trauma, concussion, cerebrovascular pathology, and neuropsychic weakness. Noopept has various analogues that have a similar effect: they eliminate disorders of memory, attention and other higher brain functions.

You should not take Noopept if:

  • liver and kidney dysfunction;
  • pregnancy;
  • during lactation;
  • minors;
  • lactase deficiency, hypolactasia, glucose-galactose malabsorption;
  • individual intolerance to the components of the drug.

The active ingredient of the drug is N-phenylacetyl-L-prolylglycine ethyl ester. The medication is administered orally in the morning and afternoon, 10 mg. The duration of therapy with Noopept is 1.5-3 months.

Pharmacodynamics

Noopept® has nootropic and neuroprotective properties. Improves learning ability and memory, acting on all phases of processing: initial information processing, consolidation, retrieval. Prevents the development of amnesia caused by electric shock, blockade of central cholinergic structures, glutamatergic receptor systems, and deprivation of the paradoxical phase of sleep.

The neuroprotective (protective) effect of the drug Noopept® is manifested in increasing the resistance of brain tissue to damaging influences (trauma, hypoxia, electroconvulsive, toxic) and reducing the degree of damage to brain neurons. The drug reduces the volume of the lesion in a thrombotic stroke model and prevents the death of neurons in cultured tissue of the cerebral cortex and cerebellum exposed to neurotoxic concentrations of glutamate and free radical oxygen.

Noopept® has an antioxidant effect, blocks voltage-gated calcium channels in neurons, weakening the neurotoxic effect of excess calcium, improves the rheological properties of blood, having antiaggregation, fibrinolytic, and anticoagulant properties.

The nootropic effect of the drug is associated with the formation of cycloprolylglycine, which is similar in structure to the endogenous cyclic dipeptide, which has antiamnestic activity, as well as the presence of a choline-positive effect.

Noopept® increases the amplitude of the transcallosal response, facilitating associative connections between the cerebral hemispheres at the level of cortical structures. Helps restore memory and other cognitive functions impaired as a result of damaging influences - brain injury, local and global ischemia, prenatal damage (alcohol, hypoxia).

The therapeutic effect of the drug in patients with organic disorders of the central nervous system manifests itself starting from 5–7 days of treatment. Initially, the anxiolytic and mild stimulating effects present in the spectrum of activity of the drug Noopept® are realized, manifested in the reduction or disappearance of anxiety, increased irritability, affective lability, and sleep disturbances. After 14–20 days of therapy, a positive effect of the drug on cognitive functions, parameters of attention and memory is revealed.

Noopept® has a vegetative-normalizing effect, helps reduce headaches, orthostatic disorders, and tachycardia.

When discontinuing the drug, no withdrawal syndrome is observed. Does not have a damaging effect on internal organs; does not lead to changes in the cellular composition of the blood and biochemical parameters of blood and urine; does not have immunotoxic, teratogenic effects, does not exhibit mutagenic properties.

Instructions for use

Registration number:LS-001577-180711
Trade name of the drug:Noopept®
Active substance:Omberacetam
Chemical name:N-phenylacetyl-L-prolylglycine ethyl ester
Dosage form:pills

Composition per tablet

Active ingredient: Omberacetam (noopept) - 10.0 mg; excipients: lactose monohydrate - 55.0 mg, potato starch - 13.5 mg, microcrystalline cellulose 101 - 21.2 mg, magnesium stearate - 0.3 mg, povidone (polyvinyl-pyrrolidone, povidone K-25) - 0.0008 mg.

Description

Tablets are white, round, flat-cylindrical with a bevel.

Pharmacotherapeutic group: nootropic agent.

ATX code: N06ВХ

Pharmacological properties

Pharmacodynamics

Noopept® has nootropic and neuroprotective properties. Improves learning ability and memory, acting on all phases of processing: initial information processing, consolidation, retrieval. Prevents the development of amnesia caused by electric shock, blockade of central cholinergic structures, glutamatergic receptor systems, and deprivation of the paradoxical phase of sleep. The neuroprotective (protective) effect of Noopept® is manifested in increasing the resistance of brain tissue to damaging influences (trauma, hypoxia, electroconvulsive, toxic) and reducing the degree of damage to brain neurons. The drug reduces the volume of the lesion in a thrombotic stroke model and prevents the death of neurons in cultured tissue of the cerebral cortex and cerebellum exposed to neurotoxic concentrations of glutamate and free radical oxygen. Noopept® has an antioxidant effect, blocks voltage-dependent calcium channels of neurons, weakening the neurotoxic effect of excess calcium, improves the rheological properties of the blood, having antiplatelet, fibrinolytic, and anticoagulant properties.

The nootropic effect of the drug is associated with the formation of cycloprolylglycine, which is similar in structure to the endogenous cyclic dipeptide, which has antiamnestic activity, as well as the presence of a choline-positive effect.

Noopept® increases the amplitude of the transcallosal response, facilitating associative connections between the cerebral hemispheres at the level of cortical structures. Promotes the restoration of memory and other cognitive functions impaired as a result of damaging influences - brain injury, local and global ischemia, prenatal damage (alcohol, hypoxia).

The therapeutic effect of the drug in patients with organic disorders of the central nervous system is manifested starting from the 5-7th day of treatment. Initially, the anxiolytic and mild stimulating effects present in the spectrum of activity of Noopept® are realized, manifested in the reduction or disappearance of anxiety, increased irritability, affective lability, and sleep disturbances. After 14-20 days of therapy, a positive effect of the drug on cognitive functions, parameters of attention and memory is revealed.

Noopept® has a vegetative-normalizing effect, helps reduce headaches, orthostatic disorders, and tachycardia.

When discontinuing the drug, no withdrawal syndrome is observed.

Does not have a damaging effect on internal organs; does not lead to changes in the cellular composition of the blood and biochemical parameters of blood and urine; does not have immunotoxic, teratogenic effects, does not exhibit mutagenic properties.

Pharmacokinetics

Omberacetam, being absorbed in the gastrointestinal tract, enters the systemic circulation unchanged, penetrates the blood-brain barrier, and is detected in the brain in higher concentrations than in the blood. The time to reach maximum concentration is on average 15 minutes. The half-life from blood plasma is 0.38 hours. Partially remains unchanged, partially metabolized to form phenylacetic acid, phenylacetylproline and cycloprolylglycine. It has high relative bioavailability (99.7%), does not accumulate in the body, and does not cause drug dependence.

Indications for use

Impaired memory, attention, other cognitive functions and emotionally labile disorders (including in elderly patients) with:

  • consequences of traumatic brain injury,
  • post-concussion syndrome,
  • cerebrovascular insufficiency (encephalopathies of various origins),
  • asthenic disorders,
  • other conditions with signs of decreased intellectual productivity.

Contraindications

Pregnancy, breastfeeding period. Age up to 18 years. Hypersensitivity to the components of the drug. Lactase deficiency, lactose intolerance, glucose-galactose malabsorption. Severe dysfunction of the liver and kidneys.

Use during pregnancy and breastfeeding

The drug is contraindicated for use during pregnancy.

If it is necessary to use the drug during breastfeeding, it is necessary to decide on stopping breastfeeding.

Directions for use and doses

Noopept® is used orally, after meals. Treatment begins with a dose of 20 mg, divided into two doses of 10 mg throughout the day (morning and afternoon). If the therapy is insufficiently effective and the drug is well tolerated, the dose is increased to 30 mg (see “Special Instructions”), distributed into three doses of 10 mg each day. You should not take the drug later than 18 hours. The duration of the course of treatment is 1.5 – 3 months. A second course of treatment, if necessary, can be carried out after 1 month.

Side effect

Allergic reactions are possible. In patients with arterial hypertension, mostly severe, while taking the drug, a rise in blood pressure may be observed.

Overdose

Specific manifestations of overdose have not been established.

Interaction with other drugs

The interaction of Noopept® with alcohol, hypnotic and antihypertensive drugs and psychostimulant drugs has not been established.

special instructions

If it is necessary to increase the dose of the drug (up to 30 mg/day), with long-term use, as well as with simultaneous use with other drugs, the occurrence of adverse reactions or worsening of the condition, you should consult a doctor.

Impact on the ability to drive vehicles and machinery

Noopept® does not affect the ability to operate machinery and vehicles.

Release form

Tablets, 10 mg.

25 tablets in a blister pack made of polyvinyl chloride film and aluminum foil.

2 blister packs along with instructions for use are placed in a cardboard pack.

Storage conditions

At a temperature not higher than 25°C.

Keep out of the reach of children.

Best before date

3 years.

Do not use after the expiration date stated on the package.

Vacation conditions

Available without a prescription.

Marketing authorization holder/organization receiving consumer complaints

OTCPharm JSC, Russia 123112, Moscow, st. Testovskaya, 10, fl. 12, room II, room 29 Tel. Fax

, Russia, 305022, Kursk, st. 2nd Aggregatnaya, 1a/18, tel./fax

Pharmacokinetics

N-phenylacetyl-L-prolylglycine ethyl ester, absorbed in the gastrointestinal tract, enters the systemic circulation unchanged, penetrates the BBB, and is determined in the brain in higher concentrations than in the blood. Tmax averages 15 minutes. T1/2 from blood plasma - 0.38 hours. Partially stored unchanged, partially metabolized with the formation of phenylacetic acid, phenylacetylproline and cycloprolylglycine. It has high relative bioavailability (99.7%), does not accumulate in the body, and does not cause drug dependence.

Indications

Noopept is indicated for a fairly large number of conditions:

  • impairments of cognitive functions of various origins;
  • emotional-volitional disorders (including in the elderly);
  • consequences of traumatic brain injury (brain contusion, diffuse axonal damage);
  • post-concussion syndrome;
  • discirculatory encephalopathy, encephalopathy of combined genesis (with the presence of a vascular component);
  • asthenia;
  • decrease in intellectual activity of various origins.

Reviews from doctors and patients about the choice of Noopept analogues

Doctors speak well of the drug Noopept. Many people prefer to prescribe it to their patients:

  1. Kolesnikova M.P., neurologist: “I always recommend Noopept to my patients. This is a new and effective remedy that has a minimum of side effects. Often, patients who asked to replace it with cheaper drugs, for example, Glycine or Piracetam, complained of headaches, insomnia, nausea, and rash.”
  2. Kharitonov S.K., therapist: “I have not prescribed medications such as Piracetam and Nootropil for a long time, as I consider them outdated. Noopept is a more modern remedy that does not have side effects. The effect of treatment is not immediately visible, so patients need to be patient.”

Patient reviews of the drug Noopept are not always positive. Many note that its action is no different from the action of cheaper analogues, however, its price is too high:

  1. Maria, 37 years old: “Noopept is a new drug that is not cheap. However, the indications and action of the product are no different from the cheaper Glycine. Therefore, I prefer to buy a long-known and cheap medicine - Glycine.”
  2. Svetlana, 52 years old: “For a long time the doctor prescribed Piracetam to me. The product helped, but I encountered side effects, so the doctor suggested I try Noopept. I liked the medicine, the first effect appeared relatively quickly, and it is necessary to take lower doses of the drug.”

Noopept is a new drug with a special formula. The product has many more well-known analogues, which have a different composition, but have a similar effect. The choice of medication should be based on individual characteristics and doctor’s recommendations.

Cheap analogues of Noopept

There are cheaper drugs - substitutes for Noopept. These medications are produced by both foreign and domestic manufacturers.

Vinpocetine

Vinpocetine pilyule_nervi-422 is a domestic psychoanaleptic based on vinpocetine, which facilitates the movement of blood through the vessels of the brain. The drug has a number of positive effects on the body: it reduces inflammation, neutralizes the negative effects of oxidants, reduces the intensity of blood flow, relieves muscle cramps, and normalizes metabolism. The active substance is a selective inhibitor of phosphodiesterase, which causes a vasodilating effect on brain vessels. After using the drug, there is a slight decrease in blood pressure.

The drug is taken orally at a dose of 5-10 mg three times a day. Injections are used for acute conditions. The drug is prescribed to relieve symptoms when:

  • disorders associated with brain injury;
  • diseases of the choroid;
  • vascular hearing loss;
  • non-purulent disease of the inner ear, vestibular vertigo;
  • VSD during menopause.

The medication differs from Noopept in a minor list of contraindications. Tablets should not be taken during pregnancy and lactation, and injections are not prescribed to patients with organic and functional myocardial damage and arrhythmia. The medicine is also not prescribed for children.

pharmachologic effect

The medicine has a pronounced nootropic and neuroprotective effect. Designed to combat cognitive impairment. Helps normalize memory and thinking, improves the educational process. It also prevents amnesia due to blockade of nerve receptors, electric shock and the absence of the paradoxical sleep phase.

Due to the obvious neuroprotective properties, resistance of brain cells and tissues to various damages is observed - injuries, hypoxia, convulsive and toxic influences.

In addition, Noopept has some antioxidant effect. Thanks to this, it helps to suppress the neurotoxic effect when calcium levels increase, normalizes blood aggregation and anticoagulation.

The drug is involved in the restoration of cognitive functions resulting from injuries, ischemia, lack of oxygen and alcohol poisoning.

The therapeutic effect of taking the medicine is observed a week after the start of the course. Patients note suppression of anxiety, irritability, restoration of memory, thinking ability and healthy sleep.

Since Noopept has a vegetative-normalizing effect, a decrease in headaches, anxiety, and tachycardia is recorded during the use of the drug.

Does not cause a complex of withdrawal symptoms; there are no teratogenic, immunotoxic and mutagenic properties.

Cost of the drug and its analogues

Noopept is a relatively inexpensive drug; its cost may vary depending on the dosage, the number of tablets in the package, region and pharmacy.

Average cost of Noopept and its analogues in Russian pharmacies:

A drugRelease form, quantityPrice in rubles
NoopeptTablets 10 mg, No. 50344
VinpocetineAmpoules 5 mg/ml, No. 10
Tablets 5 mg, No. 50

Tablets 10 mg, No. 30

47
48

91

PiracetamTablets 200 mg, No. 60
Capsules 400 mg, No. 20

20% solution in ampoules 5 ml, No. 10

27
30

30

VinpotropilCapsules 5+400, No. 30
Tablets 10+800, No. 60
158
344
NootropilTablets 1200 mg, No. 20
Tablets 800 mg, No. 30

Ampoules 5 ml, No. 12

255
277

250

AminalonTablets 250 mg, No. 50141
GlycineTablets 100 mg, No. 50
Tablets 110 mg, No. 50

Tablets 250 mg, No. 20

33
42

43

TanakanTablets 40 mg, No. 30542
DivazaTablets 100 mg, No. 100289
BilobilCapsules 80 mg, No. 20
Capsules 120 mg, No. 20
301
447
CortexinLyophilisate 10 mg/5 ml, No. 101288

The cheapest analogues of Noopept are Piracetam, Glycine and Vinpocetine. Their cost does not exceed 50 rubles. However, you cannot replace one drug with another on your own, as this can negatively affect your health.

Rating
( 2 ratings, average 4.5 out of 5 )
Did you like the article? Share with friends:
For any suggestions regarding the site: [email protected]
Для любых предложений по сайту: [email protected]