Caffeamine, 10 pcs., film-coated tablets

Caffeamine, 10 pcs., film-coated tablets

Caffeamine TB p/o N 10

Compound

• Active ingredients: caffeine - 100 mg and ergotamine tartrate - 1 mg; Excipients: excipients: potato starch, talc, stearic acid, sucrose, dextrose.

Package

Pack of 10 and 20 pcs.

pharmachologic effect

Combined drug. Caffeine causes stimulation of the central nervous system, mainly the cerebral cortex, respiratory and vasomotor centers. Increases mental and physical performance, reduces drowsiness and fatigue. It has a pronounced cardiotonic effect: it increases the strength and frequency of heart contractions, increases blood pressure during hypotension. Ergotamine causes a vasoconstrictor effect. Caffeine accelerates the absorption of ergotamine.

Pharmacokinetics After oral administration, about 62% of ergotamine is absorbed from the gastrointestinal tract. Maximum plasma concentrations are achieved 2 hours after oral administration. Plasma protein binding - 98%. Ergotamine is metabolized in the liver to form pharmacologically active metabolites. Ergotamine is excreted primarily in bile, both unchanged and in the form of metabolites. Elimination is biphasic, with half-lives of 2.7 hours and 21 hours for phases I and II, respectively. After taking the drug orally, caffeine is absorbed quickly and almost completely. Plasma protein binding is 35%. Caffeine is almost completely metabolized in the body. Metabolites are excreted mainly in the urine. The half-life is approximately 3.5 hours.

Caffeamine, indications for use

Migraine, headache due to arterial hypotension.

Contraindications

Individual intolerance to the components of the drug, pregnancy, lactation. With caution - sleep disorders, anxiety disorders, organic diseases of the cardiovascular system (including acute myocardial infarction, angina pectoris, severe atherosclerosis, paroxysmal tachycardia, frequent ventricular extrasystole, arterial hypertension, obliterating diseases of peripheral vessels), liver and/or renal failure , glaucoma, old age.

Directions for use and doses

Inside, 1-2 tablets during a headache attack, then 1 tablet 2-3 times a day for several days. The maximum single dose is 2 tablets, the daily dose is 4 tablets. It is not recommended to use for a long time (to avoid the phenomenon of ergotism): after 7 days of use, in cases requiring longer treatment, take a break (for 3-4 days).

Side effects

From the nervous system: agitation, anxiety, tremor, restlessness, headache, dizziness, convulsions, paresthesia in the extremities, increased tendon reflexes, tachypnea, insomnia; with sudden withdrawal - increased inhibition of the central nervous system, increased fatigue, drowsiness. From the cardiovascular system: tachycardia, cardialgia, increased blood pressure. From the digestive system: nausea, vomiting, diarrhea. Allergic reactions: swelling, itching. Other: with long-term use - addiction, drug dependence, weakness in the legs, myalgia, Leriche syndrome (severe cyanosis, absence of pulse in the lower extremities, pain, distal sensory disturbance).

special instructions

Effect on the ability to drive vehicles During the treatment period, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require concentration and speed of psychomotor reactions.

Drug interactions

Enhances the pharmacological effect of drugs containing ergot alkaloids and caffeine. Caffeine is an adenosine antagonist (larger doses of adenosine may be required). With the combined use of caffeine and barbiturates, primidone, anticonvulsants (hydantoin derivatives, especially phenytoin), it is possible to increase metabolism and increase the clearance of caffeine; cimetidine, oral contraceptives, disulfiram, ciprofloxacin, norfloxacin - decreased metabolism of caffeine in the liver (slowing its release and increasing its concentration in the blood). Central nervous system stimulants - may cause overstimulation of the central nervous system. Mexiletine - reduces caffeine secretion by up to 50%; nicotine - increases the rate of caffeine elimination. MAO inhibitors, furazolidone, procarbazine and selegiline - large doses of caffeine can cause the development of dangerous cardiac arrhythmias or a marked increase in blood pressure. Caffeine reduces the absorption of calcium preparations in the gastrointestinal tract. Reduces the effect of narcotic and sleeping pills; increases - non-narcotic analgesics (increased absorption). Increases the excretion of lithium drugs in urine. Accelerates absorption and enhances the effect of cardiac glycosides, increasing their toxicity. The combined use of caffeine with beta-blockers can lead to mutual suppression of therapeutic effects: with adrenergic bronchodilators - additional stimulation of the central nervous system and other additive toxic effects. Caffeine may decrease the clearance of theophylline and possibly other xanthines, increasing the potential for additive pharmacodynamic and toxic effects. The vasoconstrictor effect of the drug is enhanced by alpha-adrenergic stimulants, beta-blockers, serotonin agonists (including sumatriptan) and nicotine. Macrolides increase the toxicity of ergotamine (decreased hepatic clearance of caffeine).

Overdose

Symptoms: increased severity of side effects, including nausea, vomiting, numbness of fingers and toes, lethargy, drowsiness, epileptic seizures, stupor, coma. Treatment: gastric lavage, taking activated charcoal, and, if necessary, carrying out symptomatic therapy.

Storage conditions

In a dry place, protected from light, at a temperature not exceeding 25C°.

Best before date

2 years.

Caffeamine tab No. 10

Active substance

Caffeine + Ergotamine

Manufacturer

Tatkhimfarmpreparaty JSC (Russia)

Shelf life

2 years

Storage conditions

In a dry place, protected from light, at a temperature not exceeding 25 °C

Registration certificate number

LS-000269 dated 02/07/2018

Pharmacodynamics

The effect of Caffetamine is associated with the vasoconstrictor effect of ergotamine and the improvement of brain functions under the influence of caffeine.

Ergotamine causes a vasoconstrictor effect.

Caffeine accelerates the absorption of ergotamine and enhances the effect of ergot alkaloids in the treatment of migraine. Caffeine also causes stimulation of the central nervous system, mainly the cerebral cortex, respiratory and vasomotor centers. Increases mental and physical performance, reduces drowsiness and fatigue. Caffeine has a pronounced cardiotonic effect: it increases the strength and frequency of heart contractions, and increases blood pressure during hypotension.

Instructions

Composition and release form:
Cofetamine
tablets, film-coated, 10 or 20 pcs.
packaged. 1 tablet Caffetamine
contains: 100 mg, ergotamine tartrate 1 mg.

Properties / Action:

Caffetamine is a combined antimigraine drug. The effect of Caffetamine is associated with the vasoconstrictor effect of ergotamine and the improvement of brain functions under the influence of caffeine. Ergotamine causes a vasoconstrictor effect. Caffeine accelerates the absorption of ergotamine and enhances the effect of ergot alkaloids in the treatment of migraine. Caffeine also causes stimulation of the central nervous system, mainly the cerebral cortex, respiratory and vasomotor centers. Increases mental and physical performance, reduces drowsiness and fatigue. Caffeine has a pronounced cardiotonic effect: it increases the strength and frequency of heart contractions, increases blood pressure during hypotension.

Indications:

• vasoparalytic form of migraine;
• arterial hypotension;
• as a means of lowering intracranial pressure in vascular, traumatic and infectious lesions of the central nervous system.
  Directions for use and dosage:

  Caffeamine is prescribed orally, 1–2 tablets during a headache attack, 2 times a day, then 1 tablet 2–3 times a day for several days (up to 1 month). The maximum single dose is 2 tablets, the daily dose is 4 tablets. It is not recommended to use Caffetamine for a long time (to avoid ergotism): after 7 days of use, in cases requiring longer treatment, take a break (for 3-4 days).

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  Overdose:

  Symptoms: anxiety, nervousness, irritability, insomnia, facial flushing, increased diuresis, nausea, vomiting, muscle twitching, tachycardia or arrhythmia, psychomotor agitation, tremor, hypertension, confusion, hyperreflexia, numbness in the fingers and toes, epileptic seizures. Treatment: Caffeamine withdrawal; gastric lavage, administration of activated carbon if necessary - symptomatic therapy; beta-blockers (propranolol) prevent cardiotoxic effects and normalize blood pressure.

  Contraindications:

• hypersensitivity to caffetamine components;
• decompensated diseases of the cardiovascular system, severe hypertension or atherosclerosis;
• pregnancy and lactation period. Caffeamine is used with caution (relative contraindications):
• insomnia, sleep disorders;
• increased excitability;
• anxiety disorders (agoraphobia, panic disorders);
• organic diseases of the cardiovascular system (myocardial infarction, angina pectoris, atherosclerosis, paroxysmal tachycardia, ventricular extrasystole, arterial hypertension, obliterating diseases of peripheral vessels);
• liver and/or kidney failure;
• glaucoma (increased intraocular pressure);
• elderly age.
  Use during pregnancy and lactation:

  Caffeamine is contraindicated during pregnancy and lactation.

  Side effects:

  From the nervous system: agitation, anxiety, tremor, restlessness, headache, dizziness, convulsions, paresthesia in the extremities, increased reflexes, tachypnea, insomnia; with sudden withdrawal of caffeamine - increased inhibition of the central nervous system, increased fatigue, drowsiness. From the cardiovascular system: palpitations, tachycardia, cardialgia, hypertension (increased blood pressure). From the digestive system: nausea, vomiting, diarrhea. Allergic reactions: swelling, itching. Other: with long-term use of Caffetamine - addiction, drug dependence, weakness in the legs, myalgia, Leriche syndrome (cyanosis, absence of pulse in the lower extremities, pain, distal sensory disturbance).

  Special instructions and precautions:

  Before using Caffetamine, you should consult your doctor. Caution should be taken to avoid caffeamine overdose. Long-term use of Caffetamine is not recommended.

  Drug interactions:

  Caffeamine enhances the pharmacological effect of other drugs containing ergot alkaloids and caffeine. When using Caffetamine and barbiturates, primidone, anticonvulsants (hydantoin derivatives, phenytoin) together, it is possible to increase metabolism and increase the clearance of caffeine. When using Caffetamine and cimetidine, oral contraceptives, disulfiram, ciprofloxacin, norfloxacin together, it is possible to reduce the metabolism of caffeine in the liver, slow down its excretion and increased concentration in the blood. When Caffetamine is used together with drugs that cause CNS stimulation, excessive stimulation of the CNS is possible. Caffeine is an antagonist of adenosine. Mexiletine reduces the excretion of caffeine by up to 50%; nicotine increases the rate of caffeine excretion. Large doses of caffeine can cause the development of dangerous cardiac arrhythmias or marked increase in blood pressure while taking MAO inhibitors (furazolidone, procarbazine, selegiline). Caffeine reduces the absorption of calcium preparations (calcium gluconate, calcium carbonate, calcium and vitamin D) in the gastrointestinal tract. Caffetamine reduces the effect of narcotic analgesics and hypnotics, increases excretion of lithium drugs (lithium carbonate) in the urine, accelerates absorption and enhances the effect of cardiac glycosides (digoxin, celanide), increases their toxicity. The combined use of caffeamine with beta-blockers (atenolol, metoprolol, nebivolol) may lead to mutual suppression of therapeutic effects; with adrenergic bronchodilators (clenbuterol, salbutamol, fenoterol) - to additional stimulation of the central nervous system and additive toxic effects. Caffeine may decrease the clearance of theophylline and aminophylline, increasing the potential for additive pharmacodynamic and toxic effects. The vasoconstrictor effect of caffeamine is enhanced by alpha-adrenergic stimulants, beta-blockers, serotonin agonists (including sumatriptan) and nicotine. Macrolides (erythromycin, spiramycin, josamycin, midecamycin, clarithromycin, azithromycin, roxithromycin) increase the toxicity of ergotamine.

  Storage conditions:

  List B. In a dry place, protected from light, at a temperature not exceeding 25°C. Shelf life: 2 years. Dispensed from pharmacies with a doctor's prescription

Indications

Composition and release form:
Cofetamine
tablets, film-coated, 10 or 20 pcs.
packaged. 1 tablet Caffetamine
contains: 100 mg, ergotamine tartrate 1 mg.

Properties / Action:

Caffetamine is a combined antimigraine drug. The effect of Caffetamine is associated with the vasoconstrictor effect of ergotamine and the improvement of brain functions under the influence of caffeine. Ergotamine causes a vasoconstrictor effect. Caffeine accelerates the absorption of ergotamine and enhances the effect of ergot alkaloids in the treatment of migraine. Caffeine also causes stimulation of the central nervous system, mainly the cerebral cortex, respiratory and vasomotor centers. Increases mental and physical performance, reduces drowsiness and fatigue. Caffeine has a pronounced cardiotonic effect: it increases the strength and frequency of heart contractions, increases blood pressure during hypotension.

Indications:

• vasoparalytic form of migraine;
• arterial hypotension;
• as a means of lowering intracranial pressure in vascular, traumatic and infectious lesions of the central nervous system.
  Directions for use and dosage:

  Caffeamine is prescribed orally, 1–2 tablets during a headache attack, 2 times a day, then 1 tablet 2–3 times a day for several days (up to 1 month). The maximum single dose is 2 tablets, the daily dose is 4 tablets. It is not recommended to use Caffetamine for a long time (to avoid ergotism): after 7 days of use, in cases requiring longer treatment, take a break (for 3-4 days).

  Overdose:

  Symptoms: anxiety, nervousness, irritability, insomnia, facial flushing, increased diuresis, nausea, vomiting, muscle twitching, tachycardia or arrhythmia, psychomotor agitation, tremor, hypertension, confusion, hyperreflexia, numbness in the fingers and toes, epileptic seizures. Treatment: Caffeamine withdrawal; gastric lavage, administration of activated carbon if necessary - symptomatic therapy; beta-blockers (propranolol) prevent cardiotoxic effects and normalize blood pressure.

  Contraindications:

• hypersensitivity to caffetamine components;
• decompensated diseases of the cardiovascular system, severe hypertension or atherosclerosis;
• pregnancy and lactation period. Caffeamine is used with caution (relative contraindications):
• insomnia, sleep disorders;
• increased excitability;
• anxiety disorders (agoraphobia, panic disorders);
• organic diseases of the cardiovascular system (myocardial infarction, angina pectoris, atherosclerosis, paroxysmal tachycardia, ventricular extrasystole, arterial hypertension, obliterating diseases of peripheral vessels);
• liver and/or kidney failure;
• glaucoma (increased intraocular pressure);
• elderly age.
  Use during pregnancy and lactation:

  Caffeamine is contraindicated during pregnancy and lactation.

  Side effects:

  From the nervous system: agitation, anxiety, tremor, restlessness, headache, dizziness, convulsions, paresthesia in the extremities, increased reflexes, tachypnea, insomnia; with sudden withdrawal of caffeamine - increased inhibition of the central nervous system, increased fatigue, drowsiness. From the cardiovascular system: palpitations, tachycardia, cardialgia, hypertension (increased blood pressure). From the digestive system: nausea, vomiting, diarrhea. Allergic reactions: swelling, itching. Other: with long-term use of Caffetamine - addiction, drug dependence, weakness in the legs, myalgia, Leriche syndrome (cyanosis, absence of pulse in the lower extremities, pain, distal sensory disturbance).

  Special instructions and precautions:

  Before using Caffetamine, you should consult your doctor. Caution should be taken to avoid caffeamine overdose. Long-term use of Caffetamine is not recommended.

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  Drug interactions:

  Caffeamine enhances the pharmacological effect of other drugs containing ergot alkaloids and caffeine. When using Caffetamine and barbiturates, primidone, anticonvulsants (hydantoin derivatives, phenytoin) together, it is possible to increase metabolism and increase the clearance of caffeine. When using Caffetamine and cimetidine, oral contraceptives, disulfiram, ciprofloxacin, norfloxacin together, it is possible to reduce the metabolism of caffeine in the liver, slow down its excretion and increased concentration in the blood. When Caffetamine is used together with drugs that cause CNS stimulation, excessive stimulation of the CNS is possible. Caffeine is an antagonist of adenosine. Mexiletine reduces the excretion of caffeine by up to 50%; nicotine increases the rate of caffeine excretion. Large doses of caffeine can cause the development of dangerous cardiac arrhythmias or marked increase in blood pressure while taking MAO inhibitors (furazolidone, procarbazine, selegiline). Caffeine reduces the absorption of calcium preparations (calcium gluconate, calcium carbonate, calcium and vitamin D) in the gastrointestinal tract. Caffetamine reduces the effect of narcotic analgesics and hypnotics, increases excretion of lithium drugs (lithium carbonate) in the urine, accelerates absorption and enhances the effect of cardiac glycosides (digoxin, celanide), increases their toxicity. The combined use of caffeamine with beta-blockers (atenolol, metoprolol, nebivolol) may lead to mutual suppression of therapeutic effects; with adrenergic bronchodilators (clenbuterol, salbutamol, fenoterol) - to additional stimulation of the central nervous system and additive toxic effects. Caffeine may decrease the clearance of theophylline and aminophylline, increasing the potential for additive pharmacodynamic and toxic effects. The vasoconstrictor effect of caffeamine is enhanced by alpha-adrenergic stimulants, beta-blockers, serotonin agonists (including sumatriptan) and nicotine. Macrolides (erythromycin, spiramycin, josamycin, midecamycin, clarithromycin, azithromycin, roxithromycin) increase the toxicity of ergotamine.

  Storage conditions:

  List B. In a dry place, protected from light, at a temperature not exceeding 25°C. Shelf life: 2 years. Dispensed from pharmacies with a doctor's prescription

Contraindications

hypersensitivity to caffetamine components;

decompensated diseases of the cardiovascular system, severe hypertension or atherosclerosis;

pregnancy;

lactation period.

With caution (relative contraindications):

sleep disturbance;

increased excitability;

anxiety disorders (agoraphobia, panic disorders);

organic diseases of the cardiovascular system (myocardial infarction, angina pectoris, atherosclerosis, paroxysmal tachycardia, ventricular extrasystole, arterial hypertension, obliterating diseases of peripheral vessels);

liver and/or kidney failure;

glaucoma (increased intraocular pressure);

elderly age.

Use during pregnancy and breastfeeding

Caffeamine is contraindicated during pregnancy and lactation.

Directions for use and doses

Inside

1–2 tables each during a headache attack 2 times a day, then 1 tablet. 2–3 times a day for several days (up to 1 month). The maximum single dose is 2 tablets, the daily dose is 4 tablets.

It is not recommended to use Caffetamine for a long time (to avoid ergotism): after 7 days of use, in cases requiring longer treatment, take a break (for 3-4 days).

Side effects

From the nervous system:

agitation, anxiety, tremor, restlessness, headache, dizziness, convulsions, paresthesia in the extremities, increased reflexes, tachypnea, insomnia; with sudden withdrawal - inhibition of the central nervous system, increased fatigue, drowsiness.

From the cardiovascular system:

palpitations, tachycardia, cardialgia, hypertension (increased blood pressure).

From the digestive system:

nausea, vomiting, diarrhea.

Allergic reactions:

swelling, skin itching.

Other:

with long-term use - weakness in the legs, myalgia, Leriche syndrome (cyanosis, absence of pulse in the lower extremities, pain, distal sensory disturbance).

Interaction

Strengthens the effect of other products containing ergot alkaloids and caffeine. With the combined use of caffetamine and barbiturates, primidone, anticonvulsants - hydantoin derivatives (phenytoin), it is possible to increase metabolism and increase the clearance of caffeine.

When used together, caffeamine and cimetidine, oral contraceptives, disulfiram, ciprofloxacin, norfloxacin may reduce the metabolism of caffeine in the liver, slow its elimination and increase its concentration in the blood.

When caffeamine is used together with drugs that cause central nervous system stimulation, excessive stimulation of the central nervous system is possible.

Caffeine is an adenosine antagonist.

Mexiletine reduces caffeine excretion by up to 50%; Nicotine increases the rate of caffeine elimination.

Large doses of caffeine can cause the development of dangerous cardiac arrhythmias or a pronounced increase in blood pressure while taking MAO inhibitors (furazolidone, procarbazine, selegiline).

Caffeine reduces the absorption of calcium preparations (calcium gluconate, calcium carbonate, a combination of calcium and vitamin D) in the gastrointestinal tract.

Caffeamine reduces the effect of narcotic analgesics and sleeping pills, increases the excretion of lithium drugs (lithium carbonate) in the urine, accelerates absorption, enhances the effect, and increases the toxicity of cardiac glycosides (digoxin, celanide).

The combined use of caffeamine with beta-blockers (atenolol, metoprolol, nebivolol) may lead to mutual suppression of therapeutic effects; with adrenergic bronchodilators (clenbuterol, salbutamol, fenoterol) - to additional stimulation of the central nervous system and additive toxic effects.

Caffeine may decrease the clearance of theophylline and aminophylline, increasing the potential for additive pharmacodynamic and toxic effects.

The vasoconstrictor effect of caffeamine is enhanced by alpha-adrenergic stimulants, beta-blockers, serotonin agonists (including sumatriptan) and nicotine.

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Macrolides (erythromycin, spiramycin, josamycin, midecamycin, clarithromycin, azithromycin, roxithromycin) increase the toxicity of ergotamine.

Overdose

Symptoms:

anxiety, nervousness, irritability, insomnia, facial flushing, increased diuresis, nausea, vomiting, muscle twitching, tachycardia or arrhythmia, psychomotor agitation, tremor, hypertension, confusion, hyperreflexia, numbness in the fingers and toes, epileptic seizures.

Treatment:

Caffeamine withdrawal; gastric lavage, administration of activated carbon, and, if necessary, symptomatic therapy; beta-blockers (propranolol) prevent cardiotoxic effects and normalize blood pressure.

special instructions

Before using Caffetamine, you should consult your doctor.

Caution should be taken to avoid caffeamine overdose.

Long-term use of Caffetamine is not recommended.

Pharmgroups

Psychostimulants in combinations

Pharmaceutical actions

antimigraine