Tempalgin tablets p/o 500mg/20mg No. 10x1

Information sheet

The drug has a number of beneficial properties for the human body. It relieves pain, can lower body temperature and has a calming effect. Basically, patients themselves know what this medication is for. It is used to combat headaches and toothaches, but usually of mild or moderate intensity, as well as other uncomfortable conditions. The medicine can be recommended for use in acute respiratory diseases and high body temperature.

In addition, “tempalgin” has a calming effect on the human nervous system. It helps cope with fear or anxiety. It may also moderately reduce blood pressure. This medication acts very quickly on the human body. Most often, the effect is achieved within 30 minutes to 2 hours. The only form of release is tablets.

Pharmacological properties of the anesthetic

Tempalgin, like most drugs in this group, copes well with severe pain syndromes of various origins and effectively reduces body temperature in patients. This therapeutic effect of the drug is due to the successful combination of two active ingredients:

The basis of tempalgin is the general analgesic metamizole sodium. This substance can interrupt the conduction of pain impulses in the nerve endings of the peripheral nervous system.
The second therapeutic component included in the anesthetic is triacetonamine. Its presence makes it possible to enhance and prolong the effect of metamizole. In addition, this substance has a weak sedative effect.

It should be noted that tempalgin belongs to the class of non-narcotic analgesics; its main goal is to relieve severe pain. This remedy is not very suitable for treating the inflammatory process.

Most experts also note a rather weak sedative effect of this drug, although the duration of this effect can be from 2 to 3 hours.

The high level of ability to relieve pain allows the widespread use of tempalgin for menstrual pain, although this medicine cannot be expected to stabilize a woman’s mental and emotional background.

Will it help with headaches?

"Tempalgin" perfectly relieves symptoms of headaches. In addition, the drug should be taken if you have symptoms such as:

Toothache
Migraine
Neuralgia
Muscle pain
Joint pain
Mild abdominal pain

In combination with drugs that relieve spasms, it can be prescribed to treat various colics. It is used as an additional agent in the treatment of infectious and inflammatory diseases.

Indications and contraindications for the use of anesthetic

Like most medications used for severe abdominal pain during PMS, tempalgin has its positive and negative sides. It depends on them for what symptoms and syndromes experts prescribe this medicine.

Main indications for taking tempalgin

Doctors recommend their patients to use this drug for the following pathological conditions:

Tempalgin is widely used to lower body temperature in various viral infections.
The drug has proven itself in outpatient painful procedures and minor surgical interventions. Surgeons consider its positive side to be a weak sedative effect, which does not require long-term observation when using this anesthetic.
Tempalgin allows doctors to refuse more powerful medications, including narcotic analgesics in the postoperative period and in dental practice.
It is recommended to use this medicine in the treatment of hepatic or renal colic, but it is advisable to prescribe antispasmodics in combination with it.
This medicine is a help in the fight against any severe pain of a neuralgic nature. Tempalgin works great during menstruation.

It should be noted that although most experts recognize this drug as having a fairly low incidence of allergic reactions, the painkiller can only be taken as prescribed by a doctor.

The fact is that, like any other medicine, tempalgin has many prohibitions on its use.

Contraindications for relieving pain during menstruation

For the treatment of severe and prolonged pain during menstruation, it is preferable not to prescribe this medicine to women with a history of cardiovascular diseases. The drug in question often causes a drop in blood pressure, which can lead to the development of attacks of arrhythmia or angina.

The use of tempalgin is also prohibited in patients suffering from lung pathology, especially if the patient experiences frequent attacks of bronchial asthma. Hormones used to relieve such conditions can distort the effect of the anesthetic on the woman’s body.

Who else should not prescribe this medicine:

Tempalgin is not recommended for women with severe kidney and liver pathology.
Blood diseases, especially anemia and leukopenia, make it impossible to prescribe an analgesic during menstruation.
Experts are categorically against the use of tempalgin during pregnancy and breastfeeding.

Watch the video about the causes of painful periods:

Why can't you use

The drug is prohibited for use in the following body conditions:

Severe kidney failure
Low blood pressure
Severe liver failure
Asthma due to allergy to aspirin
Chronic heart failure
Problems with hematopoiesis
Individual intolerance

Overdose and first aid

Let us remind you that the maximum daily dose of the drug should not exceed 6 tablets. If the maximum permissible daily dose is violated, the main symptoms of poisoning usually become disorders of the gastrointestinal tract and central nervous system.

Most often, patients complain of nausea, vomiting, and loose stools. Women note a drop in blood pressure and associated tinnitus, dizziness, tachycardia, and loss of consciousness. In more severe forms of tempalgin poisoning, breathing problems, kidney dysfunction, up to complete anuria, and changes in the patient’s blood may occur.

First aid for such conditions does not differ from that for excessive use of other anesthetics. The woman's stomach is washed with a large volume of warm alkaline water, given a laxative and shock doses of activated charcoal. Blood pressure is monitored and stabilized.

We recommend reading the article about the drug “Pentalgin” for menstruation. From it you will learn about the effect of the drug on the body, indications and contraindications for use, effectiveness during menstruation.

Why are there allergies?

Any drug always has undesirable effects. Specifically, Tempalgin does not often have side effects on the body. Usually, this occurs only against the background of long-term use of the drug. They manifest themselves in organ systems as follows:

Burning sensation in the epigastrium, increased levels of ALT and AST, jaundice, increased bilirubin, cholestasis.
Increased symptoms from the central nervous system, up to the occurrence of hallucinations.
Changes in blood pressure, increased heart rate, and the appearance of cyanosis.
Renal dysfunction
Allergy in its various manifestations.

Name

Tempalgin tablet p/o 500 mg/20 mg in blister pack. in pack No. 10x1

Description

Round, biconvex, film-coated tablets, green in color, odorless.

pharmachologic effect

Tempalgin is a combination drug that contains the active substances metamizole sodium and triacetonamine-4-toluene sulfonate. It has a pronounced and long-lasting analgesic effect due to the non-narcotic analgesic metamizole sodium, which suppresses the synthesis of prostaglandins. Triacetonamine-4-toluene sulfonate reduces motor agitation and has a calming effect.

Indications for use

Acute pain after injury or surgery
Colic
Pain due to tumor diseases
Other acute or chronic severe pain when other therapeutic measures are contraindicated or ineffective
High temperature that cannot be controlled by other means.

Contraindications

In case of hypersensitivity to metamizole and other pyrazolone derivatives or pyrizalidin (including patients who have developed agranulocytosis after using these substances) or any other ingredients of analgin.
In patients with a history of aspirin asthma or analgesic intolerance syndrome (urticaria, angioedema), in patients with bronchospasm or other forms of anaphylactoid reactions to salicylates, paracetamol or other non-narcotic analgesics such as diclofenac, ibuprofen, indomethacin and naproxen).
In case of impaired bone marrow function (for example, after treatment with cytostatics) or diseases of the hematopoietic system.
Hereditary hemolytic anemia associated with deficiency of glucose-6-phosphate dehydrogenase.
Patients with systolic blood pressure below 100 mm Hg.
In acute intermittent porphyria (risk of an attack of porphyria).
In the last trimester of pregnancy.
During breastfeeding.
If acute surgical pathology is suspected.
Children under 15 years of age.

special instructions

Use extreme caution when using Tempalgin contains the pyrazolone derivative metamizole and has a rare but life-threatening risk of shock and agranulocytosis. Patients with atopic bronchial asthma and hay fever have an increased risk of developing hypersensitivity reactions. Patients with anaphylactoid reactions to metamizole are most vulnerable to the entire group of non-narcotic analgesics. Patients with anaphylactoid reactions or other immunologically mediated reactions (eg, agranulocytosis) may react in the same way to other pyrazolones and pyrazolidines. When using the drug, agranulocytosis may develop. Therefore, if an unmotivated increase in temperature, chills, sore throat, difficulty swallowing, stomatitis, as well as inflammation of the external genitalia and anus is detected, immediate discontinuation of the drug is necessary. When choosing a route of administration, it is important to remember that parenteral administration of analgin is associated with an increased risk of anaphylactic or anaphylactoid reactions. The risk of potentially severe anaphylactoid reactions to analgin increases significantly in patients with:

asthma syndrome on analgesics or angioedema on non-narcotic analgesics;
bronchial asthma, especially with concomitant rhinosinusitis and nasal polyps;
chronic urticaria;
intolerance to dyes (for example, tartrazine) and preservatives (for example, benzoates);
alcohol intolerance. These patients may react to alcoholic beverages even in small quantities with symptoms such as sneezing, watery eyes, and severe facial flushing. Such alcohol intolerance may be a sign of previously diagnosed asthma to analgesics.

When prescribed to patients with acute cardiovascular pathology, careful monitoring of hemodynamics is necessary. Use with caution in patients with blood pressure levels below 100 mmHg. Art., with myocardial infarction, multiple trauma, with anamnestic indications of liver and kidney diseases (pyelonephritis, glomerulonephritis), during treatment with cytostatics, with chronic alcoholism, a burdened allergic history, blood diseases. Analgin can lead to hypotensive reactions. These reactions may be dose dependent. These reactions usually occur with parenteral rather than enteral administration. The risk of developing such reactions increases:

with rapid intravenous administration;
in patients with previous hypotension, dehydration or dehydration, unstable blood pressure, or incipient circulatory failure (for example, in patients with multiple traumas or a heart attack);
in patients with high fever.

These patients require careful evaluation and close monitoring. Preventive measures (such as circulatory stabilization) may be necessary to reduce the risk of hypotensive reactions. In exceptional cases, analgin can be used in patients in whom a decrease in blood pressure is unacceptable, for example, with severe coronary heart disease or corresponding stenosis of the cerebral arteries. Use is possible only after careful monitoring of hemodynamic parameters. Patients with renal or hepatic insufficiency should take analgin only after a careful assessment of the benefits, risks and necessary precautions. It is necessary to consult with the patient before administering analgin. In patients with an increased risk of anaphylactic reactions, analgin can be used only after a thorough analysis of the possible risks in relation to the expected benefits. When taking analgin in such cases, the patient should be carefully monitored to ensure medical care and emergency preparedness. Important information about some of the components included in the composition The drug contains wheat starch, which is acceptable for people with celiac disease. Patients with a wheat allergy (other than celiac disease) should not use this drug.

Use of other drugs

Please tell your doctor or pharmacist if you are taking or have recently taken other medicines, including those taken without a prescription. Treatment may be affected by the simultaneous use of drugs that suppress the central nervous system, painkillers, anti-inflammatory drugs, contraceptive drugs, coumarin anticoagulants (reduce blood clotting), chlorpromazine (for the treatment of mental illnesses), chloramphenicol (an antibiotic), cyclosporine (used for tumor diseases ), sleeping pills.

Use with food and beverages

It is preferable to take the tablets after meals with plenty of water. During treatment with Tempalgin, drinking alcohol is not recommended, as the side effects of the drug may increase.

Pregnancy and breastfeeding

Ask your doctor or pharmacist for advice before using any medicine. Pregnancy It is not recommended to use Tempalgin during pregnancy. Breastfeeding The use of the drug during breastfeeding is undesirable. If treatment with the drug is required, breastfeeding should be discontinued.

Driving vehicles and working with machinery

When using Tempalgin, do not drive vehicles or operate machinery, as this drug reduces the ability to concentrate and slows down conditioned reflexes.

Mode of application

The dosage depends on the intensity of pain or fever and individual sensitivity to metamizole. In principle, the minimum dose that successfully controls pain and/or fever should be selected. It usually takes 30 to 60 minutes after oral administration before the effect occurs. Adults and adolescents aged 15 years (> 53 kg) up to 1000 mg of metamizole per dose (2 tablets). In case of insufficient effect, it is possible to increase the single dose depending on the maximum daily dose - up to 4 times a day (exceeding the daily dose is not permissible). Elderly In elderly patients, the dose should be reduced since the elimination of metabolites may be delayed. General condition and decreased creatinine clearance In patients with reduced status and decreased creatinine clearance, the dose should be reduced, since the elimination of metamizole metabolic products may be prolonged. Kidney and liver function With impaired renal and liver function, the rate of elimination is reduced; multiple doses and high doses should be avoided. Dose adjustment is usually not required. Route of Administration The route of administration is based on the desired therapeutic effect and the patient's condition. In many cases, oral administration is sufficient to provide satisfactory effect (other dosage forms of metamizole are available for intravenous or intramuscular administration to achieve rapid effect, but, usually, parenteral administration of the drug is associated with a higher risk of anaphylactic or anaphylactoid reactions). The tablets should be swallowed whole with plenty of liquid (for example, 1 glass of water). Duration of treatment The duration of treatment depends on the type and severity of the disease and is determined by the doctor. Long-term treatment with metamizole requires regular monitoring of blood counts, including counting of differentiated leukocytes. If you take more than the required dose of the drug, you may experience: nausea, dizziness, abdominal pain, weakness to the point of loss of consciousness, severely low blood pressure to the point of shock (loss of consciousness with low blood pressure), and abnormal heart rhythms . If some of these symptoms appear, you should immediately stop using the drug and consult your doctor! If you miss a dose of Tempalgin If you miss one dose, take it as soon as possible. If it is near time for your next dose, take it as usual. Do not take a double dose to make up for a missed dose. Continue to use the medicine according to the directions in this leaflet. If you have any additional questions about using this medicine, ask your doctor or pharmacist.

Possible side effects

The frequency of possible side effects listed below is determined as follows: very common (> 1/10), common (> 1/100 to 1/1000 to 1/10000

Storage conditions

In the original packaging at a temperature not exceeding 25 °C in a place protected from moisture. Keep out of the reach of children. Medicines should not be disposed of in a sewer or household waste container. Ask your pharmacist how to dispose of unused medications. These measures will contribute to environmental protection.

Best before date

Shelf life: 4 (four) years. Should not be taken after the expiration date marked on the package.

Compound

Each film-coated tablet contains the following active ingredients: metamizole sodium monohydrate 500 mg, triacetonamine-4-toluetsulfonate 20 mg. Excipients: wheat starch, microcrystalline cellulose (type 101), magnesium stearate, talc, povidone K 25. Shell: Opadry II green 85 F21526 (polyvinyl alcohol - partially hydrolyzed, macrogol 3350, talc, titanium dioxide (E 171), aluminum varnish based on quinoline yellow dye (E 104), aluminum varnish FCF based on brilliant blue dye (E 133).

Package

Primary packaging: 10 film-coated tablets are packed in a PVC/aluminum foil blister. Secondary packaging: 1 (one) or 2 (two), or 10 (ten) blisters are packaged together with a consumer leaflet in a cardboard box.

Conditions for dispensing from a pharmacy chain

Over the counter.

Buy Tempalgin tablet p/o 500mg/20mg in blister pack. in pack No. 10x1 in the pharmacy

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Instructions for use for Tempalgin tablet p/o 500mg/20mg in a blister pack. in pack No. 10x1

How to take with other medications

When combined with classic sedatives and tranquilizers, the patient's pain relief increases. Co-administration with phenothiazide derivatives usually causes an increase in body temperature. The patient may develop leukopenia when prescribed in parallel with cytostatics. There is no exception to increased toxic effects when taken with non-steroidal anti-inflammatory drugs or oral contraceptives. Increased excretion from the body occurs under the influence of taking H2 receptor blockers.

Interactions of the drug Tempalgin

The effect of metamizole potentiates the use of tricyclic antidepressants (imipramine, amitriptyline), oral contraceptives and allopurinol: they inhibit enzymes of the liver system that metabolize drugs, as a result of which the biotransformation of metamizole slows down and its toxicity increases. Barbiturates and phenylbutazone reduce the severity and shorten the duration of the pharmacodynamic effects of metamizole due to the induction of liver enzymes. Metamizole reduces the concentration of cyclosporine in the blood plasma. Chloramphenicol and other drugs that inhibit hematopoiesis, through an additive effect, enhance the myelotoxic effect of metamizole. Alcohol enhances the effect of both components of the drug. Triacetonamine-4-toluene sulfonate potentiates the effect of hypnotics, general anesthetics, narcotic and non-narcotic analgesics.

The most popular analogue

These two drugs differ significantly in their composition. Indications for their use also differ. In the presence of a stronger and more persistent pain syndrome, preference should be given to “pentalgin”, since it contains a larger number of main active ingredients, which are more effective in comparison with “tempalgin”. As for pricing policy and production, these two medicines are practically no different from each other. They are both very high quality and relatively inexpensive drugs.

Basic rules for taking the medicine

The annotation for the drug states that the recommended dose for pain relief is 1 tablet 3 times a day, but not more than 6 tablets per day. The therapeutic effect usually occurs within 15 - 20 minutes and lasts about 5 hours.

Like most drugs in this group, tempalgin is not recommended to be taken for more than 5 days. Considering the average duration of normal menstruation, this period should be enough for a woman’s complete comfort. If it is necessary to continue the period of admission, consultation with the attending physician is required.

Experts highlight a number of subtleties when relieving pain during menstruation with tempalgin:

Considering the irritating effect of this medicine on the walls of the stomach and intestines, the tablets are taken 30 minutes after meals and washed down with 0.5 liters of water.
If, at the onset of menstruation, a woman is treated for an inflammatory process with antibiotics, then the analgesic in question should be used with caution.
The use of the drug is prohibited if the etiology of abdominal pain is not clear. Taking the drug can change and smooth out the true picture and prevent specialists from diagnosing an acute surgical pathology in the patient.
Treatment of pain syndrome with tempalgin requires regular laboratory tests of the blood coagulation system and taking liver samples from the woman.
Many doctors note that when using this remedy, the color of urine may change. It becomes more saturated and acquires a dark red color. This anomaly is associated with the effect of the drug on the kidneys and should not cause concern in women.

Tempalgin helps with menstruation, but you should not try to enhance its effect by simultaneous intake of alcohol. Such experiments are fraught with the development of disorders of the central nervous system and cardiovascular system. In 100% of cases, menstrual bleeding will increase, which will only worsen the woman’s condition.

By following these simple tips, the patient can avoid many problems when taking this medicine. However, there are often situations when a woman, trying to reduce pain, exceeds the permissible dose of the drug. What to do in this case?