Triazavirin is a new drug recommended for coronavirus infection

Read in the article:

1. How Trekrezan works
2. Rules for joint reception
3. Health implications
4. What to do if compatibility breaks

Colds, stress, depression, accumulated fatigue weaken our body. There comes a time when a person is no longer able to cope on his own and seeks medical help. Typically, in such situations, doctors prescribe medications called adaptogens, which help fight the cold and stimulate the body. But not a single instruction for these medications specifies their interaction with alcohol. In our article we will tell you how such medications act in the fight against various ailments and whether they can be used in conjunction with alcoholic beverages.

How Trekrezan works

Trecrezan is an adaptogen, a general spectrum drug that helps the body cope with stressful situations and colds. Prescribed during the period of ARVI, for acclimatization to new conditions, to increase endurance during periods of physical and emotional overload. The medicine does not affect driving a car or other complex technical equipment. Available without a prescription and interacts well with other medications.

Trekrezan has a number of contraindications for use, including:

• children under 12 years of age;
• pregnancy and breastfeeding;
• disorders of the liver and kidneys and others.

The drug tones and supports the body in stressful situations, helps to resist external negative factors. Is an immunomodulator.

Admission rules

Oral tablets must be used whole, without damage, with plenty of water. The instructions recommend different therapeutic regimens for Trecrezan:

1. Prevention of ARVI - for adolescents over 12 years of age and adults, one tablet daily, after meals. The duration of the course is two weeks; during the period the patient should consume no more than 14 tablets with a total dosage of 2.8 g.
2. Treatment of ARVI - the drug is included in complex therapy. On the first day - one tablet three times a day, the next week - one tablet every day. The course does not exceed 10 units of medication and lasts 8 days.
3. Hard physical or intellectual work, increasing the body's resistance to stress factors - dosages and duration of therapeutic procedures comply with the standards for the treatment of acute respiratory viral infections.

If there is no pronounced effect or worsening of the condition after three days of use, the patient should contact the attending physician for additional consultation. The doctor will conduct a diagnosis and select a more suitable medication.

Rules for joint reception

The main thing that is worth remembering for those who take the drug Trecrezan is that this drug provokes the risk of possible complications for the liver. It can intensify headaches, increase excitability, and can also cause complications such as myocardial infarction or increased/decreased blood pressure.

In order to avoid negative side effects when taking Trecrezan, you must follow the rules for taking the drug with alcohol.

The drug can be taken 18-24 hours before drinking alcohol, as well as 8-14 hours after.

It is strictly not recommended to take the medicine together with alcohol, as well as during the period of elimination of alcohol breakdown products.

Indications for use and contraindications

The abstract recommends prescribing Trecrezan in complex therapy:

• respiratory viral infections;
• consequences of physical activity and high intellectual activity.

When taken, there is an increase in the body's resistance to hypothermia, overheating, and insufficient oxygen supply. The drug helps to cope with the consequences of sudden climate change and changes in atmospheric pressure.

Trecrezan is contraindicated in patients with individual intolerance to the component composition, pregnant and lactating women, and children under twelve years of age. The last feature is associated with insufficient information about the safety of drugs and its effectiveness for the teenage body. Particular caution is required when treating patients with diabetes mellitus.

Health implications

Taking Trecrezan together with alcohol can cause the following negative consequences:

• gastrointestinal disorders (diarrhea, constipation and others)
• cardiopalmus,
• drowsiness,
• nausea and vomiting,
• dizziness.

Despite the fact that Trecrezan is contraindicated for people with liver disease, it is recommended as an adjuvant after alcohol intoxication or poisoning with solvents and heavy metal salts. The drug helps relieve symptoms of alcohol abuse.

Immunomodulator Trekrezan: profile of general and immunotropic activity

About the article

7968

0

Regular issues of "RMZh" No. 20 dated October 23, 2005 p. 1361

Category: General articles

Authors: Shabanov P.D. , Zarubina I.V. , Bolekhan A.V. , Ryleev A.Yu. , Zhumasheva A.B. , Tsygan V.N.

For quotation:

Shabanov P.D., Zarubina I.V., Bolekhan A.V. and others. Immunomodulator Trekrezan: profile of general and immunotropic activity. RMJ. 2005;20:1361.

In recent years, methods of correction and stimulation of immunity have been actively introduced into clinical practice. Immune system disorders can manifest as hyperimmune responses, primary or secondary immune deficiencies, and various patterns of system dysfunction. Immunostimulating agents (often called immunomodulators) are drugs that activate cellular and humoral immunity, the phagocytic function of macrophages, the release of interferons, and also increase the nonspecific resistance of the body. They are used mainly to treat diseases caused by primary or secondary deficiency of the immune system or its dysfunction. Among the immunomodulators, there are drugs of microbial origin (prodigiosan, BCG vaccine), peptide (interferon-a, interferon-b, interferon-g, etc.) and synthetic (levamisole, non-steroidal anabolic agents such as methyluracil, Trecresan, etc.) and herbal immunomodulators ( preparations from Echinacea purpurea, licorice root, spirullina algae, etc.) [2]. All immunomodulators find their use in medical practice, since they have their own characteristics of impact.

New immunomodulators include the drug Trecrezan, which recently appeared on the pharmaceutical market [3]. Trecrezan is a highly effective drug with a pronounced immunostimulating and adaptogenic therapeutic effect. Trekrezan is an original drug, developed by the Irkutsk Institute of Organic Chemistry of the Russian Academy of Sciences (academician Voronkov M.G.), its tests were carried out at the Military Medical Academy and the Influenza Institute of the Russian Academy of Medical Sciences. Trecrezan is non-toxic (LD50 for rats > 3700 mg/kg with intraperitoneal and > 6500 mg/kg with oral administration of the drug), has a stress-protective effect in models of immobilization and painful hypodynamic stress, has the ability to accelerate the repair of damaged tissues (liver, myocardium, muscles) , protects internal organs from the damaging effects of toxins, microwave irradiation, and infectious factors. The drug has pronounced antioxidant activity and immunostimulating properties [3]. Let's consider some features of the immunomodulatory effect of Trekrezan. The effect of Trecrezan on indicators of nonspecific protection and the state of the immune system. In an experiment on mice, Trecrezan (20 mg/kg) when administered intraperitoneally for 6 days did not affect the weight of the thymus, but caused a slight increase (+20%) in the weight of the spleen. Trecrezan had no effect on the cell content of peritoneal exudate. The percentage of macrophages among the cells of peritoneal exudate did not change in the groups and remained within the normal range - about 30%. The percentage of T-lymphocytes in the spleen under the influence of Trecrezan increased slightly (+18%). In the control group, the content of T- and B-lymphocytes did not change. A stimulating effect of Trecrezan on resident peritoneal macrophages was noted. At the same time, a twofold increase in both spontaneous and induced ability of macrophages to restore the absorption of nitroblue tetrazolium (NBT) and also to absorb neutral red was noted. A study of the effect of the drug on the functional activity of peptone-induced neutrophils showed that Trecrezan has the ability to increase chemotactic activity by 2 times and phagocytosis of staphylococci by 80%. Thus, Trecrezan, when administered intraperitoneally for 6 days, caused an increase in the percentage of T-lymphocytes in the spleen in mice, had a stimulating effect on the functions of peritoneal phagocytes, increasing phagocytic activity and chemotaxis of neutrophils, as well as enhancing the “oxidative burst” of macrophages and their absorption capacity , activated cellular and humoral immunity, increasing phagocytosis and chemotaxis of neutrophils both in intact animals and in secondary immunodeficiency (modeled immunodeficiency). The effect of Trecrezan on the production of serum a- and g-interferon. The study was carried out in accordance with the guidelines for studying the specific activity of interferons and interferon inducers [6] at the Influenza Research Institute of the Russian Academy of Medical Sciences and the Research Institute of Children's Infections of the Russian Federal Healthcare Service (St. Petersburg) (Table 1). Evaluation of the ability of the drug Trecrezan to induce serum interferon in experiments showed that it has interferonogenic activity. In the first hours after the administration of Trecrezan, a-type interferon is produced, which is subsequently replaced by g-interferon within 24 hours. Considering the identified interferonogenic activity of Trecrezan, we can count on expanding the scope of its use. A special feature of Trekrezan's action is its ability to induce g-interferon, which has a much wider range of immunomodulatory effects compared to other types of interferons. The experimental data presented show that Trekrezan has high immunotropic activity. It stimulates all types of immunity - cellular, humoral, phagocytosis. An important feature of the action of Trecrezan is its interferonogenic activity against interferon-g, which is a rather rare phenomenon. The drug is indicated to increase immunity, strengthen the body's defenses; as an adjuvant for long-term antibiotic therapy of chronic infectious diseases. Apparently, Trekrezan can be used in the complex treatment of hepatitis B and C, as well as HIV infection. In addition, the stress-protective and antiasthenic properties of Trekrezan, along with its ability to reduce the toxic effects of many xenobiotics (including drugs), allow Trekrezan to be positioned as a modern effective immunomodulator with broad adaptogenic properties. Literature 1. Aksenov O.A.. Murina E.A. Method for indicating interferon in biological samples. RF patent No. 2093179. – 1997. 2. Zarubina I.V., Shabanov P.D. Molecular pharmacology of antihypoxants. – St. Petersburg: N–L, 2004. – 368 p. 3. Kazimirovskaya V.B., Dyakov V.M., Voronkov M.G., Kovalchuk S.F. Trecrezan: toxicology, pharmacology, clinical trial results. – Irkutsk, 1996. – 224 p. 4. Laboratory research methods in the clinic: Handbook / Ed. V.V. Menshikov. – M.: Medicine, 1987. – 368 p. 5. Methods of biochemical research / Ed. M.I. Prokhorova, L.: Leningrad State University Publishing House, 1982. – 272 p. 6. Guide to experimental (preclinical) study of new pharmacological substances / Ed. V.P. Fisenko. M.: Ministry of Health of the Russian Federation, 2000. – P.281–286. 7. Khavinson V.Kh., Morozov V.T. Methodological recommendations for conducting immunological studies (methods for assessing T- and B-immune systems). – L., 1980. – 175 p. 8. Finter NB Quantitative haemadsorption, a new assay technique. I. Assay of interferon // Virology. 1964. – Vol. 24. – P.589–97.

Content is licensed under a Creative Commons Attribution 4.0 International License.

Share the article on social networks

Recommend the article to your colleagues

What to do if compatibility breaks

If a person takes the drug together with alcohol-containing drinks, then alcohol intoxication may develop. In such a situation, it is recommended to use a sorbent to cleanse the body and provide the person with plenty of fluids. In severe cases of poisoning and in case of negative reactions of the body, it is necessary to call an ambulance.

Immunomodulators are often prescribed to patients as part of complex therapy, both for the prevention of colds and as a means to mobilize a person’s internal strength. These medications, if used together with alcohol, can cause side effects and harm your health.

If you or your loved one suffers from alcohol addiction, then sign up for a free consultation by calling the AlkoZdrav help center hotline: 8-800-775-32-63 . Specialists will answer your questions, select an effective treatment plan and accompany you throughout the entire program. We guarantee results if all our recommendations are followed.

Side effects

Like any medicine, Triazavirin can have unwanted effects. List of consequences of use:

• eosinophilia;
• allergic reaction (rashes on the skin);
• headache;
• dyspepsia (thin stool, vomiting, nausea, bloating, gastralgia, dry oral mucosa);
• the appearance of red blood cells, bacteria, epithelial cells in the urine;
• increased levels of liver enzymes (ALT, AST).
• impotence.

If symptoms appear and intensify, you should consult a doctor to adjust your therapy. In case of an overdose, severe abdominal pain, dyspepsia, vomiting, and nausea occur.

Manufacturer's recommendations

Clinical trials have not proven the possibility of Trecrezan interacting with other pharmaceuticals. The instructions recommend adhering to the following standards:

• in case of diabetes mellitus, caution is required during treatment and constant monitoring of the patient’s condition by a doctor;
• ARVI - contact a specialist is required if an elevated temperature occurs (above 39 degrees) or if it lasts more than 3-14 days, severe pain, shortness of breath, convulsive syndrome, short-term fainting appear;
• the drug does not require additional dosage adjustments for adolescents, elderly patients, people with kidney and liver pathologies;
• It is prohibited to change the dose of the medication prescribed in the annotation.

During therapeutic procedures, the effect of the active substances of the drug on the reaction rate was not noted. Patients can drive vehicles and work with dangerous moving mechanisms.

Adverse reactions and overdoses

The instructions point out that treatment with Trecrezan in exceptional cases becomes a source of non-standard responses of the body. Therapeutic procedures cause symptoms of allergic reactions, represented by:

• skin redness;
• obsessive itching;
• dermatological rashes and other manifestations of hypersensitivity;
• anaphylactic shock, Quincke's edema.

If adverse reactions occur, the patient should contact their doctor and describe in detail the deviations that have arisen.

The abstract does not mention any reported cases of overdose with serious intoxication of the body. In theory, a deliberate increase in dosage can cause signs of intolerance to the drug with allergy symptoms. If they occur, a visit to the doctor and symptomatic treatment are necessary.