Effervescent tablets ACC Long: instructions for use, price 600 mg, reviews

pharmachologic effect

The product has a mucolytic effect. Since the structure of the acetylcysteine molecule contains sulfhydryl groups, this ensures the rupture of disulfide bonds of acidic mucopolysaccharides of sputum, as a result, the viscosity of the mucus decreases.

ACC Long is also active if the patient produces purulent sputum.

Provided that the drug is used for the purpose of prevention, the severity and frequency of exacerbations in people who suffer from cystic fibrosis and chronic bronchitis .

Pharmacokinetics and pharmacodynamics

Once in the body, it is absorbed quickly. Metabolism occurs in the liver, resulting in the formation of a pharmacologically active metabolite - cysteine , also cystine , diacetylcysteine , mixed disulfides.

When taken orally, the level of bioavailability is 10% (as there is a pronounced first-pass effect). The highest level of concentration in the blood is determined after 1–3 hours. 50% bound to plasma proteins. Excreted from the body through the kidneys. The half-life is approximately 1 hour; if liver function is impaired, the half-life is 8 hours. Penetrates through the placental barrier. There is no evidence of penetration through the BBB.

Indications for use

ACC Long is used in the following cases:

for diseases of the respiratory system that are accompanied by the formation of viscous sputum, which is difficult to separate ( acute and chronic bronchitis laryngotracheitis , obstructive bronchitis , bronchiectasis , pneumonia , cystic fibrosis , bronchiolitis , bronchial asthma );
acute and chronic sinusitis
otitis media.

What diseases does ACC help with?

Regardless of the form of release, ACC is used in the treatment of respiratory diseases, which are characterized by the formation of viscous secretions that are difficult to cough up.

The medication is prescribed for:

tracheitis and laryngotracheitis;
bronchitis (chronic, acute, obstructive);
inflammation or abscess of the lungs;
cystic fibrosis;
chronic obstructive pulmonary disease;
bronchial asthma;
inflammation of bronchioles;
bronchiectasis;
sinusitis in chronic or acute form;
otitis media.

Contraindications

ACC Long is contraindicated for use in the following cases:

during pregnancy and breastfeeding ;
when the patient is under 14 years of age;
with high sensitivity to the components of the drug.

The drug is used with caution for stomach and duodenal ulcers during exacerbation, for pulmonary hemorrhage, hemoptysis, varicose veins of the esophagus, bronchial asthma , diseases of the adrenal glands, as well as for liver and kidney failure .

ACC effervescent tablets

Release form

Effervescent tablets . Round, flat-cylindrical, white, with a notch on one side, with the smell of blackberries. Reconstituted solution: colorless, transparent, with the smell of blackberries. There may be a faint gray odor.

Compound

Active ingredient: acetylcysteine (100 mg or 200 mg).

Excipients: anhydrous citric acid, sodium bicarbonate, anhydrous sodium carbonate, mannitol, anhydrous lactose, ascorbic acid, sodium citrate, sodium saccharinate, blackberry flavoring “B”.

Pharmacological group

Secretolytics and stimulants of motor function of the respiratory tract.

Action

Mucolytic agent with expectorant action. Acetylcysteine increases the volume of sputum, facilitates its discharge due to a direct effect on the rheological properties of sputum, and has an anti-inflammatory effect by suppressing the formation of free radicals and reactive oxygen-containing substances responsible for the development of inflammation in the lung tissue.

Acetylcysteine: description of the substance

Indications

Respiratory diseases and conditions accompanied by the formation of viscous and mucopurulent sputum: acute and chronic bronchitis, brochiolitis, tracheitis, laryngotracheitis, pneumonia, lung abscess, bronchiectasis, bronchial asthma, COPD, interstitial lung diseases and atelectasis due to blockage of the bronchi by mucus plug, cystic fibrosis.
Otitis media, sinusitis, acute and chronic sinusitis and rhinosinusitis (to facilitate the passage of secretions).

Contraindications and restrictions

Peptic ulcer of the stomach and duodenum in the acute phase,
hemoptysis, pulmonary hemorrhage,
pregnancy and lactation (breastfeeding),
children under 2 years of age,
lactase deficiency, lactose intolerance, glucose-galactose malabsorption,
hypersensitivity to acetylcysteine and other components of the drug.

Carefully

History of gastric and duodenal ulcers;
bronchial asthma;
obstructive bronchitis;
liver and/or kidney failure;
histamine intolerance (long-term use should be avoided);
varicose veins of the esophagus;
adrenal gland diseases;
arterial hypertension.

Application and dosage

Orally after meals immediately after dissolution, with additional fluid intake. In exceptional cases, the ready-to-use solution can be left for 2 hours.

ACC 100

Adults and children over 14 years of age : 2 effervescent tablets 2 - 3 times a day (400 - 600 mg each);
children from 6 to 14 years old : 1 effervescent tablet 3 times a day, or 2 effervescent tablets 2 times a day (300 - 400 mg);
children from 2 to 6 years : 1 effervescent tablet 2 - 3 times a day (200 - 300 mg).

For cystic fibrosis:

Children from 2 to 6 years : 1 effervescent tablet 4 times a day (400 mg);
children over 6 years old : 2 effervescent tablets 3 times a day (600 mg).

ACC 200

Adults and children over 14 years of age: 1 effervescent tablet 2-3 times a day (400 – 600 mg);
children from 6 to 14 years old: 1 effervescent tablet 2 times a day (400 mg);
children from 2 to 6 years: 1/2 effervescent tablet 2-3 times a day (200 – 300 mg).

For cystic fibrosis:

Children from 2 to 6 years: 1/2 effervescent tablet 4 times a day (400 mg);
children over 6 years of age: 1 effervescent tablet 3 times a day (600 mg).

The duration of the course is assessed individually. For acute diseases, the course of treatment is from 5 to 10 days, for the treatment of chronic diseases - several months (as recommended by a doctor).

special instructions

When working with the drug, you must use glass containers and avoid contact with metals, rubber, oxygen, and easily oxidized substances.

You should not take the drug immediately before bedtime (it is recommended to take the drug before 18.00).

Storage

In a place protected from light, at a temperature not exceeding 25 °C.

Shelf life - 2 years (in plastic tubes) or 3 years (in aluminum tubes, strips).

Production

Sandoz d.d. (Slovenia).
Salutas Pharma GmbH (Germany).
Hermes Arzneimittel GmbH (Germany).
Hermes Pharma Ges. M. b. H. (Germany).

Package

1 tube of 20 effervescent tablets or 2 or 4 plastic tubes of 25 effervescent tablets in a cardboard box.
4 effervescent tablets in strips made of three-layer material, 15 strips in a cardboard box.

Recipe

Available without a prescription.

Side effects

The following side effects may occur during treatment:

nervous system: in rare cases - tinnitus, headaches ;
digestive system: stomatitis , vomiting , diarrhea , nausea , heartburn ;
heart and blood vessels: tachycardia , low blood pressure;
allergies: bronchospasm (in isolated cases - mainly in patients with bronchial hyperreactivity), urticaria , skin rash, itching ;
other manifestations: bleeding - in isolated cases.

When ACC is contraindicated, possible adverse reactions

The drug in any dosage form is not prescribed for hypersensitivity to acetylcysteine or other substances included in the composition.

The manufacturer also lists general contraindications as:

age up to two years;
aggravated gastric and duodenal ulcers;
coughing up blood, bleeding from the lungs;
state of pregnancy and breastfeeding period.

Effervescent tablets with a dosage of 100 mg are contraindicated in case of lactase deficiency, impaired absorption of substances in the intestines, or lactose intolerance.

According to the instructions, ACC 600 mg tablets and higher dosage powder are contraindicated for children under 14 years of age.

The powder is contraindicated in case of fructose intolerance, intestinal malabsorption syndrome, or sucrose deficiency.

Possible side effects of ACC have been studied in great detail. The main ones include:

manifestations of allergies. In rare cases, itching, rashes, angioedema, increased heart rate, and a drop in blood pressure are possible. Anaphylactic shock is extremely rare;
deterioration of the respiratory system: bronchospasms, breathing disorders;
disruptions in the gastrointestinal tract: the appearance of heartburn, pain in the abdomen, attacks of nausea and vomiting.

Very rarely, tinnitus, headache, and fever may occur.

Effervescent tablets ACC Long, instructions for use (Method and dosage)

The drug 600 mg is usually prescribed to patients over 14 years of age. The instructions for use of ACC Long 600 stipulate that the patient should take 1 effervescent tablet per day, this dose corresponds to 600 mg of acetylcysteine.

The tablet is dissolved in 1 glass of water and should be taken immediately after the tablet has dissolved. It is allowed to take the prepared solution for 2 hours in exceptional cases.

If we are talking about colds, then treatment continues for 5-7 days. If it is necessary to treat other diseases that have a longer course, the duration of therapy is determined by the doctor. People with chronic bronchitis are given longer treatment to ensure infection is prevented.

It is recommended to take the drug after meals.

When treating with ACC tablets, it is recommended to take additional fluid to ensure an enhanced mucolytic effect.

Instructions for use ACC® 200 (ACC® 200)

During the use of acetylcysteine, severe skin reactions such as Stevens-Johnson syndrome and Lyell's syndrome have been observed in very rare cases. If changes occur in the skin and mucous membranes, you should immediately stop taking acetylcysteine and seek medical help.

Caution should be exercised when treating acetylcysteine in patients suffering from bronchial asthma and patients with a history of gastric or duodenal ulcers, hemoptysis, pulmonary hemorrhage, patients with esophageal varices, phenylketonuria, diseases of the adrenal glands, renal and/or liver failure.

Caution should also be exercised in patients with histamine intolerance. In such patients, long-term therapeutic courses should be avoided, since ACC® 200 affects histamine metabolism and may cause intolerance symptoms (for example, headache, rhinitis, itching).

1 effervescent tablet contains 5.7 mmol (131 mg) sodium. This should be taken into account when using the drug in patients on a controlled sodium diet (low sodium/low salt).

When dissolving the drug, it is necessary to avoid its contact with metals, rubber, oxygen, and easily oxidized substances.

Impact on the ability to drive vehicles and operate machinery

There is no evidence of a negative effect on the ability to drive vehicles or operate machinery.

Results of preclinical safety studies

In animal studies, acute toxicity was low.

When studying chronic toxicity in studies on various animal species (rats, dogs) lasting up to 1 year, no pathological changes were revealed.

Acetylcysteine is not considered to have a mutagenic effect. In vitro studies showed negative results.

No studies have been conducted on the oncogenic potential of acetylcysteine.

No congenital malformations were observed in embryotoxicity studies in rabbits and rats. Fertility, perinatal and postnatal toxicity studies showed negative results.

Acetylcysteine crosses the placental barrier in rats and is found in amniotic fluid. The concentration of the L-cysteine metabolite in the placenta and fetal tissues exceeds the concentration in the maternal blood plasma for 8 hours after administration of the drug.

Interaction

In the case of simultaneous use of acetylcysteine and cough suppressants, due to suppression of the cough reflex, the likelihood of mucus stagnation increases. Therefore, such medications must be combined with caution.

If treatment with acetylcysteine and nitroglycerin , the vasodilatory effect of nitroglycerin may be enhanced.

Acetylcysteine is not compatible pharmaceutically with a number of antibiotics (cephalosporins, penicillins, Erythromycin , Amphotericin B , Tetracycline ) and with proteolytic enzymes.

tetracycline decreases . In this regard, it is necessary to observe an interval between taking these medications of at least 2 hours.

If acetylcysteine comes into contact with rubber or metals, sulfides with a characteristic odor are formed.

special instructions

It is important to use ACC Long with caution to treat patients with bronchial asthma and obstructive bronchitis. In this case, it is necessary to ensure systematic monitoring of bronchial patency.

If side effects occur during therapy, you should stop taking it and consult a specialist.

It is recommended to dissolve the tablets in glass containers to avoid contact with rubber, metal, and easily oxidized materials.

Patients with diabetes should take into account that one tablet corresponds to 0.01 XE.

Analogs

Level 4 ATX code matches:
Mukolik

Abrol

Ambrosan

Bronchorus

ACC 100

ACC 200

ACC

Mukolwan

Lazolvan

Bromhexine 8

Bromhexine 8 Berlin-Chemie

Bromhexine

Bronchobos

Carbocisteine

Erdomed

Pulmozyme

Pectolvan C

Halixol

Ambrobene

Acetylcysteine

Analogs of the drug ACC Long are:

ACC
ACC 100
ACC 200
ESPA-NAC
Mucocil Solution Tablets
N-AC-ratiopharm
Acetylcysteine
N-acetylcysteine
Eifa AC
Acestine
Fluimucil
Mucomist
Mukobene
Mukonex

The most optimal drug must be selected individually by a specialist.

ACC Long price, where to buy

The price of 600 mg tablets is from 350 rubles for 10 pieces. Packaging of the drug 20 pcs. can be purchased at a price of 650 rubles.

Online pharmacies in RussiaRussia
Online pharmacies in UkraineUkraine

ZdravCity

Acc Long tablets spike.
600 mg 20 pcs. Hermes Arzneimittel GmbH/Salutas Pharma, GmbH RUR 523 order
Acc Long tablets spike. 600 mg 10 pcs. Hermes Arzneimittel GmbH/Salutas Pharma, GmbH
RUR 384 order

Pharmacy Dialogue

ACC long (tab. spike 600 mg No. 10) Hermes
415 rub. order
ACC long (tab.spike.600mg No.20)Hermes
RUR 539 order
ACC long (tab.spike.600mg No.20)Hermes
RUR 727 order
ACC long (spike tab. 600 mg No. 20) Salutas Pharma GmbH
690 RUR order

Pharmacy24

ACC Long 600 mg No. 10 effervescent tablets Salutas Pharma GmbH.,Nimechchina/Hermes Artsnaimittel Gmb.H.Nimechchina
146 UAH.order
ACC Long Lemon 600 mg N6 tablets Salutas Pharma GmbH, Nimechchina
130 UAH order

ACC Long

Release form

Effervescent tablets. White, round, flat-cylindrical, with a chamfer and a notch on one side, with the smell of blackberries, there may be a slight sulfur smell. The reconstituted solution is colorless, transparent, with a blackberry odor; there may be a slight sulfuric odor.

Compound

Active ingredient: acetylcysteine (600 mg).

Excipients: citric acid, sodium bicarbonate, sodium carbonate, mannitol, lactose, ascorbic acid, sodium cyclamate, sodium saccharinate dihydrate, sodium citrate dihydrate, blackberry flavor “B”.

Pharmacological group

Secretolytics and stimulants of motor function of the respiratory tract.

Action

Acetylcysteine: description of the substance

Indications

Respiratory diseases and conditions accompanied by the formation of viscous and mucopurulent sputum: acute and chronic bronchitis, tracheitis, laryngotracheitis, bronchiolitis, pneumonia, lung abscess, bronchiectasis, bronchial asthma, COPD, interstitial lung diseases and atelectasis due to blockage of the bronchi by mucus plug, sinusitis (to facilitate the passage of secretions), cystic fibrosis. Inflammation of the middle ear, acute and chronic sinusitis, rhinosinusitis.

Contraindications and restrictions

Hypersensitivity to components;
hemoptysis, pulmonary hemorrhage;
peptic ulcer of the stomach and duodenum in the acute phase;
pregnancy and lactation;
children up to 14 years of age.

Carefully

history of gastric and duodenal ulcers;
bronchial asthma;
obstructive bronchitis;
liver and/or kidney failure;
histamine intolerance (long-term use should be avoided);
varicose veins of the esophagus;
adrenal gland diseases;
arterial hypertension.

Application and dosage

Inside , after eating.

Adults and children over 14 years of age: 1 effervescent tablet once a day (600 mg).

Effervescent tablets should be dissolved in one glass of water and taken immediately after dissolution; in exceptional cases, the ready-to-use solution can be left for 2 hours. Additional fluid intake enhances the mucolytic effect of the drug. For short-term colds, the duration of use is 5-7 days. For chronic bronchitis and cystic fibrosis, the drug should be taken for a longer period of time to achieve a preventive effect.

special instructions

For patients with diabetes: 1 effervescent tablet corresponds to 0.001 XE.

Storage

In a place protected from light, at a temperature not exceeding 30 °C. Shelf life: 3 years.

Production

Sandoz d. d. (Slovenia),
Salutas Pharma GmbH (Germany),
Hermes Arzneimittel GmbH (Germany).

Package

6, 10 or 20 effervescent tablets in a polypropylene tube in a cardboard box.

Recipe

Available without a prescription.