Butadione: descriptive instructions for tablets and ointments

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

A non-steroidal anti-inflammatory drug with anti-inflammatory , analgesic and antipyretic effects. The action of Phenylbutazone is associated with the suppression of the activity of cyclooxygenases, as a result of which the synthesis of prostaglandins is inhibited. Strengthens the reabsorption of water and salts in the kidney tubules.

Butadione eliminates pain and reduces swelling during the inflammatory process. The therapeutic effect is expressed in reducing pain at rest and during movement, restoring joint mobility or increasing the range of motion in them. The anti-inflammatory effect of Butadione is superior to that of Amidopyrine . With gout, in addition to these effects, there is a 2-fold increase in urate excretion in the urine, as well as a decrease in their level in the blood.

Butadione has an effect on thrombophlebitis (hemorrhoidal veins and postoperative). This results in a reduction in pain and inflammation.

Pharmacokinetics

When applying the ointment, absorption is no more than 5%. Phenylbutazone is metabolized in the liver and excreted as metabolites by the kidneys and 1/4 through the intestines. Elimination from blood plasma is long - 70 hours, in elderly people 105 hours.

When taking tablets, absorption is high and bioavailability is 87-90%. The maximum concentration of the drug in the blood is after 1-2 hours. From the blood it passes into organs and tissues, penetrates into the cavities of the joints and through the blood-brain barrier.

Metabolized in the liver. The half-life is 19-24 hours. It is excreted by the kidneys and through the gastrointestinal tract.

Instructions for use

Butadione is a drug that has anti-inflammatory, antipyretic, and analgesic effects . Can be used externally and orally depending on the release form.

pharmachologic effect

A nonsteroidal anti-inflammatory drug whose action is aimed at suppressing the activity of cyclooxygenases. This ensures inhibition of prostaglandin synthesis. Butadione eliminates swelling during the inflammatory process and also relieves pain.

A distinctive feature of Butadion therapy is the reduction of pain not only at rest, but also during movement . Thanks to this property, the range of motion of diseased joints increases.

For gout, the use of phenylbutazone increases the excretion of urate in the urinary fluid , which reduces its concentration in the blood.

For thrombophlebitis, the drug relieves the inflammatory process and relieves pain.

Release form, composition

Butadione is available in the form of ointments and tablets . The ointment has a thick, white consistency.

Butadione is available in two dosage forms

The ointment is produced in metallized tubes with a capacity of 20 g.

The drug is produced in tablets in quantities of 10 or 20 pieces in a package of 0.15 g for adults. For children, tablets - 0.03 and 0.05 g, 10 pieces in a blister pack.

Indications for use

Butadion ointment is indicated for use in the following cases:

• rheumatic soft tissue disease: tendovaginitis, bursitis, damage to periarticular tissues;
• the presence of muscle pain of a rheumatic nature or non-rheumatic origin:
• rheumatoid arthritis;
• restoration and reduction of inflammation after bruises, overstrain or sprain of soft tissues or joints;
• the presence of radiculitis, sciatica;
• swelling of soft tissues due to muscle or joint disease;
• osteoarthritis;
• lumbago;
• hematomas of various sizes;
• thrombophlebitis of superficial venous vessels;
• inflammation of hemorrhoidal nodules;
• inflammation associated with injections;
• swelling as a result of an insect bite;
• burn damage to tissues of the first or second severity.

Butadione ointment is used to eliminate symptoms of inflammation and reduce (eliminate) pain.

Butadione tablets are used in cases:

• inflammatory or destructive processes of the musculoskeletal system: gouty arthritis, arthritis caused by lupus erythematosus, psoriatic arthritis, ankylosing spondylitis;

Butadione tablets are prescribed for arthritis and to relieve pain of various etiologies.

• the presence of pain of various etiologies (toothache, headache, tenosynovitis, migraine, bursitis, headache, arthralgia, pain after bruises, injuries, migraines, after burns);
• the presence of a febrile state against the background of colds or infectious diseases.

The tablets are used as symptomatic therapy ; the drug does not affect the rate of recovery.

Directions for use, dosage

Butadione ointment is applied externally.

For adults and children over fourteen years of age: squeeze the ointment two to three centimeters onto the affected area. Does not require intensive rubbing. Distribute the product over the surface. You need to apply the ointment two to three times a day. The course of treatment is no more than 10 days.

Important! When using the ointment, you do not need to apply a tight bandage. Just wait until the product is absorbed.

Butadione tablets are used orally after meals . The number of doses is three to four times during the day.

The dosage rate for adults is 150 mg tablet per dose, for children - 75 mg . The daily intake should not be more than 600 mg. To reduce irritation of the child’s gastric mucosa, it is permissible to drink milk after taking the tablet.

In some cases, ointment is used in parallel with tablets. This helps achieve maximum therapeutic effect. It is important to control the daily dosage of the drug.

Interaction with other drugs

When using Butadion ointment, no interactions with other drugs were noted..

Phenylbutazone can enhance the effects of photosensitizing agents . It is not recommended to use other non-steroidal anti-inflammatory drugs with ointment.

Tablets can enhance the effect of fibrinolytics, antiplatelet agents, and indirect anticoagulants .

With the parallel use of morphine, estrogens, penicillin, and glucocorticosteroids, the side effects from their use may increase.

Sulvonylurea derivatives, when taken in parallel with phenylbutazone, enhance their effect.

There is an increase in the production of active metabolites when Butadione is taken simultaneously with barbiturates, ethanol, phenytoin, rifampicin, tricyclic antidepressants.

Absorption of the drug is reduced when taking antacids and cholestyramine in parallel .

Video: “How are sore throat and rheumatism related?”

Indications for use

For tablets:

• osteoarthritis;
• ankylosing spondylitis;
• rheumatoid and lupus arthritis ;
• psoriatic arthritis;
• gouty arthritis;
• bursitis, tenosynovitis;
• algodismenorrhea;
• pain relief from burns, neuralgia, radiculitis ;
• postoperative pain syndrome;
• toothache and headache .

For ointment:

• tendovaginitis, bursitis;
• inflammation of periarticular tissues;
• muscle and tendon strains bruises ;
• hematomas;
• muscle pain;
• rheumatoid arthritis , osteoarthritis ;
• lumbago, sciatica;
• thrombophlebitis of superficial veins;
• phlebitis;
• inflammation of hemorrhoids ;
• inflammation at the sites of intramuscular and intravenous injections;
• insect bites;
• burns of the 1st and 2nd degrees.

The drug is used for symptomatic therapy to reduce pain and inflammation.

Contraindications

• intolerance to acetylsalicylic acid ;
• hypersensitivity to phenylbutazone;
• exacerbation of peptic ulcer and ulcerative colitis ;
• history of gastrointestinal bleeding;
• decompensated CHF;
• heart rhythm disturbances;
• bone marrow suppression;
• hyperkalemia;
• pregnancy in the 1st and 3rd trimester;
• liver and kidney failure ;
• age up to 12 years;
• simultaneous use of other drugs containing phenylbutazone;
• violation of the integrity of the skin in eczema and trophic lesions (for ointment).

Side effects

Butadione ointment can cause local reactions: itching, redness, peeling, eczema, photosensitivity, swelling, the appearance of papules and vesicles . Allergic reactions in the form of urticaria, Quincke's edema, bronchospasm .

When taking tablets, systemic reactions are more pronounced:

• abdominal pain, dyspepsia ;
• nausea, vomiting;
• ulceration of the gastrointestinal mucosa, with prolonged use in significant doses;
• heartburn, diarrhea;
• aphthous stomatitis ;
• bleeding - gastrointestinal, hemorrhoidal and gingival;
• liver dysfunction;
• increased blood pressure ;
• headache, drowsiness, depression, agitation, dizziness;
• noise in ears;
• anemia, agranulocytosis, leukopenia, thrombocytopenia.

Blood reactions require discontinuation of treatment. The retention of sodium and water in the body, caused by taking butadione, worsens the condition of patients with CHF and hypertension. This point also requires correction in treatment.

BUTADIONE TABLETS

Pharmachologic effect:

NSAIDs; has anti-inflammatory, analgesic and antipyretic effects associated with suppression of the activity of COX1 and COX2, which regulate the synthesis of Pg. Shows uricosuric effect.

Indications:

Inflammatory and degenerative diseases of the musculoskeletal system: rheumatoid, gouty, psoriatic arthritis, ankylosing spondylitis (Bechterew's disease), osteoarthritis, arthritis with SLE (as part of complex therapy). Pain syndrome: bursitis, tendovaginitis, arthralgia, myalgia, neuralgia, dental and headache (including migraine) pain, algodismenorrhea, pain from injuries, burns. Feverish syndrome with “colds” and infectious diseases.

Contraindications:

Hypersensitivity (including a history of aspirin-type drugs), “aspirin” triad (a combination of bronchial asthma, recurrent nasal polyposis and paranasal sinuses and intolerance to ASA and pyrazolone-type drugs), erosive and ulcerative lesions of the gastrointestinal tract in the acute stage (peptic ulcer of the stomach and duodenum, ulcerative colitis, peptic ulcer), bone marrow depression, decompensated CHF or pulmonary heart failure, severe hepatic and/or renal failure. With caution. Hyperbilirubinemia, bronchial asthma, CHF, edema, arterial hypertension, hemophilia, hypocoagulation, liver failure, chronic renal failure, hearing loss, pathology of the vestibular apparatus, blood diseases, diabetes mellitus, SLE, polymyalgia rheumatica, transient arteritis, inflammatory and ulcerogenic diseases of the gastrointestinal tract, stomatitis, pregnancy, lactation period.

Side effects:

From the digestive system: dyspepsia, NSAID gastropathy, abdominal pain, nausea, vomiting, heartburn, diarrhea or constipation; with long-term use in large doses - ulceration of the gastrointestinal mucosa, aphthous stomatitis, glossitis, erosive esophagitis, bleeding (gastrointestinal, gingival, hemorrhoidal), liver dysfunction. From the cardiovascular system: increased blood pressure, tachycardia. From the nervous system: headache, dizziness, drowsiness, depression, agitation. From the senses: hearing loss, tinnitus. From the hematopoietic organs: agranulocytosis, leukopenia, anemia, thrombocytopenia. Allergic reactions: skin rash, itching, urticaria, bronchospasm, edema syndrome, angioedema. Other: increased sweating, uterine bleeding. Overdose. Symptoms: cyanosis of the fingertips, lips, body skin, dizziness, headache, increased or decreased blood pressure, hyperventilation of the lungs, clouding of consciousness, in children - myoclonic convulsions, nausea, vomiting, abdominal pain, hemorrhages, impaired liver and kidney function. Treatment: gastric lavage, administration of activated carbon, symptomatic therapy aimed at maintaining the vital functions of the body. Forced diuresis and hemodialysis are ineffective.

Directions for use and dosage:

Orally, 0.2-0.4 g during or after meals 3-4 times a day. Children aged 6 months and older - 0.01-0.1 g (depending on age) 3-4 times a day. Duration of therapy is 2-5 weeks or more.

Special instructions:

During treatment, monitoring of the peripheral blood picture and the functional state of the liver and kidneys is necessary. If it is necessary to determine 17-ketosteroids, the drug should be discontinued 48 hours before the study. During treatment, you should refrain from engaging in potentially hazardous activities that require increased attention and speed of mental and motor reactions.

Interaction:

Enhances the effect of indirect anticoagulants, antiplatelet agents, fibrinolytics, side effects of GCS and MCS, estrogens, morphine, PAS, penicillin, hypoglycemic effect of sulfonylurea derivatives. Reduces the effectiveness of uricosuric, antihypertensive drugs and diuretics. Increases the concentration of Li+ and methotrexate in the blood. Inducers of microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites. Antacids and cholestyramine reduce absorption. Myelotoxic drugs increase the manifestations of hematotoxicity of the drug.

Instructions for use of Butadione (Method and dosage)

Butadion ointment, instructions for use

Apply externally to intact skin.

Adults and children over 14 years of age: a 2-3 cm strip is applied in a thin layer, without intensive rubbing, 2-3 times a day. Do not apply a tight bandage. Treatment lasts 7-10 days, after which it is necessary to consult a doctor.

There is no special regimen for elderly patients. If there is redness of the skin or itching at the site of application of the drug, treatment should be stopped.

Butadione tablets, instructions for use

Orally after meals, 150 mg 3-4 times a day. The highest single dose is 200 mg, the daily dose is 600 mg. The duration of therapy depends on the severity of the condition. A dose of Butadione 400–600 mg per day reduces the amount of urine in diabetes insipidus .

Children over 12 years of age are prescribed 75 mg 3 times. The irritant effect of the drug on the gastric mucosa can be reduced by drinking milk.

For joint diseases, the effect is enhanced when combined with prednisolone (intravenous drips).

Why are Butadione ointment and tablets used simultaneously? This combined use allows you to achieve greater effect. In this case, it is necessary to take into account the maximum SD.

Butadione tablets 150 mg No. 20

• Increases the concentration of lithium and methotrexate in the blood.

• Inducers of microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, rifampicin, tricyclic antidepressants) increase the production of hydroxylated active metabolites.

• Antacids and cholestyramine reduce absorption.

• Myelotoxic drugs increase the manifestations of hematotoxicity of the drug.
  

  Overdose

  Symptoms: cyanosis of the coccyxes of the fingers, lips, body skin, dizziness, headache, increased or decreased blood pressure, hyperventilation of the lungs, clouding of consciousness, in children - myoclonic convulsions, nausea, vomiting, abdominal pain, hemorrhages, impaired liver and kidney function .
  Treatment: gastric lavage, administration of activated carbon, symptomatic therapy aimed at maintaining the vital functions of the body. Forced diuresis and hemodialysis are ineffective.

  Impact on the ability to drive vehicles and operate machinery

  During treatment, you should refrain from engaging in potentially hazardous activities that require increased attention and speed of mental and motor reactions.

Overdose

When using the ointment, low absorption of the drug is observed, so an overdose is impossible. When swallowing ointment (more than 20 g), systemic reactions occur.

An overdose of tablets is manifested by cyanosis of the fingers and lips, dizziness, headache, decreased blood pressure, and clouding of consciousness .

Symptoms of overdose in children: abdominal pain, myoclonic convulsions, hemorrhages, nausea, vomiting . Treatment begins with gastric lavage, sorbents, antacids, and proton pump inhibitors are prescribed.

Price

Conditions for dispensing from pharmacies

Butadione ointment and tablets are available from pharmacies freely without a prescription.

Interaction

The interaction of the ointment with other drugs has not been described. May enhance the effect of photosensitizing drugs. It is necessary to avoid the simultaneous use of Butadione with other NPVs.

Taking tablets enhances the effect of antiplatelet agents, fibrinolytics and indirect anticoagulants. Increases the side effects of glucocorticosteroids, estrogens, morphine , penicillin. Enhances the effect of hypoglycemic drugs of sulfonylurea derivatives.

Reduces the effectiveness of antihypertensive drugs and diuretics.

Phenytoin, barbiturates, ethanol, tricyclic antidepressants and rifampicin increase the production of active metabolites of the drug. Cholestyramine and antacids reduce the absorption of butadione.

special instructions

Treatment should be carried out under the control of peripheral blood and urine. Patients with hypertension and CHF need to limit their intake of table salt. When used together with other NSAIDs, it is necessary to consult your doctor and take into account the maximum daily dose.

Do not allow the ointment to get into the eyes or mucous membranes. The ointment should not be used in the treatment of deep vein thrombophlebitis. To prevent photosensitivity when using the ointment, you need to protect the skin from sunlight.

Analogs

Level 4 ATC code matches:
Voltaren Emulgel

Ultrafastin

Indomethacin

Dicloran

Dicloran Plus

Dolgit

Nise

Ketonal

Ketorol

Febrofeed

Fastum gel

Diclofenac

Finalgel

Bystrumgel

Deep Relief

Diklovit

Artrosilene

Olfen

Fanigan Fast

Butadione-OBL, Phenylbutazone, Artrisin, Butalidone, Reumazole.

Reviews about Butadion

Analyzing reviews of the tablets, we can conclude that the drug is moderately effective. For example, for osteoarthritis, the drug was taken for 14 days without visible improvement. Due to the fact that most patients have complications from the blood and gastrointestinal tract, despite the fact that the effectiveness of the drug is average, doctors have recently recommended abandoning it.

Butadion ointment is often used. Positive reviews of Butadione ointment are associated with its use for minor injuries, sprains of muscles, ligaments and tendons. In these conditions it is very effective and economical. An ointment is indispensable for pain and redness of the skin at the sites of vaccinations, injections or insect bites.

For rheumatic joint diseases, the ointment is used as part of complex therapy, so it is impossible to evaluate its effectiveness.

Reviews

Reviews of Butadione indicate a difference in the effectiveness of ointments and tablets. Patient reviews of the drug Butadione in tablets and in the form of ointment vary.

More negative reviews about the tablets are based on the occurrence of adverse reactions from the digestive system.

Many patients complain of stomach pain and lack of therapeutic effect.

Unlike tablets, Butadion ointment has much better reviews.

Patients note the rapid elimination of muscle pain after use, and also indicate the effectiveness of the product for sprains and injuries of varying severity.

If you have had to use tablets or use Butadion ointment in your own experience, please leave your review: perhaps it will be useful to other people.

Butadion price, where to buy

You can buy it at any pharmacy in Moscow; to obtain information about the availability of the drug, you can use the data of the Federal Information Service www.poisklekarstv.ru. The price of Butadion ointment ranges from 104 rubles. up to 191 rub. Price of tablets 150 mg No. 20 from 35 rub. up to 67 rub.

• Online pharmacies in RussiaRussia
• Online pharmacies in UkraineUkraine
• Online pharmacies in KazakhstanKazakhstan

ZdravCity

• Butadione ointment for nar.
  approx. 5% tube 20g No. 1Ozon LLC 154 rub. order

Pharmacy Dialogue

• Butadione ointment (tube 5% 20g) Gedeon-Richter

  RUB 242 order

• Butadione (tab. 150 mg No. 20) Obolenskoye pharmaceutical representative.

  RUB 143 order

• Butadione ointment (tube 5% 20g) Ozone LLC

  146 RUR order

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Pharmacy24

• Butadione 0.05 g/1 g 20 g ointment VAT "Gedeon Richter", Ugorshchina
  93 UAH. order

PaniPharmacy

• Butadione ointment Butadione ointment 5% 20g Hungary, Gedeon Richter

  93 UAH order

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Release form and composition

Butadione is available in the form of tablets and ointments with the main active ingredient phenylbutazone.

Tablets of 0.15 g and film-coated tablets of 0.03 and 0.05 g.

Ointment for external use is a homogeneous white mass, has a slight specific odor, with a 5% phenylbutazone content.

Excipients: sodium carboxymethylcellulose, polysorbate 60, methyl parahydroxybenzoate, colloidal silicon dioxide, glycerol 85%, liquid paraffin, propylene glycol, purified water.

Butadion supplies the pharmacy chain with:

• Tablets – in blister packs of 10 and 20 pieces;
• Ointment - in aluminum tubes of 20 g or in dark glass jars of 10, 15, 20, 25, 30, 35 and 50 g.