Pimafukort cream and ointment: instructions for use, price and reviews. Analogues of the drug

Pimafucort is an imported universal remedy that is available in the form of ointment and cream. It has a wide range of medicinal effects: antifungal, anti-inflammatory, local antibacterial and glucocorticoid. The cost depends on the pharmacy chain and varies in the range of 500–600 rubles.

If there is a need to find a cheaper analogue of Pimafucort, you should carefully read the instructions for the substitute, study the features of use, indications and possible side effects. Pimafucort is sold without a prescription.

Compound

The amount of biologically active components does not change at all depending on the form of release of the pharmaceutical product. In both cream and ointment, the basic ratio is maintained:

natamycin – 10 mg;
neomycin sulfate – 3500 units;
micronized hydrocortisone - 10 mg.

What really distinguishes the variations in release forms to a significant extent are the excipients, there are many more of them in the cream, which indicates a more selective action of the drug. This creates a harmonious background for the active components:

F-emulsifier – 115 mg;
cethiol V 150;
cetyl ether wax – 60 mg;
sorbitan stearate – 30 mg;
macrogol stearate 100 – 20 mg;
sodium citrate – 14 mg;
methyl parahydroxybenzoate – 2 mg;
propyl parahydroxybenzoate – 0.5 mg;
purified water – up to 1000 mg.

The excipient of the ointment is only the ointment base in the amount of 976.5 mg (in mass fractions it contains 95 percent paraffin and 5 percent PE).

Composition and release form

Cream	1 g
natamycin	10 mg
neomycin (as neomycin sulfate)	3500 units
hydrocortisone micronized	10 mg
excipients: sodium citrate - 14 mg; emulsifier F - 115 mg; sorbitan stearate – 30 mg; cetyl ether wax - 60 mg; cethiol V 150; macrogol stearate 100 - 20 mg; methyl parahydroxybenzoate - 2 mg; propyl parahydroxybenzoate - 0.5 mg; purified water - up to 1000 mg

in aluminum or plastic tubes of 15 g; 1 tube in a box.

Ointment	1 g
natamycin	10 mg
neomycin (as neomycin sulfate)	3500 units
hydrocortisone micronized	10 mg
excipients: PE ointment base (95% liquid paraffin, 5% PE) - 976.5 mg

in aluminum or plastic tubes of 15 g; 1 tube in a box.

Pharmacological action

Pimafucort is a complex pharmaceutical drug, because at the same time the drug has antibacterial, anti-inflammatory and antifungal effects . Due to the presence of such an active component as neomycin sulfate , which has antibiotic properties, the medicine can help even in cases of infection with gram-negative microorganisms, for example, Proteus, Klebsiella or Escherichia . Gram-positive bacteria, such as staphylococci or enterococci , also respond well to treatment with Pimafucort.

Natamycin, another active ingredient of the drug, belongs to the pharmaceutical group of macrolides , a subgroup of synthetic polyenes, that is, like Neomycin, it is an antibiotic in nature. However, Natamycin is more active against yeast and yeast-like fungi and dermatophytes. With the help of this component, you can defeat such families of microorganisms as Candida, Aspergilus, Trichophyton and others. Natamycin is also active against protozoa, for example, Trichomonas and Fusarium .

Hydrocortisone completes the trio of active ingredients of the drug. This is a hormone, therefore its range of therapeutic effects is the widest:

reduces the sensation of itching ;
reduces the manifestations of inflammation in pathologies of the skin (especially hyperthermia and hyperemia);
inhibits hypersensitivity reactions;
suppresses active processes of alteration , exudation and proliferation ;
prevents activation of phospholipase A2 , thus stopping the synthesis of prostaglandins and the release of macrophage chemotactic factor;
inhibits the activity of hyaluronidase ;
blocks the synthesis and release of sensitized baso0 and eosinophils;
suppresses various stages of the local immune process without having a mitostatic effect .

Therefore, the question “Is Pimafucort hormonal or not?” should not stand, because the drug actually contains active micronized Hydrocortisone , which is an active endogenous hormone of the adrenal glands. However, contrary to stereotypical and unfounded rumors and fears, it is the hormonal basis that creates the diversity of the therapeutic effect of a pharmaceutical drug, which is observed during the conservative course of treatment of various diseases.

Pharmacodynamics

Neomycin is a broad-spectrum antibiotic from the group of aminoglycosides, active against a number of gram-positive (Staphylococcus spp., Enterococcus spp.) and gram-negative (Klebsiella spp., Proteus spp., Escherichia coli, etc.) bacteria.

Natamycin is a polyene antifungal drug that has a fungicidal effect against yeast and yeast-like fungi, especially Candida spp. Dermatomycetes are less sensitive to natamycin.

Hydrocortisone has anti-inflammatory and vasoconstrictor effects.

Eliminates inflammation and itching that accompany various types of dermatoses.

Pharmacodynamics and pharmacokinetics

The pharmaceutical drug has a low adsorptive threshold on intact skin, that is, the active components are practically not absorbed into the body unless the condition requires it (the bioavailability of hydrocortisone is about 1-3 percent). However, when applied to wound defects (scratches, abrasions, ulcers, etc.) or mucous membranes, Pimafucort’s ability to be absorbed increases several times. Thus, eczematous lesions absorb 2 times better than undamaged areas, and infectious lesions – 4 times better.

Pharmacokinetics

Natamycin and neomycin are practically not absorbed through intact skin and mucous membranes. Absorption of neomycin through damaged skin is possible when the drug comes into contact with wounds or ulcers. From 1 to 3% of hydrocortisone is absorbed through intact skin; with dermatitis, the amount of absorbed hydrocortisone increases by 2 times; with infectious skin lesions it can increase up to 5 times. In children, the absorption of hydrocortisone through intact skin is higher than in adults; the degree of absorption of the drug into the systemic circulation decreases with age.

Indications for use

What Pimafucort ointment helps with is listed in the following list:

cutaneous mycoses - diseases with a fungal etiology (caused by invasion of fungal microorganisms ) that affect the skin of the human body;
superficial dermatoses , if the infectious agent is sensitive to the active ingredients of the drug;
pyoderma – purulent skin lesions due to invasion of pathological microorganisms;
complication of secondary fungal and/or bacterial infection (for example, candidiasis );
otomycosis - inflammation of the external auditory canal and auricle due to infection by parasitic fungi that grow in the thickness of the skin.

Contraindications

You should not include Pimafucort cream or ointment in a course of conservative treatment if you have:

individual hypersensitivity or intolerance to the components of the pharmaceutical drug;
cutaneous form of syphilis ;
rosacea (popularly simply “ rosacea ”) is a chronic disease with damage to the facial skin due to angioedema and a recurrent course;
ichthyosis (or diffuse keratoma ) - a congenital pathology of increased keratinization of the dermis and its appendages;
anogenital itching – unpleasant sensations of discomfort in the genital area and anus;
tuberculosis with predominant damage to the skin (extrapulmonary form of the disease);
acne (ordinary acne ), regardless of the etiological factor;
skin reactions after injections;
skin diseases of oncological origin;
viral lesions of the integument;
side effects from taking pharmaceutical drugs of the corticosteroid group - perioral dermatitis or striae (striatal atrophoderma - stretched skin in the form of white or purple stripes) on the surface of the body;
increased fragility of skin blood vessels, especially at the site of treatment with the drug.

Side effects

First of all, adverse reactions occur extremely rarely ; in approximately 0.1% of cases of conservative treatment with Pimafucort cream or ointment, the following side effects may be observed:

withdrawal syndrome with abrupt cessation of the therapeutic course;
the appearance of stretch marks if the drug is used in areas of permanent skin folds;
perioral dermatitis;
atrophy or thinning of the skin;
telangiectasia (“spider veins”) and even purpura ;
hypertrichosis – excessive hair growth on unusual areas of the skin, inappropriate for gender and age;
hypersensitivity reactions to the components of the drug - skin itching , burning , hyperemic redness , local dryness ;
Increased intraocular pressure and increased risk of developing cataracts when using liniments on the face.

Directions for use and doses

Externally. For adults and children, the drug is applied to the affected areas of the skin 2–4 times a day. The duration of treatment is determined individually, taking into account the nature of the disease; the course of treatment usually does not exceed 14 days.

In children, it is used under the supervision of a physician; the drug should be applied to limited areas of the skin; occlusive dressings should not be used.

In the form of a cream, the drug is recommended for the treatment of acute and subacute dermatoses, incl. accompanied by wetting. The ointment is intended for the treatment of subacute and chronic dermatoses, especially in the presence of severe dry skin, lichenification, seborrhea, or in cases where the occlusive properties of the ointment are necessary.

Pimafukort ointment, instructions for use (Method and dosage)

The drug is prescribed in different dosage forms for the treatment of various pathologies. Thus, acute dermatoses are predominantly treated with Pimafucort cream, and chronic, sluggish pathologies are treated with ointment. The ointment is especially effective if an occlusive dressing or the skin has become dry and lichenification (a secondary morphological element of a skin rash in the form of local thickening, pigmentation and increased pattern).

The pharmaceutical preparation is applied to the affected area of the skin 2-4 times a day, depending on the extent and severity of the pathological process. The instructions for use of Pimafukort state that the duration of the course of treatment is determined by a dermatologist; it usually lasts from 2 weeks to 1 month. It is not recommended to continue treatment for more than 14 days in young children, since their skin is still in the process of formation and the use of a pharmaceutical drug can cause side effects much faster than in adults.

Pimafucort - instructions for use

The medicine is applied topically to the infected area of skin two to four times a day. Given the nature of the disease, the drug is usually prescribed for no more than 2 weeks. If during this time no changes for the better are noticeable, you should consult a doctor and discuss what can replace Pimafucort. Perhaps the diagnosis was made incorrectly, or the pathogenic pathogens are resistant to the substances in the composition.

In pediatrics, the medication is approved for use from one year of age. It is forbidden to use on damaged areas of the skin, with tuberculosis of the dermis, and with viral skin diseases.

Many patients are interested in the question of how Pimafucort is dispensed - with a prescription or not? The medicine and analogues are sold without a doctor's prescription.

Pimafucort cream or ointment – which is better?

If the doctor does not indicate the release form of Pimafucort, the patient has a question - what to buy: ointment or cream. The difference between them is not significant. The price is approximately the same, the ointment is a little more expensive. The active ingredients are similar.

The main difference is the basic components of the drug and its further action. The cream has the property of being quickly and completely absorbed. The ointment contains Vaseline, which is why it is not absorbed immediately and leaves a greasy sheen. Compared to ointment, cream can be used on damp areas of the skin.

Overdose

There is no confirmed information about drug overdose or undesirable effects of increased concentrations of the ointment, however, there is a theoretical possibility of ototoxicity , that is, damage to the hearing aid as a result of conservative treatment. This possibility appears if, during the treatment of otomycosis and the application of Pimafucort into the external auditory canal, there are cracks or perforations in the eardrum. This will open up the possibility of Neomycin affecting the middle ear, which may result in its damage and partial or complete hearing loss.

Pimafucort analogues

Composition and release forms

Cream 1 g natamycin 10 mg neomycin (in the form of neomycin sulfate) 3500 IU micronized hydrocortisone 10 mg excipients: sodium citrate - 14 mg; emulsifier F - 115 mg; sorbitan stearate – 30 mg; cetyl ether wax - 60 mg; cethiol V 150; macrogol stearate 100 - 20 mg; methyl parahydroxybenzoate - 2 mg; propyl parahydroxybenzoate - 0.5 mg; purified water - up to 1000 mg

Ointment 1 g natamycin 10 mg neomycin (in the form of neomycin sulfate) 3500 units micronized hydrocortisone 10 mg excipients: PE ointment base (95% liquid paraffin, 5% PE) - 976.5 mg

pharmachologic effect

Local antifungal, local anti-inflammatory, antibacterial. Neomycin is a broad-spectrum antibiotic from the group of aminoglycosides, active against a number of gram-positive (Staphylococcus spp., Enterococcus spp.) and gram-negative (Klebsiella spp., Proteus spp., Escherichia coli, etc.) bacteria.

Natamycin is a polyene antifungal drug that has a fungicidal effect against yeast and yeast-like fungi, especially Candida spp. Dermatomycetes are less sensitive to natamycin.

Hydrocortisone has anti-inflammatory and vasoconstrictor effects.

Eliminates inflammation and itching that accompany various types of dermatoses. Indications

Dermatoses amenable to GCS therapy, complicated by secondary bacterial and/or fungal infection (especially caused by fungi of the genus Candida). Contraindications

hypersensitivity to the components of the drug;

skin tuberculosis, skin manifestations of syphilis, viral skin infections, skin post-vaccination reactions, open wounds, ulcers;

acne, rosacea, ichthyosis;

anogenital itching, skin tumors.

Carefully:

tuberculosis (systemic lesion);

children under 1 year of age;

in patients with a history of damage to the IX pair of cranial nerves due to the use of aminoglycosides;

the presence of perforation of the tympanic membrane and direct exposure of the middle ear to neomycin (there is a risk of ototoxicity). Use during pregnancy and breastfeeding

When prescribing the drug during pregnancy, it is necessary to take into account the theoretical risk of the ototoxic effect of neomycin, and therefore the drug should not be used for a long time and should not be applied under occlusive dressings. Side effects

Side effects with external use of Pimafucort®, as with the use of other corticosteroids, develop rarely and are reversible.

Rarely, a hypersensitivity reaction (itching, burning, redness or dry skin) may occur.

Extremely rare - atrophy and thinning of the skin, telangiectasia, striae, purpura, rosacea-like and perioral dermatitis, delayed wound healing, depigmentation, hypertrichosis, withdrawal syndrome after cessation of treatment.

When using external corticosteroids for a long time, on large areas of skin or when using occlusive dressings, especially in children, side effects characteristic of systemic corticosteroids, such as suppression of adrenal cortex function, may develop.

Contact dermatitis when using neomycin. Interaction

Cross-hypersensitivity may occur between neomycin, kanamycin, paromomycin, gentamicin; cross-resistance between neomycin and other aminoglycoside antibiotics. Directions for use and doses

In children, it is used under the supervision of a physician; the drug should be applied to limited areas of the skin; occlusive dressings should not be used.

There is no information about an overdose of the drug. There is a theoretical possibility of an ototoxic effect of neomycin if the drug is applied to the area of the external auditory canal in the presence of perforation of the eardrum and direct exposure of the middle ear to neomycin. special instructions

When applying Pimafucort® to the eyelids and periorbital area, there is a risk of increased intraocular pressure and the development of cataracts.

When using the drug in children on large surfaces or under bandages, it is necessary to keep in mind the possibility of suppressing the function of the hypothalamic-pituitary-adrenal system.

In the case of prolonged treatment, in the presence of wounds and ulcers, there is a theoretical risk of ototoxic and nephrotoxic effects of neomycin.

If superinfection or excessive fungal growth occurs, discontinue use of the drug and take appropriate measures. Conditions for dispensing from pharmacies

On prescription. Storage conditions

At a temperature not exceeding 25 °C.

Keep out of the reach of children. Best before date

3 years.

Do not use after the expiration date stated on the package.

special instructions

When using the drug, you should remember the possibility of developing adrenocortical suppression - a condition when the production of corticosteroids by the adrenal glands is suppressed, since hydroxycortisone . In this case, you should immediately stop using Pimafucort and contact a qualified specialist for help.

The active ingredients of Pimafucort (Neomycin, Natamycin) are antibiotics , therefore, when carrying out conservative treatment, the general rules of antibiotic therapy :

Strictly adhere to recommendations on the duration of taking medications so that microorganisms do not develop resistance to certain groups of pharmacological drugs.
Follow the dosage of the drug flawlessly.
Do not stop the course of conservative treatment on your own, unless the reason is side effects or unwanted reactions.

Pimafucort or Triderm – which is better?

Manufacturer: Schering Plau, Belgium
Release form: cream and ointment

Active ingredients: betamethasone, gentamicin, clotrimazole

Synonyms: Akriderm GK, Kanizon Plus

The price of Pimafucort is more favorable compared to Triderm, given that both medications are imported and have a multicomponent composition.

To determine which drug is better, you should consult a doctor and have a skin scraping taken for analysis. Only from the results will it be clear which components of the drug are more sensitive to infection and which are resistant.

Pimafukort's analogs

Level 4 ATC code matches:
Fucidin G

Cortomycetin

Oxycort

Hyoxysone

At the moment, there are no identical analogues of Pimafukort ointment on the pharmaceutical market, however, there are combination drugs that include glucocorticosteroids , antifungals and antibiotics in different variations. These are pharmacological analogues of Pimafucort, because such drugs have similar therapeutic effects and are used to treat similar pathologies:

Dexa-Gentamicin ( Gentamicin and Dexamethasone );
Oxycort ( Hydrocortisone and Oxytetracycline );
Flucinar ( Neomycin and Fluocinolone ).

As a rule, the price of analogues differs from the cost of Pimafucort, since such drugs usually do not have a pronounced antifungal effect. For example, the price of Oxycort is about 50 hryvnia in Ukraine, but in online pharmacies the drugs usually cost even less.

For children

The use of the drug for young children (especially for infants and newborns ) is strictly contraindicated, since the skin of a child at such a young period of development of his own body is still in the process of formation, that is, they are gradually adapting to a new, unusual external environment. Therefore, unwanted reactions or side effects of treatment may appear much earlier, which is fraught with serious consequences, which are primarily cosmetic in nature.

Reviews of Pimafucort

Reviews about Pimafukort are filled with positive emotions. Often there are pleasant impressions from new mothers who use the cream for children to get rid of the first rashes on the child’s skin, since the drug has a small number of side effects along with the breadth of its therapeutic effect.

However, there are often reviews about the uselessness of using the ointment for a long time. Such patients, as a rule, neglect the doctor’s recommendations and independently change Pimafucort to a cheaper analogue, which should not be done under any circumstances, because the dermatologist is much more familiar with the pathology of the skin.

There are also clinical cases where, after using the ointment, an exacerbation of the underlying disease occurred. The likelihood of such an outcome is indicated by the information insert in the cardboard packaging of the drug. If the disease has entered the progression stage, you must immediately stop taking Pimafucort and contact a qualified specialist as soon as possible.

In reviews of the drug, there is often a question that is better, cream or ointment, to which there is no single correct answer, because there are differences in the indications for the use of various pharmaceutical forms, excipients that create the necessary background for the full effect of the active ingredients. So the cream more effectively fights acute pathology of the skin, while the ointment better treats chronic recurrent diseases.

Pimafucort price, where to buy

The price of Pimafukort cream, as well as the ointment, in the Russian Federation is about 400 rubles. In Ukraine, the price of Pimafukort ointment fluctuates around 130 hryvnia, depending on the selected pharmacy chain. It is more profitable to order the drug from online pharmacies, where the price of medicinal products is several times lower.