Cyclodinone drops and tablets: instructions for use, price, reviews from doctors, analogues. Is this a hormonal drug?

Compound

100 grams of Cyclodinone drops include 193-288 mg of dry extract of common twig . Additional substances: polysorbate 20, 70% sorbitol , povidone , mint flavor, water, sodium sucrose dihydrate, 96% ethanol.
1 tablet of Cyclodinone contains 3.3-4.8 mg of dry extract of common twig . Additional substances: microcrystalline cellulose, indigotine, silicon dioxide, povidone , lactose monohydrate, starch, magnesium stearate, titanium dioxide, talc, iron oxide, macrogol 6000 , emethacrylic acid copolymer, ethacrylic acid copolymer.

Pharmacodynamics and pharmacokinetics

Is cyclodinone a hormonal drug?

The medicine is obtained from raw materials of plant origin, so it is not hormonal, but has a normalizing effect on the content of sex hormones.

Mechanism of action

The main component is ordinary twig . The dopaminergic effects of the drug eliminate hyperprolactinemia prolactin production . An increased content of prolactin disrupts the synthesis of gonadotropins , which can cause disturbances in the development of follicles, the corpus luteum and ovulation , which leads to an imbalance of estradiol and progesterone and can cause mastodynia and changes in the menstrual cycle.

Prolactin demonstrates a stimulating effect on the development of cells in the mammary glands and can stimulate the appearance of connective tissue, as well as cause an enlargement of the milk ducts.

prolactin content causes regression of pathological processes in the mammary gland and reduces pain. Correct production and regulation of the proportion of gonadotropic hormones normalizes the 2nd phase of the menstrual cycle.

Cyclodinone 30 film-coated tablets

Registration Certificate Holder

BIONORICA (Germany)

Dosage form

Medicine - Cyclodinone® (Cyclodynon®)

Description

Film-coated tablets

greenish-blue color, with a matte surface, round, biconvex.

1 tab.

dry extract of common twig fruit* (7-11:1) 4 mg

Extractant:

ethanol 70% v/v. * Latin name - Vitex agnus-castus L.

Excipients

: povidone K30, colloidal silicon dioxide, potato starch, lactose monohydrate, microcrystalline cellulose, magnesium stearate, talc, titanium dioxide (E171), yellow iron oxide dye (E172), indigo carmine aluminum varnish (E132), macrogol 6000, ammonium methacrylate copolymer ( type A).

15 pcs. - blisters (2) - cardboard packs. 15 pcs. - blisters (4) - cardboard packs.

Indications

menstrual irregularities;
premenstrual syndrome;
mammalgia.

Contraindications for use

mammary cancer;
pituitary tumors;
age under 18 years (there are no data on the effectiveness and safety of the drug in this age group);
pregnancy;
breastfeeding period;
lactose intolerance, lactase deficiency, glucose-galactose malabsorption (due to lactose content in the drug);
individual hypersensitivity to the components of the drug.

With caution
It is necessary to take precautions if patients have a history of estrogen-dependent malignant neoplasms and pituitary diseases.

pharmachologic effect

The components of the drug have a normalizing effect on the concentration of sex hormones.

The main active component of the drug is common twig. The dopaminergic effects of the drug, causing a decrease in prolactin production, eliminate hyperprolactinemia. An increased concentration of prolactin disrupts the secretion of gonadotropins, which can result in disturbances in follicular maturation, ovulation and the formation of the corpus luteum, which further leads to an imbalance between estradiol and progesterone and can cause menstrual irregularities, as well as mastodynia. Unlike estrogens and other hormones, prolactin also has a direct stimulating effect on proliferative processes in the mammary glands, enhancing the formation of connective tissue and causing expansion of the milk ducts. A decrease in prolactin content leads to the reverse development of pathological processes in the mammary glands and relieves pain.

The rhythmic production and normalization of the ratio of gonadotropic hormones leads to the normalization of the second phase of the menstrual cycle.

Drug interactions

A mutual decrease in effectiveness is possible when taking dopamine receptor antagonists simultaneously, as well as interaction with dopamine receptor agonists, estrogens and antiestrogens. When taking such drugs, the patient should consult a doctor before using Cyclodinone®.

Interaction with other drugs is currently unknown.

Dosage regimen

The drug is taken orally, 1 tablet. 1 time/day, in the morning, without chewing, with a sufficient amount of water (100-200 ml).

The duration of treatment is at least 3 months (without a break during menstruation). Use of the drug for more than 3 months should be discussed with your doctor.

If symptoms of the disease persist while using the drug, the patient should consult a doctor. If after completion of treatment complaints reappear, you should consult your doctor.

There are no data on recommended doses for
renal or hepatic impairment
.

The drug should not be used to treat children and adolescents under 18 years of age.

Overdose

No cases of overdose have been registered.
Symptoms:
in case of overdose, the severity of dose-dependent side effects may increase.

Treatment:

carrying out symptomatic therapy.

Side effect

Severe allergic reactions with facial swelling, shortness of breath and dysphagia are possible. Allergic reactions from the skin (rash, urticaria), gastrointestinal disorders (pain in the epigastric region, nausea), headache, dizziness, acne, menstrual irregularities may occur. The frequency of adverse reactions is unknown, i.e. cannot be estimated based on the available data.

If the above-described adverse reactions or other adverse reactions not listed in the instructions occur, you should stop taking the drug and consult a doctor.

special instructions

Instructions for patients with diabetes: the carbohydrates included in 1 tablet of the drug are less than 0.03 bread units (XE).

If you currently have or have a history of malignant estrogen-dependent tumors, or a history of pituitary gland diseases, a doctor’s consultation is required.

The possibility of masking the clinical manifestations of a pituitary tumor secreting prolactin while taking the drug should be taken into account.

If you feel tension and swelling of the mammary glands and/or weakness, depression, as well as menstrual irregularities, you should consult a doctor for additional examination.

In order to monitor the effectiveness of the treatment, a monthly consultation with a doctor is recommended.
Effect on the ability to drive vehicles and operate machinery
When used in recommended doses, the drug does not affect the ability to perform potentially dangerous activities that require increased concentration of attention and speed of psychomotor reactions (driving vehicles, working with moving mechanisms, working as a dispatcher and operator) .

Storage conditions

The drug should be stored in its original packaging out of the reach of children at a temperature not exceeding 25°C.

Best before date

Shelf life: 3 years. Do not use the drug after the period indicated on the package.

Use during pregnancy and breastfeeding

Restrictions during pregnancy - Contraindicated. Restrictions when breastfeeding - Contraindicated.

The drug should not be used during pregnancy and breastfeeding.

As the regularity of the menstrual cycle increases while taking the drug, the likelihood of pregnancy increases. If pregnancy occurs, the drug should be discontinued.

Use in children

Restrictions for children - Contraindicated.

The drug should not be used to treat children and adolescents under the age of 18 years.

Terms of sale

The drug is available without a prescription.

Contacts for inquiries

BIONORICA LLC (Russia)

119619 Moscow, 6th st. New Gardens, 2, bldg. 1 Tel/fax

Instructions for use of Cyclodinone (Method and dosage)

How to take the drug?

The drops are taken orally, after shaking the bottle. When taking all forms of release, you must wash them down with water.

Instructions for use of drops

The medicine in this form of release is taken orally, 40 drops once a day in the morning, washed down with water.

Cyclodinone tablets, instructions for use

The tablets are also taken orally, 1 piece once a day, in the morning, with water and without chewing.

Treatment is usually carried out over the course of a quarter, without interruption during menstruation. After relief of symptoms and improvement of the patient's condition, therapy should be continued for another 2-3 weeks.

If after completion of treatment complaints reappear, you should consult your doctor.

On what day of the cycle should you start taking the medication?

You can start taking the drug regardless of the duration of your menstrual cycle.

What is the drug and how does it work?

Cyclodinone is a herbal medicine. Its main component is common twig. The drug is available in the form of tablets and drops.

Release form	Concentration of active ingredient in 1 serving	Packaging volume
Pills	4 mg	30 and 60 tablets
Drops	3.4 mg	50 and 100 ml

Medicine:

Used for cycle disorders to reduce prolactin levels. With an increased concentration of this hormone, ovulation is absent.
Normalizes female hormonal levels.
Helps restore reproductive function.

Under the influence of this medication, the level of female sex hormones is normalized, the rhythm of the menstrual cycle is restored, and as a result, the desired pregnancy occurs.

special instructions

depression while taking the medication, you should consult a doctor.

Drops are not recommended for use after anti-alcohol treatment has been completed.

Lactose intolerance (the tablets contain lactose) may cause diarrhea and pain in the epigastric region.

Patients with diabetes are allowed to take Cyclodinone both in drops and tablets, since a single dose of this drug contains up to 0.03 XE.

Does not affect the ability to drive vehicles.

Why and for what purpose is Cyclodinone prescribed when planning pregnancy?

Taking this drug is not indicated for all women. Therefore, you should understand why Cyclodinone is prescribed and what its benefits are for the female body.

For polycystic disease

With the development of polycystic disease, there is a disruption in the functioning of the ovaries. Estrogen synthesis becomes insufficient, and prolactin is produced in excessive quantities. Conception becomes impossible. With the help of the medication, hormonal levels are normalized.

For hyperprolactinemia

Functional hyperprolactinemia is considered one of the common causes of infertility. The disorder is characterized by an excessive increase in prolactin levels and a decrease in the concentration of sex hormones. As a result, ovulation does not occur and the corpus luteum does not form.

For those who have taken Cyclodinone for several months, as a rule, these problems soon disappear. The reproductive system begins to function fully.

After a frozen pregnancy

In order to restore hormonal levels after a frozen pregnancy, Cyclodinone is also often prescribed. After successful fertilization, active synthesis of prolactin begins in the woman’s body.

If it was not possible to carry the baby to term (and this is a lot of stress), the level of this hormone may remain elevated for a long time. This in turn prevents successful fertilization.

Cyclodinone analogs

Level 4 ATC code matches:
Floragin

Agnucaston

Bioselac

Trioginal

Qi-Klim

Saguenite

Gynekohel

Mastodinon

Klimaktoplan

Mamoklam

Tazalok

Gynoflor E

Klimadinon

Klimadinon Uno

Klimalanin

The most common analogues of Cyclodinone are listed below: Prefemin , Agnukaston, Mastodinone, Bromocriptine, Indinol, Mastopol.

Reviews about Cyclodinone

Reviews from doctors about Cyclodinone indicate that the drug is quite effective when used to normalize the cycle. Reviews for mastopathy and menopause characterize the product on the positive side. Among the disadvantages, high prices and frequent negative effects on the skin with long-term use are often noted.

The online forum discussions do not reveal the difference in the clinical effects of different dosage forms (tablets, drops). It is also worth recalling that pregnancy is a strict contraindication for taking the drug.

Contraindications

Not all women can take Cyclodinone when planning pregnancy.

There are a number of contraindications to taking this medication:

individual intolerance to the components of the drug;
malignant formations;
pregnancy;
lactation period;
age less than 18 years.

The drug should be taken with caution in case of epilepsy and liver diseases.

Side effects and effects

Those who have taken this medication sometimes experience side effects. As a rule, they are observed with prolonged use of the drug and increasing dosage.

The following negative changes are possible:

nausea;
gagging;
abdominal pain;
rash;
hives;
migraine;
excessive nervous excitement;
dizziness;
labored breathing.

If such symptoms appear, you should stop taking the medication and discuss further treatment tactics with a gynecologist.

Cyclodinone price, where to buy

The price of Cyclodinone in tablets No. 30 (60 tablets per package is quite difficult to find on sale) in Russia is 430-640 rubles. The price of Cyclodinone drops 50 ml ranges from 450 to 510 rubles.

Ukraine gives approximately comparable prices: the cost of the indicated package of tablets reaches 340 hryvnia, and buying 50 ml of drops will cost no more than 260 hryvnia.

Despite the fact that Cyclodinone is not a hormonal drug, it is sold in pharmacies only by prescription.