pharmachologic effect
Venotonic effect: reduces the distensibility of veins, increases the tone of veins, reduces venous congestion, enhances the vasoconstrictor effect of adrenaline, norepinephrine. One tablet contains 600 mg of diosmin, which is the optimal daily dose for the venotonic effect.
Angioprotective effect: improves microcirculation; increases capillary resistance; reduces their permeability.
Effect on the lymphatic system: improves lymphatic drainage, increases the tone and frequency of contraction of lymphatic capillaries, increases their functional density, reduces lymphatic pressure.
Has an anti-edematous effect. Reduces symptoms of inflammation (dose-dependent effect).
Reduces the adhesion of leukocytes to the venous wall and their migration into paravasal tissues; improves oxygen diffusion and perfusion in tissue. Blocks the production of free radicals, the synthesis of prostaglandins and thromboxane.
A decrease in mean venous pressure in the system of superficial and deep veins of the lower extremities was confirmed, demonstrated in a double-blind, placebo-controlled study conducted under Doppler ultrasound control; as well as increased systolic and diastolic blood pressure in patients with postoperative orthostatic hypotension.
Why is blood thinned?
Bleeding disorders can occur at any age. First of all, this problem concerns everyone over 50 years of age. Thick blood puts additional stress on the heart. This is due to the fact that it is more difficult to pump thick liquid through a huge circulatory system; more power is required, which the heart must produce. At the same time, the pulse becomes faster and the tremors become stronger. During such work, the heart muscle wears out faster, the valves fail, and the tightness of the atria is compromised.
Another danger of thick blood is the formation of blood clots. Thrombi are individual clots that form as a result of platelets sticking to each other. The resulting blood clots attach to the walls of blood vessels and interfere with blood flow. But the worst thing for a person’s life is a detached blood clot. As it rushes through the circulatory system, the current carries it to the lungs and then to the heart. By blocking the lumen of an artery in one of the organs, a blood clot causes an ischemic stroke, which often leads to death.
In addition, thick blood cannot supply organs and tissues with nutrients in a timely manner, which is why the body suffers from mild forms of hypoxia. The thicker the biological fluid, the more difficult it is for it to rise from the lower extremities to the heart. As a result, blood stagnation in the veins, thrombosis and varicose veins appears.
Pharmacokinetics
Suction and distribution
After oral administration, it is quickly absorbed from the gastrointestinal tract and is found in plasma 2 hours after administration. Cmax in blood plasma is achieved 15 hours after administration.
It is evenly distributed and accumulates in all layers of the wall of the vena cava and saphenous veins of the lower extremities, to a lesser extent in the kidneys, liver and lungs and other tissues.
Selective accumulation of diosmin and/or its metabolites in venous vessels reaches a maximum at 9 hours after administration and persists for 96 hours.
Removal
It is excreted mainly by the kidneys - 79%, as well as by the intestines - 11%, with bile - 2.4%.
Phlebodia 600
Phlebodia 600 (active ingredient - diosmin) is an original venoprotector from the French pharmaceutical company. The drug has a venotonic effect (dose-dependently increases their tone, reduces distensibility, prevents venous stagnation), accelerates the outflow of lymph, thereby ensuring the implementation of the drainage function (tons and increases the frequency of contraction of the muscular membrane of the lymphatic capillaries, increases their functional activity, reduces pressure in the lymphatic bed) , stimulates blood flow in the capillary bed (dose-dependently increases vascular resistance, reduces the permeability of capillary walls), prevents the adhesion of leukocytes to the walls of veins and inhibits their movement into paravenous tissue, improves the diffusion of molecular oxygen and promotes oxygenation of skin tissue. In addition to this, phlebodia 600 exhibits an anti-inflammatory effect, enhances the vasoconstrictor effect of catecholamines, blocks the reproduction of free radicals, the synthesis of inflammatory mediators and allergic reactions of prostaglandins and thromboxane. The drug is quickly absorbed from the gastrointestinal tract and enters the systemic circulation in therapeutically significant concentrations within 2 hours from the moment of administration. The maximum concentration of the active substance in the blood plasma is observed 5 hours after administration. The drug is evenly distributed and accumulates throughout the walls of the vena cava and superficial veins of the legs, as well as, to a lesser extent, in the internal organs (kidneys, liver, lungs). The accumulation of phlebodia 600 and its metabolites in the vessels of the venous bed reaches its highest level at 9 hours after oral administration and persists for 4 days. The main part of the drug is excreted by the kidneys, the remaining amount is excreted through the intestines.
Phlebodia 600 is available in tablet form. Before starting a course of medication, you should consult a specialist. For varicose veins with localization of the pathological process in the veins of the lower extremities, as well as for swelling, pain and cramps resulting from chronic lymphovenous insufficiency, the drug is taken on an empty stomach, 1 tablet per day.
The duration of treatment is usually 2 months. For acute hemorrhoids (or exacerbation of chronic) phlebodia 600, take 2-3 tablets per day with meals for 1 week. If for some reason a dose of the drug is missed, you should not compensate for the omissions by taking additional doses (pharmacotherapy continues as usual at the same doses). Treatment of acute hemorrhoids should be comprehensive (in other words, not based on one drug). If the clinical effect is not sufficiently pronounced, the patient should be referred for additional examination and adjustments to treatment should be made.
The effectiveness of Phlebodia 600 has been demonstrated in a number of clinical studies, the largest of which involved about 7,000 thousand patients. As part of this study, participants took 1 tablet of the drug per day (in acute cases - 2 tablets). Patients were medically examined before and at the end of the first month of treatment. In general, observation lasted for 2 months. Study participants were instructed to avoid other phlebotonics and to avoid significant adjustments to their lifestyle and routine habits (including dietary preferences and physical activity level). The results obtained at the end of the clinical trial allowed us to state the high therapeutic effectiveness of phlebodia 600 and determine the optimal ways to use the drug. The drug showed its best side, surpassing its competitors in the pharmacological “niche”. Thus, with the use of phlebodia 600, more than 80% of positive outcomes were obtained, while for other venotonics this figure did not exceed 40%. It was noted that the effectiveness of therapy depends on its duration. Thus, good results obtained by the end of the first month of the drug course, provided that the drug is continued, are transformed into excellent ones.
Dosage regimen
The drug is intended for oral administration.
For chronic lymphovenous insufficiency
Prescribe 1 tablet/day in the morning, preferably before meals. The duration of therapy is usually 2 months.
For acute hemorrhoids and exacerbation of chronic hemorrhoids
the drug is prescribed in the first 4 days, 1 tablet. 3 times/day, during meals; in the next 3 days - 1 tablet. 2 times/day, during meals. If symptoms recur, the course of treatment can be repeated as recommended by your doctor.
For chronic hemorrhoids after relief of acute phenomena
It is recommended to continue taking the drug 1 tablet. 1 time/day for 1-2 months.
If one or more doses of the drug are missed, it is necessary to continue using the drug as usual and at the usual dose.
Before using the drug, the patient should consult a doctor.
How to take and dose the medicine?
A course of treatment with this medication for circulatory disorders in the venous vessels usually lasts approximately 30 days. The procedure involves daily use of tablets in the morning before meals. If the drug is used to treat disorders in the lymphatic system, then the duration of treatment is at least 60 days. To combat other diseases, the course of taking the drug is consistent with the instructions and the attending physician, and looks like this:
- Chronic varicose veins, which manifests itself with symptoms such as swelling, fatigue and aching pain, are treated over 3-4 months; tablets must be taken every day.
- If there are necrotic skin lesions, the course of therapy can last up to six months; there is often a need for a second course after 2-3 months.
- When treating hemorrhoidal inflammation, Flebodia 600 is taken 3 times a day for the first 7 days, then 1 tablet per day is taken. The course of treatment usually lasts 1-2 months.
Side effect
The incidence of adverse reactions is presented as follows: very often (>1/10 cases), often (>1/100 and 1/1000 and 1/10000 and
The following adverse reactions have been reported while taking Phlebodia 600.
From the gastrointestinal tract:
rarely - dyspeptic disorders (heartburn, nausea, abdominal pain).
From the side of the central nervous system:
rarely - headache.
If any of the side effects indicated in the instructions are aggravated or any other side effects not specified in the instructions are noted, the patient should inform the doctor.
What to do if the ban is violated?
In case of violation of warnings about the combined use of medicine and alcoholic beverages, the following actions must be taken:
- stop further alcohol consumption;
- Drink plenty of water for the next four hours;
- in the instructions for the drug you need to read the subsection on contraindications and begin to act in accordance with it;
- during a course of treatment, the period of abstinence from alcoholic beverages is determined by the attending physician;
- It is imperative to seek medical help.
Use during pregnancy and breastfeeding
Pregnancy
The use of the drug during pregnancy is possible only as prescribed by a doctor in cases where the expected benefit to the mother outweighs the potential risk to the fetus.
Experimental studies have not revealed any teratogenic effects on the fetus. Until now, in clinical practice there have been no reports of cases of malformation or fetotoxic effects on the fetus when using the drug in pregnant women.
Breastfeeding period
Due to the lack of data on the excretion of the drug in breast milk, nursing women are not recommended to use the drug.
Thinning agents
The most affordable ones today are drugs based on acetylsalicylic acid, better known as Aspirin. Such medications are common in pharmacies and cost little. Due to the fact that acetylsalicylic acid carries certain risks for the hematopoietic system and can cause gastric bleeding or ulcers, medicine has actively begun to work on the creation of drugs free from aspirin. Such dosage forms are available in pharmacies today. This group of drugs is divided into two subgroups
- antiplatelet agents that prevent blood cells from sticking together.
- anticoagulants, which prevent the formation of fibrin clots during coagulation.
Such drugs can be prescribed not only to older people to thin the blood, but also to pregnant women, in order to ensure the best blood flow between mother and fetus. A course of taking medications from this group saturates the blood with oxygen, which is very important for the developing fetus.
