Veins are blood vessels that carry blood to the heart. In turn, blood is collected in the veins from capillaries. With healthy arteries, the circulatory system works stably. But what happens if problems arise with the veins? Swelling, pain in the legs, slight numbness, goosebumps, heaviness, impaired sensitivity in the form of paresthesia, convulsions, trophic disorders. These signs, repeated day after day, are most likely recognized by the doctor as venous insufficiency.
Excess body weight can lead to varicose veins
Chronic venous insufficiency
Chronic venous insufficiency is a common peripheral vascular disease that occurs as a result of impaired blood flow through the veins of the lower extremities and changes in the permeability of the vascular wall. Most often, venous insufficiency develops in women. The disease occurs when the valves that close the veins are unable to prevent blood from flowing back due to increased pressure on them. As a result, this leads to stretching of the walls of the venous vessels. The permeability of the vascular wall for blood and plasma proteins increases, swelling and compaction of adjacent tissues appear. Where small vessels are compressed, areas of ischemia (insufficient blood supply with oxygen) occur, which contributes to the formation of trophic ulcers.
The main risk factors for the development of chronic venous insufficiency include:
- weakness of the muscular wall of the veins (hereditary);
- overweight and obesity;
- pregnancy and childbirth;
- long-term constant work in a standing or sitting position, with limited movement (cooks, office workers, surgeons, etc.);
- chronic constipation;
- fluctuations in hormonal levels in women (contraception with hormonal drugs, hormonal treatment during menopause, etc.);
- wearing tight underwear and clothing, corsets.
The following stages of development of varicose veins are distinguished:
- Stage 0 – no major symptoms upon examination.
- Stage I - “morning fatigue” of the legs, complaints of intermittent swelling in the evenings (disappears in the morning).
- Stage II – persistent swelling, skin pigmentation disorders; some areas of the skin become thicker, the skin above them cannot be folded (lipodermatosclerosis), redness appears on the skin, accompanied by itching and weeping (eczema).
- Stage III – the formation of trophic ulcers (active or healed), difficult to treat with medication.
The disease is accompanied by pain of varying intensity and the presence of evening cramps. In the treatment of varicose veins in the early stages, compression with elastic bandages and compression hosiery, physiotherapy and therapy in a sanatorium are used.
special instructions
During treatment with Detralex, some of its features should be taken into account. This will help prevent complications and achieve the desired result of therapy.
Use during pregnancy and lactation
The use of the medicine is contraindicated in the first 3 months of pregnancy and during breastfeeding, since there is insufficient information about its safety during this period. If necessary, the doctor can prescribe pills to women in the second and third trimester of pregnancy. The duration of use and dose of Detralex during pregnancy are determined taking into account the mother’s well-being and the diagnosis.
Detrilex is contraindicated in the first trimester of pregnancy; in the subsequent period it is prescribed with great caution
Children
The drug is prohibited for use among children. There is no information about its effect on the child’s body and the possibility of developing side effects. The drug is prescribed to patients over 18 years of age.
Effect on concentration
The medicine does not affect the speed of mental and physical reactions, it is allowed among groomsmen and people whose work activities require increased concentration.
Combination with other drugs
According to the study, Detralex does not affect the action of drugs from other drug groups, but treating the disease with the help of the drug is allowed in combination with other drugs as prescribed by a specialist.
Interaction with alcohol
There was no direct interaction between alcoholic beverages and the action of Detralex, but it has been proven that alcohol has a detrimental effect on the course of hemorrhoids. Therefore, the combination of a disease and taking medications to treat it is considered unacceptable.
Composition and therapeutic effect of the drug Detralex
A therapeutic course of venotonic drugs is also prescribed. Detralex is used most often.
It is based on flavonoids - substances of plant origin. The active ingredients are hesperidin and diosmin, which eliminate venostasis (blood stagnation).
Detralex restores and increases the tone of venous walls and blood microcirculation in small vessels. Capillaries become elastic and plastic, their permeability decreases. The medicine reduces the distensibility of the veins, which reduces the release of plasma and proteins from the bloodstream into the surrounding tissues.
Detralex has an angioprotective and venotonic effect.
In addition, the drug Detralex increases the outflow of lymph, thereby providing lymphatic drainage.
Composition of the drug
The use of Detralex for hemorrhoids provides a positive result due to its uniquely selected composition. The active components of the drug are the following components:
- Diosmin;
- Hesperidin;
- magnesium stearate;
- gelatin;
- glycerol;
- hypromellose;
- titanium dioxide and others.
Diosmin is the main active ingredient that has a tonic effect on capillaries and blood vessels. Thanks to it, the walls of veins are strengthened, their permeability decreases, and elasticity increases. Diosmin prevents stagnation, strengthens the walls of blood vessels, and increases local immunity. The component undergoes a unique treatment (micronization), which allows it to be absorbed into the blood faster. Thanks to this, the effect of the drug occurs faster than when using similar products.
Hesperidin has an equally important effect. It is a flavonoid that helps enhance the effects of Diosmin. In addition, the component prevents the adhesion of leukocytes to the endothelial wall, thereby reducing the negative impact of substances synthesized during the inflammatory process on the valve flaps of blood vessels and veins.
Indications
Indications for the use of the drug Detralex are organic and functional venous-lymphatic insufficiency of the lower extremities. Detralex is also used for the symptomatic treatment of acute hemorrhoidal attacks.
The medicine Detralex can be used for tired legs
Detralex is indicated for:
- pain;
- cramps of the lower extremities;
- feeling of heaviness and fullness in the legs;
- "fatigue" in the legs.
- swelling of the lower extremities;
- trophic changes in the skin and subcutaneous tissue;
- venous trophic ulcers.
Side effects
When taking the drug Detralex, in rare cases, the following adverse reactions may develop:
- from the gastrointestinal tract: dyspepsia, diarrhea, nausea, vomiting, colitis;
- from the central nervous system: headache, dizziness, general malaise;
- from the skin: urticaria, itching, rash, isolated swelling of the face, eyelids, lips, angioedema.
If any side effects occur, you should consult your doctor and adjust your treatment.
Contraindications
According to a medical study regarding Detralex, it was proven that the drug is well tolerated by patients and rarely causes undesirable effects. If you use the tablets correctly, following the recommendations of your doctor, negative consequences can be avoided even when taking the drug for a long time.
In isolated cases, personal intolerance to the components of Detralex occurs, so its use among such patients is contraindicated. Before prescribing a medicine, you should definitely read the list of its components.
Detralex has some contraindications, so it is recommended to use the medicine only as prescribed by a doctor.
The drug is prohibited for women during breastfeeding, as there is no data on its safety during this period. Taking Detralex during pregnancy is allowed only in the second and third trimester as prescribed by a doctor in case of high need.
How to take Detralex?
Detralex is used as a symptomatic remedy for varicose veins and hemorrhoids. Often, the attending physician prescribes therapy that includes venotonic ointments or gels. When treating hemorrhoids, rectal suppositories and ointments can be used to relieve pain and inflammation, improve vascular tone, reduce blood clots and stop bleeding.
Before taking the medicine, you must carefully read the instructions
Detralex tablets are intended for oral use. Depending on the indications and general condition of the patient, the daily dose of the drug and the duration of the course of therapy are determined by the doctor.
- Venous-lymphatic insufficiency: 2 tablets/day (1 tablet in the middle of the day and 1 tablet in the evening with meals).
- Chronic hemorrhoids: 2 tablets/day (1 tablet in the middle of the day and 1 tablet in the evening with meals). After 7 days, you can change the dosage regimen of Detralex and use the drug 2 tablets once, with meals.
- Acute hemorrhoids: 6 tablets/day (2-3 tablets at equal intervals) for 4 days, then 4 tablets/day (2 tablets in the morning and 2 tablets in the evening) for the next 3 days.
The duration of treatment with Detralex depends on the severity of the disease, the patient’s medical history and, on average, is about 2-3 months. As prescribed by a doctor, the therapeutic course can be repeated.
Please note that taking Detralex for acute hemorrhoids does not replace specific therapy. That is why it is necessary to contact a specialist who will prescribe a therapeutic course, including drug treatment.
Tips for taking the drug
For people with impaired venous circulation, to increase the effectiveness of the drug, it is recommended:
- avoid standing for long periods of time and prolonged exposure to the sun;
- adjust body weight and diet;
- wear compression stockings to improve blood circulation;
- hike.
As for drinking alcohol during treatment with Detralex, there is no direct prohibition. You just need to consider the effects of alcoholic beverages on the cardiovascular system. Thus, alcohol increases blood pressure and dilates blood vessels, in turn, a sharp blood flow provokes stagnation. That is, alcohol reduces the effectiveness of treatment.
Detralex 1000 mg, 30 film-coated tablets
Registration Certificate Holder
Les Laboratoires Servier (France)
Dosage form
Medicine - Detralex® (Detralex®)
Description
Film-coated tablets
orange-pink, oval, with a notch on both sides; appearance of the tablet on the break: from pale yellow to yellow with a heterogeneous structure.
1 tab.
purified micronized flavonoid fraction 1000 mg, incl. diosmin 900 mg (90%) flavonoids in terms of hesperidin 100 mg (10%)
Excipients
: purified water, gelatin, magnesium stearate, microcrystalline cellulose, sodium carboxymethyl starch type A, talc.
Film shell composition:
sodium lauryl sulfate, macrogol 6000, orange-pink premix for film shell, consisting of: glycerol, magnesium stearate, hypromellose, macrogol 6000, red iron oxide dye, titanium dioxide, yellow iron oxide dye.
9 pcs. - blisters (2) - cardboard packs, with first opening control (if necessary). 9 pcs. - blisters (3) - cardboard packs, with first opening control (if necessary). 10 pieces. - blisters (3) - cardboard packs, with first opening control (if necessary). 10 pieces. - blisters (6) - cardboard packs, with first opening control (if necessary).
Indications
Detralex® is indicated for the treatment of symptoms of chronic venous diseases (elimination and relief of symptoms).
Treatment of symptoms of venous-lymphatic insufficiency:
- pain;
- spasms of the lower extremities;
- feeling of heaviness and fullness in the legs;
- "tired" legs.
Treatment of manifestations of venous-lymphatic insufficiency:
- swelling of the lower extremities;
- trophic changes in the skin and subcutaneous tissue;
- venous trophic ulcers.
Symptomatic treatment of acute and chronic hemorrhoids.
Contraindications for use
- hypersensitivity to the active components or excipients included in the drug;
- pregnancy (limited or no experience with use);
- period of breastfeeding (experience of use is limited or absent);
- children under 18 years of age (no experience of use).
pharmachologic effect
Pharmacodynamics
Detralex® has venotonic and angioprotective properties. The drug reduces the distensibility of veins and venous stagnation, reduces capillary permeability and increases their resistance. The results of clinical studies confirm the pharmacological activity of the drug in relation to indicators of venous hemodynamics.
A statistically significant dose-dependent effect of the drug Detralex® was demonstrated for the following venous plethysmographic parameters: venous capacity, venous distensibility, venous emptying time.
The optimal dose-effect ratio is observed when taking 1000 mg per day.
Detralex® increases venous tone: using venous occlusion plethysmography, a decrease in the time of venous emptying was shown. In patients with signs of severe microcirculation disorders, after treatment with Detralex® there is a (statistically significant compared to placebo) increase in capillary resistance, assessed by angiostereometry.
The therapeutic effectiveness of the drug Detralex® has been proven in the treatment of chronic diseases of the veins of the lower extremities, as well as in the treatment of hemorrhoids.
Drug interactions
Clinical studies have not been conducted to study the interaction of Detralex® with other drugs.
To date, no cases of drug interactions have been reported.
Dosage regimen
Inside.
The tablets should be swallowed with water. The score on the tablet is intended solely for scoring purposes to make it easier to swallow.
The recommended dose for venous-lymphatic insufficiency is 1 tablet/day, preferably in the morning, during meals.
The duration of treatment can be several months (up to 12 months). In case of recurrence of symptoms, on the recommendation of a doctor, the course of treatment can be repeated.
The recommended dose for acute hemorrhoids is 3 tablets/day (1 tablet in the morning, afternoon and evening) for 4 days, then 2 tablets/day (1 tablet in the morning and evening) for the next 3 days.
The recommended dose for chronic hemorrhoids is 1 tablet/day.
Overdose
Symptoms: data on cases of overdose of Detralex® are limited. The most common adverse reactions in cases of overdose were gastrointestinal disorders (diarrhea, nausea, abdominal pain) and skin reactions (itching, rash).
Treatment: assistance in case of overdose should consist of eliminating clinical symptoms.
In case of overdose of the drug, you should immediately consult a doctor
Side effect
Side effects of Detralex® observed during clinical trials were mild. Mostly gastrointestinal disorders were observed (diarrhea, dyspepsia, nausea, vomiting).
While taking the drug Detralex®, the following side effects were reported in the following gradation: very often (≥1/10), often (≥1/100, <1/10), infrequently (≥1/1000, <1/100) , rare (≥1/10,000, <1/1000), extremely rare (<10,000), unspecified frequency (frequency cannot be calculated from available data).
From the side of the central nervous system: rarely - dizziness, headache, general malaise.
From the gastrointestinal tract: often - diarrhea, dyspepsia, nausea, vomiting; infrequently - colitis; unspecified frequency - abdominal pain.
From the skin: rarely - skin rash, itching, urticaria; unspecified frequency - isolated swelling of the face, lips, eyelids; in exceptional cases - angioedema.
The patient should be informed that if any symptoms appear during therapy, incl. Undesirable reactions and sensations not mentioned in the instructions, as well as changes in laboratory parameters, should be reported to your doctor.
special instructions
Before starting to use the drug Detralex®, the patient is recommended to consult a doctor.
In the treatment of hemorrhoids, the use of Detralex® does not replace the specific treatment of other diseases of the rectum and anal canal. When using the drug on your own, do not exceed the maximum periods and recommended doses specified in the “Dosage regimen” section. If symptoms of hemorrhoids persist after the recommended course of therapy, you should be examined by a proctologist, who will select further therapy.
In the presence of venous circulation disorders, the maximum effect of treatment is ensured by combining therapy with a healthy (balanced) lifestyle: it is advisable to avoid long exposure to the sun, long periods of standing, and it is also recommended to reduce excess body weight. Walking and, in some cases, wearing special stockings helps improve blood circulation.
The patient should immediately consult a doctor if the condition worsens or does not improve during treatment.
Impact on the ability to drive vehicles and machinery
Clinical studies have not been conducted to study the effect of the drug Detralex® on the ability to drive a car and perform work that requires a high speed of mental and physical reactions. However, based on the available safety data, it can be concluded that Detralex® does not affect (does not have a significant effect) on these processes.
Storage conditions
The drug should be stored out of the reach of children at a temperature not exceeding 30°C.
Best before date
Shelf life: 4 years. Do not use after the expiration date stated on the package.
Use during pregnancy and breastfeeding
Restrictions during pregnancy - Contraindicated. Restrictions when breastfeeding - Contraindicated.
Pregnancy
There are no or limited data on the use of purified micronized flavonoid fraction in pregnant women.
Animal studies have not shown reproductive toxicity.
As a precautionary measure, it is preferable not to use Detralex® during pregnancy.
Breastfeeding period
It is unknown whether the purified micronized flavonoid fraction (metabolites) passes into human breast milk.
A risk for newborns and infants cannot be excluded. It is necessary to make a decision either to stop breastfeeding or to cancel therapy with Detralex®, taking into account the benefits of breastfeeding for the child and the benefits of therapy for the woman.
Effect on reproductive function
Reproductive toxicity studies showed no effect on reproductive function in rats of either sex
Use in children
Restrictions for children - Contraindicated. Use in children and adolescents under 18 years of age is contraindicated.
Terms of sale
The drug is available without a prescription.
Contacts for inquiries
SERVIER JSC (Russia)
125196 Moscow st. Lesnaya, 7, fl. 7/8/9 BC “White Gardens” Tel. Fax
Detralex during pregnancy and lactation
Detralex is not recommended for pregnant women
The use of Detralex by pregnant women and children during breastfeeding is not recommended due to insufficient research and clinical data. There is no information on the occurrence of side effects in pregnant women, nor has there been any information recorded on the ability of the active ingredients - diosmin and hesperidin - to pass into breast milk during breastfeeding, as well as in children during breastfeeding.
Stages of the disease and its classification
Like most other diseases, varicose veins go through several stages. They differ from each other in the distribution of pathology and its symptoms. It is customary to distinguish three stages:
- compensation;
- subcompensation;
- decompensation.
It must be borne in mind that complications can occur at any of these stages, but the maximum likelihood of this is possible only at the last two. Varicose veins can serve as a trigger for the development of the following pathologies:
- trophic eczema;
- deep vein thrombosis;
- erysipelas;
- thrombophlebitis.
Analogues of the drug Detralex
For problems with veins and varicose veins, it is possible to use Detralex analogues. They can have a similar therapeutic effect, but have their own contraindications, dosages and possible side effects. Be sure to consult a specialist!
So the pharmaceutical market offers us the following analogues of Detralex:
Venozol
The main active ingredients, like Detralex, are diosmin and hesperidin. Pharmacological action is similar to Detralex. Release form: tablets, gel and cream.
Vasocket
The active substance (diosmin) reduces the distensibility and increases the tone of the veins, thereby preventing the appearance of edema. Available in tablet form.
Antistax
Bioflavonoid drug belongs to the group of venotonic drugs. Available in tablet form.
Troxevasin
Produced under the trade names Venoruton, Troxerutin. Improves the condition of the walls of blood vessels and has an anti-edematous effect. Main forms of release: capsules, gel for topical use, solution for injection in ampoules.
Analogues of the drug Detralex
Anavenol
Combined venoprotective drug. Available in tablet form. Side effects: bleeding, dizziness, nausea. Contraindicated for children under 15 years of age.
Venoruton
Angioprotective drug. The active ingredient is hydroxyethylrutoside. Release form: tablets and gel for external use. Possible use in the second and third trimesters of pregnancy.
Ginkor fort
Venotonic and venoprotective drug It contains a standardized extract of ginkgo biloba, heptaminol hydrochloride and troxerutin. Available in the form of capsules and gel for external use. In case of overdose, blood pressure may increase. According to indications, the drug can be prescribed in the second and third trimesters of pregnancy. Contraindicated in hyperthyroidism and concomitant use of MAO inhibitors.
Detralex or Venarus?
Venarus is a generic drug. That is, it is based on the same active ingredients (diosmin and hesperidin), but the original drug (Detralex) always contains components of a higher degree of purification. Therefore, its effectiveness is higher and its tolerability is better. In addition, Venarus is characterized by lower bioavailability and more often provokes adverse reactions in the body. The drug is also contraindicated during lactation. The pharmacological action is similar to the drug Detralex. There is no fundamental difference between them. Recommendations for taking medications for varicose veins and hemorrhoids are identical.
Detralex or Phlebodia?
The active ingredient of the drug Phlebodia 600 is diosmin. But its concentration in Detralex is 450 mg/tablet (plus its enhancing hesperidin 50 mg/tablet), and Phlebodia 600 is available in the form of tablets with a diosmin concentration of 600 mg/tablet.
The medicine has a therapeutic effect similar to Detralex. It also increases the tone of the venous wall, improves blood flow, and normalizes the permeability of vascular walls.
Nevertheless, Detralex is absorbed into the body faster than its analogue, and its concentration in the blood plasma reaches its maximum after three to four hours.
Effect of medication for hemorrhoids
Treatment of hemorrhoids with Detralex is prescribed for various forms of pathology. The medicine has the necessary medicinal effect in chronic and acute disease, external and internal hemorrhoids. The result with proper use of the drug is as follows:
- decrease in the distensibility of veins;
- prevention of stagnant processes;
- reducing the risk of bleeding;
- increasing the elasticity of the walls of blood vessels;
- improvement of the condition of the walls of the veins of hemorrhoids;
- enhancing tissue regeneration of damaged vessels and capillaries;
- outflow of excess fluid;
- elimination of the inflammatory process;
- reduction of capillary fragility;
- improved blood flow.
Important! Detralex for hemorrhoids should be used strictly as prescribed by a doctor, since the drug has contraindications and self-treatment can cause some negative consequences.
Diosmin is the main active ingredient of the drug, which has a venotonic, angioprotective effect on hemorrhoids
